Aryl and heteroarylcylopropyl oxime ethers and their use as fungicides and insecticides

ABSTRACT

Certain cyclopropyl oxime ethers substituted by aryl and heterocyclic moieties possess broad spectrum fungicidal and insecticidal properties. These compounds are disclosed along with compositions containing these compounds and methods for controlling fungi and insects by the use of a fungitoxic or insecticidal amount of these compounds.

The present invention relates to certain aryl cyclopropyl oxime etherstructures, compositions containing these compounds and methods forcontrolling fungi and insects by the use of a fungitoxic or insecticidalamount of these compounds.

Compounds having certain bis oxime ether structures have been disclosedin U.S. Pat. No. 5,756,426. We have discovered certain new bis oximeethers which possess a cyclopropane substituted by aryl and heterocyclicmoieties. These novel derivatives possess broad spectrum fungicidal andinsecticidal properties.

The novel cyclopropyloxime ethers of the present invention have theFormula I:

wherein

X is N or CH; Y is O, S or NR₈;

A is selected from the group consisting of hydrogen, halo, cyano,(C₁-C₁₂)alkyl, and (C₁-C₁₂)alkoxy;

Z is O, N—OR₉ or N—R₁₀;

R₁ and R₈ are independently selected from the group consisting ofhydrogen and (C₁-C₄)alkyl;

R₂ is selected from the group consisting of hydrogen, (C₁-C₁₂)alkyl,halo(C₁-C₁₂)alkyl, (C₃-C₇)cycloalkyl, halo(C₃-C₇)cycloalkyl,(C₂-C₈)alkenyl, halo(C₂-C₈)alkenyl, (C₂-C₈)alkynyl, halo(C₂-C₈)alkynyl,cyano, (C₁-C₄)alkoxycarbonyl, aryl, aralkyl, heterocyclic, andheterocyclic(C₁-C₄)alkyl;

R₃ and R₇ are each independently selected from the group consisting ofhydrogen, (C₁-C₁₂)alkyl, halo(C₁-C₁₂)alkyl, (C₂-C₈)alkenyl,halo(C₂-C₈)alkenyl, (C₂-C₈)alkynyl, halo(C₂-C₈)alkynyl, aryl, aralkyl,heterocyclic and heterocyclic(C₁-C₄)alkyl, provided that at least one ofR₃ and R₇ is aryl, aralkyl, heterocyclic, or heterocyclic (C₁-C₄)alkyl;

R₄, R₅, and R₆ are each independently selected from the group consistingof hydrogen, (C₁-C₁₂)alkyl, halo(C₁-C₁₂)alkyl, (C₃-C₇)cycloalkyl,halo(C₃-C₇)cycloalkyl, (C₂-C₈)alkenyl, halo(C₂-C₈)alkenyl,(C₂-C₈)alkynyl, halo(C₂-C₈)alkynyl, halo, cyano, (C₁-C₄)alkoxycarbonyl,aryl, aralkyl, heterocyclic and heterocyclic(C₁-C₄)alkyl;

R₉ is selected from the group consisting of hydrogen, (C₁-C₁₂)alkyl,halo(C₁-C₁₂)alkyl, (C₃-C₇)cycloalkyl, halo(C₃-C₇)cycloalkyl,(C₂-C₈)alkenyl, halo(C₂-C₈)alkenyl, (C₂-C₈)alkynyl, halo(C₂-C₈)alkynyl,(C₁-C₄)alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heterocycliccarbonyl, (C₁-C₄)alkoxycarbonyl, aryl, aralkyl, heterocyclic andheterocyclic(C₁-C₄)alkyl;

R₁₀ is selected from the group consisting of hydrogen, (C₁-C₁₂)alkyl,halo(C₁-C₁₂)alkyl, (C₂-C₈)alkenyl, halo(C₂-C₈)alkenyl, (C₂-C₈)alkynyl,halo(C₂-C₈)alkynyl, aryl, aralkyl, heterocyclic orheterocyclic(C₁-C₄)alkyl, (C₁-C₄)alkylcarbonyl, and(C₁-C₄)alkoxycarbonyl, arylcarbonyl, aralkylcarbonyl, heterocycliccarbonyl, (C₁-C₄)alkylaminocarbonyl, arylaminocarbonyl, N—R₈R₉,N═CR₁R₁₂, (C₁-C₄)alkylsulfonyl, N=cyclopropyl, N=cyclobutyl,N=cyclopentyl, N=cyclohexyl, and arylsulfonyl;

R₁₁ and R₁₂ are each independently selected from the group consisting ofhydrogen, (C₁-C₁₂)alkyl, halo(C₁-C₁₂)alkyl, (C₁-C₁₂)alkoxy,halo(C₁-C₁₂)alkoxy, (C₃-C₇)cycloalkyl, halo(C₃-C₇)cycloalkyl,(C₂-C₈)alkenyl, halo(C₂-C₈)alkenyl, (C₂-C₈)alkynyl, halo(C₂-C₈)alkynyl,cyano, (C₁-C₄)alkoxycarbonyl, (C₁-C₄)alkylamino, aryl, aralkyl,heterocyclic, and heterocyclic(C₁-C₄)alkyl.

The aforementioned (C₁-C₁₂)alkyl, (C₂-C₈)alkenyl, (C₂-C₈)alkynyl and(C₃-C₇)cycloalkyl groups may be optionally substituted with up to threesubstituents selected from the group consisting of nitro, halomethyl,(C₁-C₄)alkoxycarbonyl, and cyano.

Unless otherwise limited, the following terms, as used herein, have thefollowing meanings.

The term “alkyl” means both branched and straight chain alkyl groupsfrom 1 to 12 carbon atoms. Typical alkyl groups are methyl, ethyl,n-propyl, iso-propyl, n-butyl, sec-butyl, isobutyl, t-butyl, n-pentyl,isopentyl, n-hexyl, n-heptyl, isooctyl, nonyl, decyl, undecyl, dodecyland the like. The term haloalkyl refers to an alkyl group substitutedwith 1 to 3 halogens.

The term “alkenyl” means an ethylenically unsaturated hydrocarbon group,straight or branched, having a chain length of 2 to 8 carbon atoms and 1or 2 ethylenic bonds. The term “haloalkenyl” means an alkenyl groupsubstituted with 1 to 3 halogen atoms. The term “alkynyl” means anunsaturated hydrocarbon group, straight or branched, having a chainlength of 2 to 12 carbon atoms and 1 or 2 acetylenic bonds.

The term “aryl” means phenyl or naphthyl, which maybe substituted withup to three substituents independently selected from the groupconsisting of halogen, cyano, trihalomethyl, phenyl, phenoxy,(C₁-C₄)alkyl, (C₁-C₄)alkoxy, (C₁-C₄)alkylthio, (C₁-C₄)alkylsulfoxide,halo(C₁-C₄)alkyl and halo(C₁-C₄)alkoxy.

Typical aryl substituents include but are not limited to 2-chlorophenyl,3-chlorophenyl, 4-chlorophenyl, 2-fluorophenyl, 3-fluorophenyl,4-fluorophenyl, 4-bromophenyl, 2-methylphenyl, 3-methyphenyl,4-methylphenyl, 2,4-dibromophenyl, 3,5-difluorophenyl,2,4,6-trichlorophenyl, 2-chloronapthyl, 3-(trifluoromethyl)phenyl,4-(trifluoromethyl)phenyl and 2-iodo-4-methylphenyl.

The term “heterocyclic” means a substituted or unsubstituted 6 memberedunsaturated ring containing one, two or three heteroatoms independentlyselected from oxygen, nitrogen and sulfur or to a bicyclic unsaturatedring system containing up to 10 atoms including one heteroatom selectedfrom oxygen, nitrogen and sulfur. The term “heterocyclic” also refers toa 5-membered unsaturated ring containing one, two, or three heteroatomsindependently selected from oxygen, nitrogen, and sulfur, preferably oneor two heteroatoms. Examples of heterocycles include but are not limitedto 2-, 3- or 4-pyridinyl, pyrazinyl, 2-, 4-, or 5-pyrimidinyl,pyridazinyl, pyrazole, triazolyl, imidazolyl, 2 or 3-thienyl, 2 or3-furyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl,oxadiazolyl, thiadiazolyl, quinolyl and isoquinolyl. If the heterocyclicring is substituted there may be up to two substituents independentlyselected from (C₁-C₄) alkyl, halogen, cyano, nitro, and trihalomethyl.

The term “aralkyl” means a group having an alkyl chain and an arylportion wherein the alkyl chain is from 1 to 10 carbon atoms and can bebranched or straight chain, preferably a straight chain, with the arylportion, as defined above, forming a terminal portion of the aralkylmoiety. Typical aralkyl moieties are optionally substituted benzyl,phenethyl, phenpropyl and phenbutyl moieties. Typical benzyl moietiesare 2-chlorobenzyl, 3-chlorobenzyl, 4-chlorobenzyl, 2-fluorobenzyl,3-fluorobenzyl, 4-fluorobenzyl, 4-trifluoromethylbenzyl,2,4-dichlorobenzyl, 2,4-dibromobenzyl, 2-methylbenzyl, 3-methylbenzyl,and 4-methylbenzyl. Typical phenethyl moieties are2-(2-chlorophenyl)ethyl, 2-(3-chlorophenyl)ethyl,2-(4-chlorophenyl)ethyl, 2-(2-fluorophenyl)ethyl,2-(3-fluorophenyl)ethyl, 2-(4-fluorophenyl)ethyl,2-(2-methylphenyl)ethyl, 2-(3-methyl-phenyl)ethyl,2-(4-methylphenyl)ethyl, 2-(4-trifluoromethylphenyl)ethyl,2-(2,4-dichlorophenyl)-ethyl, 2-(3,5-dimethoxyphenyl)ethyl. Typicalphenpropyl moieties are 3-phenylpropyl, 3-(2-chlorophenyl)propyl,3-(3-chlorophenyl)propyl, 3-(4-chlorophenyl)propyl,3-(2,4-dichloro-phenyl)propyl, 3-(2-fluorophenyl)propyl,3-(3-fluorophenyl)propyl, 3-(4-fluorophenyl)propyl,3-(2-methylphenyl)propyl, 3-(3-methylphenyl)propyl,3-(4-methylphenyl)ethyl, 3-(4-trifluoromethylphenyl)propyl,3-(2,4-dichlorophenyl)propyl and 3-(3,5-dimethylphenyl)propyl. Typicalphenbutyl moieties include are 4-phenylbutyl, 4-(2-chlorophenyl)butyl,4-(3-chlorophenyl)butyl, 4-(4-chlorophenyl)butyl,4-(2-fluorophenyl)butyl, 4-(3-fluorophenyl)butyl,4-(4-fluorophenyl)butyl, 4-(2-methylphenyl)butyl,4-(3-methylphenyl)butyl, 4-(4-methylphenyl)butyl and4-(2,4-dichlorophenyl)butyl.

Halogen or halo is meant to include iodo, fluoro, bromo and chloromoieties.

Because of the C═C or C═N double bonds, the novel compounds of thegeneral Formula I may be obtained in preparation as E/Z isomericmixtures. These isomers can be separated into individual components byconventional means. The cyclopropanes of Formula I may be obtained inpreparation as cis and trans isomeric mixtures which can be separatedinto individual components by conventional means. Both the individualisomeric compounds and mixtures thereof form subjects of the inventionand can be used as fungicides and insecticides.

The present invention also includes the enantiomorphs, salts andcomplexes of Formula I.

A preferred embodiment of this invention are the compounds,enantiomorphs, salts and complexes of Formula II where A is hydrogen, R₁and R₂ are hydrogen or (C₁-C₄)alkyl, R₃, R₄, R₅ and R₆ are hydrogen, R₇is aryl, aralkyl, or heterocyclic, Z is N—OR₉ where R₉ is (C₁-C₄)alkyl,and X and Y are as defined above.

A more preferred embodiment of this invention are the compounds,enantiomorphs, salts and complexes of Formula III where (in Formula II)X is N, Y is NH, R₁, R₂ and R₉ are methyl, A is hydrogen, and R₇ isaryl.

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula IV, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═Z═O, and where R₂, R₃, and R₇ are definedin Table 1.

TABLE 1 Compd. R₂ R₃ R₇ 1.1 H H Ph 1.2 H H 4-Cl(Ph) 1.3 H H 4-Br(Ph) 1.4H H 4-F(Ph) 1.5 H H 4-OCH₃(Ph) 1.6 H H 4-CF₃(Ph) 1.7 H H 4-NO₂(Ph) 1.8 HH 2,4-Cl(Ph) 1.9 H H 2,4-F(Ph) 1.10 H H 3,4-F(Ph) 1.11 CH₃ H Ph 1.12 CH₃H 2-Cl(Ph) 1.13 CH₃ H 3-Cl(Ph) 1.14 CH₃ H 4-Cl(Ph) 1.15 CH₃ H 2-Br(Ph)1.16 CH₃ H 3-Br(Ph) 1.17 CH₃ H 4-Br(Ph) 1.18 CH₃ H 2-F(Ph) 1.19 CH₃ H3-F(Ph) 1.20 CH₃ H 4-F(Ph) 1.21 CH₃ H 2-OCH₃(Ph) 1.22 CH₃ H 3-OCH₃(Ph)1.23 CH₃ H 4-OCH₃(Ph) 1.24 CH₃ H 2-CH₃(Ph) 1.25 CH₃ H 3-CH₃(Ph) 1.26 CH₃H 4-CH₃(Ph) 1.27 CH₃ H 2-CF₃(Ph) 1.28 CH₃ H 3-CF₃(Ph) 1.29 CH₃ H4-CF₃(Ph) 1.30 CH₃ H 2-NO₂(Ph) 1.31 CH₃ H 3-NO₂(Ph) 1.32 CH₃ H 4-NO₂(Ph)1.33 CH₃ H 2,3-Cl(Ph) 1.34 CH₃ H 2,4-Cl(Ph) 1.35 CH₃ H 2,5-Cl(Ph) 1.36CH₃ H 2,6-Cl(Ph) 1.37 CH₃ H 3,4-Cl(Ph) 1.38 CH₃ H 3,5-Cl(Ph) 1.39 CH₃ H2,3-F(Ph) 1.40 CH₃ H 2,4-F(Ph) 1.41 CH₃ H 2,5-F(Ph) 1.42 CH₃ H 2,6-F(Ph)1.43 CH₃ H 3,4-F(Ph) 1.44 CH₃ H 3,5-F(Ph) 1.45 C₂H₅ H Ph 1.46 C₂H₅ H2-Cl(Ph) 1.47 C₂H₅ H 3-Cl(Ph) 1.48 C₂H₅ H 4-Cl(Ph) 1.49 C₂H₅ H 4-Br(Ph)1.50 C₂H₅ H 4-F(Ph) 1.51 C₂H₅ H 4-OCH₃(Ph) 1.52 C₂H₅ H 4-CH₃(Ph) 1.53C₂H₅ H 4-NO₂(Ph) 1.54 C₂H₅ H 2,4-Cl(Ph) 1.55 C₂H₅ H 2,4-F(Ph) 1.56n-C₃H₇ H Ph 1.57 n-C₃H₇ H 2-Cl(Ph) 1.58 n-C₃H₇ H 3-Cl(Ph) 1.59 n-C₃H₇ H4-Cl(Ph) 1.60 n-C₃H₇ H 4-F(Ph) 1.61 n-C₃H₇ H 3-OCH₃(Ph) 1.62 n-C₃H₇ H4-OCH₃(Ph) 1.63 n-C₃H₇ H 4-CH₃(Ph) 1.64 n-C₃H₇ H 4-NO₂(Ph) 1.65 n-C₃H₇ H2,4-Cl(Ph) 1.66 n-C₃H₇ H 2,4-F(Ph) 1.67 iso-C₃H₇ H Ph 1.68 iso-C₃H₇ H2-Cl(Ph) 1.69 iso-C₃H₇ H 3-Cl(Ph) 1.70 iso-C₃H₇ H 4-Cl(Ph) 1.71 iso-C₃H₇H 4-Br(Ph) 1.72 iso-C₃H₇ H 4-F(Ph) 1.73 iso-C₃H₇ H 4-OCH₃(Ph) 1.74iso-C₃H₇ H 4-CH₃(Ph) 1.75 iso-C₃H₇ H 4-NO₂(Ph) 1.76 iso-C₃H₇ H2,4-Cl(Ph) 1.77 iso-C₃H₇ H 2,4-F(Ph) 1.78 n-C₄H₉ H Ph 1.79 n-C₄H₉ H2-Cl(Ph) 1.80 n-C₄H₉ H 3-Cl(Ph) 1.81 n-C₄H₉ H 4-Cl(Ph) 1.82 n-C₄H₉ H4-Br(Ph) 1.83 n-C₄H₉ H 4-F(Ph) 1.84 n-C₄H₉ H 4-OCH₃(Ph) 1.85 n-C₄H₉ H4-CH₃(Ph) 1.86 n-C₄H₉ H 4-NO₂(Ph) 1.87 n-C₄H₉ H 2,4-Cl(Ph) 1.88 n-C₄H₉ H2,4-F(Ph) 1.89 iso-C₄H₉ H Ph 1.90 iso-C₄H₉ H 2-Cl(Ph) 1.91 iso-C₄H₉ H3-Cl(Ph) 1.92 iso-C₄H₉ H 4-Cl(Ph) 1.93 iso-C₄H₉ H 4-F(Ph) 1.94 iso-C₄H₉H 3-OCH₃(Ph) 1.95 iso-C₄H₉ H 4-OCH₃(Ph) 1.96 iso-C₄H₉ H 4-CH₃(Ph) 1.97iso-C₄H₉ H 4-NO₂(Ph) 1.98 iso-C₄H₉ H 2,4-Cl(Ph) 1.99 iso-C₄H₉ H2,4-F(Ph) 1.100 C(CH₃)₃ H Ph 1.101 C(CH₃)₃ H 2-Cl(Ph) 1.102 C(CH₃)₃ H3-Cl(Ph) 1.103 C(CH₃)₃ H 4-Cl(Ph) 1.104 C(CH₃)₃ H 4-F(Ph) 1.105 C(CH₃)₃H 3-OCH₃(Ph) 1.106 C(CH₃)₃ H 4-OCH₃(Ph) 1.107 C(CH₃)₃ H 4-CH₃(Ph) 1.108C(CH₃)₃ H 4-NO₂(Ph) 1.109 C(CH₃)₃ H 2,4-Cl(Ph) 1.110 C(CH₃)₃ H 2,4-F(Ph)1.111 cyclopropyl H Ph 1.112 cyclopropyl H 2-Cl(Ph) 1.113 cyclopropyl H3-Cl(Ph) 1.114 cyclopropyl H 4-Cl(Ph) 1.115 cyclopropyl H 4-Br(Ph) 1.116cyclopropyl H 3-OCH₃(Ph) 1.117 cyclopropyl H 4-OCH₃(Ph) 1.118cyclopropyl H 4-CH_(3(Ph)) 1.119 cyclopropyl H 4-NO₂(Ph) 1.120cyclopropyl H 2,4-Cl(Ph) 1.121 cyclopropyl H 2,4-F(Ph) 1.1221-CH₃-cyclopropyl H Ph 1.123 1-CH₃-cyclopropyl H 2-Cl(Ph) 1.1241-CH₃-cyclopropyl H 3-Cl(Ph) 1.125 1-CH₃-cyclopropyl H 4-Cl(Ph) 1.1261-CH₃-cyclopropyl H 4-Br(Ph) 1.127 1-CH₃-cyclopropyl H 4-F(Ph) 1.1281-CH₃-cyclopropyl H 4-OCH₃(Ph) 1.129 1-CH₃-cyclopropyl H 4-CH₃(Ph) 1.1301-CH₃-cyclopropyl H 4-NO₂(Ph) 1.131 1-CH₃-cyclopropyl H 2,4-Cl(Ph) 1.1321-CH₃-cyclopropyl H 2,4-F(Ph) 1.133 CH₃ CH₃ Ph 1.134 CH₃ CH₃ 2-Cl(Ph)1.135 CH₃ CH₃ 3-Cl(Ph) 1.136 CH₃ CH₃ 4-Cl(Ph) 1.137 CH₃ CH₃ 4-Br(Ph)1.138 CH₃ CH₃ 4-F(Ph) 1.139 CH₃ CH₃ 4-OCH₃(Ph) 1.140 CH₃ CH₃ 4-CH₃(Ph)1.141 CH₃ CH₃ 4-NO₂(Ph) 1.142 CH₃ CH₃ 2,4-Cl(Ph) 1.143 CH₃ CH₃ 2,4-F(Ph)1.144 C₂H₅ CH₃ Ph 1.145 C₂H₅ CH₃ 2-Cl(Ph) 1.146 C₂H₅ CH₃ 3-Cl(Ph) 1.147C₂H₅ CH₃ 4-Cl(Ph) 1.148 C₂H₅ CH₃ 4-Br(Ph) 1.149 C₂H₅ CH₃ 4-F(Ph) 1.150C₂H₅ CH₃ 4-OCH₃(Ph) 1.151 C₂H₅ CH₃ 4-CH₃(Ph) 1.152 C₂H₅ CH₃ 4-NO₂(Ph)1.153 C₂H₅ CH₃ 2,4-Cl(Ph) 1.154 C₂H₅ CH₃ 2,4-F(Ph) 1.155 n-C₃H₇ CH₃ Ph1.156 n-C₃H₇ CH₃ 2-Cl(Ph) 1.157 N-C₃H₇ CH₃ 3-Cl(Ph) 1.158 N-C₃H₇ CH₃4-C#Ph) 1.159 N-C₃H₇ CH₃ 4-Br(Ph) 1.160 N-C₃H₇ CH₃ 4-F(Ph) 1.161 N-C₃H₇CH₃ 4-OCH₃(Ph) 1.162 N-C₃H₇ CH₃ 4-CH₃(Ph) 1.163 N-C₃H₇ CH₃ 4-NO₂(Ph)1.164 N-C₃H₇ CH₃ 2,4-Cl(Ph) 1.165 N-C₃H₇ CH₃ 2,4-F(Ph) 1.166 iso-C₃H₇CH₃ Ph 1.167 iso-C₃H₇ CH₃ 2-Cl(Ph) 1.168 iso-C₃H₇ CH₃ 3-Cl(Ph) 1.169iso-C₃H₇ CH₃ 4-Cl(Ph) 1.170 iso-C₃H₇ CH₃ 4-Br(Ph) 1.171 iso-C₃H₇ CH₃4-F(Ph) 1.172 iso-C₃H₇ CH₃ 4-OCH₃(Ph) 1.173 iso-C₃H₇ CH₃ 4-CH₃(Ph) 1.174iso-C₃H₇ CH₃ 4-NO₂(Ph) 1.175 iso-C₃H₇ CH₃ 2,4-Cl(Ph) 1.176 iso-C₃H₇ CH₃2,4-F(Ph) 1.177 n-C₄H₉ CH₃ Ph 1.178 n-C₄H₉ CH₃ 2-Cl(Ph) 1.179 n-C₄H₉ CH₃3-Cl(Ph) 1.180 n-C₄H₉ CH₃ 4-Cl(Ph) 1.181 n-C₄H₉ CH₃ 4-Br(Ph) 1.182n-C₄H₉ CH₃ 4-F(Ph) 1.183 n-C₄H₉ CH₃ 4-OCH₃(Ph) 1.184 n-C₄H₉ CH₃4-CH₃(Ph) 1.185 n-C₄H₉ CH₃ 4-NO₂(Ph) 1.186 n-C₄H₉ CH₃ 2,4-Cl(Ph) 1.187n-C₄H₉ CH₃ 2,4-F(Ph) 1.188 n-C₄H₉ CH₃ 4-CF₃(Ph) 1.189 Ph H Ph 1.190 Ph H2-Cl(Ph) 1.191 Ph H 3-Cl(Ph) 1.192 Ph H 4-Cl(Ph) 1.193 Ph H 4-Br(Ph)1.194 Ph H 4-F(Ph) 1.195 Ph H 4-OCH₃(Ph) 1.196 Ph H 4-CH₃(Ph) 1.197 Ph H4-NO₂(Ph) 1.198 Ph H 2,4-Cl(Ph) 1.199 Ph H 2,4-F(Ph) 1.200 Ph CH₃ Ph1.201 Ph CH₃ 2-Cl(Ph) 1.202 Ph CH₃ 3-Cl(Ph) 1.203 Ph CH₃ 4-Cl(Ph) 1.204Ph CH₃ 4-Br(Ph) 1.205 Ph CH₃ 4-F(Ph) 1.206 Ph CH₃ 4-OCH₃(Ph) 1.207 PhCH₃ 4-CH₃(Ph) 1.208 Ph CH₃ 4-NO₂(Ph) 1.209 Ph CH₃ 2,4-Cl(Ph) 1.210 PhCH₃ 2,4-F(Ph) 1.211 CN H Ph 1.212 CN H 2-Cl(Ph) 1.213 CN H 3-Cl(Ph)1.214 CN H 4-Cl(Ph) 1.215 CN H 4-Br(Ph) 1.216 CN H 4-F(Ph) 1.217 CN H4-OCH₃(Ph) 1.218 CN H 4-CH₃(Ph) 1.219 CN H 4-NO₂(Ph) 1.220 CN H2,4-Cl(Ph) 1.221 CN H 2,4-F(Ph) 1.222 CN CH₃ Ph 1.223 CN CH₃ 2-Cl(Ph)1.224 CN CH₃ 3-Cl(Ph) 1.225 CN CH₃ 4-Cl(Ph) 1.226 CN CH₃ 4-Br(Ph) 1.227CN CH₃ 4-F(Ph) 1.228 CN CH₃ 4-OCH₃(Ph) 1.229 CN CH₃ 4-CH₃(Ph) 1.230 CNCH₃ 4-NO₂(Ph) 1.231 CN CH₃ 2,4-Cl(Ph) 1.232 CN CH₃ 2,4-F(Ph) 1.233 H H1-napthyl 1.234 CH₃ H 1-napthyl 1.235 C₂H₅ H 1-napthyl 1.236 n-C₃H₇ H1-napthyl 1.237 iso-C₃H₇ H 1-napthyl 1.238 n-C₄H₉ H 1-napthyl 1.239iso-C₄H₉ H 1-napthyl 1.240 cyclopropyl H 1-napthyl 1.2411-CH₃-cyclopropyl H 1-napthyl 1.242 CN H 1-napthyl 1.243 Ph CH₃1-napthyl 1.244 H CH₃ 1-napthyl 1.245 CH₃ CH₃ 1-napthyl 1.246 C₂H₅ CH₃1-napthyl 1.247 n-C₃H₇ CH₃ 1-napthyl 1.248 iso-C₃H₇ CH₃ 1-napthyl 1.249n-C₄H₉ CH₃ 1-napthyl 1.250 iso-C₄H₉ CH₃ 1-napthyl 1.251 cyclopropyl CH₃1-napthyl 1.252 1-CH₃-cyclopropyl CH₃ 1-napthyl 1.253 CN CH₃ 1-napthyl1.254 Ph CH₃ 1-napthyl 1.255 H H 2-napthyl 1.256 CH₃ H 2-napthyl 1.257C₂H₅ H 2-napthyl 1.258 n-C₃H₇ H 2-napthyl 1.259 iso-C₃H₇ H 2-napthyl1.260 n-C₄H₉ H 2-napthyl 1.261 iso-C₄H₉ H 2-napthyl 1.262 cyclopropyl H2-napthyl 1.263 1-CH₃-cyclopropyl H 2-napthyl 1.264 CN H 2-napthyl 1.265Ph H 2-napthyl 1.266 H CH₃ 2-napthyl 1.267 CH₃ CH₃ 2-napthyl 1.268 C₂H₅CH₃ 2-napthyl 1.269 n-C₃H₇ CH₃ 2-napthyl 1.270 iso-C₃H₇ CH₃ 2-napthyl1.271 n-C₄H₉ CH₃ 2-napthyl 1.272 iso-C₄H₉ CH₃ 2-napthyl 1.273cyclopropyl CH₃ 2-napthyl 1.274 1-CH₃-cyclopropyl CH₃ 2-napthyl 1.275 CNCH₃ 2-napthyl 1.276 Ph CH5 2-napthyl 1.277 2-Cl(Ph) CH₃ 2-napthyl 1.2783-Cl(Ph) CH₃ 2-napthyl 1.279 4-Cl(Ph) CH₃ 2-napthyl 1.280 4-Br(Ph) CH₃2-napthyl 1.281 4-F(Ph) CH₃ 2-napthyl 1.282 4-OCH₃(Ph) CH₃ 2-napthyl1.283 4-CH₃(Ph) CH₃ 2-napthyl 1.284 3-CF₃(Ph) CH₃ 2-napthyl 1.285 CH₃C₂H₅ Ph 1.286 CH₃ C₂H₅ 2-Cl(Ph) 1.287 CH₃ C₂H₅ 3-Cl(Ph) 1.288 CH₃C₂H_(S) 4-Cl(Ph) 1.289 CH₃ C₂H₅ 4-Br(Ph) 1.290 CH₃ C₂H₅ 4-F(Ph) 1.291CH₃ C₂H₅ 4-OCH₃(Ph) 1.292 CH₃ C₂H₅ 4-CH₃(Ph) 1.293 CH₃ C₂H₅ 4-NO₂(Ph)1.294 CH₃ C₂H₅ 2,4-Cl(Ph) 1.295 CH₃ C₂H₅ 2,4-F(Ph) 1.296 CH₃ n-C₃H₇ Ph1.297 CH₃ n-C₃H₇ 2-Cl(Ph) 1.298 CH₃ n-C₃H₇ 3-Cl(Ph) 1.299 CH₃ n-C₃H₇4-Cl(Ph) 1.300 CH₃ n-C₃H₇ 4-Br(Ph) 1.301 CH₃ n-C₃H₇ 4-F(Ph) 1.302 CH₃n-C₃H₇ 4-OCH₃(Ph) 1.303 CH₃ n-C₃H₇ 4-CH₃(Ph) 1.304 CH₃ N-C₃H₇ 4-NO₂(Ph)1.305 CH₃ N-C₃H₇ 2,4-Cl(Ph) 1.306 CH₃ N-C₃H₇ 2,4-F(Ph) 1.307 CH₃iso-C₃H₇ Ph 1.308 CH₃ iso-C₃H₇ 2-Cl(Ph) 1.309 CH₃ iso-C₃H₇ 3-Cl(Ph)1.310 CH₃ iso-C₃H₇ 4-Cl(Ph) 1.311 CH₃ iso-C₃H₇ 4-Br(Ph) 1.312 CH₃iso-C₃H₇ 4-F(Ph) 1.313 CH₃ iso-C₃H₇ 4-OCH₃(Ph) 1.314 CH₃ iso-C₃H₇4-CH₃(Ph) 1.315 CH₃ iso-C₃H₇ 4-NO₂(Ph) 1.316 CH₃ iso-C₃H₇ 2,4-Cl(Ph)1.317 CH₃ iso-C₃H₇ 2,4-F(Ph) 1.318 CH₃ n-C₄H₉ Ph 1.319 CH₃ n-C₄H₉2-Cl(Ph) 1.320 CH₃ n-C₄H₉ 3-Cl(Ph) 1.321 CH₃ n-C₄H₉ 4-Cl(Ph) 1.322 CH₃n-C₄H₉ 4-Br(Ph) 1.323 CH₃ n-C₄H₉ 4-F(Ph) 1.324 CH₃ n-C₄H₉ 4-OCH₃(Ph)1.325 CH₃ n-C₄H₉ 4-CH₃(Ph) 1.326 CH₃ n-C₄H₉ 4-NO₂(Ph) 1.327 CH₃ n-C₄H₉2,4-Cl(Ph) 1.328 CH₃ n-C₄H₉ 2,4-F(Ph) 1.329 CH₃ cyclopropyl Ph 1.330 CH₃cyclopropyl 2-Cl(Ph)

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula V, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═Z═O, and where R₂, R₃, and R₇ are definedin Table 2.

TABLE 2 Compd. R₂ R₃ R₇ 2.1 H H Ph 2.2 H H 4-Cl(Ph) 2.3 H H 4-Br(Ph) 2.4H H 4-F(Ph) 2.5 H H 4-OCH₃(Ph) 2.6 H H 4-CF₃(Ph) 2.7 H H 4-NO₂(Ph) 2.8 HH 2,4-Cl(Ph) 2.9 H H 2,4-F(Ph) 2.10 H H 3,4-F(Ph) 2.11 CH₃ H Ph 2.12 CH₃H 2-Cl(Ph) 2.13 CH₃ H 3-Cl(Ph) 2.14 CH₃ H 4-Cl(Ph) 2.15 CH₃ H 2-Br(Ph)2.16 CH₃ H 3-Br(Ph) 2.17 CH₃ H 4-Br(Ph) 2.18 CH₃ H 2-F(Ph) 2.19 CH₃ H3-F(Ph) 2.20 CH₃ H 4-F(Ph) 2.21 CH₃ H 2-OCH₃(Ph) 2.22 CH₃ H 3-OCH₃(Ph)2.23 CH₃ H 4-OCH₃(Ph) 2.24 CH₃ H 2-CH₃(Ph) 2.25 CH₃ H 3-CH₃(Ph) 2.26 CH₃H 4-CH₃(Ph) 2.27 CH₃ H 2-CF₃(Ph) 2.28 CH₃ H 3-CF₃(Ph) 2.29 CH₃ H4-CF₃(Ph) 2.30 CH₃ H 2-NO₂(Ph) 2.31 CH₃ H 3-NO₂(Ph) 2.32 CH₃ H 4-NO₂(Ph)2.33 CH₃ H 2,3-Cl(Ph) 2.34 CH₃ H 2,4-Cl(Ph) 2.35 CH₃ H 2,5-Cl(Ph) 2.36CH₃ H 2,6-Cl(Ph) 2.37 CH₃ H 3,4-Cl(Ph) 2.38 CH₃ H 3,5-Cl(Ph) 2.39 CH₃ H2,3-F(Ph) 2.40 CH₃ H 2,4-F(Ph) 2.41 CH₃ H 2,5-F(Ph) 2.42 CH₃ H 2,6-F(Ph)2.43 CH₃ H 3,4-F(Ph) 2.44 CH₃ H 3,5-F(Ph) 2.45 C₂H₅ H Ph 2.46 C₂H₅ H2-Cl(Ph) 2.47 C₂H₅ H 3-Cl(Ph) 2.48 C₂H₅ H 4-Cl(Ph) 2.49 C₂H₅ H 4-Br(Ph)2.50 C₂H₅ H 4-F(Ph) 2.51 C₂H₅ H 4-OCH₃(Ph) 2.52 C₂H₅ H 4-CH₃(Ph) 2.53C₂H₅ H 4-NO₂(Ph) 2.54 C₂H₅ H 2,4-Cl(Ph) 2.55 C₂H₅ H 2,4-F(Ph) 2.56N-C₃H₇ H Ph 2.57 N-C₃H₇ H 2-Cl(Ph) 2.58 N-C₃H₇ H 3-Cl(Ph) 2.59 N-C₃H₇ H4-Cl(Ph) 2.60 N-C₃H₇ H 4-F(Ph) 2.61 N-C₃H₇ H 3-OCH₃(Ph) 2.62 N-C₃H₇ H4-OCH₃(Ph) 2.63 N-C₃H₇ H 4-CH₃(Ph) 2.64 N-C₃H₇ H 4-NO₂(Ph) 2.65 N-C₃H₇ H2,4-Cl(Ph) 2.66 N-C₃H₇ H 2,4-F(Ph) 2.67 iso-C₃H₇ H Ph 2.68 iso-C₃H₇ H2-Cl(Ph) 2.69 iso-C₃H₇ H 3-Cl(Ph) 2.70 iso-C₃H₇ H 4-Cl(Ph) 2.71 iso-C₃H₇H 4-Br(Ph) 2.72 iso-C₃H₇ H 4-F(Ph) 2.73 iso-C₃H₇ H 4-OCH₃(Ph) 2.74iso-C₃H₇ H 4-CH₃(Ph) 2.75 iso-C₃H₇ H 4-NO₂(Ph) 2.76 iso-C₃H₇ H2,4-Cl(Ph) 2.77 iso-C₃H₇ H 2,4-F(Ph) 2.78 n-C₄H₉ H Ph 2.79 n-C₄H₉ H2-Cl(Ph) 2.80 n-C₄H₉ H 3-Cl(Ph) 2.81 n-C₄H₉ H 4-Cl(Ph) 2.82 n-C₄H₉ H4-Br(Ph) 2.83 n-C₄H₉ H 4-F(Ph) 2.84 n-C₄H₉ H 4-OCH₃(Ph) 2.85 n-C₄H₉ H4-CH₃(Ph) 2.86 n-C₄H₉ H 4-NO₂(Ph) 2.87 n-C₄H₉ H 2,4-Cl(Ph) 2.88 n-C₄H₉ H2,4-F(Ph) 2.89 iso-C₄H₉ H Ph 2.90 iso-C₄H₉ H 2-Cl(Ph) 2.91 iso-C₄H₉ H3-Cl(Ph) 2.92 iso-C₄H₉ H 4-Cl(Ph) 2.93 iso-C₄H₉ H 4-F(Ph) 2.94 iso-C₄H₉H 3-OCH₃(Ph) 2.95 iso-C₄H₉ H 4-OCH₃(Ph) 2.96 iso-C₄H₉ H 4-CH₃(Ph) 2.97iso-C₄H₉ H 4-NO₂(Ph) 2.98 iso-C₄H₉ H 2,4-Cl(Ph) 2.99 iso-C₄H₉ H2,4-F(Ph) 2.100 C(CH₃)₃ H Ph 2.101 C(CH₃)₃ H 2-Cl(Ph) 2.102 C(CH₃)₃ H3-Cl(Ph) 2.103 C(CH₃)₃ H 4-Cl(Ph) 2.104 C(CH₃)₃ H 4-F(Ph) 2.105 C(CH₃)₃H 3-OCH₃(Ph) 2.106 C(CH₃)₃ H 4-OCH₃(Ph) 2.107 C(CH₃)₃ H 4-CH₃(Ph) 2.108C(CH₃)₃ H 4-NO₂(Ph) 2.109 C(CH₃)₃ H 2,4-Cl(Ph) 2.110 C(CH₃)₃ H 2,4-F(Ph)2.111 cyclopropyl H Ph 2.112 cyclopropyl H 2-Cl(Ph) 2.113 cyclopropyl H3-Cl(Ph) 2.114 cyclopropyl H 4-Cl(Ph) 2.115 cyclopropyl H 4-Br(Ph) 2.116cyclopropyl H 3-OCH₃(Ph) 2.117 cyclopropyl H 4-OCH₃(Ph) 2.118cyclopropyl H 4-CH₃(Ph) 2.119 cyclopropyl H 4-NO₂(Ph) 2.120 cyclopropylH 2,4-Cl(Ph) 2.121 cyclopropyl H 2,4-F(Ph) 2.122 1-CH₃-cyclopropyl H Ph2.123 1-CH₃-cyclopropyl H 2-Cl(Ph) 2.124 1-CH₃-cyclopropyl H 3-Cl(Ph)2.125 1-CH₃-cyclopropyl H 4-Cl(Ph) 2.126 1-CH₃-cyclopropyl H 4-Br(Ph)2.127 1-CH₃-cyclopropyl H 4-F(Ph) 2.128 1-CH₃-cyclopropyl H 4-OCH₃(Ph)2.129 1-CH₃-cyclopropyl H 4-CH₃(Ph) 2.130 1-CH₃-cyclopropyl H 4-NO₂(Ph)2.131 1-CH₃-cyclopropyl H 2,4-Cl(Ph) 2.132 1-CH₃-cyclopropyl H 2,4-F(Ph)2.133 CH₃ CH₃ Ph 2.134 CH₃ CH₃ 2-Cl(Ph) 2.135 CH₃ CH₃ 3-Cl(Ph) 2.136 CH₃CH₃ 4-Cl(Ph) 2.137 CH₃ CH₃ 4-Br(Ph) 2.138 CH₃ CH₃ 4-F(Ph) 2.139 CH₃ CH₃4-OCH₃(Ph) 2.140 CH₃ CH₃ 4-CH₃(Ph) 2.141 CH₃ CH₃ 4-NO₂(Ph) 2.142 CH₃ CH₃2,4-Cl(Ph) 2.143 CH₃ CH₃ 2,4-F(Ph) 2.144 C₂H₅ CH₃ Ph 2.145 C₂H₅ CH₃2-Cl(Ph) 2.146 C₂H₅ CH₃ 3-Cl(Ph) 2.147 C₂H₅ CH₃ 4-Cl(Ph) 2.148 C₂H₅ CH₃4-Br(Ph) 2.149 C₂H₅ CH₃ 4-F(Ph) 2.150 C₂H₅ CH₃ 4-OCH₃(Ph) 2.151 C₂H₅ CH₃4-CH₃(Ph) 2.152 C₂H₅ CH₃ 4-NO₂(Ph) 2.153 C₂H₅ CH₃ 2,4-Cl(Ph) 2.154 C₂H₅CH₃ 2,4-F(Ph) 2.155 N-C₃H₇ CH₃ Ph 2.156 N-C₃H₇ CH₃ 2-Cl(Ph) 2.157 N-C₃H₇CH₃ 3-Cl(Ph) 2.158 N-C₃H₇ CH₃ 4-Cl(Ph) 2.159 N-C₃H₇ CH₃ 4-Br(Ph) 2.160N-C₃H₇ CH₃ 4-F(Ph) 2.161 N-C₃H₇ CH₃ 4-OCH₃(Ph) 2.162 N-C₃H₇ CH₃4-CH₃(Ph) 2.163 N-C₃H₇ CH₃ 4-NO₂(Ph) 2.164 N-C₃H₇ CH₃ 2,4-Cl(Ph) 2.165N-C₃H₇ CH₃ 2,4-F(Ph) 2.166 iso-C₃H₇ CH₃ Ph 2.167 iso-C₃H₇ CH₃ 2-Cl(Ph)2.168 iso-C₃H₇ CH₃ 3-Cl(Ph) 2.169 iso-C₃H₇ CH₃ 4-Cl(Ph) 2.170 iso-C₃H₇CH₃ 4-Br(Ph) 2.171 iso-C₃H₇ CH₃ 4-F(Ph) 2.172 iso-C₃H₇ CH₃ 4-OCH₃(Ph)2.173 iso-C₃H₇ CH₃ 4-CH₃(Ph) 2.174 iso-C₃H₇ CH₃ 4-NO₂(Ph) 2.175 iso-C₃H₇CH₃ 2,4-Cl(Ph) 2.176 iso-C₃H₇ CH₃ 2,4-F(Ph) 2.177 n-C₄H₉ CH₃ Ph 2.178n-C₄H₉ CH₃ 2-Cl(Ph) 2.179 n-C₄H₉ CH₃ 3-Cl(Ph) 2.180 n-C₄H₉ CH₃ 4-Cl(Ph)2.181 n-C₄H₉ CH₃ 4-Br(Ph) 2.182 n-C₄H₉ CH₃ 4-F(Ph) 2.183 n-C₄H₉ CH₃4-OCH₃(Ph) 2.184 n-C₄H₉ CH₃ 4-CH₃(Ph) 2.185 n-C₄H₉ CH₃ 4-NO₂(Ph) 2.186n-C₄H₉ CH₃ 2,4-Cl(Ph) 2.187 n-C₄H₉ CH₃ 2,4-F(Ph) 2.188 n-C₄H₉ CH₃4-CF₃(Ph) 2.189 Ph H Ph 2.190 Ph H 2-Cl(Ph) 2.191 Ph H 3-Cl(Ph) 2.192 PhH 4-Cl(Ph) 2.193 Ph H 4-Br(Ph) 2.194 Ph H 4-F(Ph) 2.195 Ph H 4-OCH₃(Ph)2.196 Ph H 4-CH₃(Ph) 2.197 Ph H 4-NO₂(Ph) 2.198 Ph H 2,4-Cl(Ph) 2.199 PhH 2,4-F(Ph) 2.200 Ph CH₃ Ph 2.201 Ph CH₃ 2-Cl(Ph) 2.202 Ph CH₃ 3-Cl(Ph)2.203 Ph CH₃ 4-Cl(Ph) 2.204 Ph CH₃ 4-Br(Ph) 2.205 Ph CH₃ 4-F(Ph) 2.206Ph CH₃ 4-OCH₃(Ph) 2.207 Ph CH₃ 4-CH₃(Ph) 2.208 Ph CH₃ 4-NO₂(Ph) 2.209 PhCH₃ 2,4-Cl(Ph) 2.210 Ph CH₃ 2,4-F(Ph) 2.211 CN H Ph 2.212 CN H 2-Cl(Ph)2.213 CN H 3-Cl(Ph) 2.214 CN H 4-Cl(Ph) 2.215 CN H 4-Br(Ph) 2.216 CN H4-F(Ph) 2.217 CN H 4-OCH₃(Ph) 2.218 CN H 4-CH₃(Ph) 2.219 CN H 4-NO₂(Ph)2.220 CN H 2,4-Cl(Ph) 2.221 CN H 2,4-F(Ph) 2.222 CN CH₃ Ph 2.223 CN CH₃2-Cl(Ph) 2.224 CN CH₃ 3-Cl(Ph) 2.225 CN CH₃ 4-Cl(Ph) 2.226 CN CH₃4-Br(Ph) 2.227 CN CH₃ 4-F(Ph) 2.228 CN CH₃ 4-OCH₃(Ph) 2.229 CN CH₃4-CH₃(Ph) 2.230 CN CH₃ 4-NO₂(Ph) 2.231 CN CH₃ 2,4-Cl(Ph) 2.232 CN CH₃2,4-F(Ph) 2.233 H H 1-napthyl 2.234 CH₃ H 1-napthyl 2.235 C₂H₅ H1-napthyl 2.236 N-C₃H₇ H 1-napthyl 2.237 iso-C₃H₇ H 1-napthyl 2.238n-C₄H₉ H 1-napthyl 2.239 iso-C₄H₉ H 1-napthyl 2.240 cyclopropyl H1-napthyl 2.241 1-CH₃-cyclopropyl H 1-napthyl 2.242 CN H 1-napthyl 2.243Ph H 1-napthyl 2.244 H CH₃ 1-napthyl 2.245 CH₃ CH₃ 1-napthyl 2.246 C₂H₅CH₃ 1-napthyl 2.247 N-C₃H₇ CH₃ 1-napthyl 2.248 iso-C₃H₇ CH₃ 1-napthyl2.249 n-C₄H₉ CH₃ 1-napthyl 2.250 iso-C₄H₉ CH₃ 1-napthyl 2.251cyclopropyl CH₃ 1-napthyl 2.252 1-CH₃-cyclopropyl CH₃ 1-napthyl 2.253 CNCH₃ 1-napthyl 2.254 Ph CH₃ 1-napthyl 2.255 H H 2-napthyl 2.256 CH₃ H2-napthyl 2.257 C₂H₅ H 2-napthyl 2.258 N-C₃H₇ H 2-napthyl 2.259 iso-C₃H₇H 2-napthyl 2.260 n-C₄H₉ H 2-napthyl 2.261 iso-C₄H₉ H 2-napthyl 2.262cyclopropyl H 2-napthyl 2.263 1-CH₃-cyclopropyl H 2-napthyl 2.264 CN H2-napthyl 2.265 Ph H 2-napthyl 2.266 H CH₃ 2-napthyl 2.267 CH₃ CH₃2-napthyl 2.268 C₂H₅ CH₃ 2-napthyl 2.269 n-C₃H₇ CH₃ 2-napthyl 2.270iso-C₃H₇ CH₃ 2-napthyl 2.271 n-C₄H₉ CH₃ 2-napthyl 2.272 iso-C₄H₉ CH₃2-napthyl 2.273 cyclopropyl CH₃ 2-napthyl 2.274 1-CH₃-cyclopropyl CH₃2-napthyl 2.275 CN CH₃ 2-napthyl 2.276 Ph CH₃ 2-napthyl 2.277 2-Cl(Ph)CH₃ 2-napthyl 2.278 3-Cl(Ph) CH₃ 2-napthyl 2.279 4-Cl(Ph) CH₃ 2-napthyl2.280 4-Br(Ph) CH₃ 2-napthyl 2.281 4-F(Ph) CH₃ 2-napthyl 2.2824-OCH₃(Ph) CH₃ 2-napthyl 2.283 4-CH₃(Ph) CH₃ 2-napthyl 2.284 3-CF₃(Ph)CH₃ 2-napthyl 2.285 CH₃ C₂H₅ Ph 2.286 CH₃ C₂H₅ 2-Cl(Ph) 2.287 CH₃ C₂H₅3-Cl(Ph) 2.288 CH₃ C2Hs 4-Cl(Ph) 2.289 CH₃ C₂H₅ 4-Br(Ph) 2.290 CH₃ C₂H₅4-F(Ph) 2.291 CH₃ C₂H₅ 4-OCH₃(Ph) 2.292 CH₃ C₂H₅ 4-CH₃(Ph) 2.293 CH₃C₂H₅ 4-NO₂(Ph) 2.294 CH₃ C₂H₅ 2,4-Cl(Ph) 2.295 CH₃ C₂H₅ 2,4-F(Ph) 2.296CH₃ n-C₃H₇ Ph 2.297 CH₃ n-C₃H₇ 2-Cl(Ph) 2.298 CH₃ n-C₃H₇ 3-Cl(Ph) 2.299CH₃ n-C₃H₇ 4-Cl(Ph) 2.300 CH₃ n-C₃H₇ 4-Br(Ph) 2.301 CH₃ n-C₃H₇ 4-F(Ph)2.302 CH₃ n-C₃H₇ 4-OCH₃(Ph) 2.303 CH₃ n-C₃H₇ 4-CH₃(Ph) 2.304 CH₃ n-C₃H₇4-NO₂(Ph) 2.305 CH₃ n-C₃H₇ 2,4-Cl(Ph) 2.306 CH₃ n-C₃H₇ 2,4-F(Ph) 2.307CH₃ iso-C₃H₇ Ph 2.308 CH₃ iso-C₃H₇ 2-Cl(Ph) 2.309 CH₃ iso-C₃H₇ 3-Cl(Ph)2.310 CH₃ iso-C₃H₇ 4-Cl(Ph) 2.311 CH₃ iso-C₃H₇ 4-Br(Ph) 2.312 CH₃iso-C₃H₇ 4-F(Ph) 2.313 CH₃ iso-C₃H₇ 4-OCH₃(Ph) 2.314 CH₃ iso-C₃H₇4-CH₃(Ph) 2.315 CH₃ iso-C₃H₇ 4-NO₂(Ph) 2.316 CH₃ iso-C₃H₇ 2,4-Cl(Ph)2.317 CH₃ iso-C₃H₇ 2,4-F(Ph) 2.318 CH₃ n-C₄H₉ Ph 2.319 CH₃ n-C₄H₉2-Cl(Ph) 2.320 CH₃ n-C₄H₉ 3-Cl(Ph) 2.321 CH₃ n-C₄H₉ 4-Cl(Ph) 2.322 CH₃n-C₄H₉ 4-Br(Ph) 2.323 CH₃ n-C₄H₉ 4-F(Ph) 2.324 CH₃ n-C₄H₉ 4-OCH₃(Ph)2.325 CH₃ n-C₄H₉ 4-CH₃(Ph) 2.326 CH₃ n-C₄H₉ 4-NO₂(Ph) 2.327 CH₃ n-C₄H₉2,4-Cl(Ph) 2.328 CH₃ n-C₄H₉ 2,4-F(Ph) 2.329 CH₃ cyclopropyl Ph 2.330 CH₃cyclopropyl 2-Cl(Ph)

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula VI, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═O, and where R₂, R₃, and R₇ aredefined in Table 3.

TABLE 3 Compd. R₂ R₃ R₇ 3.1 H H Ph 3.2 H H 4-Cl(Ph) 3.3 H H 4-Br(Ph) 3.4H H 4-F(Ph) 3.5 H H 4-OCH₃(Ph) 3.6 H H 4-CF₃(Ph) 3.7 H H 4-NO₂(Ph) 3.8 HH 2,4-Cl(Ph) 3.9 H H 2,4-F(Ph) 3.10 H H 3,4-F(Ph) 3.11 CH₃ H Ph 3.12 CH₃H 2-Cl(Ph) 3.13 CH₃ H 3-Cl(Ph) 3.14 CH₃ H 4-Cl(Ph) 3.15 CH₃ H 2-Br(Ph)3.16 CH₃ H 3-Br(Ph) 3.17 CH₃ H 4-Br(Ph) 3.18 CH₃ H 2-F(Ph) 3.19 CH₃ H3-F(Ph) 3.20 CH₃ H 4-F(Ph) 3.21 CH₃ H 2-OCH₃(Ph) 3.22 CH₃ H 3-OCH₃(Ph)3.23 CH₃ H 4-OCH₃(Ph) 3.24 CH₃ H 2-CH₃(Ph) 3.25 CH₃ H 3-CH₃(Ph) 3.26 CH₃H 4-CH₃(Ph) 3.27 CH₃ H 2-CF₃(Ph) 3.28 CH₃ H 3-CF₃(Ph) 3.29 CH₃ H4-CF₃(Ph) 3.30 CH₃ H 2-NO₂(Ph) 3.31 CH₃ H 3-NO₂(Ph) 3.32 CH₃ H 4-NO₂(Ph)3.33 CH₃ H 2,3-Cl(Ph) 3.34 CH₃ H 2,4-Cl(Ph) 3.35 CH₃ H 2,5-Cl(Ph) 3.36CH₃ H 2,6-Cl(Ph) 3.37 CH₃ H 3,4-Cl(Ph) 3.38 CH₃ H 3,5-Cl(Ph) 3.39 CH₃ H2,3-F(Ph) 3.40 CH₃ H 2,4-F(Ph) 3.41 CH₃ H 2,5-F(Ph) 3.42 CH₃ H 2,6-F(Ph)3.43 CH₃ H 3,4-F(Ph) 3.44 CH₃ H 3,5-F(Ph) 3.45 C₂H₅ H Ph 3.46 C₂H₅ H2-Cl(Ph) 3.47 C₂H₅ H 3-Cl(Ph) 3.48 C₂H₅ H 4-Cl(Ph) 3.49 C₂H₅ H 4-Br(Ph)3.50 C₂H₅ H 4-F(Ph) 3.51 C₂H₅ H 4-OCH₃(Ph) 3.52 C₂H₅ H 4-CH₃(Ph) 3.53C₂H₅ H 4-NO₂(Ph) 3.54 C₂H₅ H 2,4-Cl(Ph) 3.55 C₂H₅ H 2,4-F(Ph) 3.56n-C₃H₇ H Ph 3.57 n-C₃H₇ H 2-Cl(Ph) 3.58 n-C₃H₇ H 3-Cl(Ph) 3.59 n-C₃H₇ H4-Cl(Ph) 3.60 n-C₃H₇ H 4-F(Ph) 3.61 n-C₃H₇ H 3-OCH₃(Ph) 3.62 n-C₃H₇ H4-OCH₃(Ph) 3.63 n-C₃H₇ H 4-CH₃(Ph) 3.64 n-C₃H₇ H 4-NO₂(Ph) 3.65 n-C₃H₇ H2,4-Cl(Ph) 3.66 n-C₃H₇ H 2,4-F(Ph) 3.67 iso-C₃H₇ H Ph 3.68 iso-C₃H₇ H2-Cl(Ph) 3.69 iso-C₃H₇ H 3-Cl(Ph) 3.70 iso-C₃H₇ H 4-Cl(Ph) 3.71 iso-C₃H₇H 4-Br(Ph) 3.72 iso-C₃H₇ H 4-F(Ph) 3.73 iso-C₃H₇ H 4-OCH₃(Ph) 3.74iso-C₃H₇ H 4-CH₃(Ph) 3.75 iso-C₃H₇ H 4-NO₂(Ph) 3.76 iso-C₃H₇ H2,4-Cl(Ph) 3.77 iso-C₃H₇ H 2,4-F(Ph) 3.78 n-C₄H₉ H Ph 3.79 n-C₄H₉ H2-Cl(Ph) 3.80 n-C₄H₉ H 3-Cl(Ph) 3.81 n-C₄H₉ H 4-Cl(Ph) 3.82 n-C₄H₉ H4-Br(Ph) 3.83 n-C₄H₉ H 4-F(Ph) 3.84 n-C₄H₉ H 4-OCH₃(Ph) 3.85 n-C₄H₉ H4-CH₃(Ph) 3.86 n-C₄H₉ H 4-NO₂(Ph) 3.87 n-C₄H₉ H 2,4-Cl(Ph) 3.88 n-C₄H₉ H2,4-F(Ph) 3.89 iso-C₄H₉ H Ph 3.90 iso-C₄H₉ H 2-Cl(Ph) 3.91 iso-C₄H₉ H3-Cl(Ph) 3.92 iso-C₄H₉ H 4-Cl(Ph) 3.93 iso-C₄H₉ H 4-F(Ph) 3.94 iso-C₄H₉H 3-OCH₃(Ph) 3.95 iso-C₄H₉ H 4-OCH₃(Ph) 3.96 iso-C₄H₉ H 4-CH₃(Ph) 3.97iso-C₄H₉ H 4-NO₂(Ph) 3.98 iso-C₄H₉ H 2,4-Cl(Ph) 3.99 iso-C₄H₉ H2,4-F(Ph) 3.100 C(CH₃)₃ H Ph 3.101 C(CH₃)₃ H 2-Cl(Ph) 3.102 C(CH₃)₃ H3-Cl(Ph) 3.103 C(CH₃)₃ H 4-Cl(Ph) 3.104 C(CH₃)₃ H 4-F(Ph) 3.105 C(CH₃)₃H 3-OCH₃(Ph) 3.106 C(CH₃)₃ H 4-OCH₃(Ph) 3.107 C(CH₃)₃ H 4-CH₃(Ph) 3.108C(CH₃)₃ H 4-NO₂(Ph) 3.109 C(CH₃)₃ H 2,4-Cl(Ph) 3.110 C(CH₃)₃ H 2,4-F(Ph)3.111 cyclopropyl H Ph 3.112 cyclopropyl H 2-Cl(Ph) 3.113 cyclopropyl H3-Cl(Ph) 3.114 cyclopropyl H 4-Cl(Ph) 3.115 cyclopropyl H 4-Br(Ph) 3.116cyclopropyl H 3-OCH₃(Ph) 3.117 cyclopropyl H 4-OCH₃(Ph) 3.118cyclopropyl H 4-CH₃(Ph) 3.119 cyclopropyl H 4-NO₂(Ph) 3.120 cyclopropylH 2,4-Cl(Ph) 3.121 cyclopropyl H 2,4-F(Ph) 3.122 1-CH₃-cyclopropyl H Ph3.123 1-CH₃-cyclopropyl H 2-Cl(Ph) 3.124 1-CH₃-cyclopropyl H 3-Cl(Ph)3.125 1-CH₃-cyclopropyl H 4-Cl(Ph) 3.126 1-CH₃-cyclopropyl H 4-Br(Ph)3.127 1-CH₃-cyclopropyl H 4-F(Ph) 3.128 1-CH₃-cyclopropyl H 4-OCH₃(Ph)3.129 1-CH₃-cyclopropyl H 4-CH₃(Ph) 3.130 1-CH₃-cyclopropyl H 4-NO₂(Ph)3.131 1-CH₃-cyclopropyl H 2,4-Cl(Ph) 3.132 1-CH₃-cyclopropyl H 2,4-F(Ph)3.133 CH₃ CH₃ Ph 3.134 CH₃ CH₃ 2-Cl(Ph) 3.135 CH₃ CH₃ 3-Cl(Ph) 3.136 CH₃CH₃ 4-Cl(Ph) 3.137 CH₃ CH₃ 4-Br(Ph) 3.138 CH₃ CH₃ 4-F(Ph) 3.139 CH₃ CH₃4-OCH₃(Ph) 3.140 CH₃ CH₃ 4-CH₃(Ph) 3.141 CH₃ CH₃ 4-NO₂(Ph) 3.142 CH₃ CH₃2,4-Cl(Ph) 3.143 CH₃ CH₃ 2,4-F(Ph) 3.144 C₂H₅ CH₃ Ph 3.145 C₂H₅ CH₃2-Cl(Ph) 3.146 C₂H₅ CH₃ 3-Cl(Ph) 3.147 C₂H₅ CH₃ 4-Cl(Ph) 3.148 C₂H₅ CH₃4-Br(Ph) 3.149 C₂H₅ CH₃ 4-F(Ph) 3.150 C₂H₅ CH₃ 4-OCH₃(Ph) 3.151 C₂H₅ CH₃4-CH₃(Ph) 3.152 C₂H₅ CH₃ 4-NO₂(Ph) 3.153 C₂H₅ CH₃ 2,4-Cl(Ph) 3.154 C₂H₅CH₃ 2,4-F(Ph) 3.155 n-C₃H₇ CH₃ Ph 3.156 n-C₃H₇ CH₃ 2-Cl(Ph) 3.157 n-C₃H₇CH₃ 3-Cl(Ph) 3.158 n-C₃H₇ CH₃ 4-Cl(Ph) 3.159 n-C₃H₇ CH₃ 4-Br(Ph) 3.160n-C₃H₇ CH₃ 4-F(Ph) 3.161 n-C₃H₇ CH₃ 4-OCH₃(Ph) 3.162 n-C₃H₇ CH₃4-CH₃(Ph) 3.163 n-C₃H₇ CH₃ 4-NO₂(Ph) 3.164 n-C₃H₇ CH₃ 2,4-Cl(Ph) 3.165n-C₃H₇ CH₃ 2,4-F(Ph) 3.166 iso-C₃H₇ CH₃ Ph 3.167 iso-C₃H₇ CH₃ 2-Cl(Ph)3.168 iso-C₃H₇ CH₃ 3-Cl(Ph) 3.169 iso-C₃H₇ CH₃ 4-Cl(Ph) 3.170 iso-C₃H₇CH₃ 4-Br(Ph) 3.171 iso-C₃H₇ CH₃ 4-F(Ph) 3.172 iso-C₃H₇ CH₃ 4-OCH₃(Ph)3.173 iso-C₃H₇ CH₃ 4-CH₃(Ph) 3.174 iso-C₃H₇ CH₃ 4-NO₂(Ph) 3.175 iso-C₃H₇CH₃ 2,4-Cl(Ph) 3.176 iso-C₃H₇ CH₃ 2,4-F(Ph) 3.177 n-C₄H₉ CH₃ Ph 3.178n-C₄H₉ CH₃ 2-Cl(Ph) 3.179 n-C₄H₉ CH₃ 3-Cl(Ph) 3.180 n-C₄H₉ CH₃ 4-Cl(Ph)3.181 n-C₄H₉ CH₃ 4-Br(Ph) 3.182 n-C₄H₉ CH₃ 4-F(Ph) 3.183 n-C₄H₉ CH₃4-OCH₃(Ph) 3.184 n-C₄H₉ CH₃ 4-CH₃(Ph) 3.185 n-C₄H₉ CH₃ 4-NO₂(Ph) 3.186n-C₄H₉ CH₃ 2,4-Cl(Ph) 3.187 n-C₄H₉ CH₃ 2,4-F(Ph) 3.188 n-C₄H₉ CH₃4-CF₃(Ph) 3.189 Ph H Ph 3.190 Ph H 2-Cl(Ph) 3.191 Ph H 3-Cl(Ph) 3.192 PhH 4-Cl(Ph) 3.193 Ph H 4-Br(Ph) 3.194 Ph H 4-F(Ph) 3.195 Ph H 4-OCH₃(Ph)3.196 Ph H 4-CH₃(Ph) 3.197 Ph H 4-NO₂(Ph) 3.198 Ph H 2,4-Cl(Ph) 3.199 PhH 2,4-F(Ph) 3.200 Ph CH₃ Ph 3.201 Ph CH₃ 2-Cl(Ph) 3.202 Ph CH₃ 3-Cl(Ph)3.203 Ph CH₃ 4-Cl(Ph) 3.204 Ph CH₃ 4-Br(Ph) 3.205 Ph CH₃ 4-F(Ph) 3.206Ph CH₃ 4-OCH₃(Ph) 3.207 Ph CH₃ 4-CH₃(Ph) 3.208 Ph CH₃ 4-NO₂(Ph) 3.209 PhCH₃ 2,4-Cl(Ph) 3.210 Ph CH₃ 2,4-F(Ph) 3.211 CN H Ph 3.212 CN H 2-Cl(Ph)3.213 CN H 3-Cl(Ph) 3.214 CN H 4-Cl(Ph) 3.215 CN H 4-Br(Ph) 3.216 CN H4-F(Ph) 3.217 CN H 4-OCH₃(Ph) 3.218 CN H 4-CH₃(Ph) 3.219 CN H 4-NO₂(Ph)3.220 CN H 2,4-Cl(Ph) 3.221 CN H 2,4-F(Ph) 3.222 CN CH₃ Ph 3.223 CN CH₃2-Cl(Ph) 3.224 CN CH₃ 3-Cl(Ph) 3.225 CN CH₃ 4-Cl(Ph) 3.226 CN CH₃4-Br(Ph) 3.227 CN CH₃ 4-F(Ph) 3.228 CN CH₃ 4-OCH₃(Ph) 3.229 CN CH₃4-CH₃(Ph) 3.230 CN CH₃ 4-NO₂(Ph) 3.231 CN CH₃ 2,4-Cl(Ph) 3.232 CN CH₃2,4-F(Ph) 3.233 H H 1-napthyl 3.234 CH₃ H 1-napthyl 3.235 C₂H₅ H1-napthyl 3.236 n-C₃H₇ H 1-napthyl 3.237 iso-C₃H₇ H 1-napthyl 3.238n-C₄H₉ H 1-napthyl 3.239 iso-C₄H₉ H 1-napthyl 3.240 cyclopropyl H1-napthyl 3.241 1-CH₃-cyclopropyl H 1-napthyl 3.242 CN H 1-napthyl 3.243Ph H 1-napthyl 3.244 H CH₃ 1-napthyl 3.245 CH₃ CH₃ 1-napthyl 3.246 C₂H₅CH₃ 1-napthyl 3.247 n-C₃H₇ CH₃ 1-napthyl 3.248 iso-C₃H₇ CH₃ 1-napthyl3.249 n-C₄H₉ CH₃ 1-napthyl 3.250 iso-C₄H₉ CH₃ 1-napthyl 3.251cyclopropyl CH₃ 1-napthyl 3.252 1-CH₃-cyclopropyl CH₃ 1-napthyl 3.253 CNCH₃ 1-napthyl 3.254 Ph CH₃ 1-napthyl 3.255 H H 2-napthyl 3.256 CH₃ H2-napthyl 3.257 C₂H₅ H 2-napthyl 3.258 n-C₃H₇ H 2-napthyl 3.259 iso-C₃H₇H 2-napthyl 3.260 n-C₄H₉ H 2-napthyl 3.261 iso-C₄H₉ H 2-napthyl 3.262cyclopropyl H 2-napthyl 3.263 1-CH₃-cyclopropyl H 2-napthyl 3.264 CN H2-napthyl 3.265 Ph H 2-napthyl 3.266 H CH₃ 2-napthyl 3.267 CH₃ CH₃2-napthyl 3.268 C₂H₅ CH₃ 2-napthyl 3.269 n-C₃H₇ CH₃ 2-napthyl 3.270iso-C₃H₇ CH₃ 2-napthyl 3.271 n-C₄H₉ CH₃ 2-napthyl 3.272 iso-C₄H₉ CH₃2-napthyl 3.273 cyclopropyl CH₃ 2-napthyl 3.274 1-CH₃-cyclopropyl CH₃2-napthyl 3.275 CN CH₃ 2-napthyl 3.276 Ph CH₃ 2-napthyl 3.277 2-Cl(Ph)CH₃ 2-napthyl 3.278 3-Cl(Ph) CH₃ 2-napthyl 3.279 4-Cl(Ph) CH₃ 2-napthyl3.280 4-Br(Ph) CH₃ 2-napthyl 3.281 4-OCH₃(Ph) CH₃ 2-napthyl 3.2824-CH₃(Ph) CH₃ 2-napthyl 3.283 3-CF₃(Ph) CH₃ 2-napthyl 3.284 CH₃ C₂H₅ Ph3.285 CH₃ C₂H₅ 2-Cl(Ph) 3.286 CH₃ C₂H₅ 3-Cl(Ph) 3.287 CH₃ C₂H₅ 4-Cl(Ph)3.288 CH₃ C₂H₅ 4-Br(Ph) 3.289 CH₃ C₂H₅ 4-F(Ph) 3.290 CH₃ C₂H₅ 4-OCH₃(Ph)3.291 CH₃ C₂H₅ 4-CH₃(Ph) 3.292 CH₃ C₂H₅ 4-NO₂(Ph) 3.293 CH₃ C₂H₅2,4-Cl(Ph) 3.294 CH₃ C₂H₅ 2,4-F(Ph) 3.295 CH₃ n-C₃H₇ Ph 3.296 CH₃ n-C₃H₇2-Cl(Ph) 3.297 CH₃ n-C₃H₇ 3-Cl(Ph) 3.298 CH₃ n-C₃H₇ 4-Cl(Ph) 3.299 CH₃n-C₃H₇ 4-Br(Ph) 3.300 CH₃ n-C₃H₇ 4-F(Ph) 3.301 CH₃ n-C₃H₇ 4-OCH₃(Ph)3.302 CH₃ n-C₃H₇ 4-CH₃(Ph) 3.303 CH₃ n-C₃H₇ 4-NO₂(Ph) 3.304 CH₃ n-C₃H₇2,4-Cl(Ph) 3.305 CH₃ n-C₃H₇ 2,4-F(Ph) 3.306 CH₃ iso-C₃H₇ Ph 3.307 CH₃iso-C₃H₇ 2-Cl(Ph) 3.308 CH₃ iso-C₃H₇ 3-Cl(Ph) 3.309 CH₃ iso-C₃H₇4-Cl(Ph) 3.310 CH₃ iso-C₃H₇ 4-Br(Ph) 3.311 CH₃ iso-C₃H₇ 4-F(Ph) 3.312CH₃ iso-C₃H₇ 4-OCH₃(Ph) 3.313 CH₃ iso-C₃H₇ 4-CH₃(Ph) 3.314 CH₃ iso-C₃H₇4-NO₂(Ph) 3.315 CH₃ iso-C₃H₇ 2,4-Cl(Ph) 3.316 CH₃ iso-C₃H₇ 2,4-F(Ph)3.317 CH₃ n-C₄H₉ Ph 3.318 CH₃ n-C₄H₉ 2-Cl(Ph) 3.319 CH₃ n-C₄H₉ 3-Cl(Ph)3.320 CH₃ n-C₄H₉ 4-Cl(Ph) 3.321 CH₃ n-C₄H₉ 4-Br(Ph) 3.322 CH₃ n-C₄H₉4-F(Ph) 3.323 CH₃ n-C₄H₉ 4-OCH₃(Ph) 3.324 CH₃ n-C₄H₉ 4-CH₃(Ph) 3.325 CH₃n-C₄H₉ 4-NO₂(Ph) 3.326 CH₃ n-C₄H₉ 2,4-Cl(Ph) 3.327 CH₃ n-C₄H₉ 2,4-F(Ph)

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula IV, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═O, and where R₂, R₃, and R₇ aredefined in Table 4.

TABLE 4 Compd. R₂ R₃ R₇ 4.1 H Ph Ph 4.2 H Ph 2-Cl(Ph) 4.3 H Ph 3-Cl(Ph)4.4 H Ph 4-Cl(Ph) 4.5 H Ph 2-Br(Ph) 4.6 H Ph 3-Br(Ph) 4.7 H Ph 4-Br(Ph)4.8 H Ph 2-F(Ph) 4.9 H Ph 3-F(Ph) 4.10 H Ph 4-F(Ph) 4.11 H Ph 2-OCH₃(Ph)4.12 H Ph 3-OCH₃(Ph) 4.13 H Ph 4-OCH₃(Ph) 4.14 H Ph 2-OC₂H₅(Ph) 4.15 HPh 3-OC₂H₅(Ph) 4.16 H Ph 4-OC₂H₅(Ph) 4.17 H Ph 4-OPh(Ph) 4.18 H Ph2-CH₃(Ph) 4.19 H Ph 3-CH₃(Ph) 4.20 H Ph 4-CH₃(Ph) 4.21 H Ph 2-CF₃(Ph)4.22 H Ph 3-CF₃(Ph) 4.23 H Ph 4-CF₃(Ph) 4.24 H Ph 2-NO₂(Ph) 4.25 H Ph3-NO₂(Ph) 4.26 H Ph 4-NO₂(Ph) 4.27 H Ph 2,3-Cl(Ph) 4.28 H Ph 2,4-Cl(Ph)4.29 H Ph 2,5-Cl(Ph) 4.30 H Ph 2,6-Cl(Ph) 4.31 H Ph 3,4-Cl(Ph) 4.32 H Ph3,5-Cl(Ph) 4.33 H Ph 2,3-F(Ph) 4.34 H Ph 2,4-F(Ph) 4.35 H Ph 2,5-F(Ph)4.36 H Ph 2,6-F(Ph) 4.37 H Ph 3,4-F(Ph) 4.38 H Ph 3,5-F(Ph) 4.39 CH₃ PhPh 4.40 CH₃ Ph 2-Cl(Ph) 4.41 CH₃ Ph 3-Cl(Ph) 4.42 CH₃ Ph 4-Cl(Ph) 4.43CH₃ Ph 2-Br(Ph) 4.44 CH₃ Ph 3-Br(Ph) 4.45 CH₃ Ph 4-Br(Ph) 4.46 CH₃ Ph2-F(Ph) 4.47 CH₃ Ph 3-F(Ph) 4.48 CH₃ Ph 4-F(Ph) 4.49 CH₃ Ph 2-OCH₃(Ph)4.50 CH₃ Ph 3-OCH₃(Ph) 4.51 CH₃ Ph 4-OCH₃(Ph) 4.52 CH₃ Ph 2-OC₂H₅(Ph)4.53 CH₃ Ph 3-OC₂H₅(Ph) 4.54 CH₃ Ph 4-OC₂H₅(Ph) 4.55 CH₃ Ph 2-OPh(Ph)4.56 CH₃ Ph 3-OPh(Ph) 4.57 CH₃ Ph 4-OPh(Ph) 4.58 CH₃ Ph 2-CH₃(Ph) 4.59CH₃ Ph 3-CH₃(Ph) 4.60 CH₃ Ph 4-CH₃(Ph) 4.61 CH₃ Ph 2-CF₃(Ph) 4.62 CH₃ Ph3-CF₃(Ph) 4.63 CH₃ Ph 4-CF₃(Ph) 4.64 CH₃ Ph 4-OCF₃(Ph) 4.65 CH₃ Ph2-NO₂(Ph) 4.66 CH₃ Ph 3-NO₂(Ph) 4.67 CH₃ Ph 4-NO₂(Ph) 4.68 CH₃ Ph2,3-Cl(Ph) 4.69 CH₃ Ph 2,4-Cl(Ph) 4.70 CH₃ Ph 2,5-Cl(Ph) 4.71 CH₃ Ph2,6-Cl(Ph) 4.72 CH₃ Ph 3,4-Cl(Ph) 4.73 CH₃ Ph 3,5-Cl(Ph) 4.74 CH₃ Ph2,3-F(Ph) 4.75 CH₃ Ph 2,4-F(Ph) 4.76 CH₃ Ph 2,5-F(Ph) 4.77 CH₃ Ph2,6-F(Ph) 4.78 CH₃ Ph 3,4-F(Ph) 4.79 CH₃ Ph 3,5-F(Ph) 4.80 C₂H₅ Ph2-Cl(Ph) 4.81 n-C₃H₇ Ph 3-Cl(Ph) 4.82 iso-C₃H₇ Ph 4-Cl(Ph) 4.83 n-C₄H₉Ph 4-Br(Ph) 4.84 iso-C₄H₉ Ph 4-F(Ph) 4.85 C(CH₃)₃ Ph 4-OCH₃(Ph) 4.86n-C₅H₁₁ Ph 4-CH₃(Ph) 4.87 cyclopropyl Ph 4-NO₂(Ph) 4.881-CH₃-cyclopropyl Ph 2,4-Cl(Ph) 4.89 CN Ph 2,4-F(Ph) 4.90 Ph Ph Ph 4.91Ph Ph 2-Cl(Ph) 4.92 Ph Ph 3-Cl(Ph) 4.93 Ph Ph 4-Cl(Ph) 4.94 4-Cl(Ph) PhPh 4.95 4-Cl(Ph) Ph 4-Cl(Ph) 4.96 4-F(Ph) Ph Ph 4.97 4-F(Ph) Ph 4-F(Ph)4.98 4-CF₃(Ph) Ph Ph 4.99 4-CF₃(Ph) Ph 4-CF₃(Ph) 4.100 2,4-Cl(Ph) Ph Ph4.101 2,4-Cl(Ph) Ph 2,4-Cl(Ph) 4.102 2,4-F(Ph) Ph Ph 4.103 H 2-Cl(Ph) Ph4.104 CH₃ 2-Cl(Ph) Ph 4.105 C₂H₅ 2-Cl(Ph) 2-Cl(Ph) 4.106 n-C₃H₇ 2-Cl(Ph)3-Cl(Ph) 4.107 iso-C₃H₇ 2-Cl(Ph) 4-Cl(Ph) 4.108 n-C₄H₉ 2-Cl(Ph) 4-Br(Ph)4.109 iso-C₄H₉ 2-Cl(Ph) 4-F(Ph) 4.110 C(CH₃)₃ 2-Cl(Ph) 4-OCH₃(Ph) 4.111n-C₅H₁₁ 2-Cl(Ph) 4-CH₃(Ph) 4.112 cyclopropyl 2-Cl(Ph) 4-NO₂(Ph) 4.1131-CH₃-cyclopropyl 2-Cl(Ph) 2,4-Cl(Ph) 4.114 CN 2-Cl(Ph) 2,4-F(Ph) 4.115Ph 2-Cl(Ph) 2-Cl(Ph) 4.116 Ph 2-Cl(Ph) 3-Cl(Ph) 4.117 Ph 2-Cl(Ph)4-Cl(Ph) 4.118 4-Cl(Ph) 2-Cl(Ph) Ph 4.119 4-Cl(Ph) 2-Cl(Ph) 4-Cl(Ph)4.120 4-F(Ph) 2-Cl(Ph) Ph 4.121 4-F(Ph) 2-Cl(Ph) 4-F(Ph) 4.122 4-CF₃(Ph)2-Cl(Ph) Ph 4.123 4-CF₃(Ph) 2-Cl(Ph) 4-CF₃(Ph) 4.124 2,4-Cl(Ph) 2-Cl(Ph)Ph 4.125 2,4-Cl(Ph) 2-Cl(Ph) 2,4-Cl(Ph) 4.126 2,4-F(Ph) 2-Cl(Ph) Ph4.127 H 4-Cl(Ph) Ph 4.128 CH₃ 4-Cl(Ph) Ph 4.129 C₂H₅ 4-Cl(Ph) 2-Cl(Ph)4.130 n-C₃H₇ 4-Cl(Ph) 3-Cl(Ph) 4.131 iso-C₃H₇ 4-Cl(Ph) 4-Cl(Ph) 4.132n-C₄H₉ 4-Cl(Ph) 4-Br(Ph) 4.133 iso-C₄H₉ 4-Cl(Ph) 4-F(Ph) 4.134 C(CH₃)₃4-Cl(Ph) 4-OCH₃(Ph) 4.135 n-C₅H₁₁ 4-Cl(Ph) 4-CH₃(Ph) 4.136 cyclopropyl4-Cl(Ph) 4-NO₂(Ph) 4.137 1-CH₃-cyclopropyl 4-Cl(Ph) 2,4-Cl(Ph) 4.138 CN4-Cl(Ph) 2,4-F(Ph) 4.139 Ph 4-Cl(Ph) 2-Cl(Ph) 4.140 Ph 4-Cl(Ph) 3-Cl(Ph)4.141 Ph 4-Cl(Ph) 4-Cl(Ph) 4.142 4-Cl(Ph) 4-Cl(Ph) Ph 4.143 4-Cl(Ph)4-Cl(Ph) 4-Cl(Ph) 4.144 4-F(Ph) 4-Cl(Ph) Ph 4.145 4-F(Ph) 4-Cl(Ph)4-F(Ph) 4.146 4-CF₃(Ph) 4-Cl(Ph) Ph 4.147 4-CF₃(Ph) 4-Cl(Ph) 4-CF₃(Ph)4.148 2,4-Cl(Ph) 4-Cl(Ph) Ph 4.149 2,4-Cl(Ph) 4-Cl(Ph) 2,4-Cl(Ph) 4.1502,4-F(Ph) 4-Cl(Ph) Ph 4.151 H 4-CF₃(Ph) Ph 4.152 CH₃ 4-CF₃(Ph) Ph 4.153C₂H₅ 4-CF₃(Ph) 2-Cl(Ph) 4.154 n-C₃H₇ 4-CF₃(Ph) 3-Cl(Ph) 4.155 iso-C₃H₇4-CF₃(Ph) 4-Cl(Ph) 4.156 n-C₄H₉ 4-CF₃(Ph) 4-Br(Ph) 4.157 iso-C₄H₉4-CF₃(Ph) 4-F(Ph) 4.158 C(CH₃)₃ 4-CF₃(Ph) 4-OCH₃(Ph) 4.159 n-C₅H₁₁4-CF₃(Ph) 4-CH₃(Ph) 4.160 cyclopropyl 4-CF₃(Ph) 4-NO₂(Ph) 4.1611-CH₃-cyclopropyl 4-CF₃(Ph) 2,4-Cl(Ph) 4.162 CN 4-CF₃(Ph) 2,4-F(Ph)4.163 Ph 4-CF₃(Ph) 2-Cl(Ph) 4.164 Ph 4-CF₃(Ph) 3-Cl(Ph) 4.165 Ph4-CF₃(Ph) 4-Cl(Ph) 4.166 4-Cl(Ph) 4-CF₃(Ph) Ph 4.167 4-Cl(Ph) 4-CF₃(Ph)4-Cl(Ph) 4.168 4-F(Ph) 4-CF₃(Ph) Ph 4.169 4-F(Ph) 4-CF₃(Ph) 4-F(Ph)4.170 4-CF₃(Ph) 4-CF₃(Ph) Ph 4.171 4-CF₃(Ph) 4-CF₃(Ph) 4-CF₃(Ph) 4.1722,4-Cl(Ph) 4-CF₃(Ph) Ph 4.173 2,4-Cl(Ph) 4-CF₃(Ph) 2,4-Cl(Ph) 4.1742,4-F(Ph) 4-CF₃(Ph) Ph 4.175 H 1-napthyl Ph 4.176 CH₃ 1-napthyl Ph 4.177C₂H₅ 1-napthyl 2-Cl(Ph) 4.178 n-C₃H₇ 1-napthyl 3-Cl(Ph) 4.179 iso-C₃H₇1-napthyl 4-Cl(Ph) 4.180 n-C₄H₉ 1-napthyl 4-Br(Ph) 4.181 iso-C₄H₉1-napthyl 4-F(Ph) 4.182 C(CH₃)₃ 1-napthyl 4-OCH₃(Ph) 4.183 n-C₅H₁₁1-napthyl 4-CH₃(Ph) 4.184 cyclopropyl 1-napthyl 4-NO₂(Ph) 4.1851-CH₃-cyclopropyl 1-napthyl 2,4-Cl(Ph) 4.186 CN 1-napthyl 2,4-F(Ph)4.187 Ph 1-napthyl 2-Cl(Ph) 4.188 Ph 1-napthyl 3-Cl(Ph) 4.189 Ph1-napthyl 4-Cl(Ph) 4.190 4-CT(Ph) 1-napthyl Ph 4.191 4-Cl(Ph) 1-napthyl4-Cl(Ph) 4.192 4-F(Ph) 1-napthyl Ph 4.193 4-F(Ph) 1-napthyl 4-F(Ph)4.194 4-CF₃(Ph) 1-napthyl Ph 4.195 4-CF₃(Ph) 1 -napthyl 4-CF₃(Ph) 4.1962,4-Cl(Ph) 1-napthyl Ph 4.197 2,4-Cl(Ph) 1-napthyl 2,4-Cl(Ph) 4.1982,4-F(Ph) 1-napthyl Ph 4.199 CH₃ 2-pyridyl Ph 4.200 CH₃ 3-pyridyl Ph4.201 CH₃ 4-pyridyl Ph 4.202 CH₃ 2-thienyl Ph 4.203 CH₃ 3-thienyl Ph4.204 CH₃ 2-furyl Ph 4.205 CH₃ 3-furyl Ph 4.206 CH₃ 5-pyrimidinyl Ph4.207 CH₃ 2-pyridyl 4-Cl(Ph) 4.208 CH₃ 3-pyridyl 4-Cl(Ph) 4.209 CH₃4-pyridyl 4-Cl(Ph) 4.210 CH₃ 2-thienyl 4-Cl(Ph) 4.211 CH₃ 3-thienyl4-Cl(Ph) 4.212 CH₃ 2-furyl 4-Cl(Ph) 4.213 CH₃ 3-furyl 4-Cl(Ph) 4.214 CH₃5-pyrimidinyl 4-Cl(Ph) 4.215 CH₃ 2-pyridyl 3-CF₃(Ph) 4.216 CH₃ 3-pyridyl3-CF₃(Ph) 4.217 CH₃ 4-pyridyl 3-CF₃(Ph) 4.218 CH₃ 2-thienyl 3-CF₃(Ph)4.219 CH₃ 3-thienyl 3-CF₃(Ph) 4.220 CH₃ 2-furyl 3-CF₃(Ph) 4.221 CH₃3-furyl 3-CF₃(Ph) 4.222 CH₃ 5-pyrimidinyl 3-CF₃(Ph) 4.223 CH₃ 2-pyridyl4-CF₃(Ph) 4.224 CH₃ 3-pyridyl 4-CF₃(Ph) 4.225 CH₃ 4-pyridyl 4-CF₃(Ph)4.226 CH₃ 2-thienyl 4-CF₃(Ph)

TABLE 5

Compounds 5.1 to 5.226 are compounds of Formula V, which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═O, and where R₂, R₃, and R₇are defined in Table 4.

TABLE 6

Compounds 6.1 to 6.226 are compounds of Formula VI, which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═O, and where R₂, R₃, and R₇are defined in Table 4.

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula IV, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═O, and where R₂, R₃, and R₇ aredefined in Table 7.

TABLE 7 Compd. R₂ R₃ R₇ 7.1 H H 2-pyridyl 7.2 H H 3-pyridyl 7.3 H H4-pyridyl 7.4 H H 2-thienyl 7.5 H H 3-thienyl 7.6 H H 2-furyl 7.7 H H3-furyl 7.8 H H 4-pyrimidinyl 7.9 H H 5-pyrimidinyl 7.10 H H pyrazinyl7.11 CH₃ H 2-pyridyl 7.12 CH₃ H 3-pyridyl 7.13 CH₃ H 4-pyridyl 7.14 CH₃H 2-thienyl 7.15 CH₃ H 3-thienyl 7.16 CH₃ H 2-furyl 7.17 CH₃ H 3-furyl7.18 CH₃ H 4-pyrimidinyl 7.19 CH₃ H 5-pyrimidinyl 7.20 CH₃ H pyrazinyl7.21 C₂H₅ H 2-pyridyl 7.22 C₂H₅ H 3-pyridyl 7.23 C₂H₅ H 4-pyridyl 7.24C₂H₅ H 2-thienyl 7.25 C₂H₅ H 3-thienyl 7.26 C₂H₅ H 2-furyl 7.27 C₂H₅ H3-furyl 7.28 C₂H₅ H 4-pyrimidinyl 7.29 C₂H₅ H 5-pyrimidinyl 7.30 C₂H₅ Hpyrazinyl 7.31 n-C₃H₇ H 2-pyridyl 7.32 n-C₃H₇ H 3-pyridyl 7.33 n-C₃H₇ H4-pyridyl 7.34 n-C₃H₇ H 2-thienyl 7.35 n-C₃H₇ H 3-thienyl 7.36 n-C₃H₇ H2-furyl 7.37 n-C₃H₇ H 3-furyl 7.38 n-C₃H₇ H 4-pyrimidinyl 7.39 n-C₃H₇ H5-pyrimidinyl 7.40 n-C₃H₇ H pyrazinyl 7.41 cyclopropyl H 2-pyridyl 7.42cyclopropyl H 3-pyridyl 7.43 cyclopropyl H 4-pyridyl 7.44 cyclopropyl H2-thienyl 7.45 cyclopropyl H 3-thienyl 7.46 cyclopropyl H 2-furyl 7.47cyclopropyl H 3-furyl 7.48 cyclopropyl H 4-pyrimidinyl 7.49 cyclopropylH 5-pyrimidinyl 7.50 cyclopropyl H pyrazinyl 7.51 CN H 2-pyridyl 7.52 CNH 3-pyridyl 7.53 CN H 4-pyridyl 7.54 CN H 2-thienyl 7.55 CN H 3-thienyl7.56 CN H 2-furyl 7.57 CN H 3-furyl 7.58 CN H 4-pyrimidinyl 7.59 CN H5-pyrimidinyl 7.60 CN H pyrazinyl 7.61 CH₃ CH₃ 2-pyridyl 7.62 CH₃ CH₃3-pyridyl 7.63 CH₃ CH₃ 4-pyridyl 7.64 CH₃ CH₃ 2-thienyl 7.65 CH₃ CH₃3-thienyl 7.66 CH₃ CH₃ 2-furyl 7.67 CH₃ CH₃ 3-furyl 7.68 CH₃ CH₃4-pyrimidinyl 7.69 CH₃ CH₃ 5-pyrimidinyl 7.70 CH₃ CH₃ pyrazinyl 7.71 CH₃H 2-pyridylCH₂— 7.71 CH₃ H 3-pyridylCH₂— 7.70 CH₃ H 4-pyridylCH₂— 7.71CH₃ H 2-thienylCH₂— 7.72 CH₃ H 3-thienyllCH₂— 7.73 CH₃ H 2-furylCH₂—7.74 CH₃ H 3-furylCH₂— 7.75 CH₃ CH₃ 2-pyridylCH₂— 7.76 CH₃ CH₃2-thienylCH₂— 7.77 H Ph 2-pyridyl 7.78 H Ph 3-pyridyl 7.79 H Ph4-pyridyl 7.80 H Ph 2-thienyl 7.81 H Ph 3-thienyl 7.82 H Ph 2-furyl 7.83H Ph 3-furyl 7.84 H Ph 4-pyrimidinyl 7.85 H Ph 5-pyrimidinyl 7.86 H Phpyrazinyl 7.87 CH₃ Ph 2-pyridyl 7.88 CH₃ Ph 3-pyridyl 7.89 CH₃ Ph4-pyridyl 7.90 CH₃ Ph 2-thienyl 7.91 CH₃ Ph 3-thienyl 7.92 CH₃ Ph2-furyl 7.93 CH₃ Ph 3-furyl 7.94 CH₃ Ph 4-pyrimidinyl 7.95 CH₃ Ph5-pyrimidinyl 7.96 CH₃ Ph pyrazinyl 7.97 CH₃ 2-Cl(Ph) 2-pyridyl 7.98 CH₃2-Cl(Ph) 3-pyridyl 7.99 CH₃ 2-Cl(Ph) 4-pyridyl 7.100 CH₃ 2-Cl(Ph)2-thienyl 7.101 CH₃ 2-Cl(Ph) 3-thienyl 7.102 CH₃ 2-Cl(Ph) 2-furyl 7.103CH₃ 2-Cl(Ph) 3-furyl 7.104 CH₃ 2-Cl(Ph) 4-pyrimidinyl 7.105 CH₃ 2-Cl(Ph)5-pyrimidinyl 7.106 CH₃ 2-Cl(Ph) pyrazinyl 7.107 CH₃ 4-Cl(Ph) 2-pyridyl7.108 CH₃ 4-Cl(Ph) 3-pyridyl 7.109 CH₃ 4-Cl(Ph) 4-pyridyl 7.110 CH₃4-Cl(Ph) 2-thienyl 7.111 CH₃ 4-Cl(Ph) 3-thienyl 7.112 CH₃ 4-Cl(Ph)2-furyl 7.113 CH₃ 4-Cl(Ph) 3-furyl 7.114 CH₃ 4-Cl(Ph) 4-pyrimidinyl7.115 CH₃ 4-Cl(Ph) 5-pyrimidinyl 7.116 CH₃ 4-Cl(Ph) pyrazinyl 7.117 CH₃1-napthyl 2-pyridyl 7.118 CH₃ 1-napthyl 3-pyridyl 7.119 CH₃ 1-napthyl4-pyridyl 7.120 CH₃ 1-napthyl 2-thienyl 7.121 CH₃ 1-napthyl 3-thienyl7.122 CH₃ 1-napthyl 2-furyl 7.123 CH₃ 1-napthyl 3-furyl 7.124 CH₃1-napthyl 4-pyrimidinyl 7.125 CH₃ 1-napthyl 5-pyrimidinyl 7.126 CH₃1-napthyl pyrazinyl 7.127 CN Ph 2-pyridyl 7.128 CN Ph 3-pyridyl 7.129 CNPh 4-pyridyl 7.130 CN Ph 2-thienyl 7.131 CN Ph 3-thienyl 7.132 CN Ph2-furyl 7.133 CN Ph 3-furyl 7.134 CN Ph 4-pyrimidinyl 7.135 CN Ph5-pyrimidinyl 7.136 CN Ph pyrazinyl 7.127 CN 4-Cl(Ph) 2-pyridyl 7.128 CN4-Cl(Ph) 3-pyridyl 7.129 CN 4-Cl(Ph) 4-pyridyl 7.130 CN 4-Cl(Ph)2-thienyl 7.131 CN 4-Cl(Ph) 3-thienyl 7.132 CN 4-Cl(Ph) 2-furyl 7.133 CN4-Cl(Ph) 3-furyl 7.134 CN 4-Cl(Ph) 4-pyrimidinyl 7.135 CN 4-Cl(Ph)5-pyrimidinyl 7.136 CN 4-Cl(Ph) pyrazinyl 7.127 CN 1-napthyl 2-pyridyl7.128 CN 1-napthyl 3-pyridyl 7.129 CN 1-napthyl 4-pyridyl 7.130 CN1-napthyl 2-thienyl 7.131 CN 1-napthyl 3-thienyl 7.132 CN 1-napthyl2-furyl 7.133 CN 1-napthyl 3-furyl 7.134 CN 1-napthyl 4-pyrimidinyl7.135 CN 1-napthyl 5-pyrimidinyl 7.136 CN 1-napthyl pyrazinyl 7.137 H2-pyridyl 2-pyridyl 7.138 H 3-pyridyl 2-pyridyl 7.139 H 4-pyridyl2-pyridyl 7.140 H 2-thienyl 2-pyridyl 7.141 H 3-thienyl 2-pyridyl 7.142H 2-furyl 2-pyridyl 7.143 H 3-furyl 2-pyridyl 7.144 H 4-pyrimidinyl2-pyridyl 7.145 H 5-pyrimidinyl 2-pyridyl 7.146 H pyrazinyl 2-pyridyl7.147 H 2-pyridyl 3-pyridyl 7.148 H 3-pyridyl 3-pyridyl 7.149 H4-pyridyl 3-pyridyl 7.150 H 2-thienyl 3-pyridyl 7.151 H 3-thienyl3-pyridyl 7.152 H 2-furyl 3-pyridyl 7.153 H 3-furyl 3-pyridyl 7.154 H4-pyrimidinyl 3-pyridyl 7.155 H 5-pyrimidinyl 3-pyridyl 7.156 Hpyrazinyl 3-pyridyl 7.157 H 2-pyridyl 2-thienyl 7.158 H 3-pyridyl2-thienyl 7.159 H 4-pyridyl 2-thienyl 7.160 H 2-thienyl 2-thienyl 7.161H 3-thienyl 2-thienyl 7.162 H 2-furyl 2-thienyl 7.163 H 3-furyl2-thienyl 7.164 H 4-pyrimidinyl 2-thienyl 7.165 H 5-pyrimidinyl2-thienyl 7.166 H pyrazinyl 2-thienyl 7.167 CH₃ 2-pyridyl 2-pyridyl7.168 CH₃ 3-pyridyl 2-pyridyl 7.169 CH₃ 4-pyridyl 2-pyridyl 7.170 CH₃2-thienyl 2-pyridyl 7.171 CH₃ 3-thienyl 2-pyridyl 7.172 CH₃ 2-furyl2-pyridyl 7.173 CH₃ 3-furyl 2-pyridyl 7.174 CH₃ 4-pyrimidinyl 2-pyridyl7.175 CH₃ 5-pyrimidinyl 2-pyridyl 7.176 CH₃ pyrazinyl 2-pyridyl 7.177CH₃ 2-pyridyl 3-pyridyl 7.178 CH₃ 3-pyridyl 3-pyridyl 7.179 CH₃4-pyridyl 3-pyridyl 7.180 CH₃ 2-thienyl 3-pyridyl 7.181 CH₃ 3-thienyl3-pyridyl 7.182 CH₃ 2-furyl 3-pyridyl 7.183 CH₃ 3-furyl 3-pyridyl 7.184CH₃ 4-pyrimidinyl 3-pyridyl 7.185 CH₃ 5-pyrimidinyl 3-pyridyl 7.186 CH₃pyrazinyl 3-pyridyl 7.187 CH₃ 2-pyridyl 2-thienyl 7.188 CH₃ 3-pyridyl2-thienyl 7.190 CH₃ 4-pyridyl 2-thienyl 7.191 CH₃ 2-thienyl 2-thienyl7.192 CH₃ 3-thienyl 2-thienyl 7.193 CH₃ 2-furyl 2-thienyl 7.194 CH₃3-furyl 2-thienyl 7.195 CH₃ 4-pyrimidinyl 2-thienyl 7.196 CH₃5-pyrimidinyl 2-thienyl 7.197 CH₃ pyrazinyl 2-thienyl 7.198 CN 2-pyridyl2-pyridyl 7.199 CN 3-pyridyl 2-pyridyl 7.200 CN 4-pyridyl 2-pyridyl7.201 CN 2-thienyl 2-pyridyl 7.202 CN 3-thienyl 2-pyridyl 7.203 CN2-furyl 2-pyridyl 7.204 CN 3-furyl 2-pyridyl 7.205 CN 4-pyrimidinyl2-pyridyl 7.206 CN 5-pyrimidinyl 2-pyridyl 7.207 CN pyrazinyl 2-pyridyl7.208 CN 2-pyridyl 3-pyridyl 7.209 CN 3-pyridyl 3-pyridyl 7.210 CN4-pyridyl 3-pyridyl 7.211 CN 2-thienyl 3-pyridyl 7.212 CN 3-thienyl3-pyridyl 7.213 CN 2-furyl 3-pyridyl 7.214 CN 3-furyl 3-pyridyl 7.215 CN4-pyrimidinyl 3-pyridyl 7.216 CN 5-pyrimidinyl 3-pyridyl 7.217 CNpyrazinyl 3-pyridyl 7.218 CN 2-pyridyl 2-thienyl 7.219 CN 3-pyridyl2-thienyl 7.220 CN 4-pyridyl 2-thienyl 7.221 CN 2-thienyl 2-thienyl

TABLE 8

Compounds 8.1 to 8.221 are compounds of Formula V, which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═O, and where R₂, R₃, and R₇are defined in Table 7.

Table 9: Compounds 9.1 to 9.221 are compounds of Formula V, which isFormula I with A═R₄═R₅═R₆═H, R₁═CH₃, X═N, N—H, and Z═O, and where R₂,R₃, and R₇ are defined in Table 7.

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula IV, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═O, and where R₂, R₃, and R₇ aredefined in Table 10.

TABLE 10 Compd. R₂ R₃ R₇ 10.1 H Ph H 10.2 H Ph CH₃ 10.3 H Ph C₂H₅ 10.4 HPh n-C₃H₇ 10.5 H Ph iso-C₃H₇ 10.6 H Ph n-C₄H₉ 10.7 H Ph C(CH₃)₃ 10.8 HPh n-C₅H₁₁ 10.9 H Ph cyclopropyl 10.10 H 4-Cl(Ph) H 10.11 H 4-Cl(Ph) CH₃10.12 H 4-Cl(Ph) C₂H₅ 10.13 H 4-Cl(Ph) n-C₃H₇ 10.14 H 4-Cl(Ph) iso-C₃H₇10.15 H 4-Cl(Ph) n-C₄H₉ 10.16 H 4-Cl(Ph) C(CH₃)₃ 10.17 H 4-Cl(Ph)n-C₅H₁₁ 10.18 H 4-Cl(Ph) cyclopropyl 10.19 H 4-Cl(Ph) cyclohexyl 10.20CH₃ Ph H 10.21 CH₃ Ph CH₃ 10.22 CH₃ Ph C₂H₅ 10.23 CH₃ Ph n-C₃H₇ 10.24CH₃ Ph iso-C₃H₇ 10.25 CH₃ Ph n-C₄H₉ 10.26 CH₃ Ph C(CH₃)₃ 10.27 CH₃ Phn-C₅H₁₁ 10.28 CH₃ Ph cyclopropyl 10.29 CH₃ 4-Cl(Ph) H 10.30 CH₃ 4-Cl(Ph)CH₃ 10.31 CH₃ 4-Cl(Ph) C₂H₅ 10.32 CH₃ 4-Cl(Ph) n-C₃H₇ 10.33 CH₃ 4-Cl(Ph)iso-C₃H₇ 10.34 CH₃ 4-Cl(Ph) n-C₄H₉ 10.35 CH₃ 4-Cl(Ph) C(CH₃)₃ 10.36 CH₃4-Cl(Ph) n-C₅H₁₁ 10.37 CH₃ 4-Cl(Ph) cyclopropyl 10.38 CH₃ 4-Cl(Ph)cyclohexyl 10.39 H 1-napthyl H 10.40 H 1-napthyl CH₃ 10.41 H 1-napthylC₂H₅ 10.42 H 1-napthyl n-C₃H₇ 10.43 H 1-napthyl iso-C₃H₇ 10.44 H1-napthyl n-C₄H₉ 10.45 H 1-napthyl C(CH₃)₃ 10.46 H 1-napthyl n-C₅H₁₁10.47 H 1-napthyl cyclopropyl 10.48 H 1-napthyl cyclohexyl 10.49 CH₃1-napthyl H 10.50 CH₃ 1-napthyl CH₃ 10.51 CH₃ 1-napthyl C₂H₅ 10.52 CH₃1-napthyl n-C₃H₇ 10.53 CH₃ 1-napthyl iso-C₃H₇ 10.54 CH₃ 1-napthyl n-C₄H₉10.55 CH₃ 1-napthyl C(CH₃)₃ 10.56 CH₃ 1-napthyl n-C₅H₁₁ 10.57 CH₃1-napthyl cyclopropyl 10.58 CH₃ 1-napthyl cyclohexyl 10.59 H 2-pyridyl H10.60 H 2-pyridyl CH₃ 10.61 H 2-pyridyl C₂H₅ 10.62 H 2-pyridyl n-C₃H₇10.63 H 2-pyridyl iso-C₃H₇ 10.64 H 2-pyridyl n-C₄H₉ 10.65 H 2-pyridylC(CH₃)₃ 10.66 H 2-pyridyl n-C₅H₁₁ 10.67 H 2-pyridyl cyclopropyl 10.68 H2-pyridyl cyclohexyl 10.69 H 3-pyridyl H 10.70 H 3-pyridyl CH₃ 10.71 H3-pyridyl C₂H₅ 10.72 H 3-pyridyl n-C₃H₇ 10.73 H 3-pyridyl n-C₄H₉ 10.74 H3-pyridyl iso-C₄H₉ 10.75 H 3-pyridyl C(CH₃)₃ 10.76 H 3-pyridyl n-C₅H₁₁10.77 H 3-pyridyl cyclopropyl 10.78 H 3-pyridyl cyclohexyl 10.79 H2-thienyl H 10.80 H 2-thienyl CH₃ 10.81 H 2-thienyl C₂H₅ 10.82 H2-thienyl n-C₃H₇ 10.83 H 2-thienyl iso-C₃H₇ 10.84 H 2-thienyl n-C₄H₉10.85 H 2-thienyl C(CH₃)₃ 10.86 H 2-thienyl n-C₅H₁₁ 10.87 H 2-thienylcyclopropyl 10.88 H 2-thienyl cyclohexyl 10.89 H 3-thienyl H 10.90 H3-thienyl CH₃ 10.91 H 3-thienyl C₂H₅ 10.92 H 3-thienyl n-C₃H₇ 10.93 H3-thienyl iso-C₃H₇ 10.94 H 3-thienyl n-C₄H₉ 10.95 H 3-thienyl C(CH₃)₃10.96 H 3-thienyl n-C₅H₁₁ 10.97 H 3-thienyl cyclopropyl 10.98 H3-thienyl cyclohexyl 10.99 H 2-furyl H 10.90 H 2-furyl CH₃ 10.91 H2-furyl C₂H₅ 10.92 H 2-furyl n-C₃H₇ 10.93 H 2-furyl iso-C₃H₇ 10.94 H2-furyl n-C₄H₉ 10.95 H 2-furyl C(CH₃)₃ 10.96 H 2-furyl n-C₅H₁₁ 10.97 H2-furyl cyclopropyl 10.98 H 2-furyl cyclohexyl 10.99 CH₃ 2-pyridyl H10.100 CH₃ 2-pyridyl CH₃ 10.102 CH₃ 2-pyridyl C₂H₅ 10.103 CH₃ 2-pyridyln-C₃H₇ 10.104 CH₃ 2-pyridyl iso-C₃H₇ 10.105 CH₃ 2-pyridyl n-C₄H₉ 10.106CH₃ 2-pyridyl C(CH₃)₃ 10.107 CH₃ 2-pyridyl n-C₅H₁₁ 10.108 CH₃ 2-pyridylcyclopropyl 10.109 CH₃ 2-pyridyl cyclohexyl 10.110 CH₃ 3-pyridyl H10.111 CH₃ 3-pyridyl CH₃ 10.112 CH₃ 3-pyridyl C₂H₅ 10.113 CH₃ 3-pyridyln-C₃H₇ 10.114 CH₃ 3-pyridyl iso-C₃H₇ 10.115 CH₃ 3-pyridyl n-C₄H₉ 10.116CH₃ 3-pyridyl C(CH₃)₃ 10.117 CH₃ 3-pyridyl n-C₅H₁₁ 10.118 CH₃ 3-pyridylcyclopropyl 10.119 CH₃ 3-pyridyl cyclohexyl 10.120 CH₃ 2-thienyl H10.121 CH₃ 2-thienyl CH₃ 10.122 CH₃ 2-thienyl C₂H₅ 10.123 CH₃ 2-thienyln-C₃H₇ 10.124 CH₃ 2-thienyl iso-C₃H₇ 10.125 CH₃ 2-thienyl n-C₄H₉ 10.126CH₃ 2-thienyl C(CH₃)₃ 10.127 CH₃ 2-thienyl n-C₅H₁₁ 10.128 CH₃ 2-thienylcyclopropyl 10.129 CH₃ 2-thienyl cyclohexyl 10.130 CH₃ 3-thienyl H10.131 CH₃ 3-thienyl CH₃ 10.132 CH₃ 3-thienyl C₂H₅ 10.133 CH₃ 3-thienyln-C₃H₇ 10.134 CH₃ 3-thienyl iso-C₃H₇ 10.135 CH₃ 3-thienyl n-C₄H₉ 10.136CH₃ 3-thienyl C(CH₃)₃ 10.137 CH₃ 3-thienyl n-C₅H₁₁ 10.138 CH₃ 3-thienylcyclopropyl 10.139 CH₃ 3-thienyl cyclohexyl

TABLE 11

Compounds 11.1 to 11.139 are compounds of Formula V, which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═O, and where R₂, R₃, and R₇are defined in Table 10.

TABLE 12

Compounds 12.1 to 12.139 are compounds of Formula VI, which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═O, and where R₂, R₃, and R₇are defined in Table 10.

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula VII, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═NOR₉, and where R₂, R₃, R₇ and R₉are defined in Table 13.

TABLE 13 Compd R₂ R₃ R₇ R₉ 13.1 H H Ph H 13.2 H H 4-Cl(Ph) H 13.3 H H4-Br(Ph) H 13.4 H H 4-F(Ph) H 13.5 H H 4-OCH₃(Ph) H 13.6 H H 4-CF₃(Ph) H13.7 H H Ph CH₃ 13.8 H H 4-Cl(Ph) CH₃ 13.9 H H 4-Br(Ph) CH₃ 13.10 H H4-F(Ph) CH₃ 13.11 CH₃ H Ph H 13.12 CH₃ H 2-Cl(Ph) H 13.13 CH₃ H 3-Cl(Ph)H 13.14 CH₃ H 4-Cl(Ph) H 13.15 CH₃ H 2-Br(Ph) H 13.16 CH₃ H 3-Br(Ph) H13.17 CH₃ H 4-Br(Ph) H 13.18 CH₃ H Ph CH₃ 13.19 CH₃ H 2-Cl(Ph) CH₃ 13.20CH₃ H 3-Cl(Ph) CH₃ 13.21 CH₃ H 4-Cl(Ph) CH₃ 13.22 CH₃ H 2-F(Ph) CH₃13.23 CH₃ H 3-F(Ph) CH₃ 13.24 CH₃ H 4-F(Ph) CH₃ 13.25 CH₃ H 2-CH₃(Ph)CH₃ 13.26 CH₃ H 3-CH₃(Ph) CH₃ 13.27 CH₃ H 2-CF₃(Ph) CH₃ 13.28 CH₃ H3-CF₃(Ph) CH₃ 13.29 CH₃ H 4-CF₃(Ph) CH₃ 13.30 CH₃ H 2-OCH₃(Ph) CH₃ 13.31CH₃ H 3-OCH₃(Ph) CH₃ 13.32 CH₃ H 2-OCH₃(Ph) CH₃ 13.33 CH₃ H 2,3-Cl(Ph)CH₃ 13.34 CH₃ H 2,4-Cl(Ph) CH₃ 13.35 CH₃ H 2,5-Cl(Ph) CH₃ 13.36 CH₃ H2,6-Cl(Ph) CH₃ 13.37 CH₃ H 3,4-Cl(Ph) CH₃ 13.38 CH₃ H 3,5-Cl(Ph) CH₃13.39 CH₃ H Ph C₂H₅ 13.40 CH₃ H Ph n-C₃H₇ 13.41 CH₃ H Ph iso-C₃H₇ 13.42CH₃ H Ph n-C₄H₉ 13.43 CH₃ H Ph C(CH₃)₃ 13.44 CH₃ H Ph CH₂C≡CH 13.45 C₂H₅H Ph CH₃ 13.46 C₂H₅ H 2-Cl(Ph) CH₃ 13.47 C₂H₅ H 3-Cl(Ph) CH₃ 13.48 C₂H₅H 4-Cl(Ph) CH₃ 13.49 C₂H₅ H 4-Br(Ph) CH₃ 13.50 C₂H₅ H 4-F(Ph) CH₃ 13.51C₂H₅ H 4-OCH₃(Ph) CH₃ 13.52 C₂H₅ H 4-CH₃(Ph) CH₃ 13.53 C₂H₅ H 4-NO₂(Ph)CH₃ 13.54 C₂H₅ H 2,4-Cl(Ph) CH₃ 13.55 C₂H₅ H 2,4-F(Ph) CH₃ 13.56 n-C₃H₇H Ph CH₃ 13.57 n-C₃H₇ H 2-Cl(Ph) CH₃ 13.58 n-C₃H₇ H 3-Cl(Ph) CH₃ 13.59n-C₃H₇ H 4-Cl(Ph) CH₃ 13.60 n-C₃H₇ H 4-F(Ph) CH₃ 13.61 n-C₃H₇ H3-OCH₃(Ph) CH₃ 13.62 n-C₃H₇ H 4-OCH₃(Ph) CH₃ 13.63 n-C₃H₇ H 4-CH₃(Ph)CH₃ 13.64 n-C₃H₇ H 4-NO₂(Ph) CH₃ 13.65 n-C₃H₇ H 2,4-Cl(Ph) CH₃ 13.66n-C₃H₇ H 2,4-F(Ph) CH₃ 13.67 iso-C₃H₇ H Ph CH₃ 13.68 iso-C₃H₇ H 2-Cl(Ph)CH₃ 13.69 iso-C₃H₇ H 3-Cl(Ph) CH₃ 13.70 iso-C₃H₇ H 4-Cl(Ph) CH₃ 13.71iso-C₃H₇ H 4-Br(Ph) CH₃ 13.72 iso-C₃H₇ H 4-F(Ph) CH₃ 13.73 iso-C₃H₇ H4-OCH₃(Ph) CH₃ 13.74 iso-C₃H₇ H 4-CH₃(Ph) CH₃ 13.75 iso-C₃H₇ H 4-NO₂(Ph)CH₃ 13.76 iso-C₃H₇ H 2,4-Cl(Ph) CH₃ 13.77 iso-C₃H₇ H 2,4-F(Ph) CH₃ 13.78n-C₄H₉ H Ph CH₃ 13.79 n-C₄H₉ H 2-Cl(Ph) CH₃ 13.80 n-C₄H₉ H 3-Cl(Ph) CH₃13.81 n-C₄H₉ H 4-Cl(Ph) CH₃ 13.82 n-C₄H₉ H 4-Br(Ph) CH₃ 13.83 n-C₄H₉ H4-F(Ph) CH₃ 13.84 n-C₄H₉ H 4-OCH₃(Ph) CH₃ 13.85 n-C₄H₉ H 4-CH₃(Ph) CH₃13.86 n-C₄H₉ H 4-NO₂(Ph) CH₃ 13.87 n-C₄H₉ H 2,4-Cl(Ph) CH₃ 13.88 n-C₄H₉H 2,4-F(Ph) CH₃ 13.89 iso-C₄H₉ H Ph CH₃ 13.90 iso-C₄H₉ H 2-Cl(Ph) CH₃13.91 iso-C₄H₉ H 3-Cl(Ph) CH₃ 13.92 iso-C₄H₉ H 4-Cl(Ph) CH₃ 13.93iso-C₄H₉ H 4-F(Ph) CH₃ 13.94 iso-C₄H₉ H 3-OCH₃(Ph) CH₃ 13.95 iso-C₄H₉ H4-OCH₃(Ph) CH₃ 13.96 iso-C₄H₉ H 4-CH₃(Ph) CH₃ 13.97 iso-C₄H₉ H 4-NO₂(Ph)CH₃ 13.98 iso-C₄H₉ H 2,4-Cl(Ph) CH₃ 13.99 iso-C₄H₉ H 2,4-F(Ph) CH₃13.100 C(CH₃)₃ H Ph CH₃ 13.101 C(CH₃)₃ H 2-Cl(Ph) CH₃ 13.102 C(CH₃)₃ H3-Cl(Ph) CH₃ 13.103 C(CH₃)₃ H 4-Cl(Ph) CH₃ 13.104 C(CH₃)₃ H 4-F(Ph) CH₃13.105 C(CH₃)₃ H 3-OCH₃(Ph) CH₃ 13.106 C(CH₃)₃ H 4-OCH₃(Ph) CH₃ 13.107C(CH₃)₃ H 4-CH₃(Ph) CH₃ 13.108 C(CH₃)₃ H 4-NO₂(Ph) CH₃ 13.109 C(CH₃)₃ H2,4-Cl(Ph) CH₃ 13.110 C(CH₃)₃ H 2,4-F(Ph) CH₃ 13.111 cyclopropyl H PhCH₃ 13.112 cyclopropyl H 2-Cl(Ph) CH₃ 13.113 cyclopropyl H 3-Cl(Ph) CH₃13.114 cyclopropyl H 4-Cl(Ph) CH₃ 13.115 cyclopropyl H 4-Br(Ph) CH₃13.116 cyclopropyl H 3-OCH₃(Ph) CH₃ 13.117 cyclopropyl H 4-OCH₃(Ph) CH₃13.118 cyclopropyl H 4-CH₃(Ph) CH₃ 13.119 cyclopropyl H 4-NO₂(Ph) CH₃13.120 cyclopropyl H 2,4-Cl(Ph) CH₃ 13.121 cyclopropyl H 2,4-F(Ph) CH₃13.122 1-CH₃-cyclopropyl H Ph CH₃ 13.123 1-CH₃-cyclopropyl H 2-Cl(Ph)CH₃ 13.124 1-CH₃-cyclopropyl H 3-Cl(Ph) CH₃ 13.125 1-CH₃-cyclopropyl H4-Cl(Ph) CH₃ 13.126 1-CH₃-cyclopropyl H 4-Br(Ph) CH₃ 13.1271-CH₃-cyclopropyl H 4-F(Ph) CH₃ 13.128 1-CH₃-cyclopropyl H 4-OCH₃(Ph)CH₃ 13.129 1-CH₃-cyclopropyl H 4-CH₃(Ph) CH₃ 13.130 1-CH₃-cyclopropyl H4-NO₂(Ph) CH₃ 13.131 1-CH₃-cyclopropyl H 2,4-Cl(Ph) CH₃ 13.1321-CH₃-cyclopropyl H 2,4-F(Ph) CH₃ 13.133 CH₃ CH₃ Ph H 13.134 CH₃ CH₃ PhCH₃ 13.135 CH₃ CH₃ Ph C₂H₅ 13.136 CH₃ CH₃ Ph n-C₃H₇ 13.137 CH₃ CH₃ Phiso-C₃H₇ 13.138 CH₃ CH₃ Ph n-C₄H₉ 13.139 CH₃ CH₃ Ph iso-C₄H₉ 13.140 CH₃CH₃ Ph C(CH₃)₃ 13.141 CH₃ CH₃ Ph CH₂C≡CH 13.142 CH₃ CH₃ 2-Cl(Ph) CH₃13.143 CH₃ CH₃ 3-Cl(Ph) CH₃ 13.144 C₂H₅ CH₃ Ph CH₃ 13.145 C₂H₅ CH₃2-Cl(Ph) CH₃ 13.146 C₂H₅ CH₃ 3-Cl(Ph) CH₃ 13.147 C₂H₅ CH₃ 4-Cl(Ph) CH₃13.148 C₂H₅ CH₃ 4-Br(Ph) CH₃ 13.149 C₂H₅ CH₃ 4-F(Ph) CH₃ 13.150 C₂H₅ CH₃4-OCH₃(Ph) CH₃ 13.151 C₂H₅ CH₃ 4-CH₃(Ph) CH₃ 13.152 C₂H₅ CH₃ 4-NO₂(Ph)CH₃ 13.153 C₂H₅ CH₃ 2,4-Cl(Ph) CH₃ 13.154 C₂H₅ CH₃ 2,4-F(Ph) CH₃ 13.155n-C₃H₇ CH₃ Ph CH₃ 13.156 n-C₃H₇ CH₃ 2-Cl(Ph) CH₃ 13.157 n-C₃H₇ CH₃3-Cl(Ph) CH₃ 13.158 n-C₃H₇ CH₃ 4-Cl(Ph) CH₃ 13.159 n-C₃H₇ CH₃ 4-Br(Ph)CH₃ 13.160 n-C₃H₇ CH₃ 4-F(Ph) CH₃ 13.161 n-C₃H₇ CH₃ 4-OCH₃(Ph) CH₃13.162 n-C₃H₇ CH₃ 4-CH₃(Ph) CH₃ 13.163 n-C₃H₇ CH₃ 4-NO₂(Ph) CH₃ 13.164n-C₃H₇ CH₃ 2,4-Cl(Ph) CH₃ 13.165 n-C₃H₇ CH₃ 2,4-F(Ph) CH₃ 13.166iso-C₃H₇ CH₃ Ph CH₃ 13.167 iso-C₃H₇ CH₃ 2-Cl(Ph) CH₃ 13.168 iso-C₃H₇ CH₃3-Cl(Ph) CH₃ 13.169 iso-C₃H₇ CH₃ 4-Cl(Ph) CH₃ 13.170 iso-C₃H₇ CH₃4-Br(Ph) CH₃ 13.171 iso-C₃H₇ CH₃ 4-F(Ph) CH₃ 13.172 iso-C₃H₇ CH₃4-OCH₃(Ph) CH₃ 13.173 iso-C₃H₇ CH₃ 4-CH₃(Ph) CH₃ 13.174 iso-C₃H₇ CH₃4-NO₂(Ph) CH₃ 13.175 iso-C₃H₇ CH₃ 2,4-Cl(Ph) CH₃ 13.176 iso-C₃H₇ CH₃2,4-F(Ph) CH₃ 13.177 n-C₄H₉ CH₃ Ph CH₃ 13.178 n-C₄H₉ CH₃ 2-Cl(Ph) CH₃13.179 n-C₄H₉ CH₃ 3-Cl(Ph) CH₃ 13.180 n-C₄H₉ CH₃ 4-Cl(Ph) CH₃ 13.181n-C₄H₉ CH₃ 4-Br(Ph) CH₃ 13.182 n-C₄H₉ CH₃ 4-F(Ph) CH₃ 13.183 n-C₄H₉ CH₃4-OCH₃(Ph) CH₃ 13.184 n-C₄H₉ CH₃ 4-CH₃(Ph) CH₃ 13.185 n-C₄H₉ CH₃4-NO₂(Ph) CH₃ 13.186 n-C₄H₉ CH₃ 2,4-Cl(Ph) CH₃ 13.187 n-C₄H₉ CH₃2,4-F(Ph) CH₃ 13.188 n-C₄H₉ CH₃ 4-CF₃(Ph) CH₃ 13.189 Ph H Ph H 13.190 PhH Ph CH₃ 13.191 Ph H Ph C₂H₅ 13.192 Ph H Ph n-C₃H₇ 13.193 Ph H Phiso-C₃H₇ 13.194 Ph H Ph n-C₄H₉ 13.195 Ph H Ph iso-C₄H₉ 13.196 Ph H PhC(CH₃)₃ 13.197 Ph H Ph CH₂C≡CH 13.198 Ph H 2-Cl(Ph) CH₃ 13.199 Ph H4-Cl(Ph) CH₃ 13.200 Ph CH₃ Ph CH₃ 13.201 Ph CH₃ 2-Cl(Ph) CH₃ 13.202 PhCH₃ 3-Cl(Ph) CH₃ 13.203 Ph CH₃ 4-Cl(Ph) CH₃ 13.204 Ph CH₃ 4-Br(Ph) CH₃13.205 Ph CH₃ 4-F(Ph) CH₃ 13.206 Ph CH₃ 4-OCH₃(Ph) CH₃ 13.207 Ph CH₃4-CH₃(Ph) CH₃ 13.208 Ph CH₃ 4-NO₂(Ph) CH₃ 13.209 Ph CH₃ 2,4-Cl(Ph) CH₃13.210 Ph CH₃ 2,4-F(Ph) CH₃ 13.211 CN H Ph H 13.212 CN H Ph CH₃ 13.213CN H Ph C₂H₅ 13.214 CN H Ph n-C₃H₇ 13.215 CN H Ph iso-C₃H₇ 13.216 CN HPh n-C₄H₉ 13.217 CN H Ph iso-C₄H₉ 13.218 CN H Ph C(CH₃)₃ 13.219 CN H PhCH₂C≡CH 13.220 CN H 2-Cl(Ph) CH₃ 13.221 CN H 4-Cl(Ph) CH₃ 13.222 CN CH₃Ph H 13.223 CN CH₃ 2-Cl(Ph) CH₃ 13.224 CN CH₃ 3-Cl(Ph) CH₃ 13.225 CN CH₃4-Cl(Ph) CH₃ 13.226 CN CH₃ 4-Br(Ph) CH₃ 13.227 CN CH₃ 4-F(Ph) CH₃ 13.228CN CH₃ 4-OCH₃(Ph) CH₃ 13.229 CN CH₃ 4-CH₃(Ph) CH₃ 13.230 CN CH₃4-NO₂(Ph) CH₃ 13.231 CN CH₃ 2,4-Cl(Ph) CH₃ 13.232 CN CH₃ 2,4-F(Ph) CH₃13.233 H H 1-napthyl H 13.234 CH₃ H 1-napthyl CH₃ 13.235 C₂H₅ H1-napthyl CH₃ 13.236 n-C₃H₇ H 1-napthyl CH₃ 13.237 iso-C₃H₇ H 1-napthylCH₃ 13.238 n-C₄H₉ H 1-napthyl CH₃ 13.239 iso-C₄H₉ H 1-napthyl CH₃ 13.240cyclopropyl H 1-napthyl CH₃ 13.241 1-CH₃-cyclopropyl H 1-napthyl CH₃13.242 CN H 1-napthyl CH₃ 13.243 Ph CH₃ 1-napthyl CH₃ 13.244 H CH₃1-napthyl CH₃ 13.245 CH₃ CH₃ 1-napthyl CH₃ 13.246 C₂H₅ CH₃ 1-napthyl CH₃13.247 n-C₃H₇ CH₃ 1-napthyl CH₃ 13.248 iso-C₃H₇ CH₃ 1-napthyl CH₃ 13.249n-C₄H₉ CH₃ 1-napthyl CH₃ 13.250 iso-C₄H₉ CH₃ 1-napthyl CH₃ 13.251cyclopropyl CH₃ 1-napthyl CH₃ 13.252 1-CH₃-cyclopropyl CH₃ 1-napthyl CH₃13.253 CN CH₃ 1-napthyl CH₃ 13.254 Ph CH₃ 1-napthyl CH₃ 13.255 H H2-napthyl H 13.256 CH₃ H 2-napthyl CH₃ 13.257 C₂H₅ H 2-napthyl C₂H₅13.258 n-C₃H₇ H 2-napthyl n-C₃H₇ 13.259 iso-C₃H₇ H 2-napthyl iso-C₃H₇13.260 n-C₄H₉ H 2-napthyl n-C₄H₉ 13.261 iso-C₄H₉ H 2-napthyl iso-C₄H₉13.262 cyclopropyl H 2-napthyl C(CH₃)₃ 13.263 1-CH₃-cyclopropyl H2-napthyl CH₂C≡CH 13.264 CN H 2-napthyl CH₂Ph 13.265 Ph H 2-napthylCH₂Ph 13.266 H CH₃ 2-napthyl CH₃ 13.267 CH₃ CH₃ 2-napthyl CH₃ 13.268C₂H₅ CH₃ 2-napthyl CH₃ 13.269 n-C₃H₇ CH₃ 2-napthyl CH₃ 13.270 iso-C₃H₇CH₃ 2-napthyl CH₃ 13.271 n-C₄H₉ CH₃ 2-napthyl CH₃ 13.272 iso-C₄H₉ CH₃2-napthyl CH₃ 13.273 cyclopropyl CH₃ 2-napthyl CH₃ 13.2741-CH₃-cyclopropyl CH₃ 2-napthyl CH₃ 13.275 CN CH₃ 2-napthyl CH₃ 13.276Ph CH₃ 2-napthyl CH₃ 13.277 2-Cl(Ph) CH₃ 2-napthyl CH₃ 13.278 3-Cl(Ph)CH₃ 2-napthyl CH₃ 13.279 4-Cl(Ph) CH₃ 2-napthyl CH₃ 13.280 4-Br(Ph) CH₃2-napthyl CH₃ 13.281 4-F(Ph) CH₃ 2-napthyl CH₃ 13.282 4-OCH₃(Ph) CH₃2-napthyl CH₃ 13.283 4-CH₃(Ph) CH₃ 2-napthyl CH₃ 13.284 3-CF₃(Ph) CH₃2-napthyl CH₃ 13.285 CH₃ C₂H₅ Ph CH₃ 13.286 CH₃ C₂H₅ 2-Cl(Ph) CH₃ 13.287CH₃ C₂H₅ 3-Cl(Ph) CH₃ 13.288 CH₃ C₂H₅ 4-Cl(Ph) CH₃ 13.289 CH₃ C₂H₅4-Br(Ph) CH₃ 13.290 CH₃ C₂H₅ 4-F(Ph) CH₃ 13.291 CH₃ C₂H₅ 4-OCH₃(Ph) CH₃13.292 CH₃ C₂H₅ 4-CH₃(Ph) CH₃ 13.293 CH₃ C₂H₅ 4-NO₂(Ph) CH₃ 13.294 CH₃C₂H₅ 2,4-Cl(Ph) CH₃ 13.295 CH₃ C₂H₅ 2,4-F(Ph) CH₃ 13.296 CH₃ n-C₃H₇ PhCH₃ 13.297 CH₃ n-C₃H₇ 2-Cl(Ph) CH₃ 13.298 CH₃ n-C₃H₇ 3-Cl(Ph) CH₃ 13.299CH₃ n-C₃H₇ 4-Cl(Ph) CH₃ 13.300 CH₃ n-C₃H₇ 4-Br(Ph) CH₃ 13.301 CH₃ n-C₃H₇4-F(Ph) CH₃ 13.302 CH₃ n-C₃H₇ 4-OCH₃(Ph) CH₃ 13.303 CH₃ n-C₃H₇ 4-CH₃(Ph)CH₃ 13.304 CH₃ n-C₃H₇ 4-NO₂(Ph) CH₃ 13.305 CH₃ n-C₃H₇ 2,4-Cl(Ph) CH₃13.306 CH₃ n-C₃H₇ 2,4-F(Ph) CH₃ 13.307 CH₃ iso-C₃H₇ Ph CH₃ 13.308 CH₃iso-C₃H₇ 2-Cl(Ph) CH₃ 13.309 CH₃ iso-C₃H₇ 3-Cl(Ph) CH₃ 13.310 CH₃iso-C₃H₇ 4-Cl(Ph) CH₃ 13.311 CH₃ iso-C₃H₇ 4-Br(Ph) CH₃ 13.312 CH₃iso-C₃H₇ 4-F(Ph) CH₃ 13.313 CH₃ iso-C₃H₇ 4-OCH₃(Ph) CH₃ 13.314 CH₃iso-C₃H₇ 4-CH₃(Ph) CH₃ 13.315 CH₃ iso-C₃H₇ 4-NO₂(Ph) CH₃

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula VIII, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═NOR₉, and where R₂, R₃, R₇ and R₉are defined in Table 14.

TABLE 14 Compd R₂ R₃ R₇ R₉ 14.1 H H Ph H 14.2 H H 4-Cl(Ph) H 14.3 H H4-Br(Ph) H 14.4 H H 4-F(Ph) H 14.5 H H 4-OCH₃(Ph) H 14.6 H H 4-CF₃(Ph) H14.7 H H Ph CH₃ 14.8 H H 4-Cl(Ph) CH₃ 14.9 H H 4-Br(Ph) CH₃ 14.10 H H4-F(Ph) CH₃ 14.11 CH₃ H Ph H 14.12 CH₃ H 2-Cl(Ph) H 14.13 CH₃ H 3-Cl(Ph)H 14.14 CH₃ H 4-Cl(Ph) H 14.15 CH₃ H 2-Br(Ph) H 14.16 CH₃ H 3-Br(Ph) H14.17 CH₃ H 4-Br(Ph) H 14.18 CH₃ H Ph CH₃ 14.19 CH₃ H 2-Cl(Ph) CH₃ 14.20CH₃ H 3-Cl(Ph) CH₃ 14.21 CH₃ H 4-Cl(Ph) CH₃ 14.22 CH₃ H 2-F(Ph) CH₃14.23 CH₃ H 3-F(Ph) CH₃ 14.24 CH₃ H 4-F(Ph) CH₃ 14.25 CH₃ H 2-CH₃(Ph)CH₃ 14.26 CH₃ H 3-CH₃(Ph) CH₃ 14.27 CH₃ H 2-CF₃(Ph) CH₃ 14.28 CH₃ H3-CF₃(Ph) CH₃ 14.29 CH₃ H 4-CF₃(Ph) CH₃ 14.30 CH₃ H 2-OCH₃(Ph) CH₃ 14.31CH₃ H 3-OCH₃(Ph) CH₃ 14.32 CH₃ H 4-OCH₃(Ph) CH₃ 14.33 CH₃ H 2,3-Cl(Ph)CH₃ 14.34 CH₃ H 2,4-Cl(Ph) CH₃ 14.35 CH₃ H 2,5-Cl(Ph) CH₃ 14.36 CH₃ H2,6-Cl(Ph) CH₃ 14.37 CH₃ H 3,4-Cl(Ph) CH₃ 14.38 CH₃ H 3,5-Cl(Ph) CH₃14.39 CH₃ H Ph C₂H₅ 14.40 CH₃ H Ph n-C₃H₇ 14.41 CH₃ H Ph iso-C₃H₇ 14.42CH₃ H Ph n-C₄H₉ 14.43 CH₃ H Ph C(CH₃)₃ 14.44 CH₃ H Ph CH₂C≡CH 14.45 C₂H₅H Ph CH₃ 14.46 C₂H₅ H 2-Cl(Ph) CH₃ 14.47 C₂H₅ H 3-Cl(Ph) CH₃ 14.48 C₂H₅H 4-Cl(Ph) CH₃ 14.49 C₂H₅ H 4-Br(Ph) CH₃ 14.50 C₂H₅ H 4-F(Ph) CH₃ 14.51C₂H₅ H 4-OCH₃(Ph) CH₃ 14.52 C₂H₅ H 4-CH₃(Ph) CH₃ 14.53 C₂H₅ H 4-NO₂(Ph)CH₃ 14.54 C₂H₅ H 2,4-Cl(Ph) CH₃ 14.55 C₂H₅ H 2,4-F(Ph) CH₃ 14.56 n-C₃H₇H Ph CH₃ 14.57 n-C₃H₇ H 2-Cl(Ph) CH₃ 14.58 n-C₃H₇ H 3-Cl(Ph) CH₃ 14.59n-C₃H₇ H 4-Cl(Ph) CH₃ 14.60 n-C₃H₇ H 4-F(Ph) CH₃ 14.61 n-C₃H₇ H3-OCH₃(Ph) CH₃ 14.62 n-C₃H₇ H 4-OCH₃(Ph) CH₃ 14.63 n-C₃H₇ H 4-CH₃(Ph)CH₃ 14.64 n-C₃H₇ H 4-NO₂(Ph) CH₃ 14.65 n-C₃H₇ H 2,4-Cl(Ph) CH₃ 14.66n-C₃H₇ H 2,4-F(Ph) CH₃ 14.67 iso-C₃H₇ H Ph CH₃ 14.68 iso-C₃H₇ H 2-Cl(Ph)CH₃ 14.69 iso-C₃H₇ H 3-Cl(Ph) CH₃ 14.70 iso-C₃H₇ H 4-Cl(Ph) CH₃ 14.71iso-C₃H₇ H 4-Br(Ph) CH₃ 14.72 iso-C₃H₇ H 4-F(Ph) CH₃ 14.73 iso-C₃H₇ H4-OCH₃(Ph) CH₃ 14.74 iso-C₃H₇ H 4-CH₃(Ph) CH₃ 14.75 iso-C₃H₇ H 4-NO₂(Ph)CH₃ 14.76 iso-C₃H₇ H 2,4-Cl(Ph) CH₃ 14.77 iso-C₃H₇ H 2,4-F(Ph) CH₃ 14.78n-C₄H₉ H Ph CH₃ 14.79 n-C₄H₉ H 2-Cl(Ph) CH₃ 14.80 n-C₄H₉ H 3-Cl(Ph) CH₃14.81 n-C₄H₉ H 4-Cl(Ph) CH₃ 14.82 n-C₄H₉ H 4-Br(Ph) CH₃ 14.83 n-C₄H₉ H4-F(Ph) CH₃ 14.84 n-C₄H₉ H 4-OCH₃(Ph) CH₃ 14.85 n-C₄H₉ H 4-CH₃(Ph) CH₃14.86 n-C₄H₉ H 4-NO₂(Ph) CH₃ 14.87 n-C₄H₉ H 2,4-Cl(Ph) CH₃ 14.88 n-C₄H₉H 2,4-F(Ph) CH₃ 14.89 iso-C₄H₉ H Ph CH₃ 14.90 iso-C₄H₉ H 2-Cl(Ph) CH₃14.91 iso-C₄H₉ H 3-Cl(Ph) CH₃ 14.92 iso-C₄H₉ H 4-Cl(Ph) CH₃ 14.93iso-C₄H₉ H 4-F(Ph) CH₃ 14.94 iso-C₄H₉ H 3-OCH₃(Ph) CH₃ 14.95 iso-C₄H₉ H4-OCH₃(Ph) CH₃ 14.96 iso-C₄H₉ H 4-CH₃(Ph) CH₃ 14.97 iso-C₄H₉ H 4-NO₂(Ph)CH₃ 14.98 iso-C₄H₉ H 2,4-Cl(Ph) CH₃ 14.99 iso-C₄H₉ H 2,4-F(Ph) CH₃14.100 C(CH₃)₃ H Ph CH₃ 14.101 C(CH₃)₃ H 2-Cl(Ph) CH₃ 14.102 C(CH₃)₃ H3-Cl(Ph) CH₃ 14.103 C(CH₃)₃ H 4-Cl(Ph) CH₃ 14.104 C(CH₃)₃ H 4-F(Ph) CH₃14.105 C(CH₃)₃ H 3-OCH₃(Ph) CH₃ 14.106 C(CH₃)₃ H 4-OCH₃(Ph) CH₃ 14.107C(CH₃)₃ H 4-CH₃(Ph) CH₃ 14.108 C(CH₃)₃ H 4-NO₂(Ph) CH₃ 14.109 C(CH₃)₃ H2,4-Cl(Ph) CH₃ 14.110 C(CH₃)₃ H 2,4-F(Ph) CH₃ 14.111 cyclopropyl H PhCH₃ 14.112 cyclopropyl H 2-Cl(Ph) CH₃ 14.113 cyclopropyl H 3-Cl(Ph) CH₃14.114 cyclopropyl H 4-Cl(Ph) CH₃ 14.115 cyclopropyl H 4-Br(Ph) CH₃14.116 cyclopropyl H 3-OCH₃(Ph) CH₃ 14.117 cyclopropyl H 4-OCH₃(Ph) CH₃14.118 cyclopropyl H 4-CH₃(Ph) CH₃ 14.119 cyclopropyl H 4-NO₂(Ph) CH₃14.120 cyclopropyl H 2,4-Cl(Ph) CH₃ 14.121 cyclopropyl H 2,4-F(Ph) CH₃14.122 1-CH₃-cyclopropyl H Ph CH₃ 14.123 1-CH₃-cyclopropyl H 2-Cl(Ph)CH₃ 14.124 1-CH₃-cyclopropyl H 3-Cl(Ph) CH₃ 14.125 1-CH₃-cyclopropyl H4-Cl(Ph) CH₃ 14.126 1-CH₃-cyclopropyl H 4-Br(Ph) CH₃ 14.1271-CH₃-cyclopropyl H 4-F(Ph) CH₃ 14.128 1-CH₃-cyclopropyl H 4-OCH₃(Ph)CH₃ 14.129 1-CH₃-cyclopropyl H 4-CH₃(Ph) CH₃ 14.130 1-CH₃-cyclopropyl H4-NO₂(Ph) CH₃ 14.131 1-CH₃-cyclopropyl H 2,4-Cl(Ph) CH₃ 14.1321-CH₃-cyclopropyl H 2,4-F(Ph) CH₃ 14.133 CH₃ CH₃ Ph H 14.134 CH₃ CH₃ PhCH₃ 14.135 CH₃ CH₃ Ph C₂H₅ 14.136 CH₃ CH₃ Ph n-C₃H₇ 14.137 CH₃ CH₃ Phiso-C₃H₇ 14.138 CH₃ CH₃ Ph n-C₄H₉ 14.139 CH₃ CH₃ Ph iso-C₄H₉ 14.140 CH₃CH₃ Ph C(CH₃)₃ 14.141 CH₃ CH₃ Ph CH₂C≡CH 14.142 CH₃ CH₃ 2-Cl(Ph) CH₃14.143 CH₃ CH₃ 3-Cl(Ph) CH₃ 14.144 C₂H₅ CH₃ Ph CH₃ 14.145 C₂H₅ CH₃2-Cl(Ph) CH₃ 14.146 C₂H₅ CH₃ 3-Cl(Ph) CH₃ 14.147 C₂H₅ CH₃ 4-Cl(Ph) CH₃14.148 C₂H₅ CH₃ 4-Br(Ph) CH₃ 14.149 C₂H₅ CH₃ 4-F(Ph) CH₃ 14.150 C₂H₅ CH₃4-OCH₃(Ph) CH₃ 14.151 C₂H₅ CH₃ 4-CH₃(Ph) CH₃ 14.152 C₂H₅ CH₃ 4-NO₂(Ph)CH₃ 14.153 C₂H₅ CH₃ 2,4-Cl(Ph) CH₃ 14.154 C₂H₅ CH₃ 2,4-F(Ph) CH₃ 14.155n-C₃H₇ CH₃ Ph CH₃ 14.156 n-C₃H₇ CH₃ 2-Cl(Ph) CH₃ 14.157 n-C₃H₇ CH₃3-Cl(Ph) CH₃ 14.158 n-C₃H₇ CH₃ 4-Cl(Ph) CH₃ 14.213 CN H Ph C₂H₅ 14.214CN H Ph n-C₃H₇ 14.215 CN H Ph iso-C₃H₇ 14.216 CN H Ph n-C₄H₉ 14.217 CN HPh iso-C₄H₉ 14.218 CN H Ph C(CH₃)₃ 14.219 CN H Ph CH₂C≡CH 14.220 CN H2-Cl(Ph) CH₃ 14.221 CN H 4-Cl(Ph) CH₃ 14.222 CN CH₃ Ph H 14.223 CN CH₃2-Cl(Ph) CH₃ 14.224 CN CH₃ 3-Cl(Ph) CH₃ 14.225 CN CH₃ 4-Cl(Ph) CH₃14.226 CN CH₃ 4-Br(Ph) CH₃ 14.227 CN CH₃ 4-F(Ph) CH₃ 14.228 CN CH₃4-OCH₃(Ph) CH₃ 14.229 CN CH₃ 4-CH₃(Ph) CH₃ 14.230 CN CH₃ 4-NO₂(Ph) CH₃14.231 CN CH₃ 2,4-Cl(Ph) CH₃ 14.232 CN CH₃ 2,4-F(Ph) CH₃ 14.233 H H1-napthyl H 14.234 CH₃ H 1-napthyl CH₃ 14.235 C₂H₅ H 1-napthyl CH₃14.236 n-C₃H₇ H 1-napthyl CH₃ 14.237 iso-C₃H₇ H 1-napthyl CH₃ 14.238n-C₄H₉ H 1-napthyl CH₃ 14.239 iso-C₄H₉ H 1-napthyl CH₃ 14.240cyclopropyl H 1-napthyl CH₃ 14.241 1-CH₃-cyclopropyl H 1-napthyl CH₃14.242 CN H 1-napthyl CH₃ 14.243 Ph CH₃ 1-napthyl CH₃ 14.244 H CH₃1-napthyl CH₃ 14.245 CH₃ CH₃ 1-napthyl CH₃ 14.246 C₂H₅ CH₃ 1-napthyl CH₃14.247 n-C₃H₇ CH₃ 1-napthyl CH₃ 14.248 iso-C₃H₇ CH₃ 1-napthyl CH₃ 14.249n-C₄H₉ CH₃ 1-napthyl CH₃ 14.250 iso-C₄H₉ CH₃ 1-napthyl CH₃ 14.251cyclopropyl CH₃ 1-napthyl CH₃ 14.252 1-CH₃-cyclopropyl CH₃ 1-napthyl CH₃14.253 CN CH₃ 1-napthyl CH₃ 14.254 Ph CH₃ 1-napthyl CH₃ 14.255 H H2-napthyl H 14.256 CH₃ H 2-napthyl CH₃ 14.257 C₂H₅ H 2-napthyl C₂H₅14.258 n-C₃H₇ H 2-napthyl n-C₃H₇ 14.259 iso-C₃H₇ H 2-napthyl iso-C₃H₇14.260 n-C₄H₉ H 2-napthyl n-C₄H₉ 14.261 iso-C₄H₉ H 2-napthyl iso-C₄H₉14.262 cyclopropyl H 2-napthyl C(CH₃)₃ 14.263 1-CH₃-cyclopropyl H2-napthyl CH₂C≡CH 14.264 CN H 2-napthyl CH₂Ph 14.265 Ph H 2-napthylCH₂Ph 14.266 H CH₃ 2-napthyl CH₃ 14.267 CH₃ CH₃ 2-napthyl CH₃ 14.268C₂H₅ CH₃ 2-napthyl CH₃ 14.269 n-C₃H₇ CH₃ 2-napthyl CH₃ 14.270 iso-C₃H₇CH₃ 2-napthyl CH₃ 14.271 n-C₄H₉ CH₃ 2-napthyl CH₃ 14.272 iso-C₄H₉ CH₃2-napthyl CH₃ 14.273 cyclo-C₃H₅ CH₃ 2-napthyl CH₃ 14.2741-CH₃-cyclopropyl CH₃ 2-napthyl CH₃ 14.275 CN CH₃ 2-napthyl CH₃ 14.276Ph CH₃ 2-napthyl CH₃ 14.277 2-Cl(Ph) CH₃ 2-napthyl CH₃ 14.278 3-Cl(Ph)CH₃ 2-napthyl CH₃ 14.279 4-Cl(Ph) CH₃ 2-napthyl CH₃ 14.280 4-Br(Ph) CH₃2-napthyl CH₃ 14.281 4-F(Ph) CH₃ 2-napthyl CH₃ 14.282 4-OCH₃(Ph) CH₃2-napthyl CH₃ 14.283 4-CH₃(Ph) CH₃ 2-napthyl CH₃ 14.284 3-CF₃(Ph) CH₃2-napthyl CH₃ 14.285 CH₃ C₂H₅ Ph CH₃ 14.286 CH₃ C₂H₅ 2-Cl(Ph) CH₃ 14.287CH₃ C₂H₅ 3-Cl(Ph) CH₃ 14.288 CH₃ C₂H₅ 4-Cl(Ph) CH₃ 14.289 CH₃ C₂H₅4-Br(Ph) CH₃ 14.290 CH₃ C₂H₅ 4-F(Ph) CH₃ 14.291 CH₃ C₂H₅ 4-OCH₃(Ph) CH₃14.292 CH₃ C₂H₅ 4-CH₃(Ph) CH₃ 14.293 CH₃ C₂H₅ 4-NO₂(Ph) CH₃ 14.294 CH₃C₂H₅ 2,4-Cl(Ph) CH₃ 14.295 CH₃ C₂H₅ 2,4-F(Ph) CH₃ 14.296 CH₃ n-C₃H₇ PhCH₃ 14.297 CH₃ n-C₃H₇ 2-Cl(Ph) CH₃ 14.298 CH₃ n-C₃H₇ 3-Cl(Ph) CH₃ 14.299CH₃ n-C₃H₇ 4-Cl(Ph) CH₃ 14.300 CH₃ n-C₃H₇ 4-Br(Ph) CH₃ 14.301 CH₃ n-C₃H₇4-F(Ph) CH₃ 14.302 CH₃ n-C₃H₇ 4-OCH₃(Ph) CH₃ 14.303 CH₃ n-C₃H₇ 4-CH₃(Ph)CH₃ 14.304 CH₃ n-C₃H₇ 4-NO₂(Ph) CH₃ 14.305 CH₃ n-C₃H₇ 2,4-Cl(Ph) CH₃14.306 CH₃ n-C₃H₇ 2,4-F(Ph) CH₃ 14.307 CH₃ iso-C₃H₇ Ph CH₃ 14.308 CH₃iso-C₃H₇ 2-Cl(Ph) CH₃ 14.309 CH₃ iso-C₃H₇ 3-Cl(Ph) CH₃ 14.310 CH₃iso-C₃H₇ 4-Cl(Ph) CH₃ 14.311 CH₃ iso-C₃H₇ 4-Br(Ph) CH₃ 14.312 CH₃iso-C₃H₇ 4-F(Ph) CH₃ 14.313 CH₃ iso-C₃H₇ 4-OCH₃(Ph) CH₃ 14.314 CH₃iso-C₃H₇ 4-CH₃(Ph) CH₃ 14.315 CH₃ iso-C₃H₇ 4-NO₂(Ph) CH₃

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula IX, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═NOR₉, and where R₂, R₃, R₇ and R₉are defined in Table 15.

TABLE 15 Compd R₂ R₃ R₇ R₉ 15.1 H H Ph H 15.2 H H 4-Cl(Ph) H 15.3 H H4-Br(Ph) H 15.4 H H 4-F(Ph) H 15.5 H H 4-OCH₃(Ph) H 15.6 H H 4-CF₃(Ph) H15.7 H H Ph CH₃ 15.8 H H 4-Cl(Ph) CH₃ 15.9 H H 4-Br(Ph) CH₃ 15.10 H H4-F(Ph) CH₃ 15.11 CH₃ H Ph H 15.12 CH₃ H 2-Cl(Ph) H 15.13 CH₃ H 3-Cl(Ph)H 15.14 CH₃ H 4-Cl(Ph) H 15.15 CH₃ H 2-Br(Ph) H 15.16 CH₃ H 3-Br(Ph) H15.17 CH₃ H 4-Br(Ph) H 15.18 CH₃ H Ph CH₃ 15.19 CH₃ H 2-Cl(Ph) CH₃ 15.20CH₃ H 3-Cl(Ph) CH₃ 15.21 CH₃ H 4-Cl(Ph) CH₃ 15.22 CH₃ H 2-F(Ph) CH₃15.23 CH₃ H 3-F(Ph) CH₃ 15.24 CH₃ H 4-F(Ph) CH₃ 15.25 CH₃ H 2-CH₃(Ph)CH₃ 15.26 CH₃ H 3-CH₃(Ph) CH₃ 15.27 CH₃ H 2-CF₃(Ph) CH₃ 15.28 CH₃ H3-CF₃(Ph) CH₃ 15.29 CH₃ H 4-CF₃(Ph) CH₃ 15.30 CH₃ H 2-OCH₃(Ph) CH₃ 15.31CH₃ H 3-OCH₃(Ph) CH₃ 15.32 CH₃ H 4-OCH₃(Ph) CH₃ 15.33 CH₃ H 2,3-Cl(Ph)CH₃ 15.34 CH₃ H 2,4-Cl(Ph) CH₃ 15.35 CH₃ H 2,5-Cl(Ph) CH₃ 15.36 CH₃ H2,6-Cl(Ph) CH₃ 15.37 CH₃ H 3,4-Cl(Ph) CH₃ 15.38 CH₃ H 3,5-Cl(Ph) CH₃15.39 CH₃ H Ph C₂H₅ 15.40 CH₃ H Ph n-C₃H₇ 15.41 CH₃ H Ph iso-C₃H₇ 15.42CH₃ H Ph n-C₄H₉ 15.43 CH₃ H Ph C(CH₃)₃ 15.44 CH₃ H Ph CH₂C≡CH 15.45 C₂H₅H Ph CH₃ 15.46 C₂H₅ H 2-Cl(Ph) CH₃ 15.47 C₂H₅ H 3-Cl(Ph) CH₃ 15.48 C₂H₅H 4-Cl(Ph) CH₃ 15.49 C₂H₅ H 4-Br(Ph) CH₃ 15.50 C₂H₅ H 4-F(Ph) CH₃ 15.51C₂H₅ H 4-OCH₃(Ph) CH₃ 15.52 C₂H₅ H 4-CH₃(Ph) CH₃ 15.53 C₂H₅ H 4-NO₂(Ph)CH₃ 15.54 C₂H₅ H 2,4-Cl(Ph) CH₃ 15.55 C₂H₅ H 2,4-F(Ph) CH₃ 15.56 n-C₃H₇H Ph CH₃ 15.57 n-C₃H₇ H 2-Cl(Ph) CH₃ 15.58 n-C₃H₇ H 3-Cl(Ph) CH₃ 15.59n-C₃H₇ H 4-Cl(Ph) CH₃ 15.60 n-C₃H₇ H 4-F(Ph) CH₃ 15.61 n-C₃H₇ H3-OCH₃(Ph) CH₃ 15.62 n-C₃H₇ H 4-OCH₃(Ph) CH₃ 15.63 n-C₃H₇ H 4-CH₃(Ph)CH₃ 15.64 n-C₃H₇ H 4-NO₂(Ph) CH₃ 15.65 n-C₃H₇ H 2,4-Cl(Ph) CH₃ 15.66n-C₃H₇ H 2,4-F(Ph) CH₃ 15.67 iso-C₃H₇ H Ph CH₃ 15.68 iso-C₃H₇ H 2-Cl(Ph)CH₃ 15.69 iso-C₃H₇ H 3-Cl(Ph) CH₃ 15.70 iso-C₃H₇ H 4-Cl(Ph) CH₃ 15.71iso-C₃H₇ H 4-Br(Ph) CH₃ 15.72 iso-C₃H₇ H 4-F(Ph) CH₃ 15.73 iso-C₃H₇ H4-OCH₃(Ph) CH₃ 15.74 iso-C₃H₇ H 4-CH₃(Ph) CH₃ 15.75 iso-C₃H₇ H 4-NO₂(Ph)CH₃ 15.76 iso-C₃H₇ H 2,4-Cl(Ph) CH₃ 15.77 iso-C₃H₇ H 2,4-F(Ph) CH₃ 15.78n-C₄H₉ H Ph CH₃ 15.79 n-C₄H₉ H 2-Cl(Ph) CH₃ 15.80 n-C₄H₉ H 3-Cl(Ph) CH₃15.81 n-C₄H₉ H 4-Cl(Ph) CH₃ 15.82 n-C₄H₉ H 4-Br(Ph) CH₃ 15.83 n-C₄H₉ H4-F(Ph) CH₃ 15.84 n-C₄H₉ H 4-OCH₃(Ph) CH₃ 15.85 n-C₄H₉ H 4-CH₃(Ph) CH₃15.86 n-C₄H₉ H 4-NO₂(Ph) CH₃ 15.87 n-C₄H₉ H 2,4-Cl(Ph) CH₃ 15.88 n-C₄H₉H 2,4-F(Ph) CH₃ 15.89 iso-C₄H₉ H Ph CH₃ 15.90 iso-C₄H₉ H 2-Cl(Ph) CH₃15.91 iso-C₄H₉ H 3-Cl(Ph) CH₃ 15.92 iso-C₄H₉ H 4-Cl(Ph) CH₃ 15.93iso-C₄H₉ H 4-F(Ph) CH₃ 15.94 iso-C₄H₉ H 3-OCH₃(Ph) CH₃ 15.95 iso-C₄H₉ H4-OCH₃(Ph) CH₃ 15.96 iso-C₄H₉ H 4-CH₃(Ph) CH₃ 15.97 iso-C₄H₉ H 4-NO₂(Ph)CH₃ 15.98 iso-C₄H₉ H 2,4-Cl(Ph) CH₃ 15.99 iso-C₄H₉ H 2,4-F(Ph) CH₃15.100 C(CH₃)₃ H Ph CH₃ 15.101 C(CH₃)₃ H 2-Cl(Ph) CH₃ 15.102 C(CH₃)₃ H3-Cl(Ph) CH₃ 15.103 C(CH₃)₃ H 4-Cl(Ph) CH₃ 15.104 C(CH₃)₃ H 4-F(Ph) CH₃15.105 C(CH₃)₃ H 3-OCH₃(Ph) CH₃ 15.106 C(CH₃)₃ H 4-OCH₃(Ph) CH₃ 15.107C(CH₃)₃ H 4-CH₃(Ph) CH₃ 15.108 C(CH₃)₃ H 4-NO₂(Ph) CH₃ 15.109 C(CH₃)₃ H2,4-C1(Ph) CH₃ 15.110 C(CH₃)₃ H 2,4-F(Ph) CH₃ 15.111 cyclopropyl H PhCH₃ 15.112 cyclopropyl H 2-Cl(Ph) CH₃ 15.113 cyclopropyl H 3-Cl(Ph) CH₃15.114 cyclopropyl H 4-Cl(Ph) CH₃ 15.115 cyclopropy1 H 4-Br(Ph) CH₃15.116 cyclopropyl H 3-OCH₃(Ph) CH₃ 15.117 cyclopropyl H 4-OCH₃(Ph) CH₃15.118 cyclopropyl H 4-CH₃(Ph) CH₃ 15.119 cyclopropyl H 4-NO₂(Ph) CH₃15.120 cyclopropyl H 2,4-Cl(Ph) CH₃ 15.121 cyclopropyl H 2,4-F(Ph) CH₃15.122 1-CH₃-cyclopropyl H Ph CH₃ 15.123 1-CH₃-cyclopropyl H 2-Cl(Ph)CH₃ 15.124 1-CH₃-cyclopropyl H 3-Cl(Ph) CH₃ 15.125 1-CH₃-cyclopropyl H4-Cl(Ph) CH₃ 15.126 1-CH₃-cyclopropyl H 4-Br(Ph) CH₃ 15.1271-CH₃-cyclopropyl H 4-F(Ph) CH₃ 15.128 1-CH₃-cyclopropyl H 4-OCH₃(Ph)CH₃ 15.129 1-CH₃-cyclopropyl H 4-CH₃(Ph) CH₃ 15.130 1-CH₃-cyclopropyl H4-NO₂(Ph) CH₃ 15.131 1-CH₃-cyclopropyl H 2,4-Cl(Ph) CH₃ 15.1321-CH₃-cyclopropyl H 2,4-F(Ph) CH₃ 15.133 CH₃ CH₃ Ph CH₃ 15.134 CH₃ CH₃Ph CH₃ 15.135 CH₃ CH₃ Ph C₂H₅ 15.136 CH₃ CH₃ Ph n-C₃H₇ 15.137 CH₃ CH₃ Phiso-C₅H₇ 15.138 CH₃ CH₃ Ph n-C₄H₉ 15.139 CH₃ CH₃ Ph iso-C₄H₉ 15.140 CH₃CH₃ Ph C(CH₃)₃ 15.141 CH₃ CH₃ Ph CH₂C≡CH 15.142 CH₃ CH₃ 2-Cl(Ph) CH₃15.143 CH₃ CH₃ 3-Cl(Ph) CH₃ 15.144 C₂H₅ CH₃ Ph CH₃ 15.145 C₂H₅ CH₃2-Cl(Ph) CH₃ 15.146 C₂H₅ CH₃ 3-Cl(Ph) CH₃ 15.147 C₂H₅ CH₃ 4-Cl(Ph) CH₃15.148 C₂H₅ CH₃ 4-Br(Ph) CH₃ 15.149 C₂H₅ CH₃ 4-F(Ph) CH₃ 15.150 C₂H₅ CH₃4-OCH₃(Ph) CH₃ 15.151 C₂H₅ CH₃ 4-CH₃(Ph) CH₃ 15.152 C₂H₅ CH₃ 4-NO₂(Ph)CH₃ 15.153 C₂H₅ CH₃ 2,4-Cl(Ph) CH₃ 15.154 C₂H₅ CH₃ 2,4-F(Ph) CH₃ 15.155n-C₃H₇ CH₃ Ph CH₃ 15.156 n-C₃H₇ CH₃ 2-Cl(Ph) CH₃ 15.157 n-C₃H₇ CH₃3-Cl(Ph) CH₃ 15.158 n-C₃H₇ CH₃ 4-Cl(Ph) CH₃ 15.159 n-C₃H₇ CH₃ 4-Br(Ph)CH₃ 15.160 n-C₃H₇ CH₃ 4-F(Ph) CH₃ 15.161 n-C₃H₇ CH₃ 4-OCH₃(Ph) CH₃15.162 n-C₃H₇ CH₃ 4-CH₃(Ph) CH₃ 15.163 n-C₃H₇ CH₃ 4-NO₂(Ph) CH₃ 15.164n-C₃H₇ CH₃ 2,4-Cl(Ph) CH₃ 15.165 n-C₃H₇ CH₃ 2,4-F(Ph) CH₃ 15.166iso-C₃H₇ CH₃ Ph CH₃ 15.167 iso-C₃H₇ CH₃ 2-Cl(Ph) CH₃ 15.168 iso-C₃H₇ CH₃3-Cl(Ph) CH₃ 15.169 iso-C₃H₇ CH₃ 4-Cl(Ph) CH₃ 15.170 iso-C₃H₇ CH₃4-Br(Ph) CH₃ 15.171 iso-C₃H₇ CH₃ 4-F(Ph) CH₃ 15.172 iso-C₃H₇ CH₃4-OCH₃(Ph) CH₃ 15.173 iso-C₃H₇ CH₃ 4-CH₃(Ph) CH₃ 15.174 iso-C₃H₇ CH₃4-NO₂(Ph) CH₃ 15.175 iso-C₃H₇ CH₃ 2,4-Cl(Ph) CH₃ 15.176 iso-C₃H₇ CH₃2,4-F(Ph) CH₃ 15.177 n-C₄H₉ CH₃ Ph CH₃ 15.178 n-C₄H₉ CH₃ 2-Cl(Ph) CH₃15.179 n-C₄H₉ CH₃ 3-Cl(Ph) CH₃ 15.180 n-C₄H₉ CH₃ 4-Cl(Ph) CH₃ 15.181n-C₄H₉ CH₃ 4-Br(Ph) CH₃ 15.182 n-C₄H₉ CH₃ 4-F(Ph) CH₃ 15.183 n-C₄H₉ CH₃4-OCH₃(Ph) CH₃ 15.184 n-C₄H₉ CH₃ 4-CH₃(Ph) CH₃ 15.185 n-C₄H₉ CH₃4-NO₂(Ph) CH₃ 15.186 n-C₄H₉ CH₃ 2,4-Cl(Ph) CH₃ 15.187 n-C₄H₉ CH₃2,4-F(Ph) CH₃ 15.188 n-C₄H₉ CH₃ 4-CF₃(Ph) CH₃ 15.189 Ph H Ph H 15.190 PhH Ph CH₃ 15.191 Ph H Ph C₂H₅ 15.192 Ph H Ph n-C₃H₇ 15.193 Ph H Phiso-C₃H₇ 15.194 Ph H Ph n-C₄H₉ 15.195 Ph H Ph iso-C₄H₉ 15.196 Ph H PhC(CH₃)₃ 15.197 Ph H Ph CH₂C≡CH 15.198 Ph H 2-Cl(Ph) CH₃ 15.199 Ph H4-Cl(Ph) CH₃ 15.200 Ph CH₃ Ph CH₃ 15.201 Ph CH₃ 2-Cl(Ph) CH₃ 15.202 PhCH₃ 3-Cl(Ph) CH₃ 15.203 Ph CH₃ 4-Cl(Ph) CH₃ 15.204 Ph CH₃ 4-Br(Ph) CH₃15.205 Ph CH₃ 4-F(Ph) CH₃ 15.206 Ph CH₃ 4-OCH₃(Ph) CH₃ 15.207 Ph CH₃4-CH₃(Ph) CH₃ 15.208 Ph CH₃ 4-NO₂(Ph) CH₃ 15.209 Ph CH₃ 2,4-Cl(Ph) CH₃15.210 Ph CH₃ 2,4-F(Ph) CH₃ 15.211 CN H Ph H 15.212 CN H Ph CH₃ 15.213CN H Ph C₂H₅ 15.214 CN H Ph n-C₃H₇ 15.215 CN H Ph iso-C₃H₇ 15.216 CN HPh n-C₄H₉ 15.217 CN H Ph iso-C₄H₉ 15.218 CN H Ph C(CH₃)₃ 15.219 CN H PhCH₂C≡CH 15.220 CN H 2-Cl(Ph) CH₃ 15.221 CN H 4-Cl(Ph) CH₃ 15.222 CN CH₃Ph H 15.223 CN CH₃ 2-Cl(Ph) CH₃ 15.224 CN CH₃ 3-Cl(Ph) CH₃ 15.225 CN CH₃4-Cl(Ph) CH₃ 15.226 CN CH₃ 4-Br(Ph) CH₃ 15.227 CN CH₃ 4-F(Ph) CH₃ 15.228CN CH₃ 4-OCH₃(Ph) CH₃ 15.229 CN CH₃ 4-CH₃(Ph) CH₃ 15.230 CN CH₃4-NO₂(Ph) CH₃ 15.231 CN CH₃ 2,4-Cl(Ph) CH₃ 15.232 CN CH₃ 2,4-F(Ph) CH₃15.233 H H 1-napthyl H 15.234 CH₃ H 1-napthyl CH₃ 15.235 C₂H₅ H1-napthyl CH₃ 15.236 n-C₃H₇ H 1-napthyl CH₃ 15.237 iso-C₃H₇ H 1-napthylCH₃ 15.238 n-C₄H₉ H 1-napthyl CH₃ 15.239 iso-C₄H₉ H 1-napthyl CH₃ 15.240cyclopropyl H 1-napthyl CH₃ 15.241 1-CH₃-cyclopropyl H 1-napthyl CH₃15.242 CN H 1-napthyl CH₃ 15.243 Ph CH₃ 1-napthyl CH₃ 15.244 H CH₃1-napthyl CH₃ 15.245 CH₃ CH₃ 1-napthyl CH₃ 15.246 C₂H₅ CH₃ 1-napthyl CH₃15.247 n-C₃H₇ CH₃ 1-napthyl CH₃ 15.248 iso-C₃H₇ CH₃ 1-napthyl CH₃ 15.249n-C₄H₉ CH₃ 1-napthyl CH₃ 15.250 iso-C₄H₉ CH₃ 1-napthyl CH₃ 15.251cyclopropyl CH₃ 1-napthyl CH₃ 15.252 1-CH₃-cyclopropyl CH₃ 1-napthyl CH₃15.253 CN CH₃ 1-napthyl CH₃ 15.254 Ph CH₃ 1-napthyl CH₃ 15.255 H H2-napthyl H 15.256 CH₃ H 2-napthyl CH₃ 15.257 C₂H₅ H 2-napthyl C₂H₅15.258 n-C₃H₇ H 2-napthyl n-C₃H₇ 15.259 iso-C₃H₇ H 2-napthyl iso-C₃H₇15.260 n-C₄H₉ H 2-napthyl n-C₄H₉ 15.261 iso-C₄H₉ H 2-napthyl iso-C₄H₉15.262 cyclopropyl H 2-napthyl C(CH₃)₃ 15.263 1-CH₃-cyclopropyl H2-napthyl CH₂C≡CH 15.264 CN H 2-napthyl CH₂Ph 15.265 Ph H 2-napthylCH₂Ph 15.266 H CH₃ 2-napthyl CH₃ 15.267 CH₃ CH₃ 2-napthyl CH₃ 15.268C₂H₅ CH₃ 2-napthyl CH₃ 15.269 n-C₃H₇ CH₃ 2-napthyl CH₃ 15.270 iso-C₃H₇CH₃ 2-napthyl CH₃ 15.271 n-C₄H₉ CH₃ 2-napthyl CH₃ 15.272 iso-C₄H₉ CH₃2-napthyl CH₃ 15.273 cyclopropyl CH₃ 2-napthyl CH₃ 15.2741-CH₃-cyclopropyl CH₃ 2-napthyl CH₃ 15.275 CN CH₃ 2-napthyl CH₃ 15.276Ph CH₃ 2-napthyl CH₃ 15.277 2-Cl(Ph) CH₃ 2-napthyl CH₃ 15.278 3-Cl(Ph)CH₃ 2-napthyl CH₃ 15.279 4-Cl(Ph) CH₃ 2-napthyl CH₃ 15.280 4-Br(Ph) CH₃2-napthyl CH₃ 15.281 4-F(Ph) CH₃ 2-napthyl CH₃ 15.282 4-OCH₃(Ph) CH₃2-napthyl CH₃ 15.283 4-CH₃(Ph) CH₃ 2-napthyl CH₃ 15.284 3-CF₃(Ph) CH₃2-napthyl CH₃ 15.285 CH₃ C₂H₅ Ph CH₃ 15.286 CH₃ C₂H₅ 2-Cl(Ph) CH₃ 15.287CH₃ C₂H₅ 3-Cl(Ph) CH₃ 15.288 CH₃ C₂H₅ 4-Cl(Ph) CH₃ 15.289 CH₃ C₂H₅4-Br(Ph) CH₃ 15.290 CH₃ C₂H₅ 4-F(Ph) CH₃ 15.291 CH₃ C₂H₅ 4-OCH₃(Ph) CH₃15.292 CH₃ C₂H₅ 4-CH₃(Ph) CH₃ 15.293 CH₃ C₂H₅ 4-NO₂(Ph) CH₃ 15.294 CH₃C₂H₅ 2,4-Cl(Ph) CH₃ 15.295 CH₃ C₂H₅ 2,4-F(Ph) CH₃ 15.296 CH₃ n-C₃H₇ PhCH₃ 15.297 CH₃ n-C₃H₇ 2-Cl(Ph) CH₃ 15.298 CH₃ n-C₃H₇ 3-Cl(Ph) CH₃ 15.299CH₃ n-C₃H₇ 4-Cl(Ph) CH₃ 15.300 CH₃ n-C₃H₇ 4-Br(Ph) CH₃ 15.301 CH₃ n-C₃H₇4-F(Ph) CH₃ 15.302 CH₃ n-C₃H₇ 4-OCH₃(Ph) CH₃ 15.303 CH₃ n-C₃H₇ 4-CH₃(Ph)CH₃ 15.304 CH₃ n-C₃H₇ 4-NO₂(Ph) CH₃ 15.305 CH₃ n-C₃H₇ 2,4-Cl(Ph) CH₃15.306 CH₃ n-C₃H₇ 2,4-F(Ph) CH₃ 15.307 CH₃ iso-C₃H₇ Ph CH₃ 15.308 CH₃iso-C₃H₇ 2-Cl(Ph) CH₃ 15.309 CH₃ iso-C₃H₇ 3-Cl(Ph) CH₃ 15.310 CH₃iso-C₃H₇ 4-Cl(Ph) CH₃ 15.311 CH₃ iso-C₃H₇ 4-Br(Ph) CH₃ 15.312 CH₃iso-C₃H₇ 4-F(Ph) CH₃ 15.313 CH₃ iso-C₃H₇ 4-OCH₃(Ph) CH₃ 15.314 CH₃iso-C₃H₇ 4-CH₃(Ph) CH₃ 15.315 CH₃ iso-C₃H₇ 4-NO₂(Ph) CH₃

TABLE 16

Compounds 16.1 to 16.226 are compounds of Formula VII which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═NOR₉, where R₉ is CH₃ andR₂, R₃, and R₇ are defined in Table 4.

TABLE 17

Compounds 17.1 to 17.226 are compounds of Formula VIII which is FormulaI with A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═NOR₉, where R₉ is CH₃ andR₂, R₃, and R₇ are defined in Table 4.

TABLE 18

Compounds 18.1 to 18.226 are compounds of Formula IX which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═NOR₉, where R₉ is CH₃ andR₂, R₃, and R₇ are defined in Table 4.

TABLE 19

Compounds 19.1 to 19.221 are compounds of Formula VII which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═NOR₉, where R₉ is C₂H₅ andR₂, R₃, and R₇ are defined in Table 7.

TABLE 20

Compounds 20.1 to 20.221 are compounds of Formula VIII which is FormulaI with A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═NOR₉, where R₉ is C₂H₅ andR₂, R₃, and R₇ are defined in Table 7.

TABLE 21

Compounds 21.1 to 21.221 are compounds of Formula IX which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═NOR₉, where R₉ is C₂H₅ andR₂, R₃, and R₇ are defined in Table 7.

TABLE 22

Compounds 22.1 to 23.139 are compounds of Formula VII which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═NOR₉, where R₉ is CH₂Ph andR₂, R₃, and R₇ are defined in Table 10.

TABLE 23

Compounds 23.1 to 23.139 are compounds of Formula VIII which is FormulaI with A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═NOR₉, where R₉ is CH₂Ph andR₂, R₃, and R₇ are defined in Table 10.

TABLE 24

Compounds 24.1 to 24.139 are compounds of Formula IX which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═NOR₉, where R₉ is CH₂Ph andR₂, R₃, and R₇ are defined in Table 10.

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula X, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, Z═NR₁₀ and R₁₀ is NR₈R₉, and where R₂,R₃, R₇, R₈ and R₉ are defined in Table 25.

TABLE 25 Compd R₂ R₃ R₇ R₈ R₉ 25.1 H H Ph CH₃ H 25.2 H H 4-Cl(Ph) CH₃ H25.3 H H 4-Br(Ph) CH₃ H 25.4 H H 4-F(Ph) CH₃ H 25.5 H H 4-OCH₃(Ph) CH₃ H25.6 H H 4-CF₃(Ph) CH₃ H 25.7 H H Ph CH₃ CH₃ 25.8 H H 4-Cl(Ph) CH₃ CH₃25.9 H H 4-Br(Ph) CH₃ CH₃ 25.10 H H 4-F(Ph) CH₃ CH₃ 25.11 CH₃ H Ph CH₃ H25.12 CH₃ H 2-Cl(Ph) CH₃ H 25.13 CH₃ H 3-Cl(Ph) CH₃ H 25.14 CH₃ H4-Cl(Ph) CH₃ H 25.15 CH₃ H 2-Br(Ph) CH₃ H 25.16 CH₃ H 3-Br(Ph) CH₃ H25.17 CH₃ H 4-Br(Ph) CH₃ H 25.18 CH₃ H Ph CH₃ CH₃ 25.19 CH₃ H 2-Cl(Ph)CH₃ CH₃ 25.20 CH₃ H 3-Cl(Ph) CH₃ CH₃ 25.21 CH₃ H 4-Cl(Ph) CH₃ CH₃ 25.22CH₃ H 2-Br(Ph) CH₃ CH₃ 25.23 CH₃ H 3-Br(Ph) CH₃ CH₃ 25.24 CH₃ H 4-Br(Ph)CH₃ CH₃ 25.25 CH₃ H 2-CH₃(Ph) CH₃ CH₃ 25.26 CH₃ H 3-CH₃(Ph) CH₃ CH₃25.27 CH₃ H 2-CF₃(Ph) CH₃ CH₃ 25.28 CH₃ H 3-CF₃(Ph) CH₃ CH₃ 25.29 CH₃ H4-CF₃(Ph) CH₃ CH₃ 25.30 CH₃ H 2-NO₂(Ph) CH₃ CH₃ 25.31 CH₃ H 3-NO₂(Ph)CH₃ CH₃ 25.32 CH₃ H 4-NO₂(Ph) CH₃ CH₃ 25.33 CH₃ H 2,3-Cl(Ph) CH₃ CH₃25.34 CH₃ H 2,4-Cl(Ph) CH₃ CH₃ 25.35 CH₃ H 2,5-Cl(Ph) CH₃ CH₃ 25.36 CH₃H 2,6-Cl(Ph) CH₃ CH₃ 25.37 CH₃ H 3,4-Cl(Ph) CH₃ CH₃ 25.38 CH₃ H3,5-Cl(Ph) CH₃ CH₃ 25.39 CH₃ H Ph C₂H₅ CH₃ 25.40 CH₃ H Ph n-C₃H₇ CH₃25.41 CH₃ H Ph iso-C₃H₇ CH₃ 25.42 CH₃ H Ph n-C₄H₉ CH₃ 25.43 CH₃ H Phiso-C₄H₉ CH₃ 25.44 CH₃ H Ph C(CH₃)₃ CH₃ 25.45 CH₃ H Ph H COCH₃ 25.46 CH₃H 2-Cl(Ph) H COCH₃ 25.47 CH₃ H 3-Cl(Ph) H COCH₃ 25.48 CH₃ H 4-Cl(Ph) HCOCH₃ 25.49 CH₃ H 4-Br(Ph) H COCH₃ 25.50 CH₃ H 4-F(Ph) H COCH₃ 25.51 CH₃H 4-OCH₃(Ph) H COCH₃ 25.52 CH₃ H 4-CH₃(Ph) H COCH₃ 25.53 CH₃ H 4-NO₂(Ph)H COCH₃ 25.54 CH₃ H 2,4-Cl(Ph) H COCH₃ 25.55 CH₃ H 2,4-F(Ph) H COCH₃25.56 CH₃ H Ph CH₃ COCH₃ 25.57 CH₃ H 2-Cl(Ph) CH₃ COCH₃ 25.58 CH₃ H3-Cl(Ph) CH₃ COCH₃ 25.59 CH₃ H 4-Cl(Ph) CH₃ COCH₃ 25.60 CH₃ H 4-F(Ph)CH₃ COCH₃ 25.61 CH₃ H 3-OCH₃(Ph) CH₃ COCH₃ 25.62 CH₃ H 4-OCH₃(Ph) CH₃COCH₃ 25.63 CH₃ H 4-CH₃(Ph) CH₃ COCH₃ 25.64 CH₃ H 4-NO₂(Ph) CH₃ COCH₃25.65 CH₃ H 2,4-Cl(Ph) CH₃ COCH₃ 25.66 CH₃ H 2,4-F(Ph) CH₃ COCH₃ 25.67CH₃ H Ph H COPh 25.68 CH₃ H 2-Cl(Ph) H COPh 25.69 CH₃ H 3-Cl(Ph) H COPh25.70 CH₃ H 4-Cl(Ph) H COPh 25.71 CH₃ H 4-Br(Ph) H COPh 25.72 CH₃ H4-F(Ph) H COPh 25.73 CH₃ H 4-OCH₃(Ph) H COPh 25.74 CH₃ H 4-CH₃(Ph) HCOPh 25.75 CH₃ H 4-NO₂(Ph) H COPh 25.76 CH₃ H 2,4-Cl(Ph) H COPh 25.77CH₃ H 2,4-F(Ph) H COPh 25.78 CH₃ H Ph CH₃ COPh 25.79 CH₃ H 2-Cl(Ph) CH₃COPh 25.80 CH₃ H 3-Cl(Ph) CH₃ COPh 25.81 CH₃ H 4-Cl(Ph) CH₃ COPh 25.82CH₃ H 4-Br(Ph) CH₃ COPh 25.83 CH₃ H 4-F(Ph) CH₃ COPh 25.84 CH₃ H4-OCH₃(Ph) CH₃ COPh 25.85 CH₃ H 4-CH₃(Ph) CH₃ COPh 25.86 CH₃ H 4-NO₂(Ph)CH₃ COPh 25.87 CH₃ H 2,4-Cl(Ph) CH₃ COPh 25.88 CH₃ H 2,4-F(Ph) CH₃ COPh25.89 C₂H₅ H Ph H COCH₃ 25.90 C₂H₅ H 2-Cl(Ph) H COCH₃ 25.91 C₂H₅ H3-Cl(Ph) H COCH₃ 25.92 C₂H₅ H 4-Cl(Ph) H COCH₃ 25.93 C₂H₅ H 4-F(Ph) HCOCH₃ 25.94 C₂H₅ H 3-OCH₃(Ph) H COCH₃ 25.95 C₂H₅ H 4-OCH₃(Ph) H COCH₃25.96 C₂H₅ H 4-CH₃(Ph) H COCH₃ 25.97 C₂H₅ H 4-NO₂(Ph) H COCH₃ 25.98 C₂H₅H 2,4-Cl(Ph) H COCH₃ 25.99 C₂H₅ H 2,4-F(Ph) H COCH₃ 25.100 C₂H₅ H Ph CH₃COCH₃ 25.101 C₂H₅ H 2-Cl(Ph) CH₃ COCH₃ 25.102 C₂H₅ H 3-Cl(Ph) CH₃ COCH₃25.103 C₂H₅ H 4-Cl(Ph) CH₃ COCH₃ 25.104 C₂H₅ H 4-F(Ph) CH₃ COCH₃ 25.105C₂H₅ H 3-OCH₃(Ph) CH₃ COCH₃ 25.106 C₂H₅ H 4-OCH₃(Ph) CH₃ COCH₃ 25.107C₂H₅ H 4-CH₃(Ph) CH₃ COCH₃ 25.108 C₂H₅ H 4-NO₂(Ph) CH₃ COCH₃ 25.109 C₂H₅H 2,4-Cl(Ph) CH₃ COCH₃ 25.110 C₂H₅ H 2,4-F(Ph) CH₃ COCH₃ 25.111 C₂H₅ HPh H COPh 25.112 C₂H₅ H 2-Cl(Ph) H COPh 25.113 C₂H₅ H 3-Cl(Ph) H COPh25.114 C₂H₅ H 4-Cl(Ph) H COPh 25.115 C₂H₅ H 4-Br(Ph) H COPh 25.116 C₂H₅H 3-OCH₃(Ph) H COPh 25.117 C₂H₅ H 4-OCH₃(Ph) H COPh 25.118 C₂H₅ H4-CH₃(Ph) H COPh 25.119 C₂H₅ H 4-NO₂(Ph) H COPh 25.120 C₂H₅ H 2,4-Cl(Ph)H COPh 25.121 C₂H₅ H 2,4-F(Ph) H COPh 25.122 C₂H₅ H Ph CH₃ COPh 25.123C₂H₅ H 2-Cl(Ph) CH₃ COPh 25.124 C₂H₅ H 3-Cl(Ph) CH₃ COPh 25.125 C₂H₅ H4-Cl(Ph) CH₃ COPh 25.126 C₂H₅ H 4-Br(Ph) CH₃ COPh 25.127 C₂H₅ H 4-F(Ph)CH₃ COPh 25.128 C₂H₅ H 4-OCH₃(Ph) CH₃ COPh 25.129 C₂H₅ H 4-CH₃(Ph) CH₃COPh 25.130 C₂H₅ H 4-NO₂(Ph) CH₃ COPh 25.131 C₂H₅ H 2,4-Cl(Ph) CH₃ COPh25.132 C₂H₅ H 2,4-F(Ph) CH₃ COPh 25.133 CH₃ H Ph C₂H₅ COCH₃ 25.134 CH₃ HPh n-C₃H₇ COCH₃ 25.135 CH₃ H Ph iso-C₃H₇ COCH₃ 25.136 CH₃ H Ph n-C₄H₉COCH₃ 25.137 CH₃ H Ph iso-C₄H₉ COCH₃ 25.138 CH₃ H Ph C(CH₃)₃ COCH₃25.139 CH₃ H 4-Cl(Ph) C₂H₅ COCH₃ 25.140 CH₃ H 4-Cl(Ph) n-C₃H₇ COCH₃25.141 CH₃ H 4-Cl(Ph) iso-C₃H₇ COCH₃ 25.142 CH₃ H 4-Cl(Ph) n-C₄H₉ COCH₃25.143 CH₃ H 4-Cl(Ph) iso-C₄H₉ COCH₃ 25.144 CH₃ H 4-Cl(Ph) C(CH₃)₃ COCH₃25.145 CH₃ H Ph C₂H₅ COPh 25.146 CH₃ H Ph n-C₃H₇ COPh 25.147 CH₃ H Phiso-C₃H₇ COPh 25.148 CH₃ H Ph n-C₄H₉ COPh 25.149 CH₃ H Ph C(CH₃)₃ COPh25.150 CH₃ H 4-Cl(Ph) CH₃ COCH₂Ph 25.151 CH₃ H 4-Br(Ph) CH₃ COCH₂Ph25.152 CH₃ H 4-F(Ph) CH₃ COCH₂Ph 25.153 CH₃ H 4-OCH₃(Ph) CH₃ COCH₂Ph25.154 CH₃ H 4-CH₃(Ph) CH₃ COCH₂Ph 25.155 CH₃ H 4-NO₂(Ph) CH₃ COCH₂Ph25.156 CH₃ H 2,4-Cl(Ph) CH₃ COCH₂Ph 25.157 CH₃ H 2,4-F(Ph) CH₃ COCH₂Ph25.158 CH₃ H 4-Cl(Ph) C₂H₅ COCH₂Ph 25.159 CH₃ H 4-Br(Ph) n-C₃H₇ COCH₂Ph25.160 CH₃ H 4-F(Ph) iso-C₃H₇ COCH₂Ph 25.161 CH₃ H 4-OCH₃(Ph) n-C₄H₉COCH₂Ph 25.162 CH₃ H 4-CH₃(Ph) iso-C₄H₉ COCH₂Ph 25.163 CH₃ H 4-NO₂(Ph)C(CH₃)₃ COCH₂Ph 25.164 Ph H Ph CH₃ H 25.165 Ph H 2-Cl(Ph) CH₃ H 25.166Ph H 3-Cl(Ph) CH₃ H 25.167 Ph H 4-Cl(Ph) CH₃ H 25.168 Ph H 4-Br(Ph) CH₃H 25.169 Ph H 4-F(Ph) CH₃ H 25.170 Ph H 4-OCH₃(Ph) CH₃ H 25.171 Ph H4-CH₃(Ph) CH₃ H 25.172 Ph H 4-NO₂(Ph) CH₃ H 25.173 Ph H 2,4-Cl(Ph) CH₃ H25.174 Ph H Ph CH₃ CH₃ 25.175 Ph H 2-Cl(Ph) CH₃ CH₃ 25.176 Ph H 3-Cl(Ph)CH₃ CH₃ 25.177 Ph H 4-Cl(Ph) CH₃ CH₃ 25.178 Ph H 4-Br(Ph) CH₃ CH₃ 25.179Ph H 4-F(Ph) CH₃ CH₃ 25.180 CN H 4-Cl(Ph) CH₃ H 25.181 CN H 4-Br(Ph) CH₃H 25.182 CN H 4-F(Ph) CH₃ H 25.183 CN H 4-OCH₃(Ph) CH₃ H 25.184 CN H4-CH₃(Ph) CH₃ H 25.185 CN H 4-NO₂(Ph) CH₃ H 25.186 CN H 2,4-Cl(Ph) CH₃ H25.187 CN H 2,4-F(Ph) CH₃ H 25.188 CN H 4-CF₃(Ph) CH₃ H 25.189 CN H PhCH₃ CH₃ 25.190 CN H Ph CH₃ COCH₃ 25.191 H H 1-napthyl CH₃ H 25.192 H H1-napthyl CH₃ CH₃ 25.193 H H 1-napthyl CH₃ COCH₃ 25.194 H H 1-napthylCH₃ COPh 25.195 CH₃ H 1-napthyl CH₃ H 25.196 CH₃ H 1-napthyl CH₃ CH₃25.197 CH₃ H 1-napthyl CH₃ COCH₃ 25.198 CH₃ H 1-napthyl CH₃ COPh 25.199CH₃ H 1-napthyl CH₃ COCH₂Ph 25.200 H H 1-napthyl CH₃ CO₂CH₃ 25.201 CH₃ H1-napthyl CH₃ CO₂CH₃ 25.202 H H 2-napthyl CH₃ H 25.203 H H 2-napthyl CH₃CH₃ 25.204 H H 2-napthyl CH₃ COCH₃ 25.205 H H 2-napthyl CH₃ COPh 25.206CH₃ H 2-napthyl CH₃ H 25.207 CH₃ H 2-napthyl CH₃ CH₃ 25.208 CH₃ H2-napthyl CH₃ COCH₃ 25.209 CH₃ H 2-napthyl CH₃ COPh 25.210 CH₃ H2-napthyl CH₃ COCH₂Ph 25.211 H H 2-napthyl CH₃ CO₂CH₃ 25.212 CH₃ H2-napthyl CH₃ CO₂CH₃ 25.213 H CH₃ Ph CH₃ H 25.214 H CH₃ 4-Cl(Ph) CH₃ H25.215 H CH₃ 4-Br(Ph) CH₃ H 25.216 H CH₃ 4-F(Ph) CH₃ H 25.217 H CH₃4-OCH₃(Ph) CH₃ H 25.218 H CH₃ 4-CF₃(Ph) CH₃ H 25.219 H CH₃ Ph CH₃ CH₃25.220 H CH₃ 4-Cl(Ph) CH₃ CH₃ 25.221 H CH₃ 4-Br(Ph) CH₃ CH₃ 25.222 H CH₃4-F(Ph) CH₃ CH₃ 25.223 H CH₃ 4-OCH₃(Ph) CH₃ CH₃ 25.224 H CH₃ 4-CF₃(Ph)CH₃ CH₃ 25.225 H CH₃ Ph CH₃ C₂H₅ 25.226 H CH₃ 4-Cl(Ph) CH₃ n-C₃H₇ 25.227H CH₃ 4-Br(Ph) CH₃ iso-C₃H₇ 25.228 H CH₃ 4-F(Ph) CH₃ n-C₄H₉ 25.229 H CH₃4-OCH₃(Ph) CH₃ iso-C₄H₉ 25.230 H CH₃ 4-CH₃(Ph) CH₃ C(CH₃)₃ 25.231 H CH₃4-NO₂(Ph) CH₃ CH₃ 25.232 H CH₃ 2,4-Cl(Ph) CH₃ CH₃ 25.233 H CH₃ Ph CH₃COCH₃ 25.234 H CH₃ 4-Cl(Ph) CH₃ COCH₃ 25.235 H CH₃ 4-Br(Ph) CH₃ COCH₃25.236 H CH₃ 4-F(Ph) CH₃ COCH₃ 25.237 H CH₃ 4-OCH₃(Ph) CH₃ COCH₃ 25.238H CH₃ 4-CH₃(Ph) CH₃ COCH₃ 25.239 H CH₃ 4-NO₂(Ph) CH₃ COCH₃ 25.240 H CH₃2,4-Cl(Ph) CH₃ COCH₃ 25.241 H CH₃ Ph CH₃ COPh 25.242 H CH₃ 4-Cl(Ph) CH₃COPh 25.243 H CH₃ 4-Br(Ph) CH₃ COPh 25.244 H CH₃ 4-F(Ph) CH₃ COPh 25.245H CH₃ 4-OCH₃(Ph) CH₃ COPh 25.246 H CH₃ 4-CH₃(Ph) CH₃ COPh 25.247 H CH₃4-NO₂(Ph) CH₃ COPh 25.248 H CH₃ 2,4-Cl(Ph) CH₃ COPh 25.249 CH₃ CH₃ PhCH₃ H 25.250 CH₃ CH₃ 4-Cl(Ph) CH₃ H 25.251 CH₃ CH₃ 4-Br(Ph) CH₃ H 25.252CH₃ CH₃ 4-F(Ph) CH₃ H 25.253 CH₃ CH₃ 4-OCH₃(Ph) CH₃ H 25.254 CH₃ CH₃4-CH₃(Ph) CH₃ H 25.255 CH₃ CH₃ 4-NO₂(Ph) CH₃ H 25.256 CH₃ CH₃ 2,4-Cl(Ph)CH₃ H 25.257 CH₃ CH₃ Ph CH₃ COCH₃ 25.258 CH₃ CH₃ 4-Cl(Ph) CH₃ COCH₃25.259 CH₃ CH₃ 4-Br(Ph) CH₃ COCH₃ 25.260 CH₃ CH₃ 4-F(Ph) CH₃ COCH₃25.261 CH₃ CH₃ 4-OCH₃(Ph) CH₃ COCH₃ 25.262 CH₃ CH₃ 4-CH₃(Ph) CH₃ COCH₃25.263 CH₃ CH₃ 4-NO₂(Ph) CH₃ COCH₃ 25.264 CH₃ CH₃ 2,4-Cl(Ph) CH₃ COCH₃25.265 CN CH₃ Ph CH₃ H 25.266 CN CH₃ 4-Cl(Ph) CH₃ H 25.267 CN CH₃4-Br(Ph) CH₃ H 25.268 CN CH₃ 4-F(Ph) CH₃ H 25.269 CN CH₃ 4-OCH₃(Ph) CH₃H 25.270 CN CH₃ 4-CH₃(Ph) CH₃ H 25.271 CN CH₃ 4-NO₂(Ph) CH₃ H 25.272 CNCH₃ 2,4-Cl(Ph) CH₃ H 25.273 CN CH₃ Ph CH₃ CH₃ 25.274 CN CH₃ 4-Cl(Ph) CH₃CH₃ 25.275 CN CH₃ 4-Br(Ph) CH₃ CH₃ 25.276 CN CH₃ 4-F(Ph) CH₃ CH₃ 25.277CN CH₃ 4-OCH₃(Ph) CH₃ CH₃ 25.278 CN CH₃ 4-CH₃(Ph) CH₃ CH₃ 25.279 CN CH₃4-NO₂(Ph) CH₃ CH₃ 25.280 CN CH₃ 2,4-Cl(Ph) CH₃ CH₃ 25.281 CN CH₃ Ph CH₃COCH₃ 25.282 CN CH₃ 4-Cl(Ph) CH₃ COCH₃ 25.283 CN CH₃ 4-Br(Ph) CH₃ COCH₃25.284 CN CH₃ 4-F(Ph) CH₃ COCH₃ 25.285 CN CH₃ 4-OCH₃(Ph) CH₃ COCH₃25.286 CN CH₃ 4-CH₃(Ph) CH₃ COCH₃ 25.287 CN CH₃ 4-NO₂(Ph) CH₃ COCH₃25.288 CN CH₃ 2,4-Cl(Ph) CH₃ COCH₃ 25.289 CN CH₃ Ph CH₃ COPh 25.290 CNCH₃ 4-Cl(Ph) CH₃ COPh 25.291 CN CH₃ 4-Br(Ph) CH₃ COPh 25.292 CN CH₃4-F(Ph) CH₃ COPh 25.293 CN CH₃ 4-NO₂(Ph) CH₃ COPh 25.294 CN CH₃2,4-Cl(Ph) CH₃ COPh 25.295 CN CH₃ 2,4-F(Ph) CH₃ COPh 25.296 CN H Ph C₂H₅H 25.297 CN H 2-Cl(Ph) n-C₃H₇ H 25.298 CN H 3-Cl(Ph) iso-C₃H₇ H 25.299CN H 4-Cl(Ph) n-C₄H₉ H 25.300 CN H 4-Br(Ph) iso-C₄H₉ H 25.301 CN H4-F(Ph) C(CH₃)₃ H 25.302 CN H 4-OCH₃(Ph) C₂H₅ COCH₃ 25.303 CN H4-CH₃(Ph) n-C₃H₇ COCH₃ 25.304 CN H 4-NO₂(Ph) iso-C₃H₇ COCH₃ 25.305 CN H2,4-Cl(Ph) n-C₄H₉ COCH₃ 25.306 CN H 2,4-F(Ph) iso-C₄H₉ COCH₃ 25.307 CN HPh C(CH₃)₃ COCH₃ 25.308 CN H 2-Cl(Ph) C₂H₅ COPh 25.309 CN H 3-Cl(Ph)n-C₃H₇ COPh 25.310 CN H 4-Cl(Ph) iso-C₃H₇ COPh 25.311 CH₃ H 4-Br(Ph)n-C₄H₉ COPh 25.312 CH₃ H 4-F(Ph) iso-C₄H₉ COPh 25.313 CH₃ H 4-OCH₃(Ph)C(CH₃)₃ COPh

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula XI, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, Z═NR₁₀ and R₁₀ is NR₈R₉, and where R₂,R₃, R₇, R₈ and R₉ are defined in Table 26.

TABLE 26 Compd R₂ R₃ R₇ R₈ R₉ 26.1 H H Ph CH₃ H 26.2 H H 4-Cl(Ph) CH₃ H26.3 H H 4-Br(Ph) CH₃ H 26.4 H H 4-F(Ph) CH₃ H 26.5 H H 4-OCH₃(Ph) CH₃ H26.6 H H 4-CF₃(Ph) CH₃ H 26.7 H H Ph CH₃ CH₃ 26.8 H H 4-Cl(Ph) CH₃ CH₃26.9 H H 4-Br(Ph) CH₃ CH₃ 26.10 H H 4-F(Ph) CH₃ CH₃ 26.11 CH₃ H Ph CH₃ H26.12 CH₃ H 2-Cl(Ph) CH₃ H 26.13 CH₃ H 3-Cl(Ph) CH₃ H 26.14 CH₃ H4-Cl(Ph) CH₃ H 26.15 CH₃ H 2-Br(Ph) CH₃ H 26.16 CH₃ H 3-Br(Ph) CH₃ H26.17 CH₃ H 4-Br(Ph) CH₃ H 26.18 CH₃ H Ph CH₃ CH₃ 26.19 CH₃ H 2-Cl(Ph)CH₃ CH₃ 26.20 CH₃ H 3-Cl(Ph) CH₃ CH₃ 26.21 CH₃ H 4-Cl(Ph) CH₃ CH₃ 26.22CH₃ H 2-Br(Ph) CH₃ CH₃ 26.23 CH₃ H 3-Br(Ph) CH₃ CH₃ 26.24 CH₃ H 4-Br(Ph)CH₃ CH₃ 26.25 CH₃ H 2-CH₃(Ph) CH₃ CH₃ 26.26 CH₃ H 3-CH₃(Ph) CH₃ CH₃26.27 CH₃ H 2-CF₃(Ph) CH₃ CH₃ 26.28 CH₃ H 3-CF₃(Ph) CH₃ CH₃ 26.29 CH₃ H4-CF₃(Ph) CH₃ CH₃ 26.30 CH₃ H 2-NO₂(Ph) CH₃ CH₃ 26.31 CH₃ H 3-NO₂(Ph)CH₃ CH₃ 26.32 CH₃ H 4-NO₂(Ph) CH₃ CH₃ 26.33 CH₃ H 2,3-Cl(Ph) CH₃ CH₃26.34 CH₃ H 2,4-Cl(Ph) CH₃ CH₃ 26.35 CH₃ H 2,5-Cl(Ph) CH₃ CH₃ 26.36 CH₃H 2,6-Cl(Ph) CH₃ CH₃ 26.37 CH₃ H 3,4-Cl(Ph) CH₃ CH₃ 26.38 CH₃ H3,5-Cl(Ph) CH₃ CH₃ 26.39 CH₃ H Ph C₂H₅ CH₃ 26.40 CH₃ H Ph n-C₃H₇ CH₃26.41 CH₃ H Ph iso-C₃H₇ CH₃ 26.42 CH₃ H Ph n-C₄H₉ CH₃ 26.43 CH₃ H PhiSO-C₄H₉ CH₃ 26.44 CH₃ H Ph C(CH₃)₃ CH₃ 26.45 CH₃ H Ph H COCH₃ 26.46 CH₃H 2-Cl(Ph) H COCH₃ 26.47 CH₃ H 3-Cl(Ph) H COCH₃ 26.48 CH₃ H 4-Cl(Ph) HCOCH₃ 26.49 CH₃ H 4-Br(Ph) H COCH₃ 26.50 CH₃ H 4-F(Ph) H COCH₃ 26.51 CH₃H 4-OCH₃(Ph) H COCH₃ 26.52 CH₃ H 4-CH₃(Ph) H COCH₃ 26.53 CH₃ H 4-NO₂(Ph)H COCH₃ 26.54 CH₃ H 2,4-Cl(Ph) H COCH₃ 26.55 CH₃ H 2,4-F(Ph) H COCH₃26.56 CH₃ H Ph CH₃ COCH₃ 26.57 CH₃ H 2-Cl(Ph) CH₃ COCH₃ 26.58 CH₃ H3-Cl(Ph) CH₃ COCH₃ 26.59 CH₃ H 4-Cl(Ph) CH₃ COCH₃ 26.60 CH₃ H 4-F(Ph)CH₃ COCH₃ 26.61 CH₃ H 3-OCH₃(Ph) CH₃ COCH₃ 26.62 CH₃ H 4-OCH₃(Ph) CH₃COCH₃ 26.63 CH₃ H 4-CH₃(Ph) CH₃ COCH₃ 26.64 CH₃ H 4-NO₂(Ph) CH₃ COCH₃26.65 CH₃ H 2,4-Cl(Ph) CH₃ COCH₃ 26.66 CH₃ H 2,4-F(Ph) CH₃ COCH₃ 26.67CH₃ H Ph H COPh 26.68 CH₃ H 2-Cl(Ph) H COPh 26.69 CH₃ H 3-Cl(Ph) H COPh26.70 CH₃ H 4-Cl(Ph) H COPh 26.71 CH₃ H 4-Br(Ph) H COPh 26.72 CH₃ H4-F(Ph) H COPh 26.73 CH₃ H 4-OCH₃(Ph) H COPh 26.74 CH₃ H 4-CH₃(Ph) HCOPh 26.75 CH₃ H 4-NO₂(Ph) H COPh 26.76 CH₃ H 2,4-Cl(Ph) H COPh 26.77CH₃ H 2,4-F(Ph) H COPh 26.78 CH₃ H Ph CH₃ COPh 26.79 CH₃ H 2-Cl(Ph) CH₃COPh 26.80 CH₃ H 3-Cl(Ph) CH₃ COPh 26.81 CH₃ H 4-Cl(Ph) CH₃ COPh 26.82CH₃ H 4-Br(Ph) CH₃ COPh 26.83 CH₃ H 4-F(Ph) CH₃ COPh 26.84 CH₃ H4-OCH₃(Ph) CH₃ COPh 26.85 CH₃ H 4-CH₃(Ph) CH₃ COPh 26.86 CH₃ H 4-NO₂(Ph)CH₃ COPh 26.87 CH₃ H 2,4-Cl(Ph) CH₃ COPh 26.88 CH₃ H 2,4-F(Ph) CH₃ COPh26.89 C₂H₅ H Ph H COCH₃ 26.90 C₂H₅ H 2-Cl(Ph) H COCH₃ 26.91 C₂H₅ H3-Cl(Ph) H COCH₃ 26.92 C₂H₅ H 4-Cl(Ph) H COCH₃ 26.93 C₂H₅ H 4-F(Ph) HCOCH₃ 26.94 C₂H₅ H 3-OCH₃(Ph) H COCH₃ 26.95 C₂H₅ H 4-OCH₃(Ph) H COCH₃26.96 C₂H₅ H 4-CH₃(Ph) H COCH₃ 26.97 C₂H₅ H 4-NO₂(Ph) H COCH₃ 26.98 C₂H₅H 2,4-Cl(Ph) H COCH₃ 26.99 C₂H₅ H 2,4-F(Ph) H COCH₃ 26.100 C₂H₅ H Ph CH₃COCH₃ 26.101 C₂H₅ H 2-Cl(Ph) CH₃ COCH₃ 26.102 C₂H₅ H 3-Cl(Ph) CH₃ COCH₃26.103 C₂H₅ H 4-Cl(Ph) CH₃ COCH₃ 26.104 C₂H₅ H 4-F(Ph) CH₃ COCH₃ 26.105C₂H₅ H 3-OCH₃(Ph) CH₃ COCH₃ 26.106 C₂H₅ H 4-OCH₃(Ph) CH₃ COCH₃ 26.107C₂H₅ H 4-CH₃(Ph) CH₃ COCH₃ 26.108 C₂H₅ H 4-NO₂(Ph) CH₃ COCH₃ 26.109 C₂H₅H 2,4-Cl(Ph) CH₃ COCH₃ 26.110 C₂H₅ H 2,4-F(Ph) CH₃ COCH₃ 26.111 C₂H₅ HPh H COPh 26.112 C₂H₅ H 2-Cl(Ph) H COPh 26.113 C₂H₅ H 3-Cl(Ph) H COPh26.114 C₂H₅ H 4-Cl(Ph) H COPh 26.115 C₂H₅ H 4-Br(Ph) H COPh 26.116 C₂H₅H 3-OCH₃(Ph) H COPh 26.117 C₂H₅ H 4-OCH₃(Ph) H COPh 26.118 C₂H₅ H4-CH₃(Ph) H COPh 26.119 C₂H₅ H 4-NO₂(Ph) H COPh 26.120 C₂H₅ H 2,4-Cl(Ph)H COPh 26.121 C₂H₅ H 2,4-F(Ph) H COPh 26.122 C₂H₅ H Ph CH₃ COPh 26.123C₂H₅ H 2-Cl(Ph) CH₃ COPh 26.124 C₂H₅ H 3-Cl(Ph) CH₃ COPh 26.125 C₂H₅ H4-Cl(Ph) CH₃ COPh 26.126 C₂H₅ H 4-Br(Ph) CH₃ COPh 26.127 C₂H₅ H 4-F(Ph)CH₃ COPh 26.128 C₂H₅ H 4-OCH₃(Ph) CH₃ COPh 26.129 C₂H₅ H 4-CH₃(Ph) CH₃COPh 26.130 C₂H₅ H 4-NO₂(Ph) CH₃ COPh 26.131 C₂H₅ H 2,4-Cl(Ph) CH₃ COPh26.132 C₂H₅ H 2,4-F(Ph) CH₃ COPh 26.133 CH₃ H Ph C₂H₅ COCH₃ 26.134 CH₃ HPh n-C₃H₇ COCH₃ 26.135 CH₃ H Ph iso-C₃H₇ COCH₃ 26.136 CH₃ H Ph n-C₄H₉COCH₃ 26.137 CH₃ H Ph iso-C₄H₉ COCH₃ 26.138 CH₃ H Ph C(CH₃)₃ COCH₃26.139 CH₃ H 4-Cl(Ph) C₂H₅ COCH₃ 26.140 CH₃ H 4-Cl(Ph) n-C₃H₇ COCH₃26.141 CH₃ H 4-Cl(Ph) iso-C₃H₇ COCH₃ 26.142 CH₃ H 4-Cl(Ph) n-C₄H₉ COCH₃26.143 CH₃ H 4-Cl(Ph) iso-C₄H₉ COCH₃ 26.144 CH₃ H 4-Cl(Ph) C(CH₃)₃ COCH₃26.145 CH₃ H Ph C₂H₅ COPh 26.146 CH₃ H Ph n-C₃H₇ COPh 26.147 CH₃ H Phiso-C₃H₇ COPh 26.148 CH₃ H Ph n-C₄H₉ COPh 26.149 CH₃ H Ph C(CH₃)₃ COPh26.150 CH₃ H 4-Cl(Ph) CH₃ COCH₂Ph 26.151 CH₃ H 4-Br(Ph) CH₃ COCH₂Ph26.152 CH₃ H 4-F(Ph) CH₃ COCH₂Ph 26.153 CH₃ H 4-OCH₃(Ph) CH₃ COCH₂Ph26.154 CH₃ H 4-CH₃(Ph) CH₃ COCH₂Ph 26.155 CH₃ H 4-NO₂(Ph) CH₃ COCH₂Ph26.156 CH₃ H 2,4-Cl(Ph) CH₃ COCH₂Ph 26.157 CH₃ H 2,4-F(Ph) CH₃ COCH₂Ph26.158 CH₃ H 4-Cl(Ph) C₂H₅ COCH₂Ph 26.159 CH₃ H 4-Br(Ph) n-C₃H₇ COCH₂Ph26.160 CH₃ H 4-F(Ph) iso-C₃H₇ COCH₂Ph 26.161 CH₃ H 4-OCH₃(Ph) n-C₄H₉COCH₂Ph 26.162 CH₃ H 4-CH₃(Ph) iso-C₄H₉ COCH₂Ph 26.163 CH₃ H 4-NO₂(Ph)C(CH₃)₃ COCH₂Ph 26.164 Ph H Ph CH₃ H 26.165 Ph H 2-Cl(Ph) CH₃ H 26.166Ph H 3-Cl(Ph) CH₃ H 26.167 Ph H 4-Cl(Ph) CH₃ H 26.168 Ph H 4-Br(Ph) CH₃H 26.169 Ph H 4-F(Ph) CH₃ H 26.170 Ph H 4-OCH₃(Ph) CH₃ H 26.171 Ph H4-CH₃(Ph) CH₃ H 26.172 Ph H 4-NO₂(Ph) CH₃ H 26.173 Ph H 2,4-Cl(Ph) CH₃ H26.174 Ph H Ph CH₃ CH₃ 26.175 Ph H 2-Cl(Ph) CH₃ CH₃ 26.176 Ph H 3-Cl(Ph)CH₃ CH₃ 26.177 Ph H 4-Cl(Ph) CH₃ CH₃ 26.178 Ph H 4-Br(Ph) CH₃ CH₃ 26.179Ph H 4-F(Ph) CH₃ CH₃ 26.180 CN H 4-Cl(Ph) CH₃ H 26.181 CN H 4-Br(Ph) CH₃H 26.182 CN H 4-F(Ph) CH₃ H 26.183 CN H 4-OCH₃(Ph) CH₃ H 26.184 CN H4-CH₃(Ph) CH₃ H 26.185 CN H 4-NO₂(Ph) CH₃ H 26.186 CN H 2,4-Cl(Ph) CH₃ H26.187 CN H 2,4-F(Ph) CH₃ H 26.188 CN H 4-CF₃(Ph) CH₃ H 26.189 CN H PhCH₃ CH₃ 26.190 CN H Ph CH₃ COCH₃ 26.191 H H 1-napthyl CH₃ H 26.192 H H1-napthyl CH₃ CH₃ 26.193 H H 1-napthyl CH₃ COCH₃ 26.194 H H 1-napthylCH₃ COPh 26.195 CH₃ H 1-napthyl CH₃ H 26.196 CH₃ H 1-napthyl CH₃ CH₃26.197 CH₃ H 1-napthyl CH₃ COCH₃ 26.198 CH₃ H 1-napthyl CH₃ COPh 26.199CH₃ H 1-napthyl CH₃ COCH₂Ph 26.200 H H 1-napthyl CH₃ CO₂CH₃ 26.201 CH₃ H1-napthyl CH₃ CO₂CH₃ 26.202 H H 2-napthyl CH₃ H 26.203 H H 2-napthyl CH₃CH₃ 26.204 H H 2-napthyl CH₃ COCH₃ 26.205 H H 2-napthyl CH₃ COPh 26.206CH₃ H 2-napthyl CH₃ H 26.207 CH₃ H 2-napthyl CH₃ CH₃ 26.208 CH₃ H2-napthyl CH₃ COCH₃ 26.209 CH₃ H 2-napthyl CH₃ COPh 26.210 CH₃ H2-napthyl CH₃ COCH₂Ph 26.211 H H 2-napthyl CH₃ CO₂CH₃ 26.212 CH₃ H2-napthyl CH₃ CO₂CH₃ 26.213 H CH₃ Ph CH₃ H 26.214 H CH₃ 4-Cl(Ph) CH₃ H26.215 H CH₃ 4-Br(Ph) CH₃ H 26.216 H CH₃ 4-F(Ph) CH₃ H 26.217 H CH₃4-OCH₃(Ph) CH₃ H 26.218 H CH₃ 4-CF₃(Ph) CH₃ H 26.219 H CH₃ Ph CH₃ CH₃26.220 H CH₃ 4-Cl(Ph) CH₃ CH₃ 26.221 H CH₃ 4-Br(Ph) CH₃ CH₃ 26.222 H CH₃4-F(Ph) CH₃ CH₃ 26.223 H CH₃ 4-OCH₃(Ph) CH₃ CH₃ 26.224 H CH₃ 4-CF₃(Ph)CH₃ CH₃ 26.225 H CH₃ Ph CH₃ C₂H₅ 26.226 H CH₃ 4-Cl(Ph) CH₃ n-C₃H₇ 26.227H CH₃ 4-Br(Ph) CH₃ iso-C₃H₇ 26.228 H CH₃ 4-F(Ph) CH₃ n-C₄H₉ 26.229 H CH₃4-OCH₃(Ph) CH₃ iso-C₄H₉ 26.230 H CH₃ 4-CH₃(Ph) CH₃ C(CH₃)₃ 26.231 H CH₃4-NO₂(Ph) CH₃ CH₃ 26.232 H CH₃ 2,4-Cl(Ph) CH₃ CH₃ 26.233 H CH₃ Ph CH₃COCH₃ 26.234 H CH₃ 4-Cl(Ph) CH₃ COCH₃ 26.235 H CH₃ 4-Br(Ph) CH₃ COCH₃26.236 H CH₃ 4-F(Ph) CH₃ COCH₃ 26.237 H CH₃ 4-OCH₃(Ph) CH₃ COCH₃ 26.238H CH₃ 4-CH₃(Ph) CH₃ COCH₃ 26.239 H CH₃ 4-NO₂(Ph) CH₃ COCH₃ 26.240 H CH₃2,4-Cl(Ph) CH₃ COCH₃ 26.241 H CH₃ Ph CH₃ COPh 26.242 H CH₃ 4-Cl(Ph) CH₃COPh 26.243 H CH₃ 4-Br(Ph) CH₃ COPh 26.244 H CH₃ 4-F(Ph) CH₃ COPh 26.245H CH₃ 4-OCH₃(Ph) CH₃ COPh 26.246 H CH₃ 4-CH₃(Ph) CH₃ COPh 26.247 H CH₃4-NO₂(Ph) CH₃ COPh 26.248 H CH₃ 2,4-Cl(Ph) CH₃ COPh 26.249 CH₃ CH₃ PhCH₃ H 26.250 CH₃ CH₃ 4-Cl(Ph) CH₃ H 26.251 CH₃ CH₃ 4-Br(Ph) CH₃ H 26.252CH₃ CH₃ 4-F(Ph) CH₃ H 26.253 CH₃ CH₃ 4-OCH₃(Ph) CH₃ H 26.254 CH₃ CH₃4-CH₃(Ph) CH₃ H 26.255 CH₃ CH₃ 4-NO₂(Ph) CH₃ H 26.256 CH₃ CH₃ 2,4-Cl(Ph)CH₃ R 26.257 CH₃ CH₃ Ph CH₃ COCH₃ 26.258 CH₃ CH₃ 4-Cl(Ph) CH₃ COCH₃26.259 CH₃ CH₃ 4-Br(Ph) CH₃ COCH₃ 26.260 CH₃ CH₃ 4-F(Ph) CH₃ COCH₃26.261 CH₃ CH₃ 4-OCH₃(Ph) CH₃ COCH₃ 26.262 CH₃ CH₃ 4-CH₃(Ph) CH₃ COCH₃26.263 CH₃ CH₃ 4-NO₂(Ph) CH₃ COCH₃ 26.264 CH₃ CH₃ 2,4-Cl(Ph) CH₃ COCH₃26.265 CN CH₃ Ph CH₃ H 26.266 CN CH₃ 4-Cl(Ph) CH₃ H 26.267 CN CH₃4-Br(Ph) CH₃ H 26.268 CN CH₃ 4-F(Ph) CH₃ H 26.269 CN CH₃ 4-OCH₃(Ph) CH₃H 26.270 CN CH₃ 4-CH₃(Ph) CH₃ H 26.271 CN CH₃ 4-NO₂(Ph) CH₃ H 26.272 CNCH₃ 2,4-Cl(Ph) CH₃ H 26.273 CN CH₃ Ph CH₃ CH₃ 26.274 CN CH₃ 4-Cl(Ph) CH₃CH₃ 26.275 CN CH₃ 4-Br(Ph) CH₃ CH₃ 26.276 CN CH₃ 4-F(Ph) CH₃ CH₃ 26.277CN CH₃ 4-OCH₃(Ph) CH₃ CH₃ 26.278 CN CH₃ 4-CH₃(Ph) CH₃ CH₃ 26.279 CN CH₃4-NO₂(Ph) CH₃ CH₃ 26.280 CN CH₃ 2,4-Cl(Ph) CH₃ CH₃ 26.281 CN CH₃ Ph CH₃COCH₃ 26.282 CN CH₃ 4-Cl(Ph) CH₃ COCH₃ 26.283 CN CH₃ 4-Br(Ph) CH₃ COCH₃26.284 CN CH₃ 4-F(Ph) CH₃ COCH₃ 26.285 CN CH₃ 4-OCH₃(Ph) CH₃ COCH₃26.286 CN CH₃ 4-CH₃(Ph) CH₃ COCH₃ 26.287 CN CH₃ 4-NO₂(Ph) CH₃ COCH₃26.288 CN CH₃ 2,4-Cl(Ph) CH₃ COCH₃ 26.289 CN CH₃ Ph CH₃ COPh 26.290 CNCH₃ 4-Cl(Ph) CH₃ C()Ph 26.291 CN CH₃ 4-Br(Ph) CH₃ COPh 26.292 CN CH₃4-F(Ph) CH₃ COPh 26.293 CN CH₃ 4-NO₂(Ph) CH₃ COPh 26.294 CN CH₃2,4-Cl(Ph) CH₃ COPh 26.295 CN CH₃ 2,4-F(Ph) CH₃ COPh 26.296 CN H Ph C₂H₅H 26.297 CN H 2-Cl(Ph) n-CsH7 H 26.298 CN H 3-Cl(Ph) iso-C₃H₇ H 26.299CN H 4-Cl(Ph) n-C₄H₉ H 26.300 CN H 4-Br(Ph) iso-C₄H₉ H 26.301 CN H4-F(Ph) C(CH₃)₃ H 26.302 CN H 4-OCH₃(Ph) C₂H₅ COCH₃ 26.303 CN H4-CH₃(Ph) n-C₃H₇ COCH₃ 26.304 CN H 4-NO₂(Ph) iso-C₃H₇ COCH₃ 26.305 CN H2,4-Cl(Ph) n-C₄H₉ COCH₃ 26.306 CN H 2,4-F(Ph) iso-C₄H₉ COCH₃ 26.307 CN HPh C(CH₃)₃ COCH₃ 26.308 CN H 2-Cl(Ph) C₂H₅ COPh 26.309 CN H 3-Cl(Ph)n-C₃H₇ COPh 26.310 CN H 4-Cl(Ph) iso-C₃H₇ COPh 26.311 CH₃ H 4-Br(Ph)n-C₄H₉ COPh 26.312 CH₃ H 4-F(Ph) iso-C₄H₉ COPh 26.313 CH₃ H 4-OCH₃(Ph)C(CH₃)₃ COPh

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula XII, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, Z═NR₁₀ and R₁₀ is NR₈R₉, and where R₂,R₃, R₇, R₈ and R₉ are defined in Table 27.

TABLE 27 Compd R₂ R₃ R₇ R₈ R₉ 27.1 H H Ph CH₃ H 27.2 H H 4-Cl(Ph) CH₃ H27.3 H H 4-Br(Ph) CH₃ H 27.4 H H 4-F(Ph) CH₃ H 27.5 H H 4-OCH₃(Ph) CH₃ H27.6 H H 4-CF₃(Ph) CH₃ H 27.7 H H Ph CH₃ CH₃ 27.8 H H 4-Cl(Ph) CH₃ CH₃27.9 H H 4-Br(Ph) CH₃ CH₃ 27.10 H H 4-F(Ph) CH₃ CH₃ 27.11 CH₃ H Ph CH₃ H27.12 CH₃ H 2-Cl(Ph) CH₃ H 27.13 CH₃ H 3-Cl(Ph) CH₃ H 27.14 CH₃ H4-Cl(Ph) CH₃ H 27.15 CH₃ H 2-Br(Ph) CH₃ H 27.16 CH₃ H 3-Br(Ph) CH₃ H27.17 CH₃ H 4-Br(Ph) CH₃ H 27.18 CH₃ H Ph CH₃ CH₃ 27.19 CH₃ H 2-Cl(Ph)CH₃ CH₃ 27.20 CH₃ H 3-Cl(Ph) CH₃ CH₃ 27.21 CH₃ H 4-Cl(Ph) CH₃ CH₃ 27.22CH₃ H 2-Br(Ph) CH₃ CH₃ 27.23 CH₃ H 3-Br(Ph) CH₃ CH₃ 27.24 CH₃ H 4-Br(Ph)CH₃ CH₃ 27.25 CH₃ H 2-CH₃(Ph) CH₃ CH₃ 27.26 CH₃ H 3-CH₃(Ph) CH₃ CH₃27.27 CH₃ H 2-CF₃(Ph) CH₃ CH₃ 27.28 CH₃ H 3-CF₃(Ph) CH₃ CH₃ 27.29 CH₃ H4-CF₃(Ph) CH₃ CH₃ 27.30 CH₃ H 2-NO₂(Ph) CH₃ CH₃ 27.31 CH₃ H 3-NO₂(Ph)CH₃ CH₃ 27.32 CH₃ H 4-NO₂(Ph) CH₃ CH₃ 27.33 CH₃ H 2,3-Cl(Ph) CH₃ CH₃27.34 CH₃ H 2,4-Cl(Ph) CH₃ CH₃ 27.35 CH₃ H 2,5-Cl(Ph) CH₃ CH₃ 27.36 CH₃H 2,6-Cl(Ph) CH₃ CH₃ 27.37 CH₃ H 3,4-Cl(Ph) CH₃ CH₃ 27.38 CH₃ H3,5-Cl(Ph) CH₃ CH₃ 27.39 CH₃ H Ph C₂H₅ CH₃ 27.40 CH₃ H Ph n-C₃H₇ CH₃27.41 CH₃ H Ph iso-C₃H₇ CH₃ 27.42 CH₃ H Ph n-C₄H₉ CH₃ 27.43 CH₃ H Phiso-C₄H₉ CH₃ 27.44 CH₃ H Pb C(CH₃)₃ CH₃ 27.45 CH₃ H Ph H COCH₃ 27.46 CH₃H 2-Cl(Ph) H COCH₃ 27.47 CH₃ H 3-Cl(Ph) H COCH₃ 27.48 CH₃ H 4-Cl(Ph) HCOCH₃ 27.49 CH₃ H 4-Br(Ph) H COCH₃ 27.50 CH₃ H 4-F(Ph) H COCH₃ 27.51 CH₃H 4-OCH₃(Ph) H COCH₃ 27.52 CH₃ H 4-CH₃(Ph) H COCH₃ 27.53 CH₃ H 4-NO₂(Ph)H COCH₃ 27.54 CH₃ H 2,4-Cl(Ph) H COCH₃ 27.55 CH₃ H 2,4-F(Ph) H COCH₃27.56 CH₃ H Ph CH₃ COCH₃ 27.57 CH₃ H 2-Cl(Ph) CH₃ COCH₃ 27.58 CH₃ H3-Cl(Ph) CH₃ COCH₃ 27.59 CH₃ H 4-Cl(Ph) CH₃ COCH₃ 27.60 CH₃ H 4-F(Ph)CH₃ COCH₃ 27.61 CH₃ H 3-OCH₃(Ph) CH₃ COCH₃ 27.62 CH₃ H 4-OCH₃(Ph) CH₃COCH₃ 27.63 CH₃ H 4-CH₃(Ph) CH₃ COCH₃ 27.64 CH₃ H 4-NO₂(Ph) CH₃ COCH₃27.65 CH₃ H 2,4-Cl(Ph) CH₃ COCH₃ 27.66 CH₃ H 2,4-F(Ph) CH₃ COCH₃ 27.67CH₃ H Ph H COPh 27.68 CH₃ H 2-Cl(Ph) H COPh 27.69 CH₃ H 3-Cl(Ph) H COPh27.70 CH₃ H 4-Cl(Ph) H COPh 27.71 CH₃ H 4-Br(Ph) H COPh 27.72 CH₃ H4-F(Ph) H COPh 27.73 CH₃ H 4-OCH₃(Ph) H COPh 27.74 CH₃ H 4-CH₃(Ph) HCOPh 27.75 CH₃ H 4-NO₂(Ph) H COPh 27.76 CH₃ H 2,4-Cl(Ph) H COPh 27.77CH₃ H 2,4-F(Ph) H COPh 27.78 CH₃ H Ph CH₃ COPh 27.79 CH₃ H 2-Cl(Ph) CH₃COPh 27.80 CH₃ H 3-Cl(Ph) CH₃ COPh 27.81 CH₃ H 4-Cl(Ph) CH₃ COPh 27.82CH₃ H 4-Br(Ph) CH₃ COPh 27.83 CH₃ H 4-F(Ph) CH₃ COPh 27.84 CH₃ H4-OCH₃(Ph) CH₃ COPh 27.85 CH₃ H 4-CH₃(Ph) CH₃ COPh 27.86 CH₃ H 4-NO₂(Ph)CH₃ COPh 27.87 CH₃ H 2,4-Cl(Ph) CH₃ COPh 27.88 CH₃ H 2,4-F(Ph) CH₃ COPh27.89 C₂H₅ H Ph H COCH₃ 27.90 C₂H₅ H 2-Cl(Ph) H COCH₃ 27.91 C₂H₅ H3-Cl(Ph) H COCH₃ 27.92 C₂H₅ H 4-Cl(Ph) H COCH₃ 27.93 C₂H₅ H 4-F(Ph) HCOCH₃ 27.94 C₂H₅ H 3-OCH₃(Ph) H COCH₃ 27.95 C₂H₅ H 4-OCH₃(Ph) H COCH₃27.96 C₂H₅ H 4-CH₃(Ph) H COCH₃ 27.97 C₂H₅ H 4-NO₂(Ph) H COCH₃ 27.98 C₂H₅H 2,4-Cl(Ph) H COCH₃ 27.99 C₂H₅ H 2,4-F(Ph) H COCH₃ 27.100 C₂H₅ H Ph CH₃COCH₃ 27.101 C₂H₅ H 2-Cl(Ph) CH₃ COCH₃ 27.102 C₂H₅ H 3-Cl(Ph) CH₃ COCH₃27.103 C₂H₅ H 4-Cl(Ph) CH₃ COCH₃ 27.104 C₂H₅ H 4-F(Ph) CH₃ COCH₃ 27.105C₂H₅ H 3-OCH₃(Ph) CH₃ COCH₃ 27.106 C₂H₅ H 4-OCH₃(Ph) CH₃ COCH₃ 27.107C₂H₅ H 4-CH₃(Ph) CH₃ COCH₃ 27.108 C₂H₅ H 4-NO₂(Ph) CH₃ COCH₃ 27.109 C₂H₅H 2,4-Cl(Ph) CH₃ COCH₃ 27.110 C₂H₅ H 2,4-F(Ph) CH₃ COCH₃ 27.111 C₂H₅ HPh H COPh 27.112 C₂H₅ H 2-Cl(Ph) H COPh 27.113 C₂H₅ H 3-Cl(Ph) H COPh27.114 C₂H₅ H 4-Cl(Ph) H COPh 27.115 C₂H₅ H 4-Br(Ph) H COPh 27.116 C₂H₅H 3-OCH₃(Ph) H COPh 27.117 C₂H₅ H 4-OCH₃(Ph) H COPh 27.118 C₂H₅ H4-CH₃(Ph) H COPh 27.119 C₂H₅ H 4-NO₂(Ph) H COPh 27.120 C₂H₅ H 2,4-Cl(Ph)H COPh 27.121 C₂H₅ H 2,4-F(Ph) H COPh 27.122 C₂H₅ H Ph CH₃ COPh 27.123C₂H₅ H 2-Cl(Ph) CH₃ COPh 27.124 C₂H₅ H 3-Cl(Ph) CH₃ COPh 27.125 C₂H₅ H4-Cl(Ph) CH₃ COPh 27.126 C₂H₅ H 4-Br(Ph) CH₃ COPh 27.127 C₂H₅ H 4-F(Ph)CH₃ COPh 27.128 C₂H₅ H 4-OCH₃(Ph) CH₃ COPh 27.129 C₂H₅ H 4-CH₃(Ph) CH₃COPh 27.130 C₂H₅ H 4-NO₂(Ph) CH₃ COPh 27.131 C₂H₅ H 2,4-Cl(Ph) CH₃ COPh27.132 C₂H₅ H 2,4-F(Ph) CH₃ COPh 27.133 CH₃ H Ph C₂H₅ COCH₃ 27.134 CH₃ HPh n-C₃H₇ COCH₃ 27.135 CH₃ H Ph iso-C₃H₇ COCH₃ 27.136 CH₃ H Ph n-C₄H₉COCH₃ 27.137 CH₃ H Ph iso-C₄H₉ COCH₃ 27.138 CH₃ H Ph C(CH₃)₃ COCH₃27.139 CH₃ H 4-Cl(Ph) C₂H₅ COCH₃ 27.140 CH₃ H 4-Cl(Ph) n-C₃H₇ COCH₃27.141 CH₃ H 4-Cl(Ph) iso-C₃H₇ COCH₃ 27.142 CH₃ H 4-Cl(Ph) n-C₄H₉ COCH₃27.143 CH₃ H 4-Cl(Ph) iso-C₄H₉ COCH₃ 27.144 CH₃ H 4-Cl(Ph) C(CH₃)₃ COCH₃27.145 CH₃ H Ph C₂H₅ COPh 27.146 CH₃ H Ph n-C₃H₇ COPh 27.147 CH₃ H Phiso-C₃H₇ COPh 27.148 CH₃ H Ph n-C₄H₉ COPh 27.149 CH₃ H Ph C(CH₃)₃ COPh27.150 CH₃ H 4-Cl(Ph) CH₃ COCH₂Ph 27.151 CH₃ H 4-Br(Ph) CH₃ COCH₂Ph27.152 CH₃ H 4-F(Ph) CH₃ COCH₂Ph 27.153 CH₃ H 4-OCH₃(Ph) CH₃ COCH₂Ph27.154 CH₃ H 4-CH₃(Ph) CH₃ COCH₂Ph 27.155 CH₃ H 4-NO₂(Ph) CH₃ COCH₂Ph27.156 CH₃ H 2,4-Cl(Ph) CH₃ COCH₂Ph 27.157 CH₃ H 2,4-F(Ph) CH₃ COCH₂Ph27.158 CH₃ H 4-Cl(Ph) C₂H₅ COCH₂Ph 27.159 CH₃ H 4-Br(Ph) n-C₃H₇ COCH₂Ph27.160 CH₃ H 4-F(Ph) iso-C₃H₇ COCH₂Ph 27.161 CH₃ H 4-OCH₃(Ph) n-C₄H₉COCH₂Ph 27.162 CH₃ H 4-CH₃(Ph) iso-C₄H₉ COCH₂Ph 27.163 CH₃ H 4-NO₂(Ph)C(CH₃)₃ COCH₂Ph 27.164 Ph H Ph CH₃ H 27.165 Ph H 2-Cl(Ph) CH₃ H 27.166Ph H 3-Cl(Ph) CH₃ H 27.167 Ph H 4-Cl(Ph) CH₃ H 27.168 Ph H 4-Br(Ph) CH₃H 27.169 Ph H 4-F(Ph) CH₃ H 27.170 Ph H 4-OCH₃(Ph) CH₃ H 27.171 Ph H4-CH₃(Ph) CH₃ H 27.172 Ph H 4-NO₂(Ph) CH₃ H 27.173 Ph H 2,4-Cl(Ph) CH₃ H27.174 Ph H Ph CH₃ CH₃ 27.175 Ph H 2-Cl(Ph) CH₃ CH₃ 27.176 Ph H 3-Cl(Ph)CH₃ CH₃ 27.177 Ph H 4-Cl(Ph) CH₃ CH₃ 27.178 Ph H 4-Br(Ph) CH₃ CH₃ 27.179Ph H 4-F(Ph) CH₃ CH₃ 27.180 CN H 4-Cl(Ph) CH₃ H 27.181 CN H 4-Br(Ph) CH₃H 27.182 CN H 4-F(Ph) CH₃ H 27.183 CN H 4-OCH₃(Ph) CH₃ H 27.184 CN H4-CH₃(Ph) CH₃ H 27.185 CN H 4-NO₂(Ph) CH₃ H 27.186 CN H 2,4-Cl(Ph) CH₃ H27.187 CN H 2,4-F(Ph) CH₃ H 27.188 CN H 4-CF₃(Ph) CH₃ H 27.189 CN H PhCH₃ CH₃ 27.190 CN H Ph CH₃ COCH₃ 27.191 H H 1-napthyl CH₃ H 27.192 H H1-napthyl CH₃ CH₃ 27.193 H H 1-napthyl CH₃ COCH₃ 27.194 H H 1-napthylCH₃ COPh 27.195 CH₃ H 1-napthyl CH₃ H 27.196 CH₃ H 1-napthyl CH₃ CH₃27.197 CH₃ H 1-napthyl CH₃ COCH₃ 27.198 CH₃ H 1-napthyl CH₃ COPh 27.199CH₃ H 1-napthyl CH₃ COCH₂Ph 27.200 H H 1-napthyl CH₃ CO₂CH₃ 27.201 CH₃ H1-napthyl CH₃ CO₂CH₃ 27.202 H H 2-napthyl CH₃ H 27.203 H H 2-napthyl CH₃CH₃ 27.204 H H 2-napthyl CH₃ COCH₃ 27.205 H H 2-napthyl CH₃ COPh 27.206CH₃ H 2-napthyl CH₃ H 27.207 CH₃ H 2-napthyl CH₃ CH₃ 27.208 CH₃ H2-napthyl CH₃ COCH₃ 27.209 CH₃ H 2-napthyl CH₃ COPh 27.210 CH₃ H2-napthyl CH₃ COCH₂Ph 27.211 H H 2-napthyl CH₃ CO₂CH₃ 27.212 CH₃ H2-napthyl CH₃ CO₂CH₃ 27.213 H CH₃ Ph CH₃ H 27.214 H CH₃ 4-Cl(Ph) CH₃ H27.215 H CH₃ 4-Br(Ph) CH₃ H 27.216 H CH₃ 4-F(Ph) CH₃ H 27.217 H CH₃4-OCH₃(Ph) CH₃ H 27.218 H CH₃ 4-CF₃(Ph) CH₃ H 27.219 H CH₃ Ph CH₃ CH₃27.220 H CH₃ 4-Cl(Ph) CH₃ CH₃ 27.221 H CH₃ 4-Br(Ph) CH₃ CH₃ 27.222 H CH₃4-F(Ph) CH₃ CH₃ 27.223 H CH₃ 4-OCH₃(Ph) CH₃ CH₃ 27.224 H CH₃ 4-CF₃(Ph)CH₃ CH₃ 27.225 H CH₃ Ph CH₃ C₂H₅ 27.226 H CH₃ 4-Cl(Ph) CH₃ n-C₃H₇ 27.227H CH₃ 4-Br(Ph) CH₃ iso-C₃H₇ 27.228 H CH₃ 4-F(Ph) CH₃ n-C₄H₉ 27.229 H CH₃4-OCH₃(Ph) CH₃ iso-C₄H₉ 27.230 H CH₃ 4-CH₃(Ph) CH₃ C(CH₃)₃ 27.231 H CH₃4-NO₂(Ph) CH₃ CH₃ 27.232 H CH₃ 2,4-Cl(Ph) CH₃ CH₃ 27.233 H CH₃ Ph CH₃COCH₃ 27.234 H CH₃ 4-Cl(Ph) CH₃ COCH₃ 27.235 H CH₃ 4-Br(Ph) CH₃ COCH₃27.236 H CH₃ 4-F(Ph) CH₃ COCH₃ 27.237 H CH₃ 4-OCH₃(Ph) CH₃ COCH₃ 27.238H CH₃ 4-CH₃(Ph) CH₃ COCH₃ 27.239 H CH₃ 4-NO₂(Ph) CH₃ COCH₃ 27.240 H CH₃2,4-Cl(Ph) CH₃ COCH₃ 27.241 H CH₃ Ph CH₃ COPh 27.242 H CH₃ 4-Cl(Ph) CH₃COPh 27.243 H CH₃ 4-Br(Ph) CH₃ COPh 27.244 H CH₃ 4-F(Ph) CH₃ COPh 27.245H CH₃ 4-OCH₃(Ph) CH₃ COPh 27.246 H CH₃ 4-CH₃(Ph) CH₃ COPh 27.247 H CH₃4-NO₂(Ph) CH₃ COPh 27.248 H CH₃ 2,4-Cl(Ph) CH₃ COPh 27.249 CH₃ CH₃ PhCH₃ H 27.250 CH₃ CH₃ 4-Cl(Ph) CH₃ H 27.251 CH₃ CH₃ 4-Br(Ph) CH₃ H 27.252CH₃ CH₃ 4-F(Ph) CH₃ H 27.253 CH₃ CH₃ 4-OCH₃(Ph) CH₃ H 27.254 CH₃ CH₃4-CH₃(Ph) CH₃ H 27.255 CH₃ CH₃ 4-NO₂(Ph) CH₃ H 27.256 CH₃ CH₃ 2,4-Cl(Ph)CH₃ H 27.257 CH₃ CH₃ Ph CH₃ COCH₃ 27.258 CH₃ CH₃ 4-Cl(Ph) CH₃ COCH₃27.259 CH₃ CH₃ 4-Br(Ph) CH₃ COCH₃ 27.260 CH₃ CH₃ 4-F(Ph) CH₃ COCH₃27.261 CH₃ CH₃ 4-OCH₃(Ph) CH₃ COCH₃ 27.262 CH₃ CH₃ 4-CH₃(Ph) CH₃ COCH₃27.263 CH₃ CH₃ 4-NO₂(Ph) CH₃ COCH₃ 27.264 CH₃ CH₃ 2,4-Cl(Ph) CH₃ COCH₃27.265 CN CH₃ Ph CH₃ H 27.266 CN CH₃ 4-Cl(Ph) CH₃ H 27.267 CN CH₃4-Br(Ph) CH₃ H 27.268 CN CH₃ 4-F(Ph) CH₃ H 27.269 CN CH₃ 4-OCH₃(Ph) CH₃H 27.270 CN CH₃ 4-CH₃(Ph) CH₃ H 27.271 CN CH₃ 4-NO₂(Ph) CH₃ H 27.272 CNCH₃ 2,4-Cl(Ph) CH₃ H 27.273 CN CH₃ Ph CH₃ CH₃ 27.274 CN CH₃ 4-Cl(Ph) CH₃CH₃ 27.275 CN CH₃ 4-Br(Ph) CH₃ CH₃ 27.276 CN CH₃ 4-F(Ph) CH₃ CH₃ 27.277CN CH₃ 4-OCH₃(Ph) CH₃ CH₃ 27.278 CN CH₃ 4-CH₃(Ph) CH₃ CH₃ 27.279 CN CH₃4-NO₂(Ph) CH₃ CH₃ 27.280 CN CH₃ 2,4-Cl(Ph) CH₃ CH₃ 27.281 CN CH₃ Ph CH₃COCH₃ 27.282 CN CH₃ 4-Cl(Ph) CH₃ COCH₃ 27.283 CN CH₃ 4-Br(Ph) CH₃ COCH₃27.284 CN CH₃ 4-F(Ph) CH₃ COCH₃ 27.285 CN CH₃ 4-OCH₃(Ph) CH₃ COCH₃27.286 CN CH₃ 4-CH₃(Ph) CH₃ COCH₃ 27.287 CN CH₃ 4-NO₂(Ph) CH₃ COCH₃27.288 CN CH₃ 2,4-Cl(Ph) CH₃ COCH₃ 27.289 CN CH₃ Ph CH₃ COPh 27.290 CNCH₃ 4-Cl(Ph) CH₃ COPh 27.291 CN CH₃ 4-Br(Ph) CH₃ COPh 27.292 CN CH₃4-F(Ph) CH₃ COPh 27.293 CN CH₃ 4-NO₂(Ph) CH₃ COPh 27.294 CN CH₃2,4-Cl(Ph) CH₃ COPh 27.295 CN CH₃ 2,4-F(Ph) CH₃ COPh 27.296 CN H Ph C₂H₅H 27.297 CN H 2-Cl(Ph) n-C₃H₇ H 27.298 CN H 3-Cl(Ph) iso-C₃H₇ H 27.299CN H 4-Cl(Ph) n-C₄H₉ H 27.300 CN H 4-Br(Ph) iso-C₄H₉ H 27.301 CN H4-F(Ph) C(CH₃)₃ H 27.302 CN H 4-OCH₃(Ph) C₂H₅ COCH₃ 27.303 CN H4-CH₃(Ph) n-C₃H₇ COCH₃ 27.304 CN H 4-NO₂(Ph) iso-C₃H₇ COCH₃ 27.305 CN H2,4-Cl(Ph) n-C₄H₉ COCH₃ 27.306 CN H 2,4-F(Ph) iso-C₄H₉ COCH₃ 27.307 CN HPh C(CH₃)₃ COCH₃ 27.308 CN H 2-Cl(Ph) C₂H₅ COPh 27.309 CN H 3-Cl(Ph)n-C₃H₇ COPh 27.310 CN H 4-Cl(Ph) iso-C₃H₇ COPh 27.311 CH₃ H 4-Br(Ph)n-C₄H₉ COPh 27.312 CH₃ H 4-F(Ph) iso-C₄H₉ COPh 27.313 CH₃ H 4-OCH₃(Ph)C(CH₃)₃ COPh

TABLE 28

Compounds 28.1 to 28.226 are compounds of Formula X which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═NR₁₀, R₁₀ is NHCOCH₃ andwhere R₂, R₃, and R₇ are defined in Table 4.

TABLE 29

Compounds 29.1 to 29.226 are compounds of Formula XI which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═NR₁₀, R₁₀ is NHCOCH₃ andwhere R₂, R₃, and R₇ are defined in Table 4.

TABLE 30

Compounds 30.1 to 30.226 are compounds of Formula XII which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═NR₁₀, R₁₀ is NHCOCH₃ andwhere R₂, R₃, and R₇ are defined in Table 4.

TABLE 31

Compounds 31.1 to 31.221 are compounds of Formula X which is Formula Iwith A═R₄R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═NR₁₀, R₁₀ is NHCOC₂H₅ andwhere R₂, R₃, and R₇ are defined in Table 7.

TABLE 32

Compounds 32.1 to 32.221 are compounds of Formula XI which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═NR₁₀, R₁₀ is NHCOC₂H₅ andwhere R₂, R₃, and R₇ are defined in Table 7.

TABLE 33

Compounds 33.1 to 33.221 are compounds of Formula XII which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═NR₁₀, R₁₀ is NHCOC₂H₅ andwhere R₂, R₃ and R₇ are defined in Table 7.

TABLE 34

Compounds 34.1 to 34.139 are compounds of Formula X which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═NR₁₀, R₁₀ is NHCOPh andwhere R₂, R₃, and R₇ are defined in Table 10.

TABLE 35

Compounds 35.1 to 35.139 are compounds of Formula XI which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═NR₁₀, R₁₀ is NHCOPh and whereR₂, R₃, and R₇ are defined in Table 10.

TABLE 36

Compounds 36.1 to 36.139 are compounds of Formula XII which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═NR₁₀, R₁₀ is NHCOPh andwhere R₂, R₃, and R₇ are defined in Table 10.

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula X, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, Z═NR₁₀, and where R₂, R₃, R₇, and R₁₀are defined in Table 37.

TABLE 37 Compd. R₂ R₃ R₇ R₁₀ 37.1 H H Ph CH₃ 37.2 H H 4-Cl(Ph) CH₃ 37.3H H 4-Br(Ph) CH₃ 37.4 H H 4-F(Ph) CH₃ 37.5 H H 4-OCH₃(Ph) CH₃ 37.6 H H4-CF₃(Ph) CH₃ 37.7 H H Ph CH₃ 37.8 H H 4-Cl(Ph) CH₃ 37.9 H H 4-Br(Ph)CH₃ 37.10 H H 4-F(Ph) CH₃ 37.11 CH₃ H Ph CH₃ 37.12 CH₃ H 2-Cl(Ph) CH₃37.13 CH₃ H 3-Cl(Ph) CH₃ 37.14 CH₃ H 4-Cl(Ph) CH₃ 37.15 CH₃ H 2-Br(Ph)CH₃ 37.16 CH₃ H 3-Br(Ph) CH₃ 37.17 CH₃ H 4-Br(Ph) CH₃ 37.18 CH₃ H PhC₂H₅ 37.19 CH₃ H 2-Cl(Ph) C₂H₅ 37.20 CH₃ H 3-Cl(Ph) C₂H₅ 37.21 CH₃ H4-Cl(Ph) C₂H₅ 37.22 CH₃ H 2-Br(Ph) C₂H₅ 37.23 CH₃ H 3-Br(Ph) C₂H₅ 37.24CH₃ H 4-Br(Ph) C₂H₅ 37.25 CH₃ H 2-CH₃(Ph) C₂H₅ 37.26 CH₃ H 3-CH₃(Ph)C₂H₅ 37.27 CH₃ H 2-CF₃(Ph) C₂H₅ 37.28 CH₃ H 3-CF₃(Ph) C₂H₅ 37.29 CH₃ H4-CF₃(Ph) C₂H₅ 37.30 CH₃ H 2-NO₂(Ph) C₂H₅ 37.31 CH₃ H 3-NO₂(Ph) C₂H₅37.32 CH₃ H 4-NO₂(Ph) C₂H₅ 37.33 CH₃ H 2,3-Cl(Ph) C₂H₅ 37.34 CH₃ H2,4-Cl(Ph) C₂H₅ 37.35 CH₃ H 2,5-Cl(Ph) C₂H₅ 37.36 CH₃ H 2,6-Cl(Ph) C₂H₅37.37 CH₃ H 3,4-Cl(Ph) C₂H₅ 37.38 CH₃ H 3,5-Cl(Ph) C₂H₅ 37.39 CH₃ H Phn-C₃H₇ 37.40 CH₃ H Ph iso-C₃H₇ 37.41 CH₃ H Ph n-C₄H₉ 37.42 CH₃ H Phiso-C₄H₉ 37.43 CH₃ H Ph C(CH₃)₃ 37.44 CH₃ H Ph CH₂CH═CH₂ 37.45 CH₃ H PhCH₂C≡CH 37.46 CH₃ H Ph PhCH₂ 37.47 CH₃ CH₃ Ph CH₃ 37.48 CH₃ CH₃ 4-Cl(Ph)CH₃ 37.49 CH₃ CH₃ 4-Br(Ph) CH₃ 37.50 CH₃ CH₃ 4-F(Ph) CH₃ 37.51 CH₃ CH₃4-OCH₃(Ph) CH₃ 37.52 CH₃ CH₃ 4-CH₃(Ph) CH₃ 37.53 CH₃ CH₃ 4-NO₂(Ph) CH₃37.54 CH₃ CH₃ 2,4-Cl(Ph) CH₃ 37.55 CH₃ CH₃ 2,4-F(Ph) CH₃ 37.56 CH₃ CH₃Ph C₂H₅ 37.57 CH₃ CH₃ 2-Cl(Ph) C₂H₅ 37.58 CH₃ CH₃ 3-Cl(Ph) C₂H₅ 37.59CH₃ CH₃ 4-Cl(Ph) C₂H₅ 37.60 CH₃ CH₃ 4-F(Ph) C₂H₅ 37.61 CH₃ CH₃3-OCH₃(Ph) C₂H₅ 37.62 CH₃ CH₃ 4-OCH₃(Ph) C₂H₅ 37.63 CH₃ CH₃ 4-CH₃(Ph)C₂H₅ 37.64 CH₃ CH₃ 4-NO₂(Ph) C₂H₅ 37.65 CH₃ CH₃ 2,4-Cl(Ph) C₂H₅ 37.66CH₃ CH₃ 2,4-Fh) C₂H₅ 37.67 CH₃ CH₃ Ph n-C₃H₇ 37.68 CH₃ CH₃ 2-Cl(Ph)iso-C₃H₇ 37.69 CH₃ CH₃ 3-Cl(Ph) n-C₄H₉ 37.70 CH₃ CH₃ 4-Cl(Ph) iso-C₄H₉37.71 CH₃ CH₃ 4-Br(Ph) sec-C₄H₉ 37.72 CH₃ CH₃ 4-F(Ph) C(CH₃)₃ 37.73 CH₃CH₃ 4-OCH₃(ph) CH₂CH═CH₂ 37.74 CH₃ CH₃ 4-CH₃(Ph) CH₂C≡CH 37.75 CH₃ CH₃4-NO₂(Ph) PhCH₂ 37.76 CH₃ CH₃ 2,4-Cl(Ph) PhCH₂CH₂ 37.77 CH₃ CH₃2,4-F(Ph) PhCH₂CH₂ 37.78 C₂H₅ H Ph CH₃ 37.79 C₂H₅ H 2-Cl(Ph) CH₃ 37.80C₂H₅ H 3-Cl(Ph) CH₃ 37.81 C₂H₅ H 4-Cl(Ph) CH₃ 37.82 C₂H₅ H 4-Br(Ph) CH₃37.83 C₂H₅ H 4-F(Ph) CH₃ 37.84 C₂H₅ H 4-OCH₃(Ph) CH₃ 37.85 C₂H₅ H4-CH₃(Ph) CH₃ 37.86 C₂H₅ H 4-NO₂(Ph) CH₃ 37.87 C₂H₅ H 2,4-Cl(Ph) CH₃37.88 C₂H₅ H 2,4-F(Ph) CH₃ 37.89 C₂H₅ H Ph C₂H₅ 37.90 C₂H₅ H 2-Cl(Ph)C₂H₅ 37.91 C₂H₅ H 3-Cl(Ph) C₂H₅ 37.92 C₂H₅ H 4-Cl(Ph) C₂H₅ 37.93 C₂H₅ H4-F(Ph) C₂H₅ 37.94 C₂H₅ H 3-OCH₃(Ph) C₂H₅ 37.95 C₂H₅ H 4-OCH₃(Ph) C₂H₅37.96 C₂H₅ H 4-CH₃(Ph) C₂H₅ 37.97 C₂H₅ H 4-NO₂h) C₂H₅ 37.98 C₂H₅ H2,4-Cl(Ph) C₂H₅ 37.99 C₂H₅ H 2,4-F(Ph) C₂H₅ 37.100 C₂H₅ H Ph n-C₃H₇37.101 C₂H₅ H 2-Cl(Ph) iso-C₃H₇ 37.102 C₂H₅ H 3-Cl(Ph) n-C₄H₉ 37.103C₂H₅ H 4-Cl(Ph) iso-C₄H₉ 37.104 C₂H₅ H 4-F(Ph) sec-C₄H₉ 37.105 C₂H₅ H3-OCH₃(Ph) C(CH₃)₃ 37.106 C₂H₅ H 4-OCH₃(Ph) CH₂CH═CH₂ 37.107 C₂H₅ H4-CH₃(Ph) CH₂C≡CH 37.108 C₂H₅ H 4-NO₂(Ph) PhCH₂ 37.109 C₂H₅ H 2,4-Cl(Ph)PhCH₂CH₂ 37.110 C₂H₅ H 2,4-F(Ph) CH₃ 37.111 n-C₃H₇ H Ph CH₃ 37.112n-C₃H₇ H 2-Cl(Ph) CH₃ 37.113 n-C₃H₇ H 3-Cl(Ph) CH₃ 37.114 n-C₃H₇ H4-Cl(Ph) CH₃ 37.115 n-C₃H₇ H 4-Br(Ph) CH₃ 37.116 n-C₃H₇ H 3-OCH₃(Ph) CH₃37.117 n-C₃H₇ H 4-OCH₃(Ph) CH₃ 37.118 n-C₃H₇ H 4-CH₃(Ph) CH₃ 37.119n-C₃H₇ H 4-NO₂(Ph) CH₃ 37.120 n-C₃H₇ H 2,4-Cl(Ph) CH₃ 37.121 n-C₃H₇ H2,4-F(Ph) CH₃ 37.122 n-C₃H₇ H Ph C₂H₅ 37.123 n-C₃H₇ H 2-Cl(Ph) C₂H₅37.124 n-C₃H₇ H 3-Cl(Ph) C₂H₅ 37.125 n-C₃H₇ H 4-Cl(Ph) C₂H₅ 37.126n-C₃H₇ H 4-Br(Ph) C₂H₅ 37.127 n-C₃H₇ H 4-F(Ph) C₂H₅ 37.128 n-C₃H₇ H4-OCH₃(Ph) C₂H₅ 37.129 n-C₃H₇ H 4-CH₃(Ph) C₂H₅ 37.130 n-C₃H₇ H 4-NO₂(Ph)C₂H₅ 37.131 n-C₃H₇ H 2,4-Cl(Ph) C₂H₅ 37.132 n-C₃H₇ H 2,4-F(Ph) C₂H₅37.133 n-C₃H₇ H Ph n-C₃H₇ 37.134 n-C₃H₇ H Ph iso-C₃H₇ 37.135 n-C₃H₇ H Phn-C₄H₉ 37.136 n-C₃H₇ H Ph iso-C₄H₉ 37.137 n-C₃H₇ H Ph C(CH₃)₃ 37.138n-C₃H₇ H Ph CH₂CH═CH₂ 37.139 n-C₃H₇ H Ph CH₂C≡CH 37.140 n-C₃H₇ H PhPhCH₂ 37.141 n-C₃H₇ H Ph PhCH₂CH₂ 37.142 iso-C₃H₇ H Ph C₂H₅ 37.143iso-C₃H₇ H Ph n-C₃H₇ 37.144 iso-C₃H₇ H Ph iso-C₃H₇ 37.145 iso-C₃H₇ H Phn-C₄H₉ 37.146 iso-C₃H₇ H Ph iso-C₄H₉ 37.147 iso-C₃H₇ H Ph C(CH₃)₃ 37.148iso-C₃H₇ H Ph CH₂CH═CH₂ 37.149 iso-C₃H₇ H Ph CH₂C≡CH 37.150 iso-C₃H₇ HPh PhCH₂ 37.151 iso-C₃H₇ H Ph PhCH₂CH₂ 37.152 cyclopropyl H Ph CH₃37.153 cyclopropyl H 2-Cl(Ph) CH₃ 37.154 cyclopropyl H 3-Cl(Ph) CH₃37.155 cyclopropyl H 4-Cl(Ph) CH₃ 37.156 cyclopropyl H 4-Br(Ph) CH₃37.157 cyclopropyl H 4-F(Ph) CH₃ 37.158 cyclopropyl H 4-OCH₃(Ph) CH₃37.159 cyclopropyl H 4-CH₃(Ph) CH₃ 37.160 cyclopropyl H 4-NO₂(Ph) CH₃37.161 cyclopropyl H 2,4-Cl(Ph) CH₃ 37.162 cyclopropyl H 2,4-F(Ph) CH₃37.163 cyclopropyl H 3,4-F(Ph) CH₃ 37.164 Ph H Ph CH₃ 37.165 Ph H2-Cl(Ph) C₂H₅ 37.166 Ph H 3-Cl(Ph) n-C₃H₇ 37.167 Ph H 4-Cl(Ph) iso-C₃H₇37.168 Ph H 4-Br(Ph) n-C₄H₉ 37.169 Ph H 4-F(Ph) iso-C₄H₉ 37.170 Ph H4-OCH₃(Ph) C(CH₃)₃ 37.171 Ph H 4-CH₃(Ph) CH₂CH═CH₂ 37.172 Ph H 4-NO₂(Ph)CH₂C≡CH 37.173 Ph H 2,4-Cl(Ph) PhCH₂ 37.174 CN H Ph CH₃ 37.175 CN H2-Cl(Ph) CH₃ 37.176 CN H 3-Cl(Ph) CH₃ 37.177 CN H 4-Cl(Ph) CH₃ 37.178 CNH 4-Br(Ph) CH₃ 37.179 CN H 4-F(Ph) CH₃ 37.180 CN H 4-Cl(Ph) CH₃ 37.181CN H 4-Br(Ph) CH₃ 37.182 CN H 4-F(Ph) CH₃ 37.183 CN H 4-OCH₃(Ph) CH₃37.184 CN H 4-CH₃(Ph) CH₃ 37.185 CN H 4-NO₂(Ph) CH₃ 37.186 CN H2,4-Cl(Ph) CH₃ 37.187 CN H 2,4-F(Ph) CH₃ 37.188 CN H 4-CF₃(Ph) CH₃37.189 CN H Ph C₂H₅ 37.190 CN H Ph n-C₃H₇ 37.191 CN H Ph iso-C₃H₇ 37.192CN H Ph n-C₄H₉ 37.193 CN H Ph iso-C₄H₉ 37.194 CN H Ph C(CH₃)₃ 37.195 CNH Ph CH₂CH═CH₂ 37.196 CN H Ph CH₂C≡CH 37.197 CN H Ph PhCH₂ 37.198 CH₃ H1-napthyl CH₃ 37.199 CH₃ H 1-napthyl C₂H₅ 37.200 CH₃ H 1-napthyl n-C₃H₇37.201 CH₃ H 1-napthyl iso-C₃H₇ 37.202 CH₃ H 1-napthyl n-C₄H₉ 37.203 CH₃H 1-napthyl iso-C₄H₉ 37.204 CH₃ H 1-napthyl C(CH₃)₃ 37.205 CH₃ H1-napthyl CH₂CH═CH₂ 37.206 CH₃ H 1-napthyl CH₂C≡CH 37.207 CH₃ H1-napthyl PhCH₂ 37.208 CH₃ H 2-napthyl CH₃ 37.209 CH₃ H 2-napthyl C₂H₅37.210 CH₃ H 2-napthyl n-C₃H₇ 37.211 CH₃ H 2-napthyl iso-C₃H₇ 37.212 CH₃H 2-napthyl n-C₄H₉ 37.213 CH₃ H 2-napthyl iso-C₄H₉ 37.214 CH₃ H2-napthyl C(CH₃)₃ 37.215 CH₃ H 2-napthyl CH₂CH═CH₂ 37.216 CH₃ H2-napthyl CH₂C≡CH 37.217 CH₃ H 2-napthyl PhCH₂ 37.218 CN H 1-napthyl CH₃37.219 CN H 1-napthyl C₂H₅ 37.220 CN H 1-napthyl n-C₃H₇ 37.221 CN H1-napthyl iso-C₃H₇ 37.222 CN H 1-napthyl n-C₄H₉ 37.223 CN H 1-napthyliso-C₄H₉ 37.224 CN H 1-napthyl C(CH₃)₃ 37.225 CN H 1-napthyl CH₂CH═CH₂37.226 CN H 1-napthyl CH₂C≡CH 37.227 CN H 1-napthyl PhCH₂ 37.228 CN H2-napthyl CH₃ 37.229 CN H 2-napthyl C₂H₅ 37.230 CN H 2-napthyl n-C₃H₇37.231 CN H 2-napthyl iso-C₃H₇ 37.232 CN H 2-napthyl n-C₄H₉ 37.233 CN H2-napthyl iso-C₄H₉ 37.234 CN H 2-napthyl C(CH₃)₃ 37.235 CN H 2-napthylCH₂CH═CH₂ 37.236 CN H 2-napthyl CH₂C≡CH 37.237 CN H 2-napthyl PhCH₂37.238 CH₃ CH₃ 1-napthyl CH₃ 37.239 CH₃ CH₃ 1-napthyl C₂H₅ 37.240 CH₃CH₃ 1-napthyl n-C₃H₇ 37.241 CH₃ CH₃ 1-napthyl iso-C₃H₇ 37.242 CH₃ CH₃1-napthyl n-C₄H₉ 37.243 CH₃ CH₃ 1-napthyl iso-C₄H₉ 37.244 CH₃ CH₃1-napthyl C(CH₃)₃ 37.245 CH₃ CH₃ 1-napthyl CH₂CH═CH₂ 37.246 CH₃ CH₃1-napthyl CH₂C≡CH 37.247 CH₃ CH_(s) 1-napthyl PhCH₂ 37.248 CH₃ CH₃2-napthyl CH₃ 37.249 CH₃ CH₃ 2-napthyl C₂H₅ 37.250 CH₃ CH₃ 2-napthyln-C₃H₇ 37.251 CH₃ CH₃ 2-napthyl iso-C₃H₇ 37.252 CH₃ CH₃ 2-napthyl n-C₄H₉37.253 CH₃ CH₃ 2-napthyl iso-C₄H₉ 37.254 CH₃ CH₃ 2-napthyl C(CH₃)₃37.255 CH₃ CH₃ 2-napthyl CH₂CH═CH₂ 37.256 CH₃ CH₃ 2-napthyl CH₂C≡CH37.257 CH₃ CH₃ 2-napthyl PhCH₂ 37.258 CN CH₃ 1-napthyl CH₃ 37.259 CN CH₃1-napthyl C₂H₅ 37.260 CN CH₃ 1-napthyl n-C₃H₇ 37.261 CN CH₃ 1-napthyliso-C₃H₇ 37.262 CN CH₃ 1-napthyl n-C₄H₉ 37.263 CN CH₃ 1-napthyl iso-C₄H₉37.264 CN CH₃ 1-napthyl C(CH₃)₃ 37.265 CN CH₃ 1-napthyl CH₂CH═CH₂ 37.266CN CH₃ 1-napthyl CH₂C≡CH 37.267 CN CH₃ 1-napthyl PhCH₂ 37.268 CN CH₃2-napthyl CH₃ 37.269 CN CH₃ 2-napthyl C₂H₅ 37.270 CN CH₃ 2-napthyln-C₃H₇ 37.271 CN CH₃ 2-napthyl iso-C₃H₇ 37.272 CN CH₃ 2-napthyl n-C₄H₉

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula XI, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, Z═NR₁₀, and where R₂, R₃, R₇, and R₁₀are defined in Table 38.

TABLE 38 Compd. R₂ R₃ R₇ R₁₀ 38.1 H H Ph CH₃ 38.2 H H 4-Cl(Ph) CH₃ 38.3H H 4-Br(Ph) CH₃ 38.4 H H 4-F(Ph) CH₃ 38.5 H H 4-OCH₃(Ph) CH₃ 38.6 H H4-CF₃(Ph) CH₃ 38.7 H H Ph CH₃ 38.8 H H 4-Cl(Ph) CH₃ 38.9 H H 4-Br(Ph)CH₃ 38.10 H H 4-F(Ph) CH₃ 38.11 CH₃ H Ph CH₃ 38.12 CH₃ H 2-Cl(Ph) CH₃38.13 CH₃ H 3-Cl(Ph) CH₃ 38.14 CH₃ H 4-Cl(Ph) CH₃ 38.15 CH₃ H 2-Br(Ph)CH₃ 38.16 CH₃ H 3-Br(Ph) CH₃ 38.17 CH₃ H 4-Br(Ph) CH₃ 38.18 CH₃ H PhC₂H₅ 38.19 CH₃ H 2-Cl(Ph) C₂H₅ 38.20 CH₃ H 3-Cl(Ph) C₂H₅ 38.21 CH₃ H4-Cl(Ph) C₂H₅ 38.22 CH₃ H 2-Br(Ph) C₂H₅ 38.23 CH₃ H 3-Br(Ph) C₂H₅ 38.24CH₃ H 4-Br(Ph) C₂H₅ 38.25 CH₃ H 2-CH₃(Ph) C₂H₅ 38.26 CH₃ H 3-CH₃(Ph)C₂H₅ 38.27 CH₃ H 2-CF₃(Ph) C₂H₅ 38.28 CH₃ H 3-CF₃(Ph) C₂H₅ 38.29 CH₃ H4-CF₃(Ph) C₂H₅ 38.30 CH₃ H 2-NO₂(Ph) C₂H₅ 38.31 CH₃ H 3-NO₂(Ph) C₂H₅38.32 CH₃ H 4-NO₂(Ph) C₂H₅ 38.33 CH₃ H 2,3-Cl(Ph) C₂H₅ 38.34 CH₃ H2,4-Cl(Ph) C₂H₅ 38.35 CH₃ H 2,5-Cl(Ph) C₂H₅ 38.36 CH₃ H 2,6-Cl(Ph) C₂H₅38.37 CH₃ H 3,4-Cl(Ph) C₂H₅ 38.38 CH₃ H 3,5-Cl(Ph) C₂H₅ 38.39 CH₃ H Phn-C₃H₇ 38.40 CH₃ H Ph iso-C₃H₇ 38.41 CH₃ H Ph n-C₄H₉ 38.42 CH₃ H Phiso-C₄H₉ 38.43 CH₃ H Ph C(CH₃)₃ 38.44 CH₃ H Ph CH₂CH═CH₂ 38.45 CH₃ H PhCH₂C≡CH 38.46 CH₃ H Ph PhCH₂ 38.47 CH₃ CH₃ Ph CH₃ 38.48 CH₃ CH₃ 4-Cl(Ph)CH₃ 38.49 CH₃ CH₃ 4-Br(Ph) CH₃ 38.50 CH₃ CH₃ 4-F(Ph) CH₃ 38.51 CH₃ CH₃4-OCH₃(Ph) CH₃ 38.52 CH₃ CH₃ 4-CH₃(Ph) CH₃ 38.53 CH₃ CH₃ 4-NO₂(Ph) CH₃38.54 CH₃ CH₃ 2,4-Cl(Ph) CH₃ 38.55 CH₃ CH₃ 2,4-F(Ph) CH₃ 38.56 CH₃ CH₃Ph C₂H₅ 38.57 CH₃ CH₃ 2-Cl(Ph) C₂H₅ 38.58 CH₃ CH₃ 3-Cl(Ph) C₂H₅ 38.59CH₃ CH₃ 4-Cl(Ph) C₂H₅ 38.60 CH₃ CH₃ 4-F(Ph) C₂H₅ 38.61 CH₃ CH₃3-OCH₃(Ph) C₂H₅ 38.62 CH₃ CH₃ 4-OCH₃(Ph) C₂H₅ 38.63 CH₃ CH₃ 4-CH₃(Ph)C₂H₅ 38.64 CH₃ CH₃ 4-NO₂(Ph) C₂H₅ 38.65 CH₃ CH₃ 2,4-Cl(Ph) C₂H₅ 38.66CH₃ CH₃ 2,4-F(Ph) C₂H₅ 38.67 CH₃ CH₃ Ph n-C₃H₇ 38.68 CH₃ CH₃ 2-Cl(Ph)iso-C₃H₇ 38.69 CH₃ CH₃ 3-Cl(Ph) n-C₄H₉ 38.70 CH₃ CH₃ 4-Cl(Ph) iso-C₄H₉38.71 CH₃ CH₃ 4-Br(Ph) sec-C₄H₉ 38.72 CH₃ CH₃ 4-F(Ph) C(CH₃)₃ 38.73 CH₃CH₃ 4-OCH₃(Ph) CH₂CH═CH₂ 38.74 CH₃ CH₃ 4-CH₃(Ph) CH₂C≡CH 38.75 CH₃ CH34-NO₂(Ph) PhCH₂ 38.76 CH₃ CH3 2,4-Cl(Ph) PhCH₂CH₂ 38.77 CH₃ CH32,4-F(Ph) PhCH₂CH₂ 38.78 C₂H₅ H Ph CH₃ 38.79 C₂H₅ H 2-Cl(Ph) CH₃ 38.80C₂H₅ H 3-Cl(Ph) CH₃ 38.81 C₂H₅ H 4-Cl(Ph) CH₃ 38.82 C₂H₅ H 4-Br(Ph) CH₃38.83 C₂H₅ H 4-F(Ph) CH₃ 38.84 C₂H₅ H 4-OCH₃(Ph) CH₃ 38.85 C₂H₅ H4-CH₃(Ph) CH₃ 38.86 C₂H₅ H 4-NO₂(Ph) CH₃ 38.87 C₂H₅ H 2,4-Cl(Ph) CH₃38.88 C₂H₅ H 2,4-F(Ph) CH₃ 38.89 C₂H₅ H Ph C₂H₅ 38.90 C₂H₅ H 2-Cl(Ph)C₂H₅ 38.91 C₂H₅ H 3-Cl(Ph) C₂H₅ 38.92 C₂H₅ H 4-Cl(Ph) C₂H₅ 38.93 C₂H₅ H4-F(Ph) C₂H₅ 38.94 C₂H₅ H 3-OCH₃(Ph) C₂H₅ 38.95 C₂H₅ H 4-OCH₃(Ph) C₂H₅38.96 C₂H₅ H 4-CH₃(Ph) C₂H₅ 38.97 C₂H₅ H 4-NO₂(Ph) C₂H₅ 38.98 C₂H₅ H2,4-Cl(Ph) C₂H₅ 38.99 C₂H₅ H 2,4-F(Ph) C₂H₅ 38.100 C₂H₅ H Ph n-C₃H₇38.101 C₂H₅ H 2-Cl(Ph) iso-C₃H₇ 38.102 C₂H₅ H 3-Cl(Ph) n-C₄H₉ 38.103C₂H₅ H 4-Cl(Ph) iso-C₄H₉ 38.104 C₂H₅ H 4-F(Ph) sec-C₄H₉ 38.105 C₂H₅ H3-OCH₃(Ph) C(CH₃)₃ 38.106 C₂H₅ H 4-OCH₃(Ph) CH₂CH═CH₂ 38.107 C₂H₅ H4-CH₃(Ph) CH₂C≡CH 38.108 C₂H₅ H 4-NO₂(Ph) PhCH₂ 38.109 C₂H₅ H 2,4-Cl(Ph)PhCH₂CH₂ 38.110 C₂H₅ H 2,4-F(Ph) CH₃ 38.111 n-C₃H₇ H Ph CH₃ 38.112n-C₃H₇ H 2-Cl(Ph) CH₃ 38.113 n-C₃H₇ H 3-Cl(Ph) CH₃ 38.114 n-C₃H₇ H4-Cl(Ph) CH₃ 38.115 n-C₃H₇ H 4-Br(Ph) CH₃ 38.116 n-C₃H₇ H 3-OCH₃(Ph) CH₃38.117 n-C₃H₇ H 4-OCH₃(Ph) CH₃ 38.118 n-C₃H₇ H 4-CH₃(Ph) CH₃ 38.119n-C₃H₇ H 4-NO₂(Ph) CH₃ 38.120 n-C₃H₇ H 2,4-Cl(Ph) CH₃ 38.121 n-C₃H₇ H2,4-F(Ph) CH₃ 38.122 n-C₃H₇ H Ph C₂H₅ 38.123 n-C₃H₇ H 2-Cl(Ph) C₂H₅38.124 n-C₃H₇ H 3-Cl(Ph) C₂H₅ 38.125 n-C₃H₇ H 4-Cl(Ph) C₂H₅ 38.126n-C₃H₇ H 4-Br(Ph) C₂H₅ 38.127 n-C₃H₇ H 4-F(Ph) C₂H₅ 38.128 n-C₃H₇ H4-OCH₃(Ph) C₂H₅ 38.129 n-C₃H₇ H 4-CH₃(Ph) C₂H₅ 38.130 n-C₃H₇ H 4-NO₂(Ph)C₂H₅ 38.131 n-C₃H₇ H 2,4-Cl(Ph) C₂H₅ 38.132 n-C₃H₇ H 2,4-F(Ph) C₂H₅38.133 n-C₃H₇ H Ph n-C₃H₇ 38.134 n-C₃H₇ H Ph iso-C₃H₇ 38.135 n-C₃H₇ H Phn-C₄H₉ 38.136 n-C₃H₇ H Ph iso-C₄H₉ 38.137 n-C₃H₇ H Ph C(CH₃)₃ 38.138n-C₃H₇ H Ph CH₂CH═CH₂ 38.139 n-C₃H₇ H Ph CH₂C≡CH 38.140 n-C₃H₇ H PhPhCH₂ 38.141 n-C₃H₇ H Ph PhCH₂CH₂ 38.142 iso-C₃H₇ H Ph C₂H₅ 38.143iso-C₃H₇ H Ph n-C₃H₇ 38.144 iso-C₃H₇ H Ph iso-C₃H₇ 38.145 iso-C₃H₇ H Phn-C₄H₉ 38.146 iso-C₃H₇ H Ph iso-C₄H₉ 38.147 iso-C₃H₇ H Ph C(CH₃)₃ 38.148iso-C₃H₇ H Ph CH₂CH═CH₂ 38.149 iso-C₃H₇ H Ph CH₂C≡CH 38.150 iso-C₃H₇ HPh PhCH₂ 38.151 iso-C₃H₇ H Ph PhCH₂CH₂ 38.152 cyClopropyl H 4-F(Ph) CH₃38.153 cyclopropyl H 4-OCH₃(Ph) CH₃ 38.154 cyclopropyl H 4-CH₃(Ph) CH₃38.155 cyclopropyl H 4-NO₂(Ph) CH₃ 38.156 cyclopropyl H 2,4-Cl(Ph) CH₃38.157 cyclopropyl H 2,4-F(Ph) CH₃ 38.158 cyclopropyl H 4-Cl(Ph) CH₃38.159 cyclopropyl H 4-Br(Ph) CH₃ 38.160 cyclopropyl H 4-F(Ph) CH₃38.161 cyclopropyl H 4-OCH₃(Ph) CH₃ 38.162 cyclopropyl H 4-CH₃(Ph) CH₃38.163 cyclopropyl H 4-NO₂(Ph) CH₃ 38.164 Ph H Ph CH₃ 38.165 Ph H2-Cl(Ph) C₂H₅ 38.166 Ph H 3-Cl(Ph) n-C₃H₇ 38.167 Ph H 4-Cl(Ph) iso-C₃H₇38.168 Ph H 4-Br(Ph) n-C₄H₉ 38.169 Ph H 4-F(Ph) iso-C₄H₉ 38.170 Ph H4-OCH₃(Ph) C(CH₃)₃ 38.171 Ph H 4-CH₃(Ph) CH₂CH═CH₂ 38.172 Ph H 4-NO₂(Ph)CH₂C≡CH 38.173 Ph H 2,4-Cl(Ph) PhCH₂ 38.174 CN H Ph CH₃ 38.175 CN H2-Cl(Ph) CH₃ 38.176 CN H 3-Cl(Ph) CH₃ 38.177 CN H 4-Cl(Ph) CH₃ 38.178 CNH 4-Br(Ph) CH₃ 38.179 CN H 4-F(Ph) CH₃ 38.180 CN H 4-Cl(Ph) CH₃ 38.181CN H 4-Br(Ph) CH₃ 38.182 CN H 4-F(Ph) CH₃ 38.183 CN H 4-OCH₃(Ph) CH₃38.184 CN H 4-CH₃(Ph) CH₃ 38.185 CN H 4-NO₂(Ph) CH₃ 38.186 CN H2,4-Cl(Ph) CH₃ 38.187 CN H 2,4-F(Ph) CH₃ 38.188 CN H 4-CF₃(Ph) CH₃38.189 CN H Ph C₂H₅ 38.190 CN H Ph n-C₃H₇ 38.191 CN H Ph iso-C₃H₇ 38.192CN H Ph n-C₄H₉ 38.193 CN H Ph iso-C₄H₉ 38.194 CN H Ph C(CH₃)₃ 38.195 CNH Ph CH₂CH═CH₂ 38.196 CN H Ph CH₂C≡CH 38.197 CN H Ph PhCH₂ 38.198 CH₃ H1-napthyl CH₃ 38.199 CH₃ H 1-napthyl C₂H₅ 38.200 CH₃ H 1-napthyl n-C₃H₇38.201 CH₃ H 1-napthyl iso-C₃H₇ 38.202 CH₃ H 1-napthyl n-C₄H₉ 38.203 CH₃H 1-napthyl iso-C₄H₉ 38.204 CH₃ H 1-napthyl C(CH₃)₃ 38.205 CH₃ H1-napthyl CH₂CH═CH₂ 38.206 CH₃ H 1-napthyl CH₂C≡CH 38.207 CH₃ H1-napthyl PhCH₂ 38.208 CH₃ H 2-napthyl CH₃ 38.209 CH₃ H 2-napthyl C₂H₅38.210 CH₃ H 2-napthyl n-C₃H₇ 38.211 CH₃ H 2-napthyl iso-C₃H₇ 38.212 CH₃H 2-napthyl n-C₄H₉ 38.213 CH₃ H 2-napthyl iso-C₄H₉ 38.214 CH₃ H2-napthyl C(CH₃)₃ 38.215 CH₃ H 2-napthyl CH₂CH═CH₂ 38.216 CH₃ H2-napthyl CH₂C≡CH 38.217 CH₃ H 2-napthyl PhCH₂ 38.218 CN H 1-napthyl CH₃38.219 CN H 1-napthyl C₂H₅ 38.220 CN H 1-napthyl n-C₃H₇ 38.221 CN H1-napthyl iso-C₃H₇ 38.222 CN H 1-napthyl n-C₄H₉ 38.223 CN H 1-napthyliso-C₄H₉ 38.224 CN H 1-napthyl C(CH₃)₃ 38.225 CN H 1-napthyl CH₂CH═CH₂38.226 CN H 1-napthyl CH₂C≡CH 38.227 CN H 1-napthyl PhCH₂ 38.228 CN H2-napthyl CH₃ 38.229 CN H 2-napthyl C₂H₅ 38.230 CN H 2-napthyl n-C₃H₇38.231 CN H 2-napthyl iso-C₃H₇ 38.232 CN H 2-napthyl n-C₄H₉ 38.233 CN H2-napthyl iso-C₄H₉ 38.234 CN H 2-napthyl C(CH₃)₃ 38.235 CN H 2-napthylCH₂CH═CH₂ 38.236 CN H 2-napthyl CH₂C≡CH 38.237 CN H 2-napthyl PhCH₂38.238 CH₃ CH₃ 1-napthyl CH₃ 38.239 CH₃ CH₃ 1-napthyl C₂H₅ 38.240 CH₃CH₃ 1-napthyl n-C₃H₇ 38.241 CH₃ CH₃ 1-napthyl iso-C₃H₇ 38.242 CH₃ CH₃1-napthyl n-C₄H₉ 38.243 CH₃ CH₃ 1-napthyl iso-C₄H₉ 38.244 CH₃ CH₃1-napthyl C(CH₃)₃ 38.245 CH₃ CH₃ 1-napthyl CH₂CH═CH₂ 38.246 CH₃ CH₃1-napthyl CH₂C≡CH 38.247 CH₃ CH₃ 1-napthyl PhCH₂ 38.248 CH₃ CH₃2-napthyl CH₃ 38.249 CH₃ CH₃ 2-napthyl C₂H₅ 38.250 CH₃ CH₃ 2-napthyln-C₃H₇ 38.251 CH₃ CH₃ 2-napthyl iso-C₃H₇ 38.252 CH₃ CH₃ 2-napthyl n-C₄H₉38.253 CH₃ CH₃ 2-napthyl iso-C₄H₉ 38.254 CH₃ CH₃ 2-napthyl C(CH₃)₃38.255 CH₃ CH₃ 2-napthyl CH₂CH═CH₂ 38.256 CH₃ CH₃ 2-napthyl CH₂C≡CH38.257 CH₃ CH₃ 2-napthyl PhCH₂ 38.258 CN CH₃ 1-napthyl CH₃ 38.259 CN CH₃1-napthyl C₂H₅ 38.260 CN CH₃ 1-napthyl n-C₃H₇ 38.261 CN CH₃ 1-napthyliso-C₃H₇ 38.262 CN CH₃ 1-napthyl n-C₄H₉ 38.263 CN CH₃ 1-napthyl iso-C₄H₉38.264 CN CH₃ 1-napthyl C(CH₃)₃ 38.265 CN CH₃ 1-napthyl CH₂CH═CH₂ 38.266CN CH₃ 1-napthyl CH₂C≡CH 38.267 CN CH₃ 1-napthyl PhCH₂ 38.268 CN CH₃2-napthyl CH₃ 38.269 CN CH₃ 2-napthyl C₂H₅ 38.270 CN CH₃ 2-napthyln-C₃H₇ 38.271 CN CH₃ 2-napthyl iso-C₃H₇ 38.272 CN CH₃ 2-napthyl n-C₄H₉

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula XII, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, Z═NR₁₀, and where R₂, R₃, R₇, and R₁₀are defined in Table 39.

TABLE 39 Compd. R₂ R₃ R₇ R₁₀ 39.1 H H Ph CH₃ 39.2 H H 4-Cl(Ph) CH₃ 39.3H H 4-Br(Ph) CH₃ 39.4 H H 4-F(Ph) CH₃ 39.5 H H 4-OCH₃(Ph) CH₃ 39.6 H H4-CF₃(Ph) CH₃ 39.7 H H Ph CH₃ 39.8 H H 4-Cl(Ph) CH₃ 39.9 H H 4-Br(Ph)CH₃ 39.10 H H 4-F(Ph) CH₃ 39.11 CH₃ H Ph CH₃ 39.12 CH₃ H 2-Cl(Ph) CH₃39.13 CH₃ H 3-Cl(Ph) CH₃ 39.14 CH₃ H 4-Cl(Ph) CH₃ 39.15 CH₃ H 2-Br(Ph)CH₃ 39.16 CH₃ H 3-Br(Ph) CH₃ 39.17 CH₃ H 4-Br(Ph) CH₃ 39.18 CH₃ H PhC₂H₅ 39.19 CH₃ H 2-Cl(Ph) C₂H₅ 39.20 CH₃ H 3-Cl(Ph) C₂H₅ 39.21 CH₃ H4-Cl(Ph) C₂H₅ 39.22 CH₃ H 2-Br(Ph) C₂H₅ 39.23 CH₃ H 3-Br(Ph) C₂H₅ 39.24CH₃ H 4-Br(Ph) C₂H₅ 39.25 CH₃ H 2-CH₃(Ph) C₂H₅ 39.26 CH₃ H 3-CH₃(Ph)C₂H₅ 39.27 CH₃ H 2-CF₃(Ph) C₂H₅ 39.28 CH₃ H 3-CF₃(Ph) C₂H₅ 39.29 CH₃ H4-CF₃(Ph) C₂H₅ 39.30 CH₃ H 2-NO₂(Ph) C₂H₅ 39.31 CH₃ H 3-NO₂(Ph) C₂H₅39.32 CH₃ H 4-NO₂(Ph) C₂H₅ 39.33 CH₃ H 2,3-Cl(Ph) C₂H₅ 39.34 CH₃ H2,4-Cl(Ph) C₂H₅ 39.35 CH₃ H 2,5-Cl(Ph) C₂H₅ 39.36 CH₃ H 2,6-Cl(Ph) C₂H₅39.37 CH₃ H 3,4-Cl(Ph) C₂H₅ 39.38 CH₃ H 3,5-Cl(Ph) C₂H₅ 39.39 CH₃ H Phn-C₃H₇ 39.40 CH₃ H Ph iso-C₃H₇ 39.41 CH₃ H Ph n-C₄H₉ 39.42 CH₃ H Phiso-C₄H₉ 39.43 CH₃ H Ph C(CH₃)₃ 39.44 CH₃ H Ph CH₂CH═CH₂ 39.45 CH₃ H PhCH₂C≡CH 39.46 CH₃ H Ph PhCH₂ 39.47 CH₃ CH₃ Ph CH₃ 39.48 CH₃ CH₃ 4-Cl(Ph)CH₃ 39.49 CH₃ CH₃ 4-Br(Ph) CH₃ 39.50 CH₃ CH₃ 4-F(Ph) CH₃ 39.51 CH₃ CH₃4-OCH₃(Ph) CH₃ 39.52 CH₃ CH₃ 4-CH₃(Ph) CH₃ 39.53 CH₃ CH₃ 4-NO₂(Ph) CH₃39.54 CH₃ CH₃ 2,4-Cl(Ph) CH₃ 39.55 CH₃ CH₃ 2,4-F(Ph) CH₃ 39.56 CH₃ CH₃Ph C₂H₅ 39.57 CH₃ CH₃ 2-Cl(Ph) C₂H₅ 39.58 CH₃ CH₃ 3-Cl(Ph) C₂H₅ 39.59CH₃ CH₃ 4-Cl(Ph) C₂H₅ 39.60 CH₃ CH₃ 4-F(Ph) C₂H₅ 39.61 CH₃ CH₃3-OCH₃(Ph) C₂H₅ 39.62 CH₃ CH₃ 4-OCH₃(Ph) C₂H₅ 39.63 CH₃ CH₃ 4-CH₃(Ph)C₂H₅ 39.64 CH₃ CH₃ 4-NO₂(Ph) C₂H₅ 39.65 CH₃ CH₃ 2,4-Cl(Ph) C₂H₅ 39.66CH₃ CH₃ 2,4-F(Ph) C₂H₅ 39.67 CH₃ CH₃ Ph n-C₃H₇ 39.68 CH₃ CH₃ 2-Cl(Ph)iso-C₃H₇ 39.69 CH₃ CH₃ 3-Cl(Ph) n-C₄H₉ 39.70 CH₃ CH₃ 4-Cl(Ph) iso-C₄H₉39.71 CH₃ CH₃ 4-Br(Ph) sec-C₄H₉ 39.72 CH₃ CH₃ 4-F(Ph) C(CH₃)₃ 39.73 CH₃CH₃ 4-OCH₃(Ph) CH₂CH═CH₂ 39.74 CH₃ CH₃ 4-CH₃(Ph) CH₂C≡CH 39.75 CH₃ CH₃4-NO₂(Ph) PhCH₂ 39.76 CH₃ CH₃ 2,4-Cl(Ph) PhCH₂CH₂ 39.77 CH₃ CH₃2,4-F(Ph) PhCH₂CH₂ 39.78 C₂H₅ H Ph CH₃ 39.79 C₂H₅ H 2-Cl(Ph) CH₃ 39.80C₂H₅ H 3-Cl(Ph) CH₃ 39.81 C₂H₅ H 4-Cl(Ph) CH₃ 39.82 C₂H₅ H 4-Br(Ph) CH₃39.83 C₂H₅ H 4-F(Ph) CH₃ 39.84 C₂H₅ H 4-OCH₃(Ph) CH₃ 39.85 C₂H₅ H4-CH₃(Ph) CH₃ 39.86 C₂H₅ H 4-NO₂(Ph) CH₃ 39.87 C₂H₅ H 2,4-Cl(Ph) CH₃39.88 C₂H₅ H 2,4-F(Ph) CH₃ 39.89 C₂H₅ H Ph C₂H₅ 39.90 C₂H₅ H 2-Cl(Ph)C₂H₅ 39.91 C₂H₅ H 3-Cl(Ph) C₂H₅ 39.92 C₂H₅ H 4-Cl(Ph) C₂H₅ 39.93 C₂H₅ H4-F(Ph) C₂H₅ 39.94 C₂H₅ H 3-OCH₃(Ph) C₂H₅ 39.95 C₂H₅ H 4-OCH₃(Ph) C₂H₅39.96 C₂H₅ H 4-CH₃(Ph) C₂H₅ 39.97 C₂H₅ H 4-NO₂(Ph) C₂H₅ 39.98 C₂H₅ H2,4-Cl(Ph) C₂H₅ 39.99 C₂H₅ H 2,4-F(Ph) C₂H₅ 39.100 C₂H₅ H Ph n-C₃H₇39.101 C₂H₅ H 2-Cl(Ph) iso-C₃H₇ 39.102 C₂H₅ H 3-Cl(Ph) n-C₄H₉ 39.103C₂H₅ H 4-Cl(Ph) iso-C₄H₉ 39.104 C₂H₅ H 4-F(Ph) sec-C₄H₉ 39.105 C₂H₅ H3-OCH₃(Ph) C(CH₃)₃ 39.106 C₂H₅ H 4-OCH₃(Ph) CH₂CH═CH₂ 39.107 C₂H₅ H4-CH₃(Ph) CH₂C≡CH 39.108 C₂H₅ H 4-NO₂(Ph) PhCH₂ 39.109 C₂H₅ H 2,4-Cl(Ph)PhCH₂CH₂ 39.110 C₂H₅ H 2,4-F(Ph) CH₃ 39.111 n-C₃H₇ H Ph CH₃ 39.112n-C₃H₇ H 2-Cl(Ph) CH₃ 39.113 n-C₃H₇ H 3-Cl(Ph) CH₃ 39.114 n-C₃H₇ H4-Cl(Ph) CH₃ 39.115 n-C₃H₇ H 4-Br(Ph) CH₃ 39.116 n-C₃H₇ H 3-OCH₃(Ph) CH₃39.117 n-C₃H₇ H 4-OCH₃(Ph) CH₃ 39.118 n-C₃H₇ H 4-CH₃(Ph) CH₃ 39.119n-C₃H₇ H 4-NO₂(Ph) CH₃ 39.120 n-C₃H₇ H 2,4-Cl(Ph) CH₃ 39.121 n-C₃H₇ H2,4-F(Ph) CH₃ 39.122 n-C₃H₇ H Ph C₂H₅ 39.123 n-C₃H₇ H 2-Cl(Ph) C₂H₅39.124 n-C₃H₇ H 3-Cl(Ph) C₂H₅ 39.125 n-C₃H₇ H 4-Cl(Ph) C₂H₅ 39.126n-C₃H₇ H 4-Br(Ph) C₂H₅ 39.127 n-C₂H₇ H 4-F(Ph) C₂H₅ 39.128 n-C₃H₇ H4-OCH₃(Ph) C₂H₅ 39.129 n-C₃H₇ H 4-CH₃(Ph) C₂H₅ 39.130 n-C₃H₇ H 4-NO₂(Ph)C₂H₅ 39.131 n-C₃H₇ H 2,4-Cl(Ph) C₂H₅ 39.132 n-C₃H₇ H 2,4-F(Ph) C₂H₅39.133 n-C₃H₇ H Ph n-C₃H₇ 39.134 n-C₂H₇ H Ph iso-C₃H₇ 39.135 n-C₃H₇ H Phn-C₄H₉ 39.136 n-C₃H₇ H Ph iso-C₄H₉ 39.137 n-C₃H₇ H Ph C(CH₃)₃ 39.138n-C₃H₇ H Ph CH₂CH═CH₂ 39.139 n-C₃H₇ H Ph CH₂C≡CH 39.140 n-C₃H₇ H PhPhCH₂ 39.141 n-C₃H₇ H Ph PhCH₂CH₂ 39.142 iso-C₃H₇ H Ph C₂H₅ 39.143iSO-C₃H₇ H Ph n-C₃H₇ 39.144 iso-C₃H₇ H Ph iso-C₃H₇ 39.145 iso-C₃H₇ H Phn-C₄H₉ 39.146 iso-C₃H₇ H Ph iso-C₄H₉ 39.147 iso-C₃H₇ H Ph C(CH₃)₃ 39.148iso-C₃H₇ H Ph CH₂CH═CH₂ 39.149 iso-C₃H₇ H Ph CH₂C≡CH 39.150 iso-C₃H₇ HPh PhCH₂ 39.151 iso-C₃H₇ H Ph PhCH₂CH₂ 39.152 cyclopropyl H 4-F(Ph) CH₃39.153 cyclopropyl H 4-OCH₃(Ph) CH₃ 39.154 cyclopropyl H 4-CH₃(Ph) CH₃39.155 cyclopropyl H 4-NO₂(Ph) CH₃ 39.156 cyclopropyl H 2,4-Cl(Ph) CH₃39.157 cyclopropyl H 2,4-F(Ph) CH₃ 39.158 cyclopropyl H 4-Cl(Ph) CH₃39.159 cyclopropyl H 4-Br(Ph) CH₃ 39.160 cyclopropyl H 4-F(Ph) CH₃39.161 cyclopropyl H 4-OCH₃(Ph) CH₃ 39.162 cyclopropyl H 4-CH₃(Ph) CH₃39.163 cyclopropyl H 4-NO₂(Ph) CH₃ 39.164 Ph H Ph CH₃ 39.165 Ph H2-Cl(Ph) C₂H₅ 39.166 Ph H 3-Cl(Ph) n-C₃H₇ 39.167 Ph H 4-Cl(Ph) iso-C₃H₇39.168 Ph H 4-Br(Ph) n-C₄H₉ 39.169 Ph H 4-F(Ph) iso-C₄H₉ 39.170 Ph H4-OCH₃(Ph) C(CH₃)₃ 39.171 Ph H 4-CH₃(Ph) CH₂CH═CH₂ 39.172 Ph H 4-NO₂(Ph)CH₂C≡CH 39.173 Ph H 2,4-Cl(Ph) PhCH₂ 39.174 CN H Ph CH₃ 39.175 CN H2-Cl(Ph) CH₃ 39.176 CN H 3-Cl(Ph) CH₃ 39.177 CN H 4-Cl(Ph) CH₃ 39.178 CNH 4-Br(Ph) CH₃ 39.179 CN H 4-F(Ph) CH₃ 39.180 CN H 4-Cl(Ph) CH₃ 39.181CN H 4-Br(Ph) CH₃ 39.182 CN H 4-F(Ph) CH₃ 39.183 CN H 4-OCH₃(Ph) CH₃39.184 CN H 4-CH₃(Ph) CH₃ 39.185 CN H 4-NO₂(Ph) CH₃ 39.186 CN H2,4-Cl(Ph) CH₃ 39.187 CN H 2,4-F(Ph) CH₃ 39.188 CN H 4-CF₃(Ph) CH₃39.189 CN H Ph C₂H₅ 39.190 CN H Ph n-C₃H₇ 39.191 CN H Ph iso-C₃H₇ 39.192CN H Ph n-C₄H₉ 39.193 CN H Ph iso-C₄H₉ 39.194 CN H Ph C(CH₃)₃ 39.195 CNH Ph CH₂CH═CH₂ 39.196 CN H Ph CH₂C≡CH 39.197 CN H Ph PhCH₂ 39.198 CH₃ H1-napthyl CH₃ 39.199 CH₃ H 1-napthyl C₂H₅ 39.200 CH₃ H 1-napthyl n-C₃H₇39.201 CH₃ H 1-napthyl iso-C₃H₇ 39.202 CH₃ H 1-napthyl n-C₄H₉ 39.203 CH₃H 1-napthyl iso-C₄H₉ 39.204 CH₃ H 1-napthyl C(CH₃)₃ 39.205 CH₃ H1-napthyl CH₂CH═CH₂ 39.206 CH₃ H 1-napthyl CH₂C≡CH 39.207 CH₃ H1-napthyl PhCH₂ 39.208 CH₃ H 2-napthyl CH₃ 39.209 CH₃ H 2-napthyl C₂H₅39.210 CH₃ H 2-napthyl n-C₃H₇ 39.211 CH₃ H 2-napthyl iso-C₂H₇ 39.212 CH₃H 2-napthyl n-C₄H₉ 39.213 CH₃ H 2-napthyl iso-C₄H₉ 39.214 CH₃ H2-napthyl C(CH₃)₃ 39.215 CH₃ H 2-napthyl CH₂CH═CH₂ 39.216 CH₃ H2-napthyl CH₂C≡CH 39.217 CH₃ H 2-napthyl PhCH₂ 39.218 CN H 1-napthyl CH₃39.219 CN H 1-napthyl C₂H₅ 39.220 CN H 1-napthyl n-C₃H₇ 39.221 CN H1-napthyl iso-C₃H₇ 39.222 CN H 1-napthyl n-C₄H₉ 39.223 CN H 1-napthyliso-C₄H₉ 39.224 CN H 1-napthyl C(CH₃)₃ 39.225 CN H 1-napthyl CH₂CH═CH₂39.226 CN H 1-napthyl CH₂C≡CH 39.227 CN H 1-napthyl PhCH₂ 39.228 CN H2-napthyl CH₃ 39.229 CN H 2-napthyl C₂H₅ 39.230 CN H 2-napthyl n-C₃H₇39.231 CN H 2-napthyl iso-C₃H₇ 39.232 CN H 2-napthyl n-C₄H₉ 39.233 CN H2-napthyl iso-C₄H₉ 39.234 CN H 2-napthyl C(CH₃)₃ 39.235 CN H 2-napthylCH₂CH═CH₂ 39.236 CN H 2-napthyl CH₂C≡CH 39.237 CN H 2-napthyl PhCH₂39.238 CH₃ CH₃ 1-napthyl CH₃ 39.239 CH₃ CH₃ 1-napthyl C₂H₅ 39.240 CH₃CH₃ 1-napthyl n-C₃H₇ 39.241 CH₃ CH₃ 1-napthyl iso-C₃H₇ 39.242 CH₃ CH₃1-napthyl n-C₄H₉ 39.243 CH₃ CH₃ 1-napthyl iso-C₄H₉ 39.244 CH₃ CH₃1-napthyl C(CH₃)₃ 39.245 CH₃ CH₃ 1-napthyl CH₂CH═CH₂ 39.246 CH₃ CH₃1-napthyl CH₂C≡CH 39.247 CH₃ CH₃ 1-napthyl PhCH₂ 39.248 CH₃ CH₃2-napthyl CH₃ 39.249 CH₃ CH₃ 2-napthyl C₂H₅ 39.250 CH₃ CH₃ 2-napthyln-C₃H₇ 39.251 CH₃ CH₃ 2-napthyl iso-C₃H₇ 39.252 CH₃ CH₃ 2-napthyl n-C₄H₉39.253 CH₃ CH₃ 2-napthyl iso-C₄H₉ 39.254 CH₃ CH₃ 2-napthyl C(CH₃)₃39.255 CH₃ CH₃ 2-napthyl CH₂CH═CH₂ 39.256 CH₃ CH₃ 2-napthyl CH₂C≡CH39.257 CH₃ CH₃ 2-napthyl PhCH₂ 39.258 CN CH₃ 1-napthyl CH₃ 39.259 CN CH₃1-napthyl C₂H₅ 39.260 CN CH₃ 1-napthyl n-C₃H₇ 39.261 CN CH₃ 1-napthyliso-C₃H₇ 39.262 CN CH₃ 1-napthyl n-C₄H₉ 39.263 CN CH₃ 1-napthyl iso-C₄H₉39.264 CN CH₃ 1-napthyl C(CH₃)₃ 39.265 CN CH₃ 1-napthyl CH₂CH═CH₂ 39.266CN CH₃ 1-napthyl CH₂C≡CH 39.267 CN CH₃ 1-napthyl PhCH₂ 39.268 CN CH₃2-napthyl CH₃ 39.269 CN CH₃ 2-napthyl C₂H₅ 39.270 CN CH₃ 2-napthyln-C₃H₇ 39.271 CN CH₃ 2-napthyl iso-C₃H₇ 39.272 CN CH₃ 2-napthyl n-C₄H₉

TABLE 40

Compounds 40.1 to 40.226 are compounds of Formula X which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, Z═NR₁₀, where R₁₀ is CH₃ and thesubstituents R₂, R₃, and R₇ are defined in Table 4.

TABLE 41

Compounds 41.1 to 41.226 are compounds of Formula XI which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, Z═NR₁₀, where R₁₀ is CH₃ and thesubstituents R₂, R₃, and R₇ are defined in Table 4.

TABLE 42

Compounds 42.1 to 42.226 are compounds of Formula XII which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, Z═NR₁₀, where R₁₀ is CH₃ and thesubstituents R₂, R₃, and R₇ are defined in Table 4.

TABLE 43

Compounds 43.1 to 43.221 are compounds of Formula X which is Formulawith A═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, Z═NR₁₀, where R₁₀ is C₂H₅ and thesubstituents R₂, R₃, and R₇ are defined in Table 7.

TABLE 44

Compounds 44.1 to 44.221 are compounds of Formula XI which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, Z═NR₁₀, where R₁₀ is C₂H₅ and thesubstituents R₂, R₃, and R₇ are defined in Table 7.

TABLE 45

Compounds 45.1 to 45.221 are compounds of Formula XII which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, Z═NR₁₀, where R₁₀ is C₂H₅ and thesubstituents R₂, R₃, and R₇ are defined in Table 7.

TABLE 46

Compounds 46.1 to 46.139 are compounds of Formula X which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, Z═NR₁₀, where R₁₀ is Ph and thesubstituents R₂, R₃, and R₇ are defined in Table 10.

TABLE 47

Compounds 47.1 to 47.139 are compounds of Formula XI which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, Z═NR₁₀, where R₁₀ is Ph and thesubstituents R₂, R₃, and R₇ are defined in Table 10.

TABLE 48

Compounds 48.1 to 48.139 are compounds of Formula XII which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, Z═NR₁₀, where R₁₀ is Ph and thesubstituents R₂, R₃, and R₇ are defined in Table 10.

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula X, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, Z═NR₁₀, and where R₂, R₃, R₇, R₁₀, R₁₁and R₁₂ are defined in Table 49.

TABLE 49 Compd R₂ R₃ R₇ R₁₀ R₁₁ R₁₂ 49.1 H H Ph N═CR₁₁R₁₂ CH₃ CH₃ 49.2 HH 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.3 H H 4-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.4 HH 4-F(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.5 H H 4-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.6 HH 4-CF₃(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.7 H H Ph N═CR₁₁R₁₂ CH₃ CH₃ 49.8 H H4-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.9 H H 4-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.10 H H4-F(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.11 CH₃ H Ph N═CR₁₁R₁₂ CH₃ CH₃ 49.12 CH₃ H2-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.13 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.14CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.15 CH₃ H 2-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃49.16 CH₃ H 3-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.17 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂CH₃ CH₃ 49.18 CH₃ H Ph N═CR₁₁R₁₂ H Ph 49.19 CH₃ H 2-Cl(Ph) N═CR₁₁R₁₂ HPh 49.20 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ H Ph 49.21 CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ HPh 49.22 CH₃ H 2-Br(Ph) N═CR₁₁R₁₂ H Ph 49.23 CH₃ H 3-Br(Ph) N═CR₁₁R₁₂ HPh 49.24 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂ H Ph 49.25 CH₃ H 2-CH₃(Ph) N═CR₁₁R₁₂ HPh 49.26 CH₃ H 3-CH₃(Ph) N═CR₁₁R₁₂ H Ph 49.27 CH₃ H 2-CF₃(Ph) N═CR₁₁R₁₂H Ph 49.28 CH₃ H 3-CF₃(Ph) N═CR₁₁R₁₂ H Ph 49.29 CH₃ H 4-CF₃(Ph)N═CR₁₁R₁₂ H Ph 49.30 CH₃ H 2-NO₂(Ph) N═CR₁₁R₁₂ H Ph 49.31 CH₃ H3-NO₂(Ph) N═CR₁₁R₁₂ H Ph 49.32 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ H Ph 49.33 CH₃H 2,3-Cl(Ph) N═CR₁₁R₁₂ H Ph 49.34 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ H Ph 49.35CH₃ H 2,5-Cl(Ph) N═CR₁₁R₁₂ H Ph 49.36 CH₃ H 2,6-Cl(Ph) N═CR₁₁R₁₂ H Ph49.37 CH₃ H 3,4-Cl(Ph) N═CR₁₁R₁₂ H Ph 49.38 CH₃ H 3,5-Cl(Ph) N═CR₁₁R₁₂ HPh 49.39 CH₃ H Ph N═CR₁₁R₁₂ CH₃ Ph 49.40 CH₃ H 2-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph49.41 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.42 CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃Ph 49.43 CH₃ H 2-Br(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.44 CH₃ H 3-Br(Ph) N═CR₁₁R₁₂CH₃ Ph 49.45 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.46 CH₃ H 2-CH₃(Ph)N═CR₁₁R₁₂ CH₃ Ph 49.47 CH₃ H 3-CH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.48 CH₃ H2-CF₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.49 CH₃ H 3-CF₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.50CH₃ H 4-F(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.51 CH₃ H 4-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph49.52 CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.53 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂CH₃ Ph 49.54 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.55 CH₃ H 2,4-F(Ph)N═CR₁₁R₁₂ CH₃ Ph 49.56 CH₃ H Ph N═CR₁₁R₁₂ Ph Ph 49.57 CH₃ H 2-Cl(Ph)N═CR₁₁R₁₂ Ph Ph 49.58 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 49.59 CH₃ H4-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 49.60 CH₃ H 4-F(Ph) N═CR₁₁R₁₂ Ph Ph 49.61 CH₃ H3-OCH₃(Ph) N═CR₁₁R₁₂ Ph Ph 49.62 CH₃ H 4-OCH₃(Ph) N═CR₁₁R₁₂ Ph Ph 49.63CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph Ph 49.64 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph Ph49.65 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 49.66 CH₃ H 2,4-F(Ph) N═CR₁₁R₁₂Ph Ph 49.67 C₂H₅ H Ph N═CR₁₁R₁₂ CH₃ CH₃ 49.68 C₂H₅ H 2-Cl(Ph) N═CR₁₁R₁₂CH₃ CH₃ 49.69 C₂H₅ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.70 C₂H₅ H 4-Cl(Ph)N═CR₁₁R₁₂ CH₃ CH₃ 49.71 C₂H₅ H 4-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.72 C₂H₅ H4-F(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.73 C₂H₅ H 4-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ CH₃49.74 C₂H₅ H 4-CH₃(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.75 C₂H₅ H 4-NO₂(Ph)N═CR₁₁R₁₂ CH₃ CH₃ 49.76 C₂H₅ H 2,4-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.77 C₂H₅ H2,4-F(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.78 C₂H₅ H Ph N═CR₁₁R₁₂ CH₃ CH₃ 49.79 C₂H₅H 2-Cl(Ph) N═CR₁₁R₁₂ H Ph 49.80 C₂H₅ H 3-Cl(Ph) N═CR₁₁R₁₂ H Ph 49.81C₂H₅ H 4-Cl(Ph) N═CR₁₁R₁₂ H Ph 49.82 C₂H₅ H 4-Br(Ph) N═CR₁₁R₁₂ H Ph49.83 C₂H₅ H 4-F(Ph) N═CR₁₁R₁₂ H Ph 49.84 C₂H₅ H 4-OCH₃(Ph) N═CR₁₁R₁₂ HPh 49.85 C₂H₅ H 4-CH₃(Ph) N═CR₁₁R₁₂ H Ph 49.86 C₂H₅ H 4-NO₂(Ph)N═CR₁₁R₁₂ H Ph 49.87 C₂H₅ H 2,4-Cl(Ph) N═CR₁₁R₁₂ H Ph 49.88 C₂H₅ H2,4-F(Ph) N═CR₁₁R₁₂ H Ph 49.89 C₂H₅ H Ph N═CR₁₁R₁₂ CH₃ Ph 49.90 C₂H₅ H2-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.91 C₂H₅ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.92C₂H₅ H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.93 C₂H₅ H 4-F(Ph) N═CR₁₁R₁₂ CH₃ Ph49.94 C₂H₅ H 3-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.95 C₂H₅ H 4-OCH₃(Ph)N═CR₁₁R₁₂ CH₃ Ph 49.96 C₂H₅ H 4-CH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.97 C₂H₅ H4-NO₂(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.98 C₂H₅ H 2,4-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph49.99 C₂H₅ H 2,4-F(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.100 C₂H₅ H Ph N═CR₁₁R₁₂ Ph Ph49.101 C₂H₅ H 2-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 49.102 C₂H₅ H 3-Cl(Ph) N═CR₁₁R₁₂Ph Ph 49.103 C₂H₅ H 4-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 49.104 C₂H₅ H 4-F(Ph)N═CR₁₁R₁₂ Ph Ph 49.105 C₂H₅ H 3-OCH₃(Ph) N═CR₁₁R₁₂ Ph Ph 49.106 C₂H₅ H4-OCH₃(Ph) N═CR₁₁R₁₂ Ph Ph 49.107 C₂H₅ H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph Ph49.108 C₂H₅ H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph Ph 49.109 C₂H₅ H 2,4-Cl(Ph)N═CR₁₁R₁₂ Ph Ph 49.110 C₂H₅ H 2,4-F(Ph) N═CR₁₁R₁₂ Ph Ph 49.111 iso-C₃H₇H Ph N═CR₁₁R₁₂ CH₃ CH₃ 49.112 iso-C₃H₇ H 2-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃49.113 iso-C₃H₇ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 49.114 iso-C₃H₇ H 4-Cl(Ph)N═CR₁₁R₁₂ CH₃ CH₃ 49.115 iso-C₃H₇ H 4-Br(Ph) N═CR₁₁R₁₂ H Ph 49.116iso-C₃H₇ H 3-OCH₃(Ph) N═CR₁₁R₁₂ H Ph 49.117 iso-C₃H₇ H 4-OCH₃(Ph)N═CR₁₁R₁₂ H Ph 49.118 iso-C₃H₇ H 4-CH₃(Ph) N═CR₁₁R₁₂ H Ph 49.119iso-C₃H₇ H 4-NO₂(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.120 iso-C₃H₇ H 2,4-Cl(Ph)N═CR₁₁R₁₂ CH₃ Ph 49.121 iso-C₃H₇ H 2,4-F(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.122cyclopropyl H Ph N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.123 cyclopropyl H 2-Cl(Ph)N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.124 cyclopropyl H 3-Cl(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 49.125 cyclopropyl H 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.126cyclopropyl H 4-Br(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.127 cyclopropyl H4-F(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.128 cyclopropyl H 4-OCH₃(Ph) N═CR₁₁R₁₂Ph 4-pyridyl 49.129 cyclopropyl H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl49.130 cyclopropyl H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 49.131 cyclopropylH 2,4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 49.132 cyclopropyl H 2,4-F(Ph)N═CR₁₁R₁₂ Ph 4-pyridyl 49.133 CH₃ H 1-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 49.134C₂H₅ H 1-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 49.135 n-C₃H₇ H 1-napthyl N═CR₁₁R₁₂CH₃ CH₃ 49.136 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 49.137 cyclopropylH 1-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 49.138 CH₃ H 1-napthyl N═CR₁₁R₁₂ H Ph49.139 C₂H₅ H 1-napthyl N═CR₁₁R₁₂ H Ph 49.140 n-C₃H₇ H 1-napthylN═CR₁₁R₁₂ H Ph 49.141 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂ H Ph 49.142cyclopropyl H 1-napthyl N═CR₁₁R₁₂ H Ph 49.143 CH₃ H 1-napthyl N═CR₁₁R₁₂CH₃ Ph 49.144 C₂H₅ H 1-napthyl N═CR₁₁R₁₂ CH₃ Ph 49.145 n-C₃H₇ H1-napthyl N═CR₁₁R₁₂ CH₃ Ph 49.146 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂ CH₃ Ph49.147 cyclopropyl H 1-napthyl N═CR₁₁R₁₂ CH₃ Ph 49.148 CH₃ H 1-napthylN═CR₁₁R₁₂ Ph Ph 49.149 C₂H₅ H 1-napthyl N═CR₁₁R₁₂ Ph Ph 49.150 n-C₃H₇ H1-napthyl N═CR₁₁R₁₂ Ph Ph 49.151 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂ Ph Ph49.152 cyclopropyl H 1-napthyl N═CR₁₁R₁₂ Ph Ph 49.153 CH₃ H 2-napthylN═CR₁₁R₁₂ CH₃ CH₃ 49.154 C₂H₅ H 2-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 49.155n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 49.156 iso-C₃H₇ H 2-napthylN═CR₁₁R₁₂ CH₃ CH₃ 49.157 cyclopropyl H 2-napthyl N═CR₁₁R₁₂ CH₃ CH₃49.158 CH₃ H 2-napthyl N═CR₁₁R₁₂ H Ph 49.159 C₂H₅ H 2-napthyl N═CR₁₁R₁₂H Ph 49.160 n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ H Ph 49.161 iso-C₃H₇ H2-napthyl N═CR₁₁R₁₂ H Ph 49.162 cyclopropyl H 2-napthyl N═CR₁₁R₁₂ H Ph49.163 CH₃ H 2-napthyl N═CR₁₁R₁₂ CH₃ Ph 49.164 C₂H₅ H 2-napthylN═CR₁₁R₁₂ CH₃ Ph 49.165 n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ Ph 49.166iso-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ Ph 49.167 cyclopropyl H 2-napthylN═CR₁₁R₁₂ CH₃ Ph 49.168 CH₃ H 2-napthyl N═CR₁₁R₁₂ Ph Ph 49.169 C₂H₅ H2-napthyl N═CR₁₁R₁₂ Ph Ph 49.170 n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ Ph Ph49.171 iso-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ Ph Ph 49.172 cyclopropyl H2-napthyl N═CR₁₁R₁₂ Ph Ph 49.173 CH₃ H Ph N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.174CH₃ H 2-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.175 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 49.176 CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.177 CH₃ H4-Br(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.178 CH₃ H 4-F(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 49.179 CH₃ H 4-OCH₃(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.180 CH₃ H4-CH₃(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.181 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 49.182 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.183 CH₃ H2,4-F(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.184 CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 49.185 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.186 CH₃ H2,4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.187 CH₃ H 2,4-F(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 49.188 CH₃ H 4-CF₃(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.189 CH₃ H PhN═CR₁₁R₁₂ Ph 4-pyridyl 49.190 CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl49.191 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 49.192 CH₃ H 4-F(Ph)N═CR₁₁R₁₂ Ph 4-pyridyl 49.193 CH₃ H 4-OCH₃(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl49.194 CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 49.195 CH₃ H 4-NO₂(Ph)N═CR₁₁R₁₂ Ph 4-pyridyl 49.196 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl49.197 CH₃ H 2,4-F(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 49.198 CH₃ H 4-CF₃(Ph)N═CR₁₁R₁₂ Ph 4-pyridyl 49.199 CH₃ H Ph N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.200 CH₃H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.201 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂ CH₃N(CH₃)₂ 49.202 CH₃ H 4-F(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.203 CH₃ H4-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.204 CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ CH₃N(CH₃)₂ 49.205 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.206 CH₃ H2,4-Cl(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.207 CH₃ H 2,4-F(Ph) N═CR₁₁R₁₂ CH₃N(CH₃)₂ 49.208 CH₃ H 4-CF₃(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.209 CH₃ H PhN═cyclopentyl 49.210 CH₃ H 4-Cl(Ph) N═cyclopentyl 49.211 CH₃ H 4-Br(Ph)N═cyclopentyl 49.212 CH₃ H 4-F(Ph) N═cyclopentyl 49.213 CH₃ H 4-OCH₃(Ph)N═cyclopentyl 49.214 CH₃ H 4-CH₃(Ph) N═cyclopentyl 49.215 CH₃ H4-NO₂(Ph) N═cyclopentyl 49.216 CH₃ H 2,4-Cl(Ph) N═cyclopentyl 49.217 CH₃H 2,4-F(Ph) N═cyclopentyl 49.218 CH₃ H 4-CF₃(Ph) N═cyclopentyl 49.219CH₃ H Ph N═cyclohexyl 49.220 CH₃ H 4-Cl(Ph) N═cyclohexyl 49.221 CH₃ H4-Br(Ph) N═cyclohexyl 49.222 CH₃ H 4-F(Ph) N═cyclohexyl 49.223 CH₃ H4-OCH₃(Ph) N═cyclohexyl 49.224 CH₃ H 4-CH₃(Ph) N═cyclohexyl 49.225 CH₃ H4-NO₂(Ph) N═cyclohexyl 49.226 CH₃ H 2,4-Cl(Ph) N═cyclohexyl 49.227 CH₃ H2,4-F(Ph) N═cyclohexyl 49.228 CH₃ H 4-CF₃(Ph) N═cyclohexyl 49.229 CH₃ H1-napthyl N═cyclopentyl 49.230 C₂H₅ H 1-napthyl N═cyclopentyl 49.231n-C₃H₇ H 1-napthyl N═cyclopentyl 49.232 iso-C₃H₇ H 1-napthylN═cyclopentyl 49.233 cyclopropyl H 1-napthyl N═cyclopentyl 49.234 CH₃ H1-napthyl N═cyclohexyl 49.235 C₂H₅ H 1-napthyl N═cyclohexyl 49.236n-C₃H₇ H 1-napthyl N═cyclohexyl 49.237 iso-C₃H₇ H 1-napthyl N═cyclohexyl49.238 cyclopropyl H 1-napthyl N═cyclohexyl 49.239 CH₃ H 2-napthylN═cyclopentyl 49.240 C₂H₅ H 2-napthyl N═cyclopentyl 49.241 n-C₃H₇ H2-napthyl N═cyclopentyl 49.242 iso-C₃H₇ H 2-napthyl N═cyclopentyl 49.243cyclopropyl H 2-napthyl N═cyclopentyl 49.244 CH₃ H 2-napthylN═cyclohexyl 49.245 C₂H₅ H 2-napthyl N═cyclohexyl 49.246 n-C₃H₇ H2-napthyl N═cyclohexyl 49.247 iso-C₃H₇ H 2-napthyl N═cyclohexyl 49.248cyclopropyl H 2-napthyl N═cyclohexyl 49.249 CH₃ H 1-napthyl N═CR₁₁R₁₂CH₃ N(CH₃)₂ 49.250 C₂H₅ H 1-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.251 n-C₃H₇H 1-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.252 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂CH₃ N(CH₃)₂ 49.253 cyclopropyl H 1-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.254CH₃ H 2-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.255 C₂H₅ H 2-napthyl N═CR₁₁R₁₂CH₃ N(CH₃)₂ 49.256 n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.257iso-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.258 cyclopropyl H2-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 49.259 CH₃ CH₃ Ph N═CR₁₁R₁₂ H Ph 49.260C₂H₅ CH₃ 4-Cl(Ph) N═CR₁₁R₁₂ H Ph 49.261 n-C₃H₇ CH₃ 4-Br(Ph) N═CR₁₁R₁₂ HPh 49.262 iso-C₂H₇ CH₃ 4-F(Ph) N═CR₁₁R₁₂ H Ph 49.263 CH₃ CH₃ PhN═CR₁₁R₁₂ CH₃ Ph 49.264 C₂H₅ CH₃ 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.265 n-C₃H₇CH₃ 4-Br(Ph) N═CR₁₁R₁₂ CH₃ Ph 49.266 iso-C₃H₇ CH₃ 4-F(Ph) N═CR₁₁R₁₂ CH₃Ph 49.267 CH₃ CH₃ Ph N═CR₁₁R₁₂ Ph Ph 49.268 C₂H₅ CH₃ 4-Cl(Ph) N═CR₁₁R₁₂Ph Ph 49.269 n-C₃H₇ CH₃ 4-Br(Ph) N═CR₁₁R₁₂ Ph Ph 49.270 iso-C₃H₇ CH₃4-F(Ph) N═CR₁₁R₁₂ Ph Ph 49.271 CH₃ CH₃ Ph N═CR₁₁R₁₂ Ph 4-Cl(Ph) 49.272C₂H₅ CH₃ 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph)

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula XI, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, Z═NR₁₀, and where R₂, R₃, R₇, R₁₀, R₁₁and R₁₂ are defined in Table 50.

TABLE 50 Compd. R₂ R₃ R₇ R₁₀ R₁₁ R₁₂ 50.1 H H Ph N═CR₁₁R₁₂ CH₃ CH₃ 50.2H H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.3 H H 4-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.4H H 4-F(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.5 H H 4-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.6H H 4-CF₃(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.7 H H Ph N═CR₁₁R₁₂ CH₃ CH₃ 50.8 H H4-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.9 H H 4-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.10 H H4-F(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.11 CH₃ H Ph N═CR₁₁R₁₂ CH₃ CH₃ 50.12 CH₃ H2-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.13 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.14CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.15 CH₃ H 2-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃50.16 CH₃ H 3-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.17 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂CH₃ CH₃ 50.18 CH₃ H Ph N═CR₁₁R₁₂ H Ph 50.19 CH₃ H 2-Cl(Ph) N═CR₁₁R₁₂ HPh 50.20 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ H Ph 50.21 CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ HPh 50.22 CH₃ H 2-Br(Ph) N═CR₁₁R₁₂ H Ph 50.23 CH₃ H 3-Br(Ph) N═CR₁₁R₁₂ HPh 50.24 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂ H Ph 50.25 CH₃ H 2-CH₃(Ph) N═CR₁₁R₁₂ HPh 50.26 CH₃ H 3-CH₃(Ph) N═CR₁₁R₁₂ H Ph 50.27 CH₃ H 2-CF₃(Ph) N═CR₁₁R₁₂H Ph 50.28 CH₃ H 3-CF₃(Ph) N═CR₁₁R₁₂ H Ph 50.29 CH₃ H 4-CF₃(Ph)N═CR₁₁R₁₂ H Ph 50.30 CH₃ H 2-NO₂(Ph) N═CR₁₁R₁₂ H Ph 50.31 CH₃ H3-NO₂(Ph) N═CR₁₁R₁₂ H Ph 50.32 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ H Ph 50.33 CH₃H 2,3-Cl(Ph) N═CR₁₁R₁₂ H Ph 50.34 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ H Ph 50.35CH₃ H 2,5-Cl(Ph) N═CR₁₁R₁₂ H Ph 50.36 CH₃ H 2,6-Cl(Ph) N═CR₁₁R₁₂ H Ph50.37 CH₃ H 3,4-Cl(Ph) N═CR₁₁R₁₂ H Ph 50.38 CH₃ H 3,5-Cl(Ph) N═CR₁₁R₁₂ HPh 50.39 CH₃ H Ph N═CR₁₁R₁₂ CH₃ Ph 50.40 CH₃ H 2-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph50.41 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.42 CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃Ph 50.43 CH₃ H 2-Br(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.44 CH₃ H 3-Br(Ph) N═CR₁₁R₁₂CH₃ Ph 50.45 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.46 CH₃ H 2-CH₃(Ph)N═CR₁₁R₁₂ CH₃ Ph 50.47 CH₃ H 3-CH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.48 CH₃ H2-CF₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.49 CH₃ H 3-CF₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.50CH₃ H 4-F(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.51 CH₃ H 4-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph50.52 CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.53 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂CH₃ Ph 50.54 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.55 CH₃ H 2,4-F(Ph)N═CR₁₁R₁₂ CH₃ Ph 50.56 CH₃ H Ph N═CR₁₁R₁₂ Ph Ph 50.57 CH₃ H 2-Cl(Ph)N═CR₁₁R₁₂ Ph Ph 50.58 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 50.59 CH₃ H4-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 50.60 CH₃ H 4-F(Ph) N═CR₁₁R₁₂ Ph Ph 50.61 CH₃ H3-OCH₃(Ph) N═CR₁₁R₁₂ Ph Ph 50.62 CH₃ H 4-OCH₃(Ph) N═CR₁₁R₁₂ Ph Ph 50.63CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph Ph 50.64 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph Ph50.65 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 50.66 CH₃ H 2,4-F(Ph) N═CR₁₁R₁₂Ph Ph 50.67 C₂H₅ H Ph N═CR₁₁R₁₂ CH₃ CH₃ 50.68 C₂H₅ H 2-Cl(Ph) N═CR₁₁R₁₂CH₃ CH₃ 50.69 C₂H₅ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.70 C₂H₅ H 4-Cl(Ph)N═CR₁₁R₁₂ CH₃ CH₃ 50.71 C₂H₅ H 4-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.72 C₂H₅ H4-F(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.73 C₂H₅ H 4-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ CH₃50.74 C₂H₅ H 4-CH₃(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.75 C₂H₅ H 4-NO₂(Ph)N═CR₁₁R₁₂ CH₃ CH₃ 50.76 C₂H₅ H 2,4-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.77 C₂H₅ H2,4-F(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.78 C₂H₅ H Ph N═CR₁₁R₁₂ CH₃ CH₃ 50.79 C₂H₅H 2-Cl(Ph) N═CR₁₁R₁₂ H Ph 50.80 C₂H₅ H 3-Cl(Ph) N═CR₁₁R₁₂ H Ph 50.81C₂H₅ H 4-Cl(Ph) N═CR₁₁R₁₂ H Ph 50.82 C₂H₅ H 4-Br(Ph) N═CR₁₁R₁₂ H Ph50.83 C₂H₅ H 4-F(Ph) N═CR₁₁R₁₂ H Ph 50.84 C₂H₅ H 4-OCH₃(Ph) N═CR₁₁R₁₂ HPh 50.85 C₂H₅ H 4-CH₃(Ph) N═CR₁₁R₁₂ H Ph 50.86 C₂H₅ H 4-NO₂(Ph)N═CR₁₁R₁₂ H Ph 50.87 C₂H₅ H 2,4-Cl(Ph) N═CR₁₁R₁₂ H Ph 50.88 C₂H₅ H2,4-F(Ph) N═CR₁₁R₁₂ H Ph 50.89 C₂H₅ H Ph N═CR₁₁R₁₂ CH₃ Ph 50.90 C₂H₅ H2-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.91 C₂H₅ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.92C₂H₅ H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.93 C₂H₅ H 4-F(Ph) N═CR₁₁R₁₂ CH₃ Ph50.94 C₂H₅ H 3-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.95 C₂H₅ H 4-OCH₃(Ph)N═CR₁₁R₁₂ CH₃ Ph 50.96 C₂H₅ H 4-CH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.97 C₂H₅ H4-NO₂(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.98 C₂H₅ H 2,4-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph50.99 C₂H₅ H 2,4-F(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.100 C₂H₅ H Ph N═CR₁₁R₁₂ Ph Ph50.101 C₂H₅ H 2-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 50.102 C₂H₅ H 3-Cl(Ph) N═CR₁₁R₁₂Ph Ph 50.103 C₂H₅ H 4-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 50.104 C₂H₅ H 4-F(Ph)N═CR₁₁R₁₂ Ph Ph 50.105 C₂H₅ H 3-OCH₃(Ph) N═CR₁₁R₁₂ Ph Ph 50.106 C₂H₅ H4-OCH₃(Ph) N═CR₁₁R₁₂ Ph Ph 50.107 C₂H₅ H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph Ph50.108 C₂H₅ H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph Ph 50.109 C₂H₅ H 2,4-Cl(Ph)N═CR₁₁R₁₂ Ph Ph 50.110 C₂H₅ H 2,4-F(Ph) N═CR₁₁R₁₂ Ph Ph 50.111 iso-C₃H₇H Ph N═CR₁₁R₁₂ CH₃ CH₃ 50.112 iso-C₃H₇ H 2-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃50.113 iSO-C₃H₇ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 50.114 iSO-C₃H₇ H 4-Cl(Ph)N═CR₁₁R₁₂ CH₃ CH₃ 50.115 iso-C₃H₇ H 4-Br(Ph) N═CR₁₁R₁₂ H Ph 50.116iso-C₃H₇ H 3-OCH₃(Ph) N═CR₁₁R₁₂ H Ph 50.117 iso-C₃H₇ H 4-OCH₃(Ph)N═CR₁₁R₁₂ H Ph 50.118 iso-C₃H₇ H 4-CH₃(Ph) N═CR₁₁R₁₂ H Ph 50.119iso-C₃H₇ H 4-NO₂(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.120 iso-C₃H₇ H 2,4-Cl(Ph)N═CR₁₁R₁₂ CH₃ Ph 50.121 iso-C₃H₇ H 2,4-F(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.122cyclopropyl H Ph N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.123 cyclopropyl H 2-Cl(Ph)N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.124 cyclopropyl H 3-Cl(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 50.125 cyclopropyl H 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.126cyclopropyl H 4-Br(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.127 cyclopropyl H4-F(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.128 cyclopropyl H 4-OCH₃(Ph) N═CR₁₁R₁₂Ph 4-pyridyl 50.129 cyclopropyl H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl50.130 cyclopropyl H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 50.131 cyclopropylH 2,4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 50.132 cyclopropyl H 2,4-F(Ph)N═CR₁₁R₁₂ Ph 4-pyridyl 50.133 CH₃ H 1-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 50.134C₂H₅ H 1-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 50.135 n-C₃H₇ H 1-napthyl N═CR₁₁R₁₂CH₃ CH₃ 50.136 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 50.137 cyclopropylH 1-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 50.138 CH₃ H 1-napthyl N═CR₁₁R₁₂ H Ph50.139 C₂H₅ H 1-napthyl N═CR₁₁R₁₂ H Ph 50.140 n-C₃H₇ H 1-napthylN═CR₁₁R₁₂ H Ph 50.141 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂ H Ph 50.142cyclopropyl H 1-napthyl N═CR₁₁R₁₂ H Ph 50.143 CH₃ H 1-napthyl N═CR₁₁R₁₂CH₃ Ph 50.144 C₂H₅ H 1-napthyl N═CR₁₁R₁₂ CH₃ Ph 50.145 n-C₃H₇ H1-napthyl N═CR₁₁R₁₂ CH₃ Ph 50.146 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂ CH₃ Ph50.147 cyclopropyl H 1-napthyl N═CR₁₁R₁₂ CH₃ Ph 50.148 CH₃ H 1-napthylN═CR₁₁R₁₂ Ph Ph 50.149 C₂H₅ H 1-napthyl N═CR₁₁R₁₂ Ph Ph 50.150 n-C₃H₇ H1-napthyl N═CR₁₁R₁₂ Ph Ph 50.151 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂ Ph Ph50.152 cyclopropyl H 1-napthyl N═CR₁₁R₁₂ Ph Ph 50.153 CH₃ H 2-napthylN═CR₁₁R₁₂ CH₃ CH₃ 50.154 C₂H₅ H 2-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 50.155n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 50.156 iso-C₃H₇ H 2-napthylN═CR₁₁R₁₂ CH₃ CH₃ 50.157 cyclopropyl H 2-napthyl N═CR₁₁R₁₂ CH₃ CH₃50.158 CH₃ H 2-napthyl N═CR₁₁R₁₂ H Ph 50.159 C₂H₅ H 2-napthyl N═CR₁₁R₁₂H Ph 50.160 n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ H Ph 50.161 iso-C₃H₇ H2-napthyl N═CR₁₁R₁₂ H Ph 50.162 cyclopropyl H 2-napthyl N═CR₁₁R₁₂ H Ph50.163 CH₃ H 2-napthyl N═CR₁₁R₁₂ CH₃ Ph 50.164 C₂H₅ H 2-napthylN═CR₁₁R₁₂ CH₃ Ph 50.165 n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ Ph 50.166iso-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ Ph 50.167 cyclopropyl H 2-napthylN═CR₁₁R₁₂ CH₃ Ph 50.168 CH₃ H 2-napthyl N═CR₁₁R₁₂ Ph Ph 50.169 C₂H₅ H2-napthyl N═CR₁₁R₁₂ Ph Ph 50.170 n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ Ph Ph50.171 iso-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ Ph Ph 50.172 cyclopropyl H2-napthyl N═CR₁₁R₁₂ Ph Ph 50.173 CH₃ H Ph N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.174CH₃ H 2-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.175 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 50.176 CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.177 CH₃ H4-Br(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.178 CH₃ H 4-F(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 50.179 CH₃ H 4-OCH₃(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.180 CH₃ H4-CH₃(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.181 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 50.182 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.183 CH₃ H2,4-F(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.184 CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 50.185 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.186 CH₃ H2,4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.187 CH₃ H 2,4-F(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 50.188 CH₃ H 4-CF₃(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.189 CH₃ H PhN═CR₁₁R₁₂ Ph 4-pyridyl 50.190 CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl50.191 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 50.192 CH₃ H 4-F(Ph)N═CR₁₁R₁₂ Ph 4-pyridyl 50.193 CH₃ H 4-OCH₃(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl50.194 CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 50.195 CH₃ H 4-NO₂(Ph)N═CR₁₁R₁₂ Ph 4-pyridyl 50.196 CH₃ H 2 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl50.197 CH₃ H 2,4-F(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 50.198 CH₃ H 4-CF₃(Ph)N═CR₁₁R₁₂ Ph 4-pyridyl 50.199 CH₃ H Ph N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.200 CH₃H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.201 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂ CH₃N(CH₃)₂ 50.202 CH₃ H 4-F(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.203 CH₃ H4-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.204 CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ CH₃N(CH₃)₂ 50.205 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.206 CH₃ H2,4-Cl(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.207 CH₃ H 2,4-F(Ph) N═CR₁₁R₁₂ CH₃N(CH₃)₂ 50.208 CH₃ H 4-CF₃(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.209 CH₃ H PhN═cyclopentyl 50.210 CH₃ H 4-Cl(Ph) N═cyclopentyl 50.211 CH₃ H 4-Br(Ph)N═cyclopentyl 50.212 CH₃ H 4-F(Ph) N═cyclopentyl 50.213 CH₃ H 4-OCH₃(Ph)N═cyclopentyl 50.214 CH₃ H 4-CH₃(Ph) N═cyclopentyl 50.215 CH₃ H4-NO₂(Ph) N═cyclopentyl 50.216 CH₃ H 2,4-Cl(Ph) N═cyclopentyl 50.217 CH₃H 2,4-F(Ph) N═cyclopentyl 50.218 CH₃ H 4-CF₃(Ph) N═cyclopentyl 50.219CH₃ H Ph N═cyclohexyl 50.220 CH₃ H 4-Cl(Ph) N═cyclohexyl 50.221 CH₃ H4-Br(Ph) N═cyclohexyl 50.222 CH₃ H 4-F(Ph) N═cyclohexyl 50.223 CH₃ H4-OCH₃(Ph) N═cyclohexyl 50.224 CH₃ H 4-CH₃(Ph) N═cyclohexyl 50.225 CH₃ H4-NO₂(Ph) N═cyclohexyl 50.226 CH₃ H 2,4-Cl(Ph) N═cyclohexyl 50.227 CH₃ H2,4-F(Ph) N═cyclohexyl 50.228 CH₃ H 4-CF₃(Ph) N═cyclohexyl 50.229 CH₃ H1-napthyl N═cyclopentyl 50.230 C₂H₅ H 1-napthyl N═cyclopentyl 50.231n-C₃H₇ H 1-napthyl N═cyclopentyl 50.232 iso-C₃H₇ H 1-napthylN═cyclopentyl 50.233 cyclopropyl H 1-napthyl N═cyclopentyl 50.234 CH₃ H1-napthyl N═cyclohexyl 50.235 C₂H₅ H 1-napthyl N═cyclohexyl 50.236n-C₃H₇ H 1-napthyl N═cyclohexyl 50.237 iso-C₃H₇ H 1-napthyl N═cyclohexyl50.238 cyclopropyl H 1-napthyl N═cyclohexyl 50.239 CH₃ H 2-napthylN═cyclopentyl 50.240 C₂H₅ H 2-napthyl N═cyclopentyl 50.241 n-C₃H₇ H2-napthyl N═cyclopentyl 50.242 iso-C₃H₇ H 2-napthyl N═cyclopentyl 50.243cyclopropyl H 2-napthyl N═cyclopentyl 50.244 CH₃ H 2-napthylN═cyclohexyl 50.245 C₂H₅ H 2-napthyl N═cyclohexyl 50.246 n-C₃H₇ H2-napthyl N═cyclohexyl 50.247 iso-C₃H₇ H 2-napthyl N═cyclohexyl 50.248cyclopropyl H 2-napthyl N═cyclohexyl 50.249 CH₃ H 1-napthyl N═CR₁₁R₁₂CH₃ N(CH₃)₂ 50.250 C₂H₅ H 1-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.251 n-C₃H₇H 1-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.252 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂CH₃ N(CH₃)₂ 50.253 cyclopropyl H 1-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.254CH₃ H 2-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.255 C₂H₅ H 2-napthyl N═CR₁₁R₁₂CH₃ N(CH₃)₂ 50.256 n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.257iso-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.258 cyclopropyl H2-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 50.259 CH₃ CH₃ Ph N═CR₁₁R₁₂ H Ph 50.260C₂H₅ CH₃ 4-Cl(Ph) N═CR₁₁R₁₂ H Ph 50.261 n-C₃H₇ CH₃ 4-Br(Ph) N═CR₁₁R₁₂ HPh 50.262 iso-C₃H₇ CH₃ 4-F(Ph) N═CR₁₁R₁₂ H Ph 50.263 CH₃ CH₃ PhN═CR₁₁R₁₂ CH₃ Ph 50.264 C₂H₅ CH₃ 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 50.265 n-C₃H₇CH₃ 4-Br(Ph) N═CR₁₁R₁₂ CH Ph 50.266 iso-C₃H₇ CH₃ 4-F(Ph) N═CR₁₁R₁₂ CH₃Ph 50.267 CH₃ CH₃ Ph N═CR₁₁R₁₂ Ph Ph 50.268 C₂H₅ CH₃ 4-Cl(Ph) N═CR₁₁R₁₂Ph Ph 50.269 n-C₃H₇ CH₃ 4-Br(Ph) N═CR₁₁R₁₂ Ph Ph 50.270 iso-C₃H₇ CH₃4-F(Ph) N═CR₁₁R₁₂ Ph Ph 50.271 CH₃ CH₃ Ph N═CR₁₁R₁₂ Ph 4-Cl(Ph) 50.272C₂H₅ CH₃ 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph)

Typical compounds encompassed by the present invention of Formula Iinclude those compounds of Formula XII, which is Formula I withA═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, Z═NR₁₀, and where R₂, R₃, R₇, R₁₀, R₁₁and R₁₂ are defined in Table 51.

TABLE 51 Compd. R₂ R₃ R₇ R₁₀ R₁₁ R₁₂ 51.1 H H Ph N═CR₁₁R₁₂ CH₃ CH₃ 51.2H H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.3 H H 4-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.4H H 4-F(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.5 H H 4-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.6H H 4-CF₃(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.7 H H Ph N═CR₁₁R₁₂ CH₃ CH₃ 51.8 H H4-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.9 H H 4-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.10 H H4-F(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.11 CH₃ H Ph N═CR₁₁R₁₂ CH₃ CH₃ 51.12 CH₃ H2-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.13 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.14CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.15 CH₃ H 2-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃51.16 CH₃ H 3-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.17 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂CH₃ CH₃ 51.18 CH₃ H Ph N═CR₁₁R₁₂ H Ph 51.19 CH₃ H 2-Cl(Ph) N═CR₁₁R₁₂ HPh 51.20 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ H Ph 51.21 CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ HPh 51.22 CH₃ H 2-Br(Ph) N═CR₁₁R₁₂ H Ph 51.23 CH₃ H 3-Br(Ph) N═CR₁₁R₁₂ HPh 51.24 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂ H Ph 51.25 CH₃ H 2-CH₃(Ph) N═CR₁₁R₁₂ HPh 51.26 CH₃ H 3-CH₃(Ph) N═CR₁₁R₁₂ H Ph 51.27 CH₃ H 2-CF₃(Ph) N═CR₁₁R₁₂H Ph 51.28 CH₃ H 3-CF₃(Ph) N═CR₁₁R₁₂ H Ph 51.29 CH₃ H 4-CF₃(Ph)N═CR₁₁R₁₂ H Ph 51.30 CH₃ H 2-NO₂(Ph) N═CR₁₁R₁₂ H Ph 51.31 CH₃ H3-NO₂(Ph) N═CR₁₁R₁₂ H Ph 51.32 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ H Ph 51.33 CH₃H 2,3-Cl(Ph) N═CR₁₁R₁₂ H Ph 51.34 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ H Ph 51.35CH₃ H 2,5-Cl(Ph) N═CR₁₁R₁₂ H Ph 51.36 CH₃ H 2,6-Cl(Ph) N═CR₁₁R₁₂ H Ph51.37 CH₃ H 3,4-Cl(Ph) N═CR₁₁R₁₂ H Ph 51.38 CH₃ H 3,5-Cl(Ph) N═CR₁₁R₁₂ HPh 51.39 CH₃ H Ph N═CR₁₁R₁₂ CH₃ Ph 51.40 CH₃ H 2-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph51.41 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.42 CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃Ph 51.43 CH₃ H 2-Br(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.44 CH₃ H 3-Br(Ph) N═CR₁₁R₁₂CH₃ Ph 51.45 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.46 CH₃ H 2-CH₃(Ph)N═CR₁₁R₁₂ CH₃ Ph 51.47 CH₃ H 3-CH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.48 CH₃ H2-CF₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.49 CH₃ H 3-CF₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.50CH₃ H 4-F(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.51 CH₃ H 4-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph51.52 CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.53 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂CH₃ Ph 51.54 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.55 CH₃ H 2,4-F(Ph)N═CR₁₁R₁₂ CH₃ Ph 51.56 CH₃ H Ph N═CR₁₁R₁₂ Ph Ph 51.57 CH₃ H 2-Cl(Ph)N═CR₁₁R₁₂ Ph Ph 51.58 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 51.59 CH₃ H4-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 51.60 CH₃ H 4-F(Ph) N═CR₁₁R₁₂ Ph Ph 51.61 CH₃ H3-OCH₃(Ph) N═CR₁₁R₁₂ Ph Ph 51.62 CH₃ H 4-OCH₃(Ph) N═CR₁₁R₁₂ Ph Ph 51.63CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph Ph 51.64 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph Ph51.65 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 51.66 CH₃ H 2,4-F(Ph) N═CR₁₁R₁₂Ph Ph 51.67 C₂H₅ H Ph N═CR₁₁R₁₂ CH₃ CH₃ 51.68 C₂H₅ H 2-Cl(Ph) N═CR₁₁R₁₂CH₃ CH₃ 51.69 C₂H₅ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.70 C₂H₅ H 4-Cl(Ph)N═CR₁₁R₁₂ CH₃ CH₃ 51.71 C₂H₅ H 4-Br(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.72 C₂H₅ H4-F(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.73 C₂H₅ H 4-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ CH₃51.74 C₂H₅ H 4-CH₃(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.75 C₂H₅ H 4-NO₂(Ph)N═CR₁₁R₁₂ CH₃ CH₃ 51.76 C₂H₅ H 2,4-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.77 C₂H₅ H2,4-F(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.78 C₂H₅ H Ph N═CR₁₁R₁₂ CH₃ CH₃ 51.79 C₂H₅H 2-Cl(Ph) N═CR₁₁R₁₂ H Ph 51.80 C₂H₅ H 3-Cl(Ph) N═CR₁₁R₁₂ H Ph 51.81C₂H₅ H 4-Cl(Ph) N═CR₁₁R₁₂ H Ph 51.82 C₂H₅ H 4-Br(Ph) N═CR₁₁R₁₂ H Ph51.83 C₂H₅ H 4-F(Ph) N═CR₁₁R₁₂ H Ph 51.84 C₂H₅ H 4-OCH₃(Ph) N═CR₁₁R₁₂ HPh 51.85 C₂H₅ H 4-CH₃(Ph) N═CR₁₁R₁₂ H Ph 51.86 C₂H₅ H 4-NO₂(Ph)N═CR₁₁R₁₂ H Ph 51.87 C₂H₅ H 2,4-Cl(Ph) N═CR₁₁R₁₂ H Ph 51.88 C₂H₅ H2,4-F(Ph) N═CR₁₁R₁₂ H Ph 51.89 C₂H₅ H Ph N═CR₁₁R₁₂ CH₃ Ph 51.90 C₂H₅ H2-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.91 C₂H₅ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.92C₂H₅ H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.93 C₂H₅ H 4-F(Ph) N═CR₁₁R₁₂ CH₃ Ph51.94 C₂H₅ H 3-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.95 C₂H₅ H 4-OCH₃(Ph)N═CR₁₁R₁₂ CH₃ Ph 51.96 C₂H₅ H 4-CH₃(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.97 C₂H₅ H4-NO₂(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.98 C₂H₅ H 2,4-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph51.99 C₂H₅ H 2,4-F(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.100 C₂H₅ H Ph N═CR₁₁R₁₂ Ph Ph51.101 C₂H₅ H 2-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 51.102 C₂H₅ H 3-Cl(Ph) N═CR₁₁R₁₂Ph Ph 51.103 C₂H₅ H 4-Cl(Ph) N═CR₁₁R₁₂ Ph Ph 51.104 C₂H₅ H 4-F(Ph)N═CR₁₁R₁₂ Ph Ph 51.105 C₂H₅ H 3-OCH₃(Ph) N═CR₁₁R₁₂ Ph Ph 51.106 C₂H₅ H4-OCH₃(Ph) N═CR₁₁R₁₂ Ph Ph 51.107 C₂H₅ H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph Ph51.108 C₂H₅ H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph Ph 51.109 C₂H₅ H 2,4-Cl(Ph)N═CR₁₁R₁₂ Ph Ph 51.110 C₂H₅ H 2,4-F(Ph) N═CR₁₁R₁₂ Ph Ph 51.111 iso-C₃H₇H Ph N═CR₁₁R₁₂ CH₃ CH₃ 51.112 iso-C₃H₇ H 2-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃51.113 iso-C₃H₇ H 3-Cl(Ph) N═CR₁₁R₁₂ CH₃ CH₃ 51.114 iso-C₃H₇ H 4-Cl(Ph)N═CR₁₁R₁₂ CH₃ CH₃ 51.115 iso-C₃H₇ H 4-Br(Ph) N═CR₁₁R₁₂ H Ph 51.116iso-C₃H₇ H 3-OCH₃(Ph) N═CR₁₁R₁₂ H Ph 51.117 iso-C₃H₇ H 4-OCH₃(Ph)N═CR₁₁R₁₂ H Ph 51.118 iso-C₃H₇ H 4-CH₃(Ph) N═CR₁₁R₁₂ H Ph 51.119iso-C₃H₇ H 4-NO₂(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.120 iso-C₃H₇ H 2,4-Cl(Ph)N═CR₁₁R₁₂ CH₃ Ph 51.121 iso-C₃H₇ H 2,4-F(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.122cyclopropyl H Ph N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.123 cyclopropyl H 2-Cl(Ph)N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.124 cyclopropyl H 3-Cl(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 51.125 cyclopropyl H 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.126cyclopropyl H 4-Br(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.127 cyclopropyl H4-F(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.128 cyclopropyl H 4-OCH₃(Ph) N═CR₁₁R₁₂Ph 4-pyridyl 51.129 cyclopropyl H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl51.130 cyclopropyl H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 51.131 cyclopropylH 2,4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 51.132 cyclopropyl H 2,4-F(Ph)N═CR₁₁R₁₂ Ph 4-pyridyl 51.133 CH₃ H 1-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 51.134C₂H₅ H 1-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 51.135 n-C₃H₇ H 1-napthyl N═CR₁₁R₁₂CH₃ CH₃ 51.136 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 51.137 cyclopropylH 1-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 51.138 CH₃ H 1-napthyl N═CR₁₁R₁₂ H Ph51.139 C₂H₅ H 1-napthyl N═CR₁₁R₁₂ H Ph 51.140 n-C₃H₇ H 1-napthylN═CR₁₁R₁₂ H Ph 51.141 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂ H Ph 51.142cyclopropyl H 1-napthyl N═CR₁₁R₁₂ H Ph 51.143 CH₃ H 1-napthyl N═CR₁₁R₁₂CH₃ Ph 51.144 C₂H₅ H 1-napthyl N═CR₁₁R₁₂ CH₃ Ph 51.145 n-C₃H₇ H1-napthyl N═CR₁₁R₁₂ CH₃ Ph 51.146 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂ CH₃ Ph51.147 cyclopropyl H 1-napthyl N═CR₁₁R₁₂ CH₃ Ph 51.148 CH₃ H 1-napthylN═CR₁₁R₁₂ Ph Ph 51.149 C₂H₅ H 1-napthyl N═CR₁₁R₁₂ Ph Ph 51.150 n-C₃H₇ H1-napthyl N═CR₁₁R₁₂ Ph Ph 51.151 iso-C₃H₇ H 1-napthyi N═CR₁₁R₁₂ Ph Ph51.152 cyclopropyl H 1-napthyl N═CR₁₁R₁₂ Ph Ph 51.153 CH₃ H 2-napthylN═CR₁₁R₁₂ CH₃ CH₃ 51.154 C₂H₅ H 2-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 51.155n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ CH₃ 51.156 iso-C₃H₇ H 2-napthylN═CR₁₁R₁₂ CH₃ CH₃ 51.157 cyclopropyl H 2-napthyl N═CR₁₁R₁₂ CH₃ CH₃51.158 CH₃ H 2-napthyl N═CR₁₁R₁₂ H Ph 51.159 C₂H₅ H 2-napthyl N═CR₁₁R₁₂H Ph 51.160 n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ H Ph 51.161 iso-C₃H₇ H2-napthyl N═CR₁₁R₁₂ H Ph 51.162 cyclopropyl H 2-napthyl N═CR₁₁R₁₂ H Ph51.163 CH₃ H 2-napthyl N═CR₁₁R₁₂ CH₃ Ph 51.164 C₂H₅ H 2-napthylN═CR₁₁R₁₂ CH₃ Ph 51.165 n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ Ph 51.166iso-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ Ph 51.167 cyclopropyl H 2-napthylN═CR₁₁R₁₂ CH₃ Ph 51.168 CH₃ H 2-napthyl N═CR₁₁R₁₂ Ph Ph 51.169 C₂H₅ H2-napthyl N═CR₁₁R₁₂ Ph Ph 51.170 n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ Ph Ph51.171 iso-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ Ph Ph 51.172 cyclopropyl H2-napthyl N═CR₁₁R₁₂ Ph Ph 51.173 CH₃ H Ph N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.174CH₃ H 2-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.175 CH₃ H 3-Cl(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 51.176 CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.177 CH₃ H4-Br(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.178 CH₃ H 4-F(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 51.179 CH₃ H 4-OCH₃(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.180 CH₃ H4-CH₃(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.181 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 51.182 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.183 CH₃ H2,4-F(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.184 CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 51.185 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.186 CH₃ H2,4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.187 CH₃ H 2,4-F(Ph) N═CR₁₁R₁₂ Ph4-Cl(Ph) 51.188 CH₃ H 4-CF₃(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.189 CH₃ H PhN═CR₁₁R₁₂ Ph 4-pyridyl 51.190 CH₃ H 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl51.191 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 51.192 CH₃ H 4-F(Ph)N═CR₁₁R₁₂ Ph 4-pyridyl 51.193 CH₃ H 4-OCH₃(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl51.194 CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 51.195 CH₃ H 4-NO₂(Ph)N═CR₁₁R₁₂ Ph 4-pyridyl 51.196 CH₃ H 2,4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl51.197 CH₃ H 2,4-F(Ph) N═CR₁₁R₁₂ Ph 4-pyridyl 51.198 CH₃ H 4-CF₃(Ph)N═CR₁₁R₁₂ Ph 4-pyridyl 51.199 CH₃ H Ph N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.200 CH₃H 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.201 CH₃ H 4-Br(Ph) N═CR₁₁R₁₂ CH₃N(CH₃)₂ 51.202 CH₃ H 4-F(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.203 CH₃ H4-OCH₃(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.204 CH₃ H 4-CH₃(Ph) N═CR₁₁R₁₂ CH₃N(CH₃)₂ 51.205 CH₃ H 4-NO₂(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.206 CH₃ H2,4-Cl(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.207 CH₃ H 2,4-F(Ph) N═CR₁₁R₁₂ CH₃N(CH₃)₂ 51.208 CH₃ H 4-CF₃(Ph) N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.209 CH₃ H PhN═cyclopentyl 51.210 CH₃ H 4-Cl(Ph) N═cyclopentyl 51.211 CH₃ H 4-Br(Ph)N═cyclopentyl 51.212 CH₃ H 4-F(Ph) N═cyclopentyl 51.213 CH₃ H 4-OCH₃(Ph)N═cyclopentyl 51.214 CH₃ H 4-CH₃(Ph) N═cyclopentyl 51.215 CH₃ H4-NO₂(Ph) N═cyclopentyl 51.216 CH₃ H 2,4-Cl(Ph) N═cyclopentyl 51.217 CH₃H 2,4-F(Ph) N═cyclopentyl 51.218 CH₃ H 4-CF₃(Ph) N═cyclopentyl 51.219CH₃ H Ph N═cyclohexyl 51.220 CH₃ H 4-Cl(Ph) N═cyclohexyl 51.221 CH₃ H4-Br(Ph) N═cyclohexyl 51.222 CH₃ H 4-F(Ph) N═cyclohexyl 51.223 CH₃ H4-OCH₃(Ph) N═cyclohexyl 51.224 CH₃ H 4-CH₃(Ph) N═cyclohexyl 51.225 CH₃ H4-NO₂(Ph) N═cyclohexyl 51.226 CH₃ H 2,4-Cl(Ph) N═cyclohexyl 51.227 CH₃ H2,4-F(Ph) N═cyclohexyl 51.228 CH₃ H 4-CF₃(Ph) N═cyclohexyl 51.229 CH₃ H1-napthyl N═cyclopentyl 51.230 C₂H₅ H 1-napthyl N═cyclopentyl 51.231n-C₃H₇ H 1-napthyl N═cyclopentyl 51.232 iso-C₃H₇ H 1-napthylN═cyclopentyl 51.233 cyclopropyl H 1-napthyl N═cyclopentyl 51.234 CH₃ H1-napthyl N═cyclohexyl 51.235 C₂H₅ H 1-napthyl N═cyclohexyl 51.236n-C₃H₇ H 1-napthyl N═cyclohexyl 51.237 iso-C₃H₇ H 1-napthyl N═cyclohexyl51.238 cyclopropyl H 1-napthyl N═cyclohexyl 51.239 CH₃ H 2-napthylN═cyclopentyl 51.240 C₂H₅ H 2-napthyl N═cyclopentyl 51.241 n-C₃H₇ H2-napthyl N═cyclopentyl 51.242 iso-C₃H₇ H 2-napthyl N═cyclopentyl 51.243cyclopropyl H 2-napthyl N═cyclopentyl 51.244 CH₃ H 2-napthylN═cydlohexyl 51.245 C₂H₅ H 2-napthyl N═cyclohexyl 51.246 n-C₃H₇ H2-napthyl N═cyclohexyl 51.247 iso-C₃H₇ H 2-napthyl N═cyclohexyl 51.248cyclopropyl H 2-napthyl N═cyclohexyl 51.249 CH₃ H 1-napthyl N═CR₁₁R₁₂CH₃ N(CH₃)₂ 51.250 C₂H₅ H 1-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.251 n-C₃H₇H 1-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.252 iso-C₃H₇ H 1-napthyl N═CR₁₁R₁₂CH₃ N(CH₃)₂ 51.253 cyclopropyl H 1-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.254CH₃ H 2-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.255 C₂H₅ H 2-napthyl N═CR₁₁R₁₂CH₃ N(CH₃)₂ 51.256 n-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.257iso-C₃H₇ H 2-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.258 cyclopropyl H2-napthyl N═CR₁₁R₁₂ CH₃ N(CH₃)₂ 51.259 CH₃ CH₃ Ph N═CR₁₁R₁₂ H Ph 51.260C₂H₅ CH₃ 4-Cl(Ph) N═CR₁₁R₁₂ H Ph 51.261 n-C₃H₇ CH₃ 4-Br(Ph) N═CR₁₁R₁₂ HPh 51.262 iso-C₃H₇ CH₃ 4-F(Ph) N═CR₁₁R₁₂ H Ph 51.263 CH₃ CH₃ PhN═CR₁₁R₁₂ CH₃ Ph 51.264 C₂H₅ CH₃ 4-Cl(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.265 n-C₃H₇CH₃ 4-Br(Ph) N═CR₁₁R₁₂ CH₃ Ph 51.266 iso-C₃H₇ CH₃ 4-F(Ph) N═CR₁₁R₁₂ CH₃Ph 51.267 CH₃ CH₃ Ph N═CR₁₁R₁₂ Ph Ph 51.268 C₂H₅ CH₃ 4-Cl(Ph) N═CR₁₁R₁₂Ph Ph 51.269 n-C₃H₇ CH₃ 4-Br(Ph) N═CR₁₁R₁₂ Ph Ph 51.270 iso-C₃H₇ CH₃4-F(Ph) N═CR₁₁R₁₂ Ph Ph 51.271 CH₃ CH₃ Ph N═CR₁₁R₁₂ Ph 4-Cl(Ph) 51.272C₂H₅ CH₃ 4-Cl(Ph) N═CR₁₁R₁₂ Ph 4-Cl(Ph)

TABLE 52

Compounds 52.1 to 52.226 are compounds of Formula X which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═NR₁₀, where R₁₀ is N═C(H)Phand the substituents R₂, R₃, and R₇ are defined in Table 4.

TABLE 53

Compounds 53.1 to 53.226 are compounds of Formula XI which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═NR₁₀, where R₁₀ is N═C(H)Phand the substituents R₂, R₃, and R₇ are defined in Table 4.

TABLE 54

Compounds 54.1 to 54.226 are compounds of Formula XII which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═NR₁₀, where R₁₀ is N═C(H)Phand the substituents R₂, R₃, and R₇ are defined in Table 4.

TABLE 55

Compounds 55.1 to 55.221 are compounds of Formula X which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═NR₁₀, where R₁₀ isN═C(CH₃)Ph and the substituents R₂, R₃, and R₇ are defined in Table 7.

TABLE 56

Compounds 56.1 to 56.221 are compounds of Formula XI which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═NR₁₀, where R₁₀ is N═C(CH₃)Phand the substituents R₂, R₃, and R₇ are defined in Table 7.

TABLE 57

Compounds 57.1 to 57.221 are compounds of Formula XII which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═NR₁₀, where R₁₀ isN═C(CH₃)Ph and the substituents R₂, R₃, and R₇ are defined in Table 7.

TABLE 58

Compounds 58.1 to 58.139 are compounds of Formula X which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═CH, Y═O, and Z═NR₁₀, where R₁₀ is N═CCPh₂and the substituents R₂, R₃, and R₇ are defined in Table 7.

TABLE 59

Compounds 59.1 to 59.139 are compounds of Formula XI which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═O, and Z═NR₁₀, where R₁₀ is N═CCPh₂and the substituents R₂, R₃, and R₇ are defined in Table 7.

TABLE 60

Compounds 60.1 to 60.139 are compounds of Formula XII which is Formula Iwith A═R₄═R₅═R₆═H, R₁═CH₃, X═N, Y═NH, and Z═NR₁₀, where R₁₀ is N═C═CPh₂and the substituents R₂, R₃, and R₇ are defined in Table 7.

As used in Tables 1 to 60 Ph is understood to be phenyl.

The preparation of certain bis-oximes is described in U.S. Pat. Nos.5,756,426 and 5,863,951 and references cited therein. The specificmethods for the preparation of cyclopropyl bis oximes of Formula I ofthe present invention are described in the following schemes. Scheme Adescribes the preparation of compounds of the Formula (I) where X is CHor N, and Y is O (compounds of formula XV and XVI). The cyclopropyloximes (XIII) are reacted with the appropriately substituted benzylderivatives (XIV) where L is a halogen, such as bromo, chloro or iodo,preferably a benzyl bromide. A cyclopropyl substituted oxime representedby the general formula (XIII) is treated, at room temperature, with anappropriate base to form an anion, followed by the addition of thebenzyl bromides (XIV). Typical bases employed are metal hydrides such assodium hydride, alkoxides such as sodium methoxide and hydroxide basessuch as sodium or potassium hydroxide and alkali bases such as sodium orpotassium carbonate. Typical solvents employed with hydride bases areN,N-dimethylformamide (DMF) and tetrahydrofuran (THF); with hydroxidebases DMF, THF, methyl ethyl ketone (MEK) and acetone and with alkalibases solvents such as DMF, acetone, and MEK.

As shown in Scheme A, the N—O bond in C(R₂)═N—O— and

can exist as E and Z isomers. It should be recognized that the E and Zisomers can also be produced as well as mixtures. When isomers areproduced they are designated isomer A (higher R_(f) on thin layerchromatography) and isomer B (lower R_(f) on thin layer chromatography).The determination of which isomer, A or B possesses the E or Z geometrycan be made by such conventional techniques as X ray crystallography orby spectroscopic means such as nuclear magnetic resonance spectroscopy.The compounds of the of Formula I of the present invention have beenproduced as a single stereoisomer for the N—O bond in C(R2)═N—O— and hasbeen assigned the E configuration by nuclear magnetic resonancespectroscopy. Additionally, compounds of Formula I can exist as isomersabout the Z═C. It should be recognized that the regioisomers can also beproduced as well as mixtures. When isomers are produced they aredesignated isomer A (higher R_(f) on thin layer chromatography) andisomer B (lower R_(f) on thin layer chromatography). The determinationof which isomer, A or B possesses the E or Z geometry can be made bysuch conventional techniques as X ray crystallography or byspectroscopic means such as nuclear magnetic resonance spectroscopy.When Z is NOR₉ the compounds designated as isomer A have the E geometryfor R₉ON═C and compounds designated as isomer B have the Z geometry forR₉ON═C. The compounds designated as A or B in the subsequent tablesrefer to the isomers of NOR₉

Compounds of formula XV (X is CH) are prepared by alkylation with methylE-α-(2-bromomethylphenyl)-β-methoxyacrylate (XIV, where A═H, X═CH and Lis Br) in the presence of a base, preferably NaOH or KOH, in a solvent,preferably acetone or methyl ethyl ketone. MethylE-α-(2-bromomethylphenyl)-β-methoxyacrylate, as a single E isomer, canbe prepared in two steps from 2-methylphenylacetate as describedpreviously in U.S. Pat. No. 4,914,128, columns 3-4. Compounds of formulaXVI (X═N) are prepared by the reaction with methylE-2-(bromomethyl)phenylglyoxylate O-methyloxime (XIV, where A═H, X═N andL is Br) in the presence of a base, preferably NaOH or KOH, in asolvent, preferably acetone or methyl ethyl ketone. Methyl2-(bromomethyl)phenylglyoxylate O-methyloxime can be prepared asdescribed in U.S. Pat. No. 4,999,042, columns 17-18 and 5,157,144,columns 17-18. Methyl 2-(bromomethyl)phenylglyoxylate O-methyl-oxime isprepared from methyl 2-methylphenyl-acetate by treatment with an alkylnitrite under basic conditions to provide after methylation, methyl2-methyl-phenyl-glyoxalate O-methyl oxime which can also be preparedfrom methyl 2-methyl-phenylglyoxalate by treatment with 2-hydroxylaminehydrochloride and methylation or by treatment with methoxylaminehydrochloride.

As shown in scheme B compounds of formula XVIII (X═N, Y═NH) can beprepared by the aminolysis of oximinoacetate XVI. The aminolysis ofoximinoacetate to oximinoacetamides has been described in U.S. Pat. No.5,185,342, cols. 22, 48 and 57, U.S. Pat. No. 5,221,691, cols. 26-27 andU.S. Pat. No. 5,407,902, col. 8. For example, compounds of Table 14 offormula VIII where X is N and Y is O are treated with 40% aqueousmethylamine in methanol to provide compounds of Table 15 of formula IXwhere Y is NH. Alternatively, as is shown in scheme B intermediatecyclopropanes oximes, XIII, are reacted with N-methyl(E)-2-methoxyimino-2-[2-(bromomethyl)phenyl]-acetamide (XIV, where A═Hand L═Br) in the presence of a base such as an hydroxide base preferablyin a solvent such as acetone or methyl ethyl ketone to provide compoundsof Table 15 of formula IX. N-methyl(E)-2-methoxy-imino-2-[2-(bromomethyl)phenyl]acetamide is described inU.S. Pat. No. 5,387,714, col. 14.

The synthesis of compounds of formula I where Z is O is described inscheme C and follow the methods of schemes A and B. In scheme C thecompounds of formula IV and V (A═H) can be prepared from oxime XIX byalkylation with XIV. Compounds of formula VI (A═H) can be prepared byalkylation of XIX with bromide XVII or by aminolysis of V as describedin Scheme C.

Compounds of Formula I where Z is NOR₉ (compounds of Formula VII, VIII,IX) can be prepared, as shown in scheme D, by condensation of compoundsIV, V and VI with an hydroxylamine such as R₉ONH₂. The condensation canbe carried out from room temperature to reflux, preferably at roomtemperature, in an appropriate solvent such as methanol or ethanol inthe presence of an appropriate alkali such as sodium hydroxide,potassium carbonate or pyridine. Additionally, hydroxylaminehydrochloride can be utilized (R₉ is hydrogen) and the compounds VII′,VIII′ and IX′ are obtained. Alkylation with R₉—L where L is a leavinggroup such as Br or Cl provides VII, VIII and IX. The compounds offormula X,XI and XII where Z is N—R₁₀, such as imines and hydrazones,are prepared as shown in scheme D by condensation of the ketones IV, Vand VI, with an amine or hydrazine derivative. A general description ofthe synthesis of oximes with and imines is described in March, AdvancedOrganic Chemistry, 4th Ed, pp. 896-897, 904-907 and references therein.The oximes, imines, hydrazones of the general formula VII to XII whenobtained as a mixture of syn or anti isomers can be separated intoindividual isomers by conventional chromatographic techniques. Theisomer with the higher Rf on thin layer chromatography is designatedisomer A and the isomer with the lower Rf on thin layer chromatographyis designated isomer B. The stereochemistry of isomer A and B can bedetermined by standard techniques such as nuclear magnetic resonancespectroscopy.

As is shown in scheme E the compounds of formula VII to XII can beprepared from the oxime intermediate XIX, by condensation methodsdescribed in Scheme D, leading to intermediate oximes XX and XXI. Theseoximes intermediates can be alkylated as described in schemes A,B and Cto provide the products VII to XII.

The oximes of the general formula XIX can be obtained as shown in schemeF. A general description of the synthesis of α-oximinoketones vianitrosation is described in March, Advanced Organic Chemistry, 4th Ed,pp. 592-593 and references therein. For the compounds of the presentinvention the cyclopropylketones, XXII are reacted with an alkyl nitritesuch as t-butylnitrite or isoamylnitrite under basic conditions toprovide the corresponding α-oximino cyclopropylketones XIX. Thishydroxyimino intermediate, XIX, is typically produced as one majorstereoisomer as shown in scheme F. Typically the cyclopropyl ketone in asolvent such as t-butanol and the alkyl nitrite, typicallyt-butylnitrite, is added to a solution t-butanol containing a base suchas potassium t-butoxide and is stirred at room temperature. Theα-hydroxyimino cyclopropylketones XIX are alkylated as in schemes C andE to provide compounds of the formula IV, V and VI.

The cyclopropyl ketones XXII can be prepared by conventional techniquesas is shown in scheme G. The unsaturated intermediate XXIII (scheme G)is reacted with a sulfur ylide, prepared from a dimethylsulfoxonium saltin the presence of a base, resulting in the substituted acylcyclopropanes, XXII. The chemistry of sulfur ylides is described inTrost and Melvin, Sulfur Ylids, Academic Press, New York, N.Y. 1975 andin Block, Reactions of Organosulfur Compounds, pp. 91-123, AcademicPress, New York, N.Y. 1978. Typical reaction conditions for sulfur ylideformation from a dimethylsulfoxonium salt utilizes bases such ashydroxides, metal hydrides and alkoxides in solvents such asdimethoxy-ethane, dimethylsulfoxide and water depending on the baseemployed. The reactions are conducted from 0 to 20° C. preferably from10-15° C. and preferably with alkali metal hydroxides indimethylsulfoxide. Typically dimethylsulfoxonium methylide is preparedfrom trimethylsulfoxonium iodide in dimethylsulfoxide in the presence ofpowdered sodium hydroxide at room temperature. The unsaturated ketones,XXIII, are typically added drop wise to the ylide and stirred at roomtemperature.

The α,β-unsaturated ketones XXIII can be prepared by conventionalcondensation techniques. A extensive description of the synthesis ofα,β-unsaturated ketones (enones) is described in March, Advanced OrganicChemistry, 4th Ed, pp. 937-955 and references therein. For exampleOrganic Reactions, Volume 16 describes the general aldol condensation ofketones and aldehydes. For intermediates of formula XXIII of thisinvention, in general the ketones can be R₇COR₆ where R₇ and R₆ aredefined previously. When R₆ is hydrogen the aldehydes are for examplesubstituted benzaldehydes or heterocyclic aldehydes. The ketones can beR₂CH₂COCH₂R₃ where R₂ and R₃ are described previously. Preferably forthe enones derived via a condensation reaction R₃ is H and is thereforea methyl ketone. Likewise R₂ can be hydrogen which provides enones andcyclopropanes leading to the compounds of formula I where R₂ ishydrogen. Typically the ketone, R₂CH₂COCH₂R₃, is dissolved in ahydroxylic solvent, such as methanol or ethanol, to which is added dropwise the aldehyde or ketone R₇COR₆ followed by the base or alternativelya solution of the aldehyde in an aqueous basic solution is added. Thetypical bases used can be alkali metal hydroxides, such as barium,potassium or sodium hydroxide and the drop wise addition is conductedfrom 0° C. to 35° C. preferably at ambient temperature. When the enoneis derived from a methylketone (R₃ is hydrogen) the solvent can be themethylketone to which is added R₇COR₆ followed by the aqueous hydroxidesolution.

Alternatively the α,β-unsaturated cyclopropyl ketones XXII can beprepared from cyclopropyl nitriles XXV which are prepared viacyclopropanation of the acrylonitriles XXIV as is described in Scheme H.The acrylonitriles XXIV starting materials, shown in Scheme H can beprepared by conventional synthetic methods as described in March,Advanced Organic Chemistry, 4th Ed, pp. 937-955 and references therein.

For example the nitrile derivative R₃CH₂CN is condensed with the ketoneor aldehyde R₇COR₆, in the presence of a base to provide theacrylonitriles XXIV. Preferably R₃ in R₃CH₂CN is an aryl or heteroarylgroup as defined previously for R₃. Typically the nitrile is dissolvedin a solvent such as ethanol and water to which is added the aldehyde orketone followed by a base. Typical bases used can be alkali metalhydroxides, such as barium, potassium or sodium hydroxide and themixture is stirred typically at ambient temperature. The acrylonitrileXXIV is treated as is described in Scheme H with a sulfur ylide toprovide the cyclopropyl nitriles XXV. The cyclopropyl nitrile XXV istransformed to the cyclopropyl ketones by organometallic addition to thenitrile followed by hydrolysis. For example the standard Grignardreagents R₂CH₂MgX or organolithium reagents, R₂CH₂Li add to the nitrilefunctionality to provide the ketones XXII. The addition reaction tonitriles are described in March, Advanced Organic Chemistry, 4th Ed,pp.935-936 and references cited therein. When R₂MgX is a methylGrignard, such as methylmagnesium bromide the resulting methyl ketone.R₂═H, provides compounds of the present invention where R₂═H.

The compounds of this invention can be made according to the followingprocedures:

EXAMPLE 1 Preparation of Methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azahepta-3-en-1-yl)phenyl]propenoateCompound 1.11 of Table 1 Preparation of trans-1-phenyl-1-hexen-3-one

To a 250 ml round bottom flask equipped with magnetic stirrer wascharged 36 g (0.5 moles) of methylethyl ketone, 100 mls of ethanol, and10 mls of water. To this solution was then added 0.5 g of bariumhydroxide monohydrate, followed by 10.6 g (0.1 moles) of benzaldehyde.The flask was stoppered and stirred overnight at ambient temperature.The reaction mixture was then poured into 200 mls of water and extractedwith 3×100 mls of ethyl ether. The ether extract was washed with 100 mlsof saturated aqueous sodium bisulfite solution, followed by 100 mls ofwater, and 100 mls of saturated aqueous sodium chloride solution. Theether extract was then dried over anhydrous magnesium sulfate, filteredand concentrated on a rotary evaporator to afford 15.1 g of a paleyellow liquid in 94% isolated yield, which was consistent with thedesired product trans-1-phenyl-1-hexen-3-one upon analysis by 300 Mz ₁HNMR.

NMR (300 MHz, ₁H, CDCl₃, TMS=0 ppm) 1.17 (t, 3H), 2.7 (q, 2H), 6.7 (d,1H), 7.4 (m, 3H), 7.6 (m, 3H)

Preparation of trans-2-phenylcyclopropylethylketone

To a 500 ml round bottom flask equipped with magnetic stirrer, nitrogeninlet, and pressure equalized addition funnel was charged 22 g (0.1moles) of trimethylsulfoxonium iodide, 4.0 g (0.1 moles) of powderedsodium hydroxide, and 150 mls of dimethylsulfoxide. The solution wasstirred at ambient temperature for 30 minutes, followed by the rapidaddition of the trans-1-phenyl-1-hexen-3-one(15.1 g, 0.0945 moles) in100 mls of dimethylsulfoxide. The reaction was then stirred for 10minutes at ambient temperature, then poured into 200 mls of water andextracted with 3×100 mls of ethyl ether. The ether extract was washedwith 2×100 mls of water, and 100 mls of saturated aqueous sodiumchloride solution. The ether extract was dried over anhydrous magnesiumsulfate, filtered and concentrated on a rotary evaporator to afford 12.5g of a thick yellow liquid which was purified by high vacuumdistillation. (78-85 ° C. @ 0.1 mm Hg). The pure fractions were combinedto afford 8.2 g of a clear colorless liquid in an 50% isolated yieldwhich was consistent with the desired product,trans-2-phenylcyclopropylethylketone upon analysis by 300 Mz ₁H NMR.

NMR (300 MHz, ₁H, CDCl₃, TMS=0 ppm) 1.1 (t, 3H), 1.3 (m, 1H), 1.7 (m,1H), 2.2 (m, 1H), 2.5 (m, 1H), 2.6 (q, 2H), 7.1 (d, 2H), 7.2-7.4 (m,3H).

Preparation of 2-hydroxyimino-1-(trans-2-phenylcyclopropyl)-1-propanone

To a dry 500 ml round bottom flask equipped with magnetic stirrer,nitrogen inlet, reflux condenser, and side arm addition funnel wascharged 5.7 g. (0.0505 moles) of potassium t-butoxide and 150 ml oft-butanol. When all of the solid was dissolved, the ketonetrans-2-phenyl-cyclopropylethylketone (8.0 g, 0.0459 moles)was added inon portion, followed by the drop wise addition of 5.7 g (0.0505 moles)of 90% t-butyl nitrite. The reaction was stirred for 3 hours at ambienttemperature then carefully quenched with 100 mls 0.1 N aqueoushydrochloric acid solution. The mixture was extracted with 3×100 mls ofethyl ether. The ether extract was then washed with 2×100 mls of waterand 100 mls of saturated aqueous sodium chloride solution, then driedover anhydrous magnesium sulfate, filtered, and concentrated on a rotaryevaporator to afford 8.2 g of a thick brown liquid which wascrystallized from methylene chloride and hexane. The resulting solid wascollected by vacuum filtration to afford 5.1 g of a tan solid in a 55%isolated yield which was consistent with the desired product as a singlehydroxyimino isomer of2-hydroxyimino-1-(trans-2-phenyl-cyclopropyl)-1-propanone upon analysisby 300 Mz ₁H NMR.

NMR (300 MHz, ₁H, CDCl₃, TMS=0 ppm) 1.4 (m, 1H), 1.7 (m, 1H), 2.0 (s,3H), 2.6 (m, 1H), 3.1 (m, 1H), 7.1 (d, 2H), 7.2-7.4 (m, 3H), 8.1 (bs,1H).

Preparation of Methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapentta-3-en-1-yl)phenyl]propenoate

To a 250 ml round bottom flask equipped with magnetic stirrer wascharged 3.0 g (0.0148 moles) of2-hydroxyimino-1-(trans-2-phenylcyclopropyl)-1-propanone in 100 mls ofanhydrous dimethylformamide, and 4.1 g (0.0295 moles) of powderedpotassium carbonate. The reaction mixture was stirred at ambienttemperature for a total of 0.5 hours, followed by the addition of methyl(E)-α-[2-(bromomethyl)phenyl]-β-methoxyacrylate (4.2 g, 0.0148 moles) inone portion. The reaction was stoppered and stirred overnight at ambienttemperature. The reaction mixture was then was poured into 100 mls ofwater and extracted with 3×100 mls of ether. The ether extract waswashed with 2×100 mls of water, 100 mls of saturated aqueous sodiumchloride solution, dried over anhydrous magnesium sulfate, filtered, andconcentrated on a rotary evaporator to afford 6.0 g of a thick amberliquid which was chromatographed on silica gel with 20% ethyl acetate,80% hexane. The pure fractions were combined and concentrated on arotary evaporator to afford 5.5 g of a thick pale yellow oil in 91.3%isolated yield which was consistent with the desired product as a singleoximino isomer of methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]propenoateupon analysis by 300 Mz ₁H NMR.

NMR (300 MHz, ₁H, CDCl₃, TMS=0 ppm) 1.4 (m, 1H), 1.7 (m, 1H), 1.95 (s,3H), 2.55 (m, 1H), 3.2 (m, 1H), 3.65 (s, 3H), 3.75 (s, 3H), 5.2 (s, 2H),7.1-7.4 (m, 9H), 7.5 (s, 1H)

EXAMPLE 2 Preparation of methoxylimine isomer A Methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]propenoate—Compound13.18A of Table 13

To a 1000 ml round bottom flask equipped with magnetic stirrer wascharged 56.4 g (0.138 moles) of methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azahepta-3-en-1-yl)phenyl]propenoatein 600 mls of anhydrous methanol, 23.2 g (0.277 moles) of methoxylaminehydrochloride, and 22 g (0.277 moles) of anhydrous pyridine. Thereaction mixture was stirred at ambient temperature for a total of 24hours, then refluxed for approximately 2 hours. The reaction mixture wasthen cooled and poured into 1000 mls of water and extracted with 3×200mls of ether. The ether extract was washed with 200 mls of 0.1 N aqueoushydrochloric acid solution, 2×100 mls of water and 200 mls of saturatedaqueous sodium chloride solution, dried over anhydrous magnesiumsulfate, filtered, and concentrated on a rotary evaporator to afford 62g of a thick amber liquid which was chromatographed on silica gel with20% ethyl acetate, 80% hexane. The pure fractions were combined andconcentrated on a rotary evaporator to afford 48 g of a thick paleyellow oil in a 79.8% isolated yield which was consistent with thedesired product, methoxylimine isomer A, methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]propenoateupon analysis by 300 Mz ₁H NMR.

NMR (300 MHz, ₁H, CDCl₃, TMS=0 ppm) 1.2 (m, 1H), 1.8 (m, 1H), 2.0 (s,3H), 2.45 (m, 1H), 2.7 (m, 1H), 3.66 (s, 3H), 3.75 (s, 3H), 3.9 (s, 3H),5.1 (s, 2H), 7.1-7.4 (m, 9H), 7.56 (s, 1H).

EXAMPLE 3 Preparation of (E)-Methyl2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]-2-methoxyiminoacetateCompound 2.11 of Table 2

To a 250 ml round bottom flask equipped with magnetic stirrer wascharged 2.0 g (0.00985 moles) of2-hydroxyimino-1-(trans-2-phenylcyclopropyl)-1-propanone in 100 mls ofanhydrous dimethylformamide, and 2.8 g (0.0197 moles) of powderedpotassium carbonate. The reaction mixture was stirred at ambienttemperature for a total of 0.5 hours, followed by the addition of methyl2-(bromomethyl)phenylglyoxylate O-methyloxime (2.8 g, 0.00985 moles) inone portion. The reaction was stoppered and stirred overnight at ambienttemperature. The reaction mixture was then was poured into 100 mls ofwater and extracted with 3×100 mls of ether. The ether extract waswashed with 2×100 mls of water, 100 mls of saturated aqueous sodiumchloride solution, dried over anhydrous magnesium sulfate, filtered, andconcentrated on a rotary evaporator to afford 4.1 g of a thick amberliquid in a 100% isolated yield which was consistent with the desiredproduct as a single oximino isomer of (E)-methyl2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]-2-methoxy-iminoacetateupon analysis by 300 Mz ₁H NMR.

NMR (300 MHz, ₁H, CDCl₃, TMS=0 ppm) 1.4 (m, 1H), 1.7 (m, 1H), 1.95 (s,3H), 2.55 (m, 1H), 3.1 (m, 1H), 3.8 (s, 3H), 4.0 (s, 3H), 5.15 (s, 2H),7.1-7.4 (m, 9H)

EXAMPLE 4 Preparation of methoxylimine isomer A(E)-methyl-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]2-methoxyiminoacetate—Compound 14.18A of Table 14

To a 1000 ml round bottom flask equipped with magnetic stirrer wascharged 87 g (0.213 moles) of the (E)-methyl2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]-2-methoxyiminoacetate600 mls of anhydrous methanol, 35.6 g (0.426 moles) of methoxylaminehydrochloride, and 33.7 g (0.426 moles) of anhydrous pyridine. Thereaction mixture was stirred at ambient temperature for a total of 24hours, then refluxed for approximately 2 hours. The reaction mixture wasthen cooled and poured into 1000 mls of water and extracted with 3×200mls of ether. The ether extract was washed with 200 mls of 0.1 N aqueoushydrochloric acid solution, 2×100 mls of water and 200 mls of saturatedaqueous sodium chloride solution, dried over anhydrous magnesiumsulfate, filtered, and concentrated on a rotary evaporator to afford athick amber liquid which crystallized upon standing Slurried the solidin hexane and collected by vacuum filtration. Isolated 66.1 g of a tansolid in 71% isolated yield which was consistent with the desiredproduct, methoxylimine isomer A,(E)-methyl-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]2-methoxyiminoacetate upon analysis by 300 Mz ₁H NMR

NMR (300 MHz, ₁H, CDCl₃, TMS=0 ppm) 1.1 (m, 1H), 1.8 (m, 1H), 2.0 (s,3H), 2.45 (m, 1H), 2.7 (m, 1H), 3.8 (s, 3H), 3.9 (s, 3H), 4.0 (s, 3H),5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H)

EXAMPLE 5 Preparation of methoxylimine isomer A, N-Methyl(E)2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]2-methoxyiminoacetamide—Compound 1518A of Table 15

To a 1000 ml round bottom flask equipped with magnetic stirrer wascharged 66.1 g (0.151 moles) of methoxylimine isomer A of(E)-methyl-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]2-methoxyiminoacetate, 500 mls of anhydrous methanol, and 23.5 g (0.3moles) of 40% aqueous methylamine solution. The reaction mixture wasstirred at ambient temperature for a total of 24 hours, then poured into1000 mls of water and extracted with 3×200 mls of ether. The etherextract was washed with 200 mls of 0.1 N aqueous hydrochloric acidsolution, 2×100 mls of water and 200 mls of saturated aqueous sodiumchloride solution, dried over anhydrous magnesium sulfate, filtered, andconcentrated on a rotary evaporator to afford a thick amber liquid whichcrystallized upon standing. Isolated 62 g of a tan solid in a 94%isolated yield which was consistent with the desired product,methoxylimine isomer A: N-methyl(E)2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]2-methoxyiminoacetatamide upon analysis by 300 Mz ₁H NMR.

NMR (300 MHz, ₁H, CDCl₃, TMS=0 ppm) 1.2 (m, 1H), 1.8 (m, 1H), 2.0 (s,3H), 2.45 (m, 1H), 2.8 (m, 1H), 2.9 (d, 3H), 3.9 (s, 3H), 3.92 (s, 3H),5.0 (s, 2H), 6.8 (bs, 1H), 7.0 (d, 2H), 7.1-7.4 (m, 7H)

EXAMPLE 6 Preparation of Methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]propenoateCompound 1.67 of Table 1 Preparation oftrans-5-methyl-1-phenyl-1-hexen-3-one

To a 250 ml round bottom flask equipped with magnetic stirrer wascharged 11.6 g (0.116 moles) of 4-methyl-2-pentanone, 100 mls ofethanol, and 10 mls of water. To this solution was then added 0.5 g ofbarium hydroxide monohydrate, followed by 12.3 g (0.116 moles) ofbenzaldehyde. The flask was stoppered and stirred overnight at ambienttemperature. The reaction mixture was then poured into 200 mls of waterand extracted with 3×100 mls of ethyl ether. The ether extract waswashed with 100 mls of saturated aqueous sodium bisulfite solution,followed by 100 mls of water, and 100 mls of saturated aqueous sodiumchloride solution. The ether extract was then dried over anhydrousmagnesium sulfate, filtered and concentrated on a rotary evaporator toafford 19.8 g of a pale yellow liquid in a 91% isolated yield which wasconsistent with the desired producttrans-5-methyl-1-phenyl-1-hexen-3-one upon analysis by 300 Mz ₁H NMR.

NMR (300 MHz, ₁H, CDCl₃, TMS=0 ppm) 0.99 (d, 6H), 2.2 (m, 1H), 2.5 (d,2H), 7.7 (d, 1H), 7.4 (m, 3H), 7.6 (m, 3H)

Preparation of trans-2-phenylcyclopropyl iso-butylketone

To a 500 ml round bottom flask equipped with magnetic stirrer, nitrogeninlet, and pressure equalized addition funnel was charged 23 g (0.104moles) of trimethylsulfoxonium iodide, 4.2 g (0.104 moles) of powderedsodium hydroxide, and 150 mls of dimethylsulfoxide. The solution wasstirred at ambient temperature for 30 minutes, followed by the rapidaddition of trans-5-methyl-1-phenyl-1-hexen-3-one, (19.6 g, 0.104 moles)in 100 mls of dimethylsulfoxide. The reaction was then stirred for 60minutes at ambient temperature, then poured into 200 mls of water andextracted with 3×100 mls of ethyl ether. The ether extract was washedwith 2×100 mls of water, and 100 mls of saturated aqueous sodiumchloride solution. The ether extract was dried over anhydrous magnesiumsulfate, filtered and concentrated on a rotary evaporator to afford 18.4g of a thick yellow liquid in a 87.6% isolated which was consistent withthe desired product, trans-2-phenylcyclopropyl iso-butylketone uponanalysis by 300 Mz ₁H NMR. yield.

NMR (300 MHz, ₁H, CDCl₃, TMS=0 ppm) 0.95 (d, 6H), 1.4 (m, 1H), 1.7 (m,1H), 2.2 (m, 2H), 2.4 (d, 2H), 2.45 (m, 1H), 7.1 (d, 2H), 7.2-7.4 (m, 3

Preparation of2-hydroxyimino-3-methyl-1-(trans-2-phenylcyclopropyl)-1-butanone

To a dry 500 ml round bottom flask equipped with magnetic stirrer,nitrogen inlet, reflux condenser, and side arm addition funnel wascharged 11.2 g. (0.1 moles) of potassium t-butoxide and 150 ml oft-butanol. When all of the solid was dissolved,trans-2-phenylcyclopropyl iso-butylketone(18.4 g, 0.0911 moles)was addedin on portion, followed by the drop wise addition of 32 g (0.282 moles)of 90% t-butyl nitrite. The reaction was stirred for 3 hours at ambienttemperature then carefully quenched with 100 mls 0.1 N aqueoushydrochloric acid solution. The mixture was extracted with 3×100 mls ofethyl ether. The ether extract was then washed with 2×100 mls of waterand 100 mls of saturated aqueous sodium chloride solution, then driedover anhydrous magnesium sulfate, filtered, and concentrated on a rotaryevaporator to afford 9.1 g of a thick brown liquid which crystallizedupon standing. The resulting solid was slurried in hexane and collectedby vacuum filtration to afford 8.4 g of a tan solid in a 40% isolatedyield which was consistent with the desired product as a singlehydroxyimino isomer,2-hydroxyimino-3-methyl-1-(trans-2-phenylcyclopropyl)-1-butanone uponanalysis by 300 Mz ₁H NMR. 40% isolated yield.

NMR (300 MHz, ₁H NMR, CDCl₃, TMS=0 ppm) 1.2 (d, 6H), 1.3 (m, 1H), 1.7(m, 1H), 2.5 (m, 1H), 3.1 (m, 1H), 3.4 (q, 1H), 7.1 (d, 2H), 7.2-7.4 (m,3H), 8.1 (bs, 1H).

Preparation of Methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azahepta-3-en-1-yl)phenyl]propenoate

To a 50 ml round bottom flask equipped with magnetic stirrer was charged1.0 g (0.00432 moles) of2-hydroxyimino-3-methyl-1-(trans-2-phenylcyclopropyl)-1-butanone, 10 mlsof anhydrous dimethylformamide, and 1.2 g (0.00865 moles) of powderedpotassium carbonate. The reaction mixture was stirred at ambienttemperature for a total of 0.5 hours, followed by the addition of methyl(E)-α-[2-(bromomethyl)phenyl]-β-methoxyacrylate(1.3 g, 0.00432 moles) inone portion. The reaction was stoppered and stirred overnight at ambienttemperature. The reaction mixture was then was poured into 100 mls ofwater and extracted with 3×100 mls of ether. The ether extract waswashed with 2×100 mls of water, 100 mls of saturated aqueous sodiumchloride solution, dried over anhydrous magnesium sulfate, filtered, andconcentrated on a rotary evaporator to afford 1.8 g of a thick amberliquid which was chromatographed on silica gel with 20% ethyl acetate,80% hexane. The pure fractions were combined and concentrated on arotary evaporator to afford 1.2 g of a thick pale yellow oil in a 64%isolated yield which was consistent with the desired product as a singleoximino isomer, methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]propenoateupon analysis by 300 Mz ₁H NMR.

NMR (300 MHz, ₁H NMR, CDCl₃, TMS=0 ppm) 1.2 (d, 6H), 1.3 (m, 1H), 1.6(m, 1H), 2.55 (m, 1H), 3.1 (m, 1H), 3.4 (q, 1H), 3.7 (s, 3H), 3.78 (s,3H), 5.15 (s, 2H), 7.1-7.5 (m, 9H), 7.6 (s, 1H)

EXAMPLE 7 Preparation of methoxylimine isomers A and B: Methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-isopropyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]propenoateCompound 13.67A and 13.67B of Table 13

To a 100 ml round bottom flask equipped with magnetic stirrer wascharged 1.0 g (0.00229 moles) of single oximino isomer of methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]propenoate50 mls of anhydrous methanol, 1.0 g (0.0115 moles) of methoxylaminehydrochloride, and 1.0 g (0.0115 moles) of anhydrous pyridine. Thereaction mixture was stirred at ambient temperature for a total of 24hours, then refluxed for approximately 10 minutes. The reaction mixturewas then cooled and poured into 100 mls of water and extracted with3×100 mls of ether. The ether extract was washed with 100 mls of 0.1 Naqueous hydrochloric acid solution, 2×100 mls of water and 100 mls ofsaturated aqueous sodium chloride solution, dried over anhydrousmagnesium sulfate, filtered, and concentrated on a rotary evaporator toafford 1.1 g of a thick amber liquid which was chromatographed on silicagel with 20% ethyl acetate, 80% hexane. The pure fractions were combinedand concentrated on a rotary evaporator to afford 350 mg of a thick paleyellow oil consistent with the desired product as methoxylimine isomerA, methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-isopropyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]propenoateupon analysis by 300 Mz ₁H NMR, and 530 mg of a thick pale yellow oilconsistent with the desired product as methoxylimine isomer B, methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-isopropyl-2,7-dioxa-3,6-diazaocta-3-en-1-yl)phenyl]propenoateupon analysis by 300 Mz ₁H NMR in a combined 85% isolated yield.

Methoxylimine Isomer A: NMR (300 MHz, ₁H NMR, CDCl₃, TMS=0 ppm) 1.2 (m,7H), 1.3 (m, 1H), 2.2 (m, 1H), 2.4 (m, 1H), 3.4 (q, 1H), 3.7 (s, 3H),3.78 (s, 3H), 3.9 (s, 3H), 5.05 (s, 2H), 7.1-7.5 (m, 9H), 7.6 (s, 1H)

Methoxylimine Isomer B: NMR (300 MHz, ₁H NMR, CDCl₃, TMS=0 ppm) 1.2 (m,7H), 1.3 (m, 1H), 1.8 (m, 1H), 2.2 (m, 1H), 3.1 (q, 1H), 3.6 (s, 3H),3.70 (s, 3H), 3.75 (s, 3H), 5.0 (s, 2H), 7.1-7.4 (m, 9H), 7.5 (s, 1H).

EXAMPLE 8 Preparation of hydroxylimine isomer A: Methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazahepta-3,5-dien-1-yl)phenyl]propenoateCompound 13.11A of Table 13

To a 100 ml round bottom flask equipped with magnetic stirrer wascharged 1.0 g (0.00245 moles) a single oximino isomer of methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapentta-3-en-1-yl)phenyl]propenoate,50 mls of anhydrous methanol, 1.7 g (0.0245 moles) of hydroxylaminehydrochloride, and 1.9 g (0.0245 moles) of anhydrous pyridine. Thereaction mixture was stirred at ambient temperature for a total of 24hours, then refluxed for approximately 2 hours. The reaction mixture wasthen cooled and poured into 100 mls of water and extracted with 3×100mls of ether. The ether extract was washed with 100 mls of 0.1 N aqueoushydrochloric acid solution, 2×100 mls of water and 100 mls of saturatedaqueous sodium chloride solution, dried over anhydrous magnesiumsulfate, filtered, and concentrated on a rotary evaporator to afford 1.1g of a thick amber liquid which was chromatographed on silica gel with15% ethyl acetate, 85% hexane. The pure fractions were combined andconcentrated on a rotary evaporator to afford 650 mg of a thick clearcolorless oil in a 63% isolated yield which was consistent with thedesired product as a single hydroxyimino isomer A, methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazahepta-3,5-dien-1-yl)phenyl]propenoateupon analysis by 300 Mz ₁H NMR.

NMR (300 MHz, ₁H NMR, CDCl₃, TMS=0 ppm) 1.8 (m, 1H), 2.0 (s, 3H), 2.5(m, 1H), 2.7 (m, 1H), 3.65 (s, 3H), 3.75 (s, 3H), 5.05 (s, 2H), 7.1 (d,2H), 7.2-7.5 (m, 7H), 7.56 (s, 1H), 8.3 (bs, 1H)

EXAMPLE 9 Preparation of methoxylimine isomer A of Methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazadeca-3,5-dien-1-yl)phenyl]-2propenoate Compound 13.40A of Table 13

To a 50 ml round bottom flask equipped with magnetic stirrer was charged0.2 g, (0.000474 moles) of hydroxyimino isomer A, methyl(E)-3-methoxy-2-[2(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazahepta-3,5-dien-1-yl)phenyl]propenoate10 mls of anhydrous dimethylformamide, and 0.13 g (0.00095 moles) ofpowdered potassium carbonate. The reaction mixture was stirred atambient temperature for a total of 0.5 hours, followed by the additionof the 1-bromopropane (0.065 g, 0.0005 moles) in one portion. Thereaction was stoppered and stirred overnight at ambient temperature Thereaction mixture was then was poured into 100 mls of water and extractedwith 3×100 mls of ether. The ether extract was washed with 2×100 mls ofwater, 100 mls of saturated aqueous sodium chloride solution, dried overanhydrous magnesium sulfate, filtered, and concentrated on a rotaryevaporator to afford 0.2 g of a thick amber liquid which waschromatographed on silica gel with 20% ethyl acetate, 80% hexane. Thepure fractions were combined and concentrated on a rotary evaporator toafford 120 mg of a thick clear colorless oil in a 55% isolated yieldconsistent with the desired product.,: methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazadeca-3,5-dien-1-yl)phenyl]propenoate,n-propoxyimine isomer A upon analysis by 300 Mz ₁H NMR.

NMR (300 MHz, ₁H NMR, CDCl₃, TMS=0 ppm) 0.85 (t, 3H), 1.1 (m, 1H), 1.6(q, 2H), 1.8 (m, 1H), 2.0 (s, 3H), 2.4 (m, 1H), 2.6 (m, 1H), 3.6 (s,3H), 3.7 (s, 3H), 4.0 (t, 2H), 5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m,7H), 7.6 (s, 1H)

EXAMPLE 10 Preparation of Methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-8,8-dimethyl-2,7-dioxa-3,6-diazanona-3,5-dien-1-yl)phenyl]propenoateCompound 13.43 of Table 13

To a 100 ml round bottom flask equipped with magnetic stirrer wascharged 0.5 g (0.00122 moles) of a single oximino isomer of methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapentta-3-en-1-yl)phenyl]propenoate,50 mls of anhydrous methanol, 1.5 g (0.0122 moles) of O-t-butylhydroxylamine HCl, and 0.98 g (0.0122 moles) of anhydrous pyridine. Thereaction mixture was stirred at ambient temperature for a total of 24hours, then refluxed for approximately 2 hours. The reaction mixture wasthen cooled and poured into 100 mls of water and extracted with 3×100mls of ether. The ether extract was washed with 100 mls of 0.1 N aqueoushydrochloric acid solution, 2×100 mls of water and 100 mls of saturatedaqueous sodium chloride solution, dried over anhydrous magnesiumsulfate, filtered, and concentrated on a rotary evaporator to afford 0.6g of a thick yellow liquid in a 100% isolated yield which was consistentwith the desired product a methyl(E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-8,8-dimethyl-2,7-dioxa-3,6-diazanona-3,5-dien-1-yl)phenyl]propenoateas mixture of t-butoxyimine isomers: upon analysis by 300 Mz ₁H NMR,.

NMR (300 MHz, ₁H NMR,TMS=0 ppm) 1.2 (m, 10H), 1.8 (m, 1H), 2.0 (s, 3H),2.4 (m, 1H), 2.6 (m, 1H), 3.6 (s, 3H), 3.7 (s, 3H), 4.0 (t, 2H), 5.0 (s,2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H), 7.6 (s, 1H).

Proton NMR data (300 MHz) are provided in Table 61 for typical examplesof Tables 1 to 60 and are illustrative of the present invention*

TABLE 61 Compound # NMR DATA  1.11 1.4(m, 1H), 1.8(m, 1H), 1.95(s, 3H),2.5(m, 1H), 3.15(m, 1H), 3.65(s, 3H), 3.75(s, 3H), 5.2(s, 2H),7.1-7.4(m, 9H), 7.55(s, 1H)  1.22 1.5(m, 1H), 1.8(m, 1H), 1.95(s, 3H),2.6(m, 1H), 3.1(m, 1H), 3.65(s, 3H), 3.75(s, 3H), 3.8(s, 3H), 5.2(s,2H), 6.8(m, 3H), 7.1-7.4(m, 5H), 7.55(s, 1H)  1.24 1.4(m, 1H), 1.75(m,1H), 2.0(s, 3H), 2.3(s, 3H), 2.5(m, 1H), 3.1(m, 1H), 3.65(s, 3H),3.75(s, 3H), 5.2(s, 2H), 7.1-7.4(m, 8H), 7.55(s, 1H)  1.25 1.5(m, 1H),1.8(m, 1H), 1.95(s, 3H), 2.35(s, 3H), 2.5(m, 1H), 3.1(m, 1H), 3.65(s,3H), 3.75(s, 3H), 5.2(s, 2H), 7.0-7.5(m, 8H), 7.55(s, 1H)  1.56 0.85(t,3H), 1.4(m, 3H), 1.7(m, 1H), 2.5(m, 3H), 3.1(m, 1H), 3.7(s, 3H), 3.75(s,3H), 5.2(s, 2H), 7.1-7.4(m, 9H); 7.6(s, 1H)  1.67 1.2(d, 6H), 1.3(m,1H), 1.7(m, 1H), 2.5(m, 1H), 3.1(m, 1H), 3.4(m, 1H), 3.7(s, 3H), 3.75(s,3H), 5.15(s, 2H), 7.0-7.5(m, 9H), 7.6(s, 1H)  1.78 0.9(t, 3H), 1.4(m,5H), 1.8(m, 1H), 2.5(m, 3H), 3.2(m, 1H), 3.65(s, 3H), 3.75(s, 3H),5.2(s, 2H), 7.1-7.4(m, 9H), 7.55(s, 1H)  2.1 1.4(m, 1H), 1.8(m, 1H),2.6(m, 1H), 3.05(m, 1H), 3.8(s, 3H), 4.0(s, 3H), 5.2(s, 2H), 7.1-7.45(m,9H), 7.5(s, 1H)  2.11 1.4(m, 1H), 1.8(m, 1H), 1.95(s, 3H), 2.5(m, 1H),3.1(m, 1H), 3.8(s, 3H), 3.95(s, 3H), 5.15(s, 2H), 7.1-7.5(m, 9H)  2.141.4(m, 1H), 1.8(m, 1H), 1.95(s, 3H), 2.5(m, 1H), 3.1(m, 1H), 3.9(s, 3H),4.05(s, 3H), 5.15(s, 2H), 7.0(d, 2H), 7.1-7.5(m, 6H)  2.22 1.45(m, 1H),1.7(m, 1H), 1.9(s, 3H), 2.6(m, 1H), 3.1(m, 1H), 3.79(s, 3H), 3.8(s, 3H),4.0(s, 3H), 5.2(s, 2H), 6.8(m, 3H), 7.1-7.4(m, 5H)  2.24 1.4(m, 1H),1.75(m, 1H), 2.0(s, 3H), 2.25(s, 3H), 2.5(m, 1H), 3.05(m, 1H), 3.8(s,3H), 4.0(s, 3H), 5.2(s, 2H), 7.1-7.4(m, 8H)  2.25 1.5(m, 1H), 1.8(m,1H), 1.95(s, 3H), 2.3(s, 3H), 2.6(m, 1H), 3.1(m, 1H), 3.8(s, 3H), 4.0(s,3H), 5.2(s,2H), 7.1-7.4(m, 8H)  2.45 0.95(t, 3H), 1.3(m, 1H), 1.8(m,1H), 2.5(m, 3H), 3.2(m, 1H), 3.7(s, 3H), 3.75(s, 3H), 5.2(s, 2H),7.0-7.5(m, 9H), 7.55(s, 1H)  2.45 1.0(t, 3H), 1.3(m, 1H), 1.8(m, 1H),2.5(m, 3H), 3.1(m, 1H), 3.8(s, 3H), 4.0(s, 3H), 5.15(s, 2H), 7.0-7.5(m,9H)  2.56 0.9(t, 3H), 1.4(m, 3H), 1.7(m, 1H), 2.5(m, 3H), 3.1(m, 1H),3.8(s, 3H), 4.0(s, 3H), 5.1(s, 2H), 7.1-7.4(m, 9H)  2.67 1.15(d, 6H),1.25(m, 1H), 1.7(m, 1H), 2.5(m, 1H), 3.1(m, 1H), 3.4(m, 1H), 3.8(s, 3H),4.0(s, 3H), 5.1(s, 2H), 7.0-7.5(m, 9H)  2.78 0.85(t, 3H), 1.4(m, SH),1.75(m, 1H), 2.5(m, 3H), 3.2(m, 1H), 3.8(s, 3H), 4.0(s, 3H), 5.15(s,2H), 7.1-7.5(m, 9H)  3.22 1.4(m, 1H), 1.7(m, 1H), 1.85(s, 3H), 2.5(m,1H), 2.8(d, 3H), 3.1(m, 1H), 3.75(s, 3H), 3.85(s, 3H), 5.1(s, 2H),6.8(m, 3H), 7.1-7.4(m, 6H) 10.5 1.0(d, 6H), 1.3(m, 1H), 1.6(m, 2H),3.55(m, 1H), 3.65(s, 3H), 3.75(s, 3H), 5.0(s, 2H), 7.1-7.4(m, 9H),7.55(s, 1H) 13.7 1.15-1.3 (m, 2H), 2.15-2.25 (m, 1H), 2.26-2.4 (m, 1H),3.65 (s, 3H), 3.85 (s, 3H), 5.07 (s, 2H), 7.0-7.6 (m, 10H), 7.56 (s,1H), 8.33 (s, 1H) 13.11A 1.8 (m, 1H), 2.0 (s, 3H), 2.5 (m, 1H), 2.7 (m,1H), 3.65 (s, 3H), 3.75 (s, 3H), 5.05 (s, 2H), 7.1 (d, 2H), 7.2-7.5 (m,7H), 7.56 (s, 1H), 8.3 bs, 1H) 13.18A 1.2 (m, 1H), 1.8 (m, 1H), 2.0 (s,3H), 2.45 (m, 1H), 2.7 (m, 1H), 3.66 (s, 3H), 3.75 (s, 3H), 3.9 (s, 3H),5.1 (s, 2H), 7.1-7.4 (m, 9H), 7.56 (s, 1H) 13.18B 1.2 (m, 1H), 1.4 (m,1H), 1.8(m, 1H), 1.95 (s, 3H), 2.2 (m, 1H), 3.6 (s, 3H), 3.7 (s, 3H),3.85 (s, 3H), 5.1 (s, 2H), 6.9 (d, 2H), 7.1-7.4 (m, 7H), 7.56 (s, 1H)13.20A 1.1 (m, 1H), 1.8 (m, 1H), 2.0 (s, 3H), 2.4 (m, 1H), 2.7 (m, 1H),3.6 (s, 3H), 3.7 (s, 3H), 3.85 (s, 3H), 5.0 (s, 2H), 7.0 (d, 2H),7.1-7.4 (m, 6H), 7.6 (s, 1H) 13.22A 1.2 (m, 1H), 1.8 (m, 1H), 2.0 (s,3H), 2.4 (m, 1H), 2.9 (m, 1H), 3.7 (s, 3H), 3.8 (s, 3H), 3.95 (s, 3H),5.0 (s, 2H), 6.9-7.0 (m, 3H), 7.1-7.4 (m, 5H), 7.6 (s, 1H) 13.23 1.2 (m,1H), 1.8 (m, 1H), 2.0 (s, 3H), 2.3 (m, 1H), 2.5 (m, 1H), 3.65 (s, 3H),3.8 (s, 3H), 3.9 (s, 3H), 5.0 (s, 2H), 6.8.0-7.0 (m, 3H), 7.1-7.4 (m,5H), 7.6 (s, 1H) 13.25A 1.2 (m, 1H), 1.8 (m, 1H), 2.0 (s, 3H), 2.25 (s,3H), 2.45 (m, 1H), 2.8 (m, 1H), 3.6 (s, 3H), 3.75 (s, 3H), 3.9 (s, 3H),5.1 (s, 2H), 7.1-7.4 (m, 8H), 7.6 (s, 1H) 13.26 1.2 (m, 1H), 1.8 (m,1H), 2.0 (s, 3H), 2.3 (s, 3H), 2.5 (m, 1H), 2.8 (m, 1H), 3.65 (s, 3H),3.75 (s, 3H), 3.9 (s, 3H), 5.1 (s, 2H), 6.9-7.0 (m, 3H), 7.1-7.4 (m,SH), 7.6 (s, 1H) 13.39 1.1 (m, 1H), 1.3 (t, 3H), 1.8 (m, 1H), 2.0 (s,3H), 2.4 (m, 1H), 2.7 (m, 1H), 3.6 (s, 3H), 3.7 (s, 3H), 4.1 (m, 2H),5.1 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H), 7.6 (s, 1H) 13.40A 0.85 (t,3H), 1.1 (m, 1H), 1.6 (q, 2H), 1.8 (m, 1H), 2.0 (s, 3H), 2.4 (m, 1H),2.6 (m, 1H), 3.6 (s, 3H), 3.7 (s, 3H), 4.0 (t, 2H), 5.0 (s, 2H), 7.0 (d,2H), 7.1-7.4 (m, 7H), 7.6 (s, 1H) 13.42A 0.9 (t, 3H), 1.1 (m, 1H), 1.3(m, 2H), 1.6 (m, 2H), 1.8 (m, 1H), 2.0 (s, 3H), 2.4 (m, 1H), 2.7 (m,1H), 3.65 (s, 3H), 3.75 (s, 3H), 4.1 (t, 2H), 5.0 (s, 2H), 7.0 (d, 2H),7.1-7.4 (m, 7H), 7.6 (s, 1H) 13.43 1.2 (m, 10H), 1.8 (m, 1H), 2.0 (s,3H), 2.4 (m, 1H), 2.6 (m, 1H), 3.6 (s, 3H), 3.7 (s, 3H), 4.0 (t, 2H),5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H), 7.6 (s, 1H) 13.44A 1.1 (m,1H), 1.8 (m, 1H), 1.95 (s, 3H), 2.4 (m, 1H), 2.5 (s, 1H), 2.7 (m, 1H),3.6 (s, 3H), 3.7 (s, 3H), 4.6 (d, 2H), 5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4(m, 7H), 7.6 (s, 1H) 13.45A 1.0 (t, 3H), 1.1 (m, 1H), 1.3 (m, 1H),1.8(m, 1H), 2.2 (m, 1H), 2.5 (q, 2H), 3.6 (s, 3H), 3.7 (s, 3H), 3.75 (s,3H), 5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H), 7.6 (s, 1H) 13.45B 1.0(t, 3H), 1.1 (m, 1H), 1.3 (m, 1H), 1.7(m, 1H), 2.5 (m, 1H), 2.6 (q, 2H),3.65 (s, 3H), 3.75 (s, 3H), 3.9 (s, 3H), 5.0 (s, 2H), 7.0 (d, 2H),7.1-7.4 (m, 7H), 7.6 (s, 1H) 13.56A 0.95 (t, 3H), 1.2 (m, 1H), 1.5 (m,2H), 1.7 (m, 1H), 2.45 (m, 1H), 2.7 (m, 3H), 3.65 (s, 3H), 3.75 (s, 3H),3.9 (s, 3H), 5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H), 7.6 (s, 1H)13.67A 1.2 (m, 7H), 1.3 (m, 1H), 2.2 (m, 1H), 2.4 (m, 1H), 3.4 (q, 1H),3.7 (s, 3H), 3.78 (s, 3H), 3.9 (s, 3H), 5.05 (s, 2H), 7.1-7.5 (m, 9H),7.6 (s, 1H) 13.67B 1.2 (m, 7H), 1.3 (m, 1H), 1.8 (m, 1H), 2.2 (m, 1H),3.1 (q, 1H), 3.6 (s, 3H), 3.70 (s, 3H), 3.75 (s, 3H), 5.0 (s, 2H),7.1-7.4 (m, 9H), 7.5 (s, 1H) 13.78A 0.9 (t, 3H), 1.2 (m, 1H), 1.4 (m,2H), 1.5 (m, 2H), 1.8 (m, 1H), 2.4 (m, 1H), 2.6 (m, 3H), 3.65 (s, 3H),3.75 (s, 3H), 3.9 (s, 3H), 5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H),7.6 (s, 1H) 14.7 1.10-1.25 (m, 2H), 2.10-2.20(m, 1H), 2.25-2.35 (m, 1H),2.87-2.88 (d, 3H), 3.85 (s, 3H), , 3.92 (s, 3H), 5.05(s,2H), 6.6-6.8(1)r s, 1H), 7.0-7.5 (m, 9H,) 8.29 (s, 1H) 14.18A 1.1 (m, 1H), 1.8 (m,1H), 2.0 (s, 3H), 2.45 (m, 1H), 2.7 (m, 1H), 3.8 (s, 3H), 3.9 (s, 3H),4.0 (s, 3H), 5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H) 14.20 1.2 (m,1H), 1.8 (m, 1H), 2.0 (s, 3H), 2.4 (m, 1H), 2.6 (m, 1H), 3.8 (s, 3H),3.9 (s, 3H), 4.0 (s, 3H), 5.0 (s, 2H), 6.9 (d, 2H), 7.1-7.4 (m, 6H)14.21 1.2 (m, 1H), 1.8 (m, 1H), 2.0 (s, 3H), 2.4 (m, 1H), 2.7 (m, 1H),3.8 (s, 3H), 3.9 (s, 3H), 4.0 (s, 3H), 5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4(m, 6H) 14.22 1.2 (m, 1H), 1.8 (m, 1H), 2.0 (s, 3H), 2.4 (m, 1H), 2.7(m, 1H), 3.75 (s, 3H), 3.85 (s, 3H), 3.95 (s, 3H), 5.0 (s, 2H), 6.9-7.2(m, 3H), 7.3-7.5 (m, 5H) 14.23 1.2 (m, 1H), 1.8 (m, 1H), 2.o (s, 3H),2.3 (m, 1H), 2.5 (m, 1H), 3.7 (s, 3H), 3.85 (s, 3H), 3.95 (s, 3H), 4.95(s, 2H), 6.8.0-7.0 (m, 3H), 7.1-7.4 (m, 5H) 14.25A 1.2 (m, 1H), 1.8 (m,1H), 2.0 (s, 3H), 2.25 (s, 3H), 2.5 (m, 1H), 2.8 (m, 1H), 3.8 (s, 3H),3.9 (s, 3H), 4.0 (s, 3H), 5.1 (s, 2H), 7.1-7.2 (m, 5H), 7.4 (m, 3H)14.26 1.2 (m, 1H), 1.8 (m, 1H), 2.0 (s, 3H), 2.3 (s, 3H), 2.4 (m, 1H),2.6 (m, 1H), 3.8 (s, 3H), 3.9 (s, 3H), 4.0 (s, 3H), 5.0 (s, 2H), 7.0-7.2(m, 3H), 7.3-7.5 (m, 5H) 14.31 1.2 (m, 1H), 1.8 (m, 1H), 2.0 (s, 3H),2.4 (m, 1H), 2.55 (m, 1H), 3.7 (s, 3H), 3.75 (s, 3H), 3.9 (s, 3H), 3.95(s, 3H), 5.0 (s, 2H), 6.7 (d, 2H), 7.1-7.4 (m, 6H) 14.45 1.1 (t, 3H),1.2 (m, 1H), 1.8 (m, 1H), 2.4 (m, 2H), 2.5 (q, 2H), 3.8 (s, 3H), 3.9 (s,3H), 4.0 (s, 3H), 5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H) 14.56A 0.95(t, 3H), 1.2 (m, 1H), 1.5 (m, 2H), 1.7 (m, 1H), 2.45 (m, 1H), 2.7 (m,3H), 3.8 (s, 3H), 3.9 (s, 3H), 4.0 (s, 3H), 5.0 (s, 2H), 7.0 (d, 2H),7.1-7.4 (m, 7H) 14.67A 1.2 (m, 7H), 1.4 (m, 1H), 2.2 (m, 1H), 2.4 (m,1H), 3.2 (q, 1H), 3.8 (s, 3H), 3.9 (s, 3H), 4.0 (s, 3H), 5.0 (s, 2H),7.0 (d, 2H), 7.1-7.4 (m, 7H) 14.67B 1.2 (m, 7H), 1.3 (m, 1H), 1.8 (m,1H), 2.2 (m, 1H), 3.1 (q, 1H), 3.8 (s, 6H), 3.95 (s, 3H), 5.0 (s, 2H),7.0 (d, 2H), 7.1-7.4 (m, 7H) 14.78A 0.9 (t, 3H), 1.2 (m, 1H), 1.4 (m,2H), 1.5 (m, 2H), 1.7 (m, 1H), 2.4 (m, 1H), 2.6 (m, 3H), 3.8 (s, 3H),3.9 (s, 3H), 4.0 (s, 3H), 5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H) 15.71.10-1.25 (m, 2H), 2.10-2.20(m, 1H), 2.25-2.25 (m, 1H), 3.82 (s, 3H),3.85 (s, 3H), 3.99 (s, 3H), 5.04 (s,2H), 7.0-7.5 (m, 9H), 7.56 (s, 1H),8.28 (s, 1H) 15.21 1.2 (m, 1H), 1.7 (m, 1H), 1.9 (s, 3H), 2.2 (m, 1H),2.6 (m, 1H), 2.9 (d, 3H), 3.8 (s, 3H), 3.9 (s, 3H), 5.0 (s, 2H), 6.8 bs,1H), 7.0 (d, 2H), 7.1-7.4 (m, 6H) 15.18A 1.2 (m, 1H), 1.8 (m, 1H), 2.0(s, 3H), 2.45 (m, 1H), 2.8 (m, 1H), 2.9 (d, 3H), 3.9 (s, 3H), 3.92 (s,3H), 5.0 (s, 2H), 6.8 (1)s, 1H), 7.0 (d, 2H), 7.1-7.4 (m, 7H) 15.18B 1.2(m, 1H), 1.4 (m, 1H), 1.8 (m, 1H), 1.95 (s, 3H), 2.2 (m, 1H), 2.85 (d,3H), 3.9 (s, 3H), 3.95 (s, 3H), 5.0 (s, 2H), 6.7 bs, 1H), 7.0 (d, 2H),7.1-7.4 (m, 7H) 15.20 1.1 (m, 1H), 1.8 (m, 1H), 1.9 (s, 3H), 2.3 (m,1H), 2.6 (m, 1H), 2.8 (d, 3H), 3.85 (d, 6H), 5.0 (s, 2H), 6.7 bs, 1H),6.9-7.4 (m, 8H) 15.22A 1.1 (m, 1H), 1.8 (m, 1H), 1.9 (s, 3H), 2.3 (m,1H), 2.8 (d, 3H), 2.9 (m, 1H), 3.85 (d, 6H), 5.0 (s, 2H), 6.7 bs, 1H),6.9-7.4 (m, 8H) 15.24 1.1 (m, 1H), 1.7 (m, 1H), 1.9 (s, 3H), 2.2 (m,1H), 2.6 (m, 1H), 2.8 (d, 3H), 3.85 (d, 6H), 4.98 (s, 2H), 6.8 bs, 1H),6.9-7.4 (m, 8H) 15.25A 1.2 (m, 1H), 1.8 (m, 1H), 2.0 (s, 3H), 2.2 (s,3H), 2.6 (m, 1H), 2.8 (m, 1H), 2.85 (d, 3H), 3.85 (s, 6H), 4.95 (s, 2H),6.8 bs, 1H), 7.0-7.4 (m, 8H) 15.26A 1.2 (m, 1H), 1.7 (m, 1H), 1.9 (s,3H), 2.2 (s, 3H), 2.4 (m, 1H), 2.7 (m, 1H), 2.8 (d, 3H), 3.85 (d, 6H),4.98 (s, 2H), 6.8 bs, 1H), 6.9-7.4 (m, 8H) 15.26B 1.1 (m, 1H), 1.4 (m,1H), 1.8 (m, 1H), 1.9 (s, 3H), 2.1 (m, 1H), 2.2 (s, 3H), 2.8 (d, 3H),3.75 (s, 3H), 3.85 (s, 3H), 4.95 (s, 2H), 6.7 bs, 1H), 6.8 (d, 2H),6.9-7.4 (m, 6H) 15.31 1.2 (m, 1H), 1.8 (m, 1H), 1.95 (s, 3H), 2.4 (m,1H), 2.55 (m, 1H), 2.9 (d, 3H), 3.75 (s, 3H), 3.8 (s, 3H), 3.83 (s, 3H),5.0 (s, 2H), 6.6 (d, 2H), 7.1-7.4 (m, 6H) 15.45 1.0 (t, 3H), 1.2 (m,1H), 1.7 (m, 1H), 2.3 (m, 2H), 2.4 (m, 1H), 2.5 (q, 2H), 2.8 (d, 2H),3.8 (s, 3H), 3.85 (s, 3H), 4.95 (s, 2H), 6.7 bs, 1H), 6.9 (d, 2H),7.1-7.4 (m, 7H) 15.56A 0.9 (t, 3H), 1.2 (m, 1H), 1.5 (m, 2H), 1.8 (m,1H), 2.4 (m, 1H), 2.6 (m, 3H), 2.9 (d, 3H), 3.9 (s, 3H), 4.0 (s, 3H),5.0 (s, 2H), 6.8 bs, 1H), 7.0 (d, 2H), 7.1-7.4 (m, 7H) 15.67A 1.1 (m,7H), 1.2 (m, 1H), 2.2 (m, 1H), 2.4 (m, 1H), 2.9 (d, 3H), 3.1 (q, 1H),3.8 (s, 3H), 3.9 (s, 3H), 4.95 (s, 2H), 6.8 (1,s, 1H), 7.0 (d, 2H),7.1-7.4 (m, 7H) 15.67B 1.1 (m, 6H), 1.2 (m, 1H), 1.4 (m, 1H), 1.8 (m,1H), 2.2 (m, 1H), 2.8 (d, 3H), 3.0 (q, 1H), 3.75 (s, 3H), 3.9 (s, 3H),4.95 (s, 2H), 6.7 (1,s, 1H), 7.0 (d, 2H), 7.1-7.4 (m, 7H) 15.78A 0.9 (t,3H), 1.2 (m, 1H), 1.4(m, 2H), 1.5 (m, 2H), 1.7 (m, 1H), 2.4 (m, 1H), 2.6(m, 3H), 2.9 (d, 3H), 3.9 (s, 3H), 4.0 (s, 3H), 5.0 (s, 2H), 6.8 bs,1H), 7.0 (d, 2H), 7.1-7.4 (m, 7H) *NMR data for compounds designated byA or B are data for one single stereoisomer for R₉ON═C Compounds withoutdesignation are a mixture of stereoisomers and the data provided is forthe major isomer.

EXAMPLE 11

Numerous compounds of this invention were tested for fungicidal activityin vivo against the diseases described below. The compounds weredissolved a 1:1 mixture of acetone and methanol or N,N-dimethylformamideand diluted with a 2:1:1 mixture of water, acetone, and methanol (byvolume) or water, respectively, to achieve the appropriateconcentration. The solution was sprayed onto the plants, and allowed todry (two hours). Then the plants were inoculated with fungal spores.Each test utilized control plants which were sprayed with theappropriate solvent mixture and inoculated. For these protective tests,the plants were inoculated one day after treating the plants with thefungicide compound. The remainder of the technique of each of the testsis given below along with the results for various compounds describedherein by the Compound # against the various fungi at a dose of 150grams per hectare. The results are percent disease control are comparedto the untreated check wherein one hundred was rated as complete diseasecontrol and zero as no disease control.

Wheat Leaf Rust (WLR)

Puccinia recondita (f. sp. tritici) was cultured on 7-day old wheat(cultivar Fielder) over a 12-day period in the greenhouse. Spores werecollected from the leaves by settling on aluminum foil. The spores werecleaned by sieving through a 250-micron opening screen and stored dry.The dried spores were used within one month. A spore suspension wasprepared from dry uredia by adding 20 mg (9.5 million spores) per ml ofSoltrol oil. The suspension was dispensed into gelatin capsules (0.7 mlcapacity) which attach to the oil atomizers. One capsule is used perflat of twenty 2-inch square pots of 7-day old wheat plants, cultivarFielder After waiting for at least 15 minutes for the oil to evaporatefrom the wheat leaves, the plants were placed in a dark mist chamber(18-20° C. and 100% to relative humidity) for 24 hours. The plants werethen placed in the greenhouse and evaluated after 12 days for disease

Wheat Leaf Blotch (SNW)

Cultures of Septoria nodorum was maintained on Czapek-Dox V-8 juice agarplates in an incubator at 20° C. with alternating periods of 12 hours oflight and 12 hours of darkness for 2 weeks. A water suspension of thespores was obtained by shaking the portion of the plate with fungalmaterial in deionized water and filtering through cheesecloth. Thespore-containing water suspension was diluted to a spore concentrationof 3.0×10⁶ spores per ml. The inoculum was dispersed by a De Vilbissatomizer over one-week old Fielder wheat plants which had beenpreviously sprayed with the fungicide compound. The inoculated plantswere placed in a humidity cabinet at 20° C. with alternating 12 hours oflight and 12 hours of darkness for 7 days. The inoculated seedlings werethen moved to a controlled environment room at 20° C. for 2 days ofincubation. Disease control values were recorded as percent control.

Wheat Powdery Mildew (WPM)

Erysiphe graminis (f. sp. tritici) was cultured on wheat seedlings,cultivar Fielder, in a controlled temperature room at 18° C. Mildewspores were shaken from the culture plants onto 7-day old wheatseedlings which had been previously sprayed with the fungicide compound.The inoculated seedlings were kept in a controlled temperature room at18° C. and subirrigated. The percent disease control was rated 7 daysafter the inoculation.

Cucumber Powdery Mildew (CPM)

Sphaerotheca fulginea was maintained on cucumber plants, cultivar. BushChampion, in the greenhouse. Inoculum was prepared by placing five toten heavily mildewed cucumber leaves in a glass jar with 500 ml of watercontaining one drop of Tween 80 per 100 ml. After shaking the liquid andleaves, the inoculum was filtered through cheese cloth and misted ontothe plants with a squirt bottle mister. The spore count was 100,000spores/ml. The plants were then placed in the greenhouse for infectionand incubation. The plants were scored seven days after inoculation.Disease control values were recorded as percent control.

Tomato Late Blight (TLB)

Cultures of Phytophthora infestans were maintained on green pea-amendedagar for two to three weeks. The spores were washed from the agar withwater and dispersed with a De Vilbiss atomizer over the leaves of 3-weekold Pixie tomato plants which had been previously treated withexperimental fungicides. The inoculated plants were placed in a humiditycabinet at 20° C. for 24 hours for infection. The plants were thenremoved to a controlled environment room at 20° C. and 90% humidity. Theplants were scored for disease control after five days.

Grape Downy Mildew (GDM)

Plasmopara viticola was maintained on leaves of grape plants, cultivar.Delaware, in a controlled temperature chamber at 20° C. in humid airwith moderate light intensity for 7 to 8 days. A water suspension of thespores from infested leaves was obtained and the spore concentration wasadjusted to about 3×10⁵ per ml of water. Delaware grape plants wereinoculated by spraying the underside of leaves with a De Vilbissatomizer until small drops were observed on the leaves. The inoculatedplants were incubated in a mist chamber for 24 hours at 20° C. Theplants were then removed to a controlled environmental room at 20° C.Disease control values were recorded as percent control seven days afterinoculation.

Rice Blast (RB)

Cultures of Pyricularia oryzae were maintained on potato dextrose agarfor two to three weeks. The spores were washed from the agar with watercontaining 1 drop of Tween 80 per 100 ml water. After filtering thespore suspension through two layers of cheese cloth, the spore count wasadjusted to 5×10₅. The spore suspension was sprayed onto 12-day old riceplants, cultivar M-1, using a De Vilbiss atomizer. The inoculated plantswere placed in a humidity cabinet at 20 C. for 36 hours to allow forinfection. After the infection period, the plants were placed in thegreenhouse. After 6 days, the plants were scored for disease control.

Cucumber Anthracnose (CA)

The fungal pathogen Colletotrichum lagenarium was cultured on potatodextrose agar (PDA) in the dark at 22 C for a period of 8 to 14 days.Spores of C. Lagenarium were removed from the PDA plates by flooding theplate surface with distilled water, amended with 0.5% v/w of yeastextract. The upper surface of the fungal colony was scraped with a bluntinstrument until most of the spores were released into the aqueousenvironment. The spore suspension was filtered though cheesecloth, andthe spore count was adjusted by adding more water, containing the yeastextract, until 3.0×10⁶ spores per ml was achieved.

The chemically-treated cucumber plants were 15-days old, cultivar BushChampion. The upper leaf surface of the plants were sprayed with thespore suspension until runoff, using a hand-held pump spray bottle. Theplants were placed in a fluorescent-lighted mist chamber (12 hr light,12 hr dark) for 48 hours. After that infection period, the plants wereplaced in a growth chamber for 3 days at 25 C and 90% humidity. Thetreated plants were then evaluated for disease control.

Botrytis (BOT)

The fungal pathogen Botrytis cinerea was cultured on potato dextroseagar (PDA) under fluorescent lights (12 hr on, 12 hr off) for a periodof 2 to 3 weeks. Spores of B. cinerea were removed from the PDA platesby flooding the plate surface with distilled water, amended with 0.5%v/w of yeast extract. The upper surface of the fungal colony was scrapedwith a rubber instrument until most of the spores were released into theaqueous environment. The spore suspension was filtered thoughcheesecloth, and the spore count was adjusted by adding more water,containing the yeast extract, until 3.0×10⁶ spores per ml was achieved.

Chemically-treated sweet bell pepper plants were 19-days old, cultivarCalifornia Wonder. The entire leaf surface of the plants were sprayedwith the spore suspension until runoff, using a De Vilbiss atomizer. Theplants were placed in a low light mist chamber (12 hr light, 12 hr dark)at 22 C for 4 or 5 days. The treated plants were then evaluated fordisease control.

When tested against wheat leaf rust at 150 grams per hectare compounds1.11, 1.24, 1.25, 2.24, 2.25, 3.22, 13.7, 13.11A, 13.18A, 13.18B,13.20A, 13.22A, 13.39, 13.40A, 13.42A, 13.44A, 13.45A, 13.45B, 13.56A,13.67B, 14.18A, 14.20, 15.7, 15.2115.18A, 15.18B, 15.20, 15.22A, 15.24,15.31, 15.45, 15.56A, 15.67A and 15.78 exhibited 99% or better control.

When tested against septoria nodorum at 150 grams per hectare compounds1.11, 2.14, 13.18A, 13.18B, 14.21 , 14.18A, 15.7, 15.18A and 15.18Bexhibited 90% or better control.

When tested against wheat powdery mildew at 150 grams per hectarecompounds 1.24, 1.25, 2.11, 2.45, 3.22, 13.7, 13.18A, 13.22A, 13.23,14.7,14.18A 14.21, 14,22, 14.23, 14.45, 14.67A, 15.18B, 15.24, 15.26Aand 15.31, exhibited 90% or better control.

When tested against cucumber powdery mildew at a dose of 150 grams perhectare, compounds, 13.18A, 13.20A, 13.22A, 13.23, 13.25A, 13.26, 13.39,13.40A, 13.42A, 13.43, 13.44A, 13.45A, 13.56A, 13.67A, 14.20, 14.22,14.25A, 14.26, 14.31, 14.45, 14.67A, 15.18A, 15,18B, 15.20, 15.22A,15.24, 15.25A, 15.26A, 15.26B, 15.31, 15.45, 15.56A and 15.67A exhibited100 % control.

When tested against tomato late blight at 150 grams/hectare compounds1.11, 1.22, 1.24, 1.25, 2.11, 2.45, 3.22, 13.18A, 13.23, 13.45B, 13.67A,15.21, 15.18A 15.26A, 15.45, 15.67A and 15.67B exhibited 90% or bettercontrol.

When tested against grape downy mildew at 150 grams/hectare compounds2.1, 2.11, 2.14, 13.7, 13.18A, 13.18B, 14.7, 14.18A, 14.21, 15.7,15.18A, 15.18B, 15.25A, and 15.67A exhibited 99% or better control.

When tested against rice blast at 150 grams/hectare compounds1.11,1.22,1.24,1.25, 2.24, 13.18A, 13.18B, 13.23, 13.25A, 13.45A, 14.21,14.18A 14.23, 14.26, 14.45, 15.18A, 15.18B, 15.21, 15.25A, 15.26A,15.26B,16.24, 15.31 and 15.45 exhibited 90% or better control.

When tested against cucumber anthracnose at 150 grams/hectare compounds1.24, 13.18A, 13.18B, 13.23, 13.25A, 13.26, 13.45A, 13.67A, 14.21,14.22, 14.26, 15,7, 15.21, 15.18A, 15.18B,15.25A, 15.26A, 15.26B, 15.45,15.56A and 15.67A exhibited 90% or better control.

When tested against botrytis at 150 grams/hectare compounds 1.22, 3.22,13.22A, 13.26, 14.67B, 15.7 and 15.18A exhibited 85% or better control.

The compounds of this invention are useful as agricultural fungicidesand, as such, can be applied to various loci such as the seed, the soilor the foliage.

The compounds of this invention can be applied as fungicidal sprays bymethods commonly employed, such as conventional high-volume hydraulicsprays, low-volume sprays, air-blast spray, aerial sprays and dusts. Thedilution and rate of application will depend upon the type of equipmentemployed, the method of application, plants to be treated and diseasesto be controlled. Generally, the compounds of this invention will beapplied in amount of from about 0.005 kilogram to about 50 kilograms perhectare and preferably from about 0.025 to about 25 kilograms perhectare of the active ingredient.

As a seed protectant, the amount of toxicant coated on the seed isusually at a dosage rate of from about 0.05 to about 20, preferably fromabout 0.05 to about 4, and more preferably from about 0.1 to about 1grams per hundred kilograms of seed. As a soil fungicide the chemicalcan be incorporated in the soil or applied to the surface usually at arate of from about 0.02 to about 20, preferably from about 0.05 to about10, and more preferably from about 0.1 to about 5 kilograms per hectare.As a foliar fungicide, the toxicant is usually applied to growing plantsat a rate of from about 0.01 to about 10, preferably from about 0.02 to5, and more preferably from about 0.25 to about 1 kilograms per hectare

Inasmuch as the compounds of this invention display fungicidal activity,these compounds can be combined with other known fungicides to providebroad spectrum activity. Suitable fungicides include, but are notlimited to, those compounds listed in U.S. Pat. No. 5,252,594 (see inparticular columns 14 and 15). Other known fungicides which an becombined with the compounds of this invention are dimethomorph,famoxadone, zoxamide, cymoxanil, thifluzamide, furalaxyl, ofurace,benalaxyl, oxadixyl, propamocarb, cyprofuram, fenpiclonil, fludioxonil,pyrimethanil, cyprodinil, triticonazole, fluquinconazole, metconazole,spiroxamine, carpropamid, azoxystrobin, kresoxim-methyl, metominostrobinand trifloxystrobin.

The compounds of this invention can be advantageously employed invarious ways. Since these compounds possess broad spectrum fungicidalactivity, they can be employed in the storage of cereal grain. Thesecompounds can also be employed as fungicides in cereals including wheat,barley and rye, in rice, peanuts, beans and grapes, on turf, in fruit,nut and vegetable orchards, and for golf course applications.

Examples of diseases against which the compounds of the invention areuseful include helminthosporium of corn and barley, wheat and barleypowdery mildew, wheat leaf and stem rusts, tomato early blight, tomatolate blight, peanut early leaf spot, grape powdery mildew, grape blackrot, apple scab, apple powdery mildew, cucumber powdery mildew, brownrot of fruits, botrytis, bean powdery mildew, cucumber anthracnose,wheat septoria nodorum, rice sheath blight and rice blast.

EXAMPLE 12

Numerous compounds of this invention were tested for insecticidalactivity in vivo against the insects described below. The following testmethod was used to evaluate compounds of the present invention forinsecticidal activity. The compound to be evaluated was dissolved in anappropriate solvent, usually a mix of acetone, methanol and water, andsprayed over three excised leaf disks using a flat fan nozzle. Afterspraying, the leaf disks were allowed to dry. A disk was infested withthe leaf chewing insects (southern armyworm) and a second leaf disk wasalready infested with the two-spotted spider mite prior to spraying. Thetested insect species were:

AW southern armyworm Spodoptera eridamia

MTA two-spotted spider mite Teranychus uricate

Observations as percent control were made by visual inspection 24-48hours after spraying.

When tested against southern army worm at 150 grams/hectare compounds13.20A, 13.26, 13.39, 13.40A, 13.42A and 13.45A provided 100% control.

When tested against two-spotted spider mite at 150 grams/hectarecompounds 1.22, 13.20A, 13.22A, 13.26, 13.39, 13.40A, 13.42A, 13.45A,13.56A and 15.20 provided 100% control.

The compositions and compounds of this invention can be applied directlyto the locus to be protected, as for example, the area around or uponeconomic plants infected with insects or to plants on which infestationis to be prevented. Examples of injurious insects belong to the ordersLepidoptera, Coleoptera, Diptera, Thysanoptera, Hymenoptera,Heteroptera, Homoptera, Orthoptera, and Acarina. The compounds andcompositions may be used either as contact or systemic pesticides. Thecompounds of the invention are applied to the insect's habitat at a rateof 0.0005 to 10 kilograms per hectare, preferably 0.05 to 5 and mostpreferably from 0.1 to 1 kilogram per hectare.

In the practice of the method of the invention, the active compound maybe applied to the soil or foliage where it is absorbed by the plant,translocated to other plant parts and ultimately ingested by the pest orinsects by means of ingestion of the plant part(s). This means ofapplication is referred to as systemic application. Alternatively, theactive compound may be applied to the soil and contacted therein withthe insects and other pests to be controlled. This means of applicationis referred to as soil application. In another alternative, the activecompound may be foliarly applied to the plants to be freed from insectsand other pests which feed on the foliage.

Compositions and formulations according to the present invention mayalso include known pesticidal compounds. This expands the spectrum ofactivity of the preparation and may give rise to synergism. Suitableinsecticides known in the art include those listed in U.S. Pat. No.5,075,471, see in particular columns 14 and 15.

The compounds of the present invention can be used in the form ofcompositions or formulations. Examples of the preparation ofcompositions and formulations can be found in the American ChemicalSociety publication “Pesticidal Formulation Research,” (1969), Advancesin Chemistry Series No. 86, written by Wade Van Valkenburg; and theMarcel Dekker, Inc. publication “Pesticide Formulations”, (1973) editedby Wade Van Valkenburg. In these compositions and formulations, theactive substance is mixed with conventional inert agronomicallyacceptable (i.e., plant compatible and/or pesticidally inert) pesticidediluents or extenders such as solid carrier material or liquid carriermaterial, of the type usable in conventional pesticide compositions orformulations. By “agronomically acceptable carrier is meant anysubstance which can be used to dissolve, disperse of diffuse the activeingredient in the composition without impairing the active ingredientseffectiveness and which by itself has no significant detrimental effecton the soil, equipment, desirable plants, or agronomic environment. Ifdesired, adjuvants such as surfactants, stabilizers, antifoam agents andanti-drift agents may also be combined.

Examples of compositions and formulations according to the invention areaqueous solutions and dispersions, oily solutions and oil dispersions,pastes, dusting powders, wettable powders, emulsifiable concentrates,flowables, granules, baits, invert emulsions, aerosol compositions andfumigating candles. Wettable powders, pastes, flowables and emulsifiableconcentrates are concentrated preparations which are diluted with waterbefore or during use. In such formulations, the compounds are extendedwith a liquid or solid carrier and, when desired, suitable surfactantsare incorporated. Baits are preparations generally comprising a food orother substance attractive to insects, that includes at least onecompound of the instant invention.

It is usually desirable, particularly in the case of foliar sprayformulations, to include adjuvants, such as wetting agents, spreadingagents, dispersing agents, stickers, adhesive and the like in accordancewith agricultural practices. Such adjuvants commonly used in the art,and a discussion of adjuvants can be found in many references, such asin the John W. McCutcheon, Inc. publication “Detergents and Emulsifiers,Annual.”

The active compounds of the present invention may be employed alone orin the form of mixtures with one another and/or with such solid and/orliquid dispersible carrier vehicles and/or with other known compatibleactive agents, especially plant protection agents, such as otherinsecticides, arthropodicides, nematicides, fungicides, bactericides,rodenticides, herbicides, fertilizers, growth-regulating agents,synergists.

In the compositions of the invention, the active compound is present inan amount substantially between about 0.0001 (1:999, 999)−99 (99:1) % byweight. For compositions suitable for storage or transportation, theamount of active ingredient is preferably between about 0.5 (1:199)−90(9:1) % by weight, and more preferably between about 1 (1:99)−75 (3:1) %by weight of the mixture. Compositions suitable for direct applicationor field application generally contain the active compound in an amountsubstantially between about 0.0001 (1:999, 999)−95 (19:1) %, preferablybetween about 0.0005 (1:199, 999)−90 (9:1) % by weight, and morepreferably between about 0.001 (1:99, 999)−75 (3:1) % by weight of themixture. The composition can also be stated as a ratio of the compoundto the carrier. In the present invention the weight ratio of thesematerials active compound/carrier) can vary from 99:1 (99%) to 1:4 (20%)and more preferably from 10:1 (91%) to 1:3 (25%).

In general, the compounds of this invention can be dissolved in certainsolvents such as acetone, methanol, ethanol, dimethylformamide, pyridineor dimethyl sulfoxide and such solutions can be diluted with water. Theconcentrations of the solution can vary from about 1% to about 0% with apreferred range being from about 5% to about 50%.

For the preparation of emulsifiable concentrates, the compound can bedissolved in suitable organic solvents, or a mixture of solvents,together with an emulsifying agent to enhance dispersion of the compoundin water. The concentration of the active ingredient in emulsifiableconcentrates is usually from about 10% to about 90%, and in flowableemulsion concentrates, can be as high as about 75%.

Wettable powders suitable for spraying, can be prepared by admixing thecompound with a finely divided solid, such as clays, inorganic silicatesand carbonates, and silicas and incorporating wetting agents, stickingagents, and/or dispersing agents in such mixtures. The concentration ofactive ingredients in such formulations is usually in the range of fromabout 20% to about 99%, preferably from about 40% to about 75%. Atypical wettable powder is made by blending 50 parts of a compound ofFormula I, 45 parts of a synthetic precipitated hydrated silicondioxide, such as that sold under the trademark Hi-Sil®, and 5 parts ofsodium lignosulfonate. In another preparation a kaolin type (Barden)clay is used in place of the Hi-Sil in the above wettable powder, and inanother such preparation 25% of the Hi-Sil is replaced with a syntheticsodium silicoaluminate sold under the trademark Zeolex®7.

Dusts are prepared by mixing compounds of Formula I, or theenantiomorphs, salts and complexes thereof with finely divided inertsolids which can be organic or inorganic in nature. Materials useful forthis purpose include botanical flours, silicas, silicates, carbonatesand clays. One convenient method of preparing a dust is to dilute awettable powder with a finely divided carrier. Dust concentratescontaining from about 20% to about 80% of the active ingredient arecommonly made and are subsequently diluted to from about 1% to about 10%use concentration.

The active compounds can be applied as insecticide sprays by methodscommonly employed, such as conventional high-gallonage hydraulic sprays,low gallonage sprays, ultra-low-volume sprays, air blast spray, aerialsprays, and dusts.

The present invention also contemplates methods of killing, combating orcontrolling pests which compromises contacting pests with a combative ortoxic amount (i.e. a pesticidally effective amount) of at least oneactive compound of the invention alone or together with a carriervehicle (composition or formulation) as noted above. The term contactingas employed in the specification and claims means applying to at leastone of (a) such pests and (b) the corresponding habit at thereof (i.e.,the locus to be protected, for example, to a growing crop or to an areawhere a crop is to be grown) the active compound of this invention aloneor as a constituent of a composition or formulation.

In addition to the aforementioned ingredients the preparations accordingto the invention may also contain other substances commonly used inpreparations of this kind. For example, a lubricant, such as calciumstearate or magnesium stearate, may be added to a wettable powder or toa mixture to be granulated. Furthermore there may, for example, be addedadhesives such as polyvinylalcohol-cellulose derivatives or othercolloidal materials, such as casein, to improve the adherence of thepesticide to the surface to be protected.

We claim:
 1. A compound of the formula:

wherein X is N or CH; Y is O, S or NR₈; A is selected from the groupconsisting of hydrogen, halo, cyano, (C₁-C₁₂)alkyl, and (C₁-C₁₂)alkoxy;Z is O, N—OR₉ or N—R₁₀; R₁ and R₈ are independently selected from thegroup consisting of hydrogen and (C₁-C₄)alkyl; R₂ is selected from thegroup consisting of hydrogen, (C₁-C₁₂)alkyl, halo(C₁-C₁₂)alkyl,(C₃-C₇)cycloalkyl, halo(C₃-C₇)cycloalkyl, (C₂-C₈)alkenyl,halo(C₂-C₈)alkenyl, (C₂-C₈)alkynyl, halo(C₂-C₈)alkynyl, cyano,(C₁-C₄)alkoxycarbonyl, aryl, aralkyl, heterocyclic, andheterocyclic(C₁-C₄)alkyl; R₃ and R₇ are each independently selected fromthe group consisting of hydrogen, (C₁-C₁₂)alkyl, halo(C₁-C₁₂)alkyl,(C₂-C₈)alkenyl, halo(C₂-C₈)alkenyl, (C₂-C₈)alkynyl, halo(C₂-C₈)alkynyl,aryl, aralkyl, heterocyclic and heterocyclic(C₁-C₄)alkyl, provided thatat least one of R₃ and R₇ is aryl, aralkyl, heterocyclic, orheterocyclic(C₁-C₄)alkyl; R₄, R₅ and R₆ are each independently selectedfrom the group consisting of hydrogen, (C₁-C₁₂)alkyl, halo(C₁-C₁₂)alkyl,(C₃-C₇)cycloalkyl, halo(C₃-C₇)cycloalkyl, (C₂-C₈)alkenyl,halo(C₂-C₈)alkenyl, (C₂-C₈)alkynyl, halo(C₂-C₈)alkynyl, halo, cyano,(C₁-C₄)alkoxycarbonyl, aryl, aralkyl, heterocyclic andheterocyclic(C₁-C₄)alkyl; R₉ is selected from the group consisting ofhydrogen, (C₁-C₁₂)alkyl, halo(C₁-C₁₂)alkyl, (C₃-C₇)cycloalkyl,halo(C₃-C₇)cycloalkyl, (C₂-C₈)alkenyl, halo(C₂-C₈)alkenyl,(C₂-C₈)alkynyl, halo(C₂-C₈)alkynyl, (C₁-C₄)alkylcarbonyl, arylcarbonyl,aralkylcarbonyl, heterocyclic carbonyl, (C₁-C₄)alkoxycarbonyl, aryl,aralkyl, heterocyclic and heterocyclic(C₁-C₄)alkyl; R₁₀ is selected fromthe group consisting of hydrogen, (C₁-C₁₂)alkyl, halo(C₁-C₁₂)alkyl,(C₂-C₈)alkenyl, halo(C₂-C₈)alkenyl, (C₂-C₈)alkynyl, halo(C₂-C₈)alkynyl,aryl, aralkyl, heterocyclic or heterocyclic(C₁-C₄)alkyl,(C₁-C₄)alkylcarbonyl, and (C₁-C₄)alkoxycarbonyl, arylcarbonyl,aralkylcarbonyl, heterocyclic carbonyl, (C₁-C₄)alkylaminocarbonyl,arylaminocarbonyl, N—R₈R₉, N═CR₁₁R₁₂, (C₁-C₄)alkylsulfonyl,N=cyclopropyl, N=cyclobutyl, N=cyclopentyl, N=cyclohexyl, N=benzyl, andarylsulfonyl; R₁₁ and R₁₂ are each independently selected from the groupconsisting of hydrogen, (C₁-C₁₂)alkyl, halo(C₁-C₁₂)alkyl,(C₁-C₁₂)alkoxy, halo(C₁-C₁₂)alkoxy, (C₃-C₇)cycloalkyl,halo(C₃-C₇)cycloalkyl, (C₂-C₈)alkenyl, halo(C₂-C₈)alkenyl,(C₂-C₈)alkynyl, halo(C₂-C₈)alkynyl, cyano, (C₁-C₄)alkoxycarbonyl,(C₁-C₄)alkylamino, aryl, aralkyl, heterocyclic, andheterocyclic(C₁-C₄)alkyl.
 2. The compound of claim 1 wherein X is CH, Yis O, Z is NOR₉, R₂ is (C₁-C₁₂)alkyl, and R₃ is H or (C₁-C₄)alkyl. 3.The compound of claim 2 wherein R₉ is (C₁-C₄) and R₇ is selected fromthe group consisting of phenyl, 2-chlorophenyl, 2-fluorophenyl,2-trifluoromethylphenyl, 3-chlorophenyl, 3-fluorophenyl,3-trifluoromethylphenyl, 4-chlorophenyl, 4-fluorophenyl,4-trifluoromethylphenyl 2,4-dichlorophenyl, and 2,6-dichlorophenyl. 4.The compound of claim 1 wherein X is N, Y is O or NH, Z is NOR₉, R₂ is(C₁-C₁₂)alkyl, and R₃ is H or (C₁-C₄)alkyl.
 5. The compound of claim 4wherein R₉ is (C₁-C₄) and R₇ is selected from the group consisting ofphenyl, 2-chlorophenyl, 2-fluorophenyl, 2-trifluoromethylphenyl,3-chlorophenyl, 3-fluorophenyl, 3-trifluoromethylphenyl, 4-chlorophenyl,4-fluorophenyl, 4-trifluoromethylphenyl, 2,4-dichlorophenyl, and2,6-dichlorophenyl.
 6. The compound of claim 1 where the compound iswhere the compound is N-methyl2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]-2-methoxyiminoacetamide.7. The compound of claim 1 where the compound is N-methyl2-[2-(5-trans-(2-(4-chlorophenyl)cyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]-2-methoxyiminoacetamide.8. A fungicidal composition for controlling phytopathogenic fungi whichcomprises an agronomically acceptable carrier and the compound of claim1 wherein the ratio of the carrier to the compound is between 99:1 and1:4.
 9. A method for controlling phytopathogenic fungi which comprisesapplying the compound of claim 1 to the locus where control is desired,at a rate of from 0.005 to 50 kilograms per hectare.
 10. A method forcontrolling insects which comprises applying to the insects' habitat thecompound of claim 1 at a rate of from 0.005 to 10 kilograms per hectare.